间苯三酚治疗体外受精-胚胎移植助孕后阴道流血患者的临床研究
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摘要
目的研究间苯三酚在体外受精-胚胎移植助孕后出现阴道流血患者的治疗作用。方法选取2015-01~2017-01该院行体外受精-胚胎移植助孕后获得宫内临床单胎妊娠,且在孕12周之前出现阴道流血及伴有腹痛症状的患者为研究对象。纳入研究对象的患者共计84例,随机分为对照组和研究组各42例。对照组实行单纯黄体支持用药方案。研究组在黄体支持用药的同时给予间苯三酚注射液治疗。观察比较两组患者阴道流血改善情况、腹痛症状缓解情况、不良反应发生情况和患者妊娠结局(包括两组患者的流产率、活产率及新生儿畸形率)等情况。结果研究组患者腹痛缓解及阴道流血情况改善明显,与对照组比较差异均有统计学意义(P<0.05),且无不良反应发生;两组的流产率、活产率比较差异均无统计学意义(P>0.05),两组均无畸形儿出生。结论间苯三酚可以有效地改善体外受精-胚胎移植助孕后阴道流血患者的症状,安全有效。
Objective To study the clinical effectiveness of phloroglucinol in treatment of vaginal bleeding after in-vitro fertilization and embryo transfer. Methods 84 patients suffered from vaginal bleeding and abdominal pain after in-vitro fertilization and embryo transfer were collected in the People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to January 2017 and were randomly divided into the control group and the research group,with 42 cases in each group. The patients in the control group were treated with progesterone alone,and those in the research group were treated with progesterone and phloroglucinol simultaneously. The adverse reactions,the improvements of clinical symptoms such as vaginal bleeding and abdominal pain were observed and compared between the two groups. The pregnancy outcomes such as abortion rate,live birth rate and neonatal malformation rate were compared between the two groups. Results The improvements of vaginal bleeding and abdominal pain in the research group were better than those in the control group( P < 0. 05). No adverse reactions were observed in both of the two groups. There were no significant differences in the abortion rate and live birth rate between the two groups( P >0. 05). The malformed newborn was not founded in both of the two groups. Conclusion Phloroglucinol is safe and effective in improving the clinical symptoms of vaginal bleeding after in-vitro fertilization and embryo transfer.
Objective To study the clinical effectiveness of phloroglucinol in treatment of vaginal bleeding after in-vitro fertilization and embryo transfer. Methods 84 patients suffered from vaginal bleeding and abdominal pain after in-vitro fertilization and embryo transfer were collected in the People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to January 2017 and were randomly divided into the control group and the research group,with 42 cases in each group. The patients in the control group were treated with progesterone alone,and those in the research group were treated with progesterone and phloroglucinol simultaneously. The adverse reactions,the improvements of clinical symptoms such as vaginal bleeding and abdominal pain were observed and compared between the two groups. The pregnancy outcomes such as abortion rate,live birth rate and neonatal malformation rate were compared between the two groups. Results The improvements of vaginal bleeding and abdominal pain in the research group were better than those in the control group( P < 0. 05). No adverse reactions were observed in both of the two groups. There were no significant differences in the abortion rate and live birth rate between the two groups( P >0. 05). The malformed newborn was not founded in both of the two groups. Conclusion Phloroglucinol is safe and effective in improving the clinical symptoms of vaginal bleeding after in-vitro fertilization and embryo transfer.
引文
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2 王冬梅,严倩,曲绪琴,等.体外受精-胚胎移植后妇女的妊娠结局[J].泰山医学院学报,2013,34(8):598-600.
3 杨帅,付婷婷,刘冰.体外受精-胚胎移植先兆流产患者妊娠结局的探讨[J].中华临床医师杂志(电子版),2013,7(17):8003-8004.
4 卢瑾文,杨菁,尹太郎,等.体外受精-胚胎移植后阴道出血原因及临床转归分析[J].武汉大学学报(医学版),2009,30(5):660-662.
5 Pasch LA,Gregorich SE,Katz PK,et al.Psychological distress and in vitro fertilization outcome[J].Fertil Steril,2012,98(2):459-464.
6 徐丽平,杨广清,吴方贵,等.体外受精-胚胎移植不同阶段焦虑、抑郁情绪与治疗结局的相关性[J].现代临床护理,2014,13(5):27-30.
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8 朱亮,全松,邢福祺.体外受精-胚胎移植后单胎妊娠自然流产相关因素分析[J].广东医学,2007,28(10):1558-1560.
9 Zhu L,Li Y,Xu A.Influence of controlled ovarian hyperstimulation on uterine peristalsis in infertile women[J].Hum Reprod,2012,27(9):2684-2689.
