干扰素的抗纤维化作用在眼部应用的研究进展
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摘要
纤维修复可有助于恢复组织的正常结构,但又可导致瘢痕的形成。抗纤维化的药物有很多种,其中干扰素(IFN)是一种生物制剂,在临床上能够很好地治疗纤维瘢痕性疾病。本文主要回顾干扰素的生物学特性和抗纤维化机制,分析常用抗纤维化药物的作用效果及不良反应,总结干扰素在眼部的抗纤维化作用,探讨了干扰素应用的新进展。
Fiber repair can help to restore the normal structure of organization, but can lead to the formation of scar. There are several kinds of anti fibrosis drug.Interferon(IFN) is a kind of biological agents,and it is well to treat fibrous scar disease in the clinical. Here is to review the biological characteristics and anti fibrosis mechanisms of interferon, analyze the effects and adverse reactions of anti fibrosis drug, summarize the anti fibrosis effects of interferon in ocular, and introduce the application progress of interferon.
Fiber repair can help to restore the normal structure of organization, but can lead to the formation of scar. There are several kinds of anti fibrosis drug.Interferon(IFN) is a kind of biological agents,and it is well to treat fibrous scar disease in the clinical. Here is to review the biological characteristics and anti fibrosis mechanisms of interferon, analyze the effects and adverse reactions of anti fibrosis drug, summarize the anti fibrosis effects of interferon in ocular, and introduce the application progress of interferon.
引文
[1]Euncan MR,Berman B.Gamma interferon in the lymphokine and beta interferon the monokine responsible for inhitition of fibroblast collagen production and late but not early fibroblast proliferation.J Exp Med,1985,162:516-527
[2]Latina MA,Belmonte SJ,Park C,et al.Gamma interferon effects on human fibroblasts from Tenon”s capsule.Invest Ophthalmol Vis Sci,1991,32:2806-2815
[3]迟惠,费兴波,赖炽香.干扰素对兔小梁切除术后滤过泡的影响.中华眼科杂志,1995,31:218-220
[4]胡楠,邱孝芝,龚启荣,等.干扰素抑制晶状体上皮的实验研究.中华眼科杂志,1999,35:107-109
[5]辛晓蓉,李敏.γ-干扰素对肿瘤坏死因子α促进牛晶状体上皮细胞增殖的抑制作用.眼科新进展,2003,23(1):27-29
[6]熊新春,杜蜀华,魏厚仁.干扰素α-2b对结膜下成纤维细胞生长形态的影响.眼科,1999,8(4):233-234
[7]Kahari VW,Heino J,Vuorio T,et al.Interferon-αand interferon-γreduce excessive collagen synthesis and procollagen m RNA levels of scleroderma fibroblasts in culture.Biochem Biophys Acta,1988,968:45
[8]Beresford JN,Taylor GT,Triffitt J T,et al.Interferon and bone-a comparison of the effects of interferon-αand interferon-γin cultures of human bone-derived cells and an osteosarcoma cell line.Eur J Biochem,1990,193:589
[9]Giraud JP,Pouliquen Y,Offret G,et al.Statistical morphometric studies in normal human and rabbit corneal stroma.Exp Eye Res1975;21:221
[10]Last JA,Armstrong LG,Reiser KM,et al.Biosynthesis of collagen crossliks[J].Int J Biochem,1990,22(6):559
[11]Desmouliere A,Rubbia Brandi L,Abdiu A,et al.Alpha-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblast and is modulated by gamma-interferon[J].Exp Cell Res,1992,201(1):64.
[12]Park SC,Kim JH.Effect of steroids and nonsteroidal anti-inflammatory agents on stromal wound healing following excimer keratectomy in rabbits.Ophthalmic Surg Lasers,1996,27:481-486
[13]张明昌,李斌,胡燕华,严浩.干扰素α-2b治疗准分子激光角膜切削术后角膜上皮下混浊的实验研究.中华眼科杂志,2003,39:146-149.