10 Fanchin R,Ayoubi JM,Righini C,et al.Uterine contractility decreases at the time of blastocyst transfers[J].Hum Reprod,2001,16(6):1115-1119.
11 Kido A,Togashi K,Hatayama H,et al.Uterine peristalsis in women with repeated IVF failures:possible therapeutic effect of hyoscine bromide[J].Obstet Gynaecol Can,2009,31(8):732-735.
12 王泳晓,周娟,何丽亚,等.间苯三酚与黄体酮联合治疗先兆流产合并绒毛膜下血肿的临床分析[J].实用中西医结合临床,2014,14(6):19-21.
13 Moraloglu O,Tonguc E,Var T,et al.Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF[J].Reprod Biomed Online,2010,21(3):338-343.
14 李健和,易利丹,彭六保,等.间苯三酚的药理作用与临床应用[J].中国新药与临床杂志,2011,30(7):494-499.
15 Andersen FA.Amended final safety assessment of polyvinyl acetate[J].Int J Toxicol,1996(2):166-176.
16 刘梅兰,陈慧,范涛,等.间苯三酚用于妊娠20周前先兆流产治疗的多中心临床研究[J].热带医学杂志,2013,13(8):961-963.
17 李欧.间苯三酚对孕20周前先兆流产治疗效果的影响分析[J].中国卫生标准管理,2016,7(16):98-99.
18 王兴红.间苯三酚治疗晚期先兆流产30例临床观察[J].中国临床新医学,2009,2(12):1303-1304.
19 Xu A,Li Y,Zhu L,et al.Inhibition of endometrial fundocervical wave by phloroglucinol and the outcome of in vitro fertilization[J].Reprod Biol,2013,13(1):88-91.
2 王冬梅,严倩,曲绪琴,等.体外受精-胚胎移植后妇女的妊娠结局[J].泰山医学院学报,2013,34(8):598-600.
3 杨帅,付婷婷,刘冰.体外受精-胚胎移植先兆流产患者妊娠结局的探讨[J].中华临床医师杂志(电子版),2013,7(17):8003-8004.
4 卢瑾文,杨菁,尹太郎,等.体外受精-胚胎移植后阴道出血原因及临床转归分析[J].武汉大学学报(医学版),2009,30(5):660-662.
5 Pasch LA,Gregorich SE,Katz PK,et al.Psychological distress and in vitro fertilization outcome[J].Fertil Steril,2012,98(2):459-464.
6 徐丽平,杨广清,吴方贵,等.体外受精-胚胎移植不同阶段焦虑、抑郁情绪与治疗结局的相关性[J].现代临床护理,2014,13(5):27-30.
7 Lathi RB,Milki AA.Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection[J].Fertil Steril,2004,81(5):1270-1272.
8 朱亮,全松,邢福祺.体外受精-胚胎移植后单胎妊娠自然流产相关因素分析[J].广东医学,2007,28(10):1558-1560.
9 Zhu L,Li Y,Xu A.Influence of controlled ovarian hyperstimulation on uterine peristalsis in infertile women[J].Hum Reprod,2012,27(9):2684-2689.
10 Fanchin R,Ayoubi JM,Righini C,et al.Uterine contractility decreases at the time of blastocyst transfers[J].Hum Reprod,2001,16(6):1115-1119.
11 Kido A,Togashi K,Hatayama H,et al.Uterine peristalsis in women with repeated IVF failures:possible therapeutic effect of hyoscine bromide[J].Obstet Gynaecol Can,2009,31(8):732-735.
12 王泳晓,周娟,何丽亚,等.间苯三酚与黄体酮联合治疗先兆流产合并绒毛膜下血肿的临床分析[J].实用中西医结合临床,2014,14(6):19-21.
13 Moraloglu O,Tonguc E,Var T,et al.Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF[J].Reprod Biomed Online,2010,21(3):338-343.
14 李健和,易利丹,彭六保,等.间苯三酚的药理作用与临床应用[J].中国新药与临床杂志,2011,30(7):494-499.
15 Andersen FA.Amended final safety assessment of polyvinyl acetate[J].Int J Toxicol,1996(2):166-176.
16 刘梅兰,陈慧,范涛,等.间苯三酚用于妊娠20周前先兆流产治疗的多中心临床研究[J].热带医学杂志,2013,13(8):961-963.
17 李欧.间苯三酚对孕20周前先兆流产治疗效果的影响分析[J].中国卫生标准管理,2016,7(16):98-99.
18 王兴红.间苯三酚治疗晚期先兆流产30例临床观察[J].中国临床新医学,2009,2(12):1303-1304.
19 Xu A,Li Y,Zhu L,et al.Inhibition of endometrial fundocervical wave by phloroglucinol and the outcome of in vitro fertilization[J].Reprod Biol,2013,13(1):88-91.