[14]钟一声,王康孙.肝素和干扰素对角膜基质细胞的影响.眼外伤职业眼病杂志,1999,21(4):302-304
[15]孙兴才,吴静安,李海丽.γ-干扰素对人角膜基质细胞I、III型胶原合成的抑制作用.中国实用眼科杂志,1997,15(12):720-722
[16]林乐理,贾广学,陈军.干扰素抑制角膜新生血管的实验研究.中国实用眼科杂志,2003,21(7):加页9-加页10
[17]Detroakis ET,Sourvinos G,Spandidos DA.Detection of herpes simplex virus and human papilloma virus in ophthalmic pterygium.Cornea,2001,20:164-167
[18]Hill JC,Maske R.Pathogenesis of pterygium.Eye,1989,3:218-226
[19]吕明,张晓农.重组人干扰素α1b滴眼液对体外培养翼状胬肉成纤维细胞增殖的影响.临床眼科杂志,2002,10(6):506-509
[20]王涛.γ-干扰素在青光眼滤过性手术伤口愈合中的调节作用[J].国外医学眼科学分册1999;23(5):266-270
[21]陈松.青光眼滤过性手术中抗瘢痕形成药物的研究近况[J]国外医学眼科学分册1994;19(4):193-203
[22]Gilies MC.Su T.Reduction of in vitro retinal microvascular permeability by interferon[J].Invest Ophthalmol Vis Sci 1994;35:2087
[23]杨松林,王力强,周骏.干扰素对瘢痕成纤维细胞的生物学作用[J].中华整形外科杂志1998;14(2):107-109
[24]张秀兰,彭大伟,曾淑君,郑湖玲.干扰素α-2b对兔眼角膜毒性的实验研究.中国实用眼科杂志,1998,16(3):141-142
[25]田杰,刘新昌,赵素贞.青光眼滤过术中γ-干扰素抗增殖作用的临床观察.眼科新进展,2003,23(4):274-275
[26]Lundgren B,Ocklind A,Holst A,Harfatrand A.Inflammatory response in the rabbit eye after intraocular implantation with poly(methyl methacrylate)and heparin surface modified intraocular lenses[J].J Cataract Refract Surg 1992;18:65-70
[27]Ueno H,Wariishi S,Moriki T,Yagvu K.Floating cells in anterior chamber after IOL implantation[J].Jpn J Ophthalmol 1991;35:359
[28]周朝晖,何守志,陈香美,陈中华.人工晶体植入术后房水肿瘤坏死因子和白细胞介素1含量的研究[J].中华眼科杂志1996;32(5):301-303.
[29]张士胜,王康孙,李贵仁.肿瘤坏死因子与眼部疾病[J].国外医学眼科学分册2001;25(3):176-181
[30]胡楠,桑爱民,吴坚,朱蓉嵘,陈辉,管怀进.眼内应用γ-干扰素防治白内障的实验研究.眼视光学杂志,2003,5(4):212-214
[31]李锦文,Leonard M Hjelmeland.γ干扰素防治增殖性玻璃体视网膜病变的实验研究.眼科研究,1993,11(4):259-261
[32]Kertes PJ,Britton WA,Addison DJ,et al.Toxicity of intravitreal interferon alpha-2b.Invest Ophthalmol Vis Sci,1994,35(4):1534
[33]Fung WE.Am J Ophthalmol.1991,112:349
[34]Engler C et al.Br J Ophthalmol.1994,78:749
[35]Miller JM et al.Ophthalmol.1993,100:2
[36]李亚萍,孙大军,刘早霞,张晓光,拱中华.干扰素-α、干扰素-γ对视网膜新生血管抑制作用的对比研究.中华实验诊断学,2001,8(6):669-670
[37]Kawase K,Nishimura K,Yamamoto T,et al.Anterior chamber reaction after mitomycin and 5-flurouracil trabeculectomy:a comparative study Ophthalmic Surg,1993,24(1):24
[38]孙春茗.638例干扰素的不良反应分析.天津药学,2002,14(2):30-31
[39]Yamada H,Mizobuchi K,Isogai Y.Acute onset of ocular complications with interferon[J].Lancet,1994,343(8902):914.
[40]杜军.干扰素治疗与眼底出血[J].国外医学·老年医学分册,1995,16(4):189-190
[41]卢立标,包香英,何富强.干扰素在临床应用中的副作用[J].广西医学,2003,25(4):572-574
[42]Rinehart JJ,Malspeis L,Young D,et al.Phase I/II trial of human recombinant interferon gamma in renal cell carcinoma[J].J Boil Response Mod,1986,5(4):300-308
[2]Latina MA,Belmonte SJ,Park C,et al.Gamma interferon effects on human fibroblasts from Tenon”s capsule.Invest Ophthalmol Vis Sci,1991,32:2806-2815
[3]迟惠,费兴波,赖炽香.干扰素对兔小梁切除术后滤过泡的影响.中华眼科杂志,1995,31:218-220
[4]胡楠,邱孝芝,龚启荣,等.干扰素抑制晶状体上皮的实验研究.中华眼科杂志,1999,35:107-109
[5]辛晓蓉,李敏.γ-干扰素对肿瘤坏死因子α促进牛晶状体上皮细胞增殖的抑制作用.眼科新进展,2003,23(1):27-29
[6]熊新春,杜蜀华,魏厚仁.干扰素α-2b对结膜下成纤维细胞生长形态的影响.眼科,1999,8(4):233-234
[7]Kahari VW,Heino J,Vuorio T,et al.Interferon-αand interferon-γreduce excessive collagen synthesis and procollagen m RNA levels of scleroderma fibroblasts in culture.Biochem Biophys Acta,1988,968:45
[8]Beresford JN,Taylor GT,Triffitt J T,et al.Interferon and bone-a comparison of the effects of interferon-αand interferon-γin cultures of human bone-derived cells and an osteosarcoma cell line.Eur J Biochem,1990,193:589
[9]Giraud JP,Pouliquen Y,Offret G,et al.Statistical morphometric studies in normal human and rabbit corneal stroma.Exp Eye Res1975;21:221
[10]Last JA,Armstrong LG,Reiser KM,et al.Biosynthesis of collagen crossliks[J].Int J Biochem,1990,22(6):559
[11]Desmouliere A,Rubbia Brandi L,Abdiu A,et al.Alpha-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblast and is modulated by gamma-interferon[J].Exp Cell Res,1992,201(1):64.
[12]Park SC,Kim JH.Effect of steroids and nonsteroidal anti-inflammatory agents on stromal wound healing following excimer keratectomy in rabbits.Ophthalmic Surg Lasers,1996,27:481-486
[13]张明昌,李斌,胡燕华,严浩.干扰素α-2b治疗准分子激光角膜切削术后角膜上皮下混浊的实验研究.中华眼科杂志,2003,39:146-149.
[14]钟一声,王康孙.肝素和干扰素对角膜基质细胞的影响.眼外伤职业眼病杂志,1999,21(4):302-304
[15]孙兴才,吴静安,李海丽.γ-干扰素对人角膜基质细胞I、III型胶原合成的抑制作用.中国实用眼科杂志,1997,15(12):720-722
[16]林乐理,贾广学,陈军.干扰素抑制角膜新生血管的实验研究.中国实用眼科杂志,2003,21(7):加页9-加页10
[17]Detroakis ET,Sourvinos G,Spandidos DA.Detection of herpes simplex virus and human papilloma virus in ophthalmic pterygium.Cornea,2001,20:164-167
[18]Hill JC,Maske R.Pathogenesis of pterygium.Eye,1989,3:218-226
[19]吕明,张晓农.重组人干扰素α1b滴眼液对体外培养翼状胬肉成纤维细胞增殖的影响.临床眼科杂志,2002,10(6):506-509
[20]王涛.γ-干扰素在青光眼滤过性手术伤口愈合中的调节作用[J].国外医学眼科学分册1999;23(5):266-270
[21]陈松.青光眼滤过性手术中抗瘢痕形成药物的研究近况[J]国外医学眼科学分册1994;19(4):193-203
[22]Gilies MC.Su T.Reduction of in vitro retinal microvascular permeability by interferon[J].Invest Ophthalmol Vis Sci 1994;35:2087
[23]杨松林,王力强,周骏.干扰素对瘢痕成纤维细胞的生物学作用[J].中华整形外科杂志1998;14(2):107-109
[24]张秀兰,彭大伟,曾淑君,郑湖玲.干扰素α-2b对兔眼角膜毒性的实验研究.中国实用眼科杂志,1998,16(3):141-142
[25]田杰,刘新昌,赵素贞.青光眼滤过术中γ-干扰素抗增殖作用的临床观察.眼科新进展,2003,23(4):274-275
[26]Lundgren B,Ocklind A,Holst A,Harfatrand A.Inflammatory response in the rabbit eye after intraocular implantation with poly(methyl methacrylate)and heparin surface modified intraocular lenses[J].J Cataract Refract Surg 1992;18:65-70
[27]Ueno H,Wariishi S,Moriki T,Yagvu K.Floating cells in anterior chamber after IOL implantation[J].Jpn J Ophthalmol 1991;35:359
[28]周朝晖,何守志,陈香美,陈中华.人工晶体植入术后房水肿瘤坏死因子和白细胞介素1含量的研究[J].中华眼科杂志1996;32(5):301-303.
[29]张士胜,王康孙,李贵仁.肿瘤坏死因子与眼部疾病[J].国外医学眼科学分册2001;25(3):176-181
[30]胡楠,桑爱民,吴坚,朱蓉嵘,陈辉,管怀进.眼内应用γ-干扰素防治白内障的实验研究.眼视光学杂志,2003,5(4):212-214
[31]李锦文,Leonard M Hjelmeland.γ干扰素防治增殖性玻璃体视网膜病变的实验研究.眼科研究,1993,11(4):259-261
[32]Kertes PJ,Britton WA,Addison DJ,et al.Toxicity of intravitreal interferon alpha-2b.Invest Ophthalmol Vis Sci,1994,35(4):1534
[33]Fung WE.Am J Ophthalmol.1991,112:349
[34]Engler C et al.Br J Ophthalmol.1994,78:749
[35]Miller JM et al.Ophthalmol.1993,100:2
[36]李亚萍,孙大军,刘早霞,张晓光,拱中华.干扰素-α、干扰素-γ对视网膜新生血管抑制作用的对比研究.中华实验诊断学,2001,8(6):669-670
[37]Kawase K,Nishimura K,Yamamoto T,et al.Anterior chamber reaction after mitomycin and 5-flurouracil trabeculectomy:a comparative study Ophthalmic Surg,1993,24(1):24
[38]孙春茗.638例干扰素的不良反应分析.天津药学,2002,14(2):30-31
[39]Yamada H,Mizobuchi K,Isogai Y.Acute onset of ocular complications with interferon[J].Lancet,1994,343(8902):914.
[40]杜军.干扰素治疗与眼底出血[J].国外医学·老年医学分册,1995,16(4):189-190
[41]卢立标,包香英,何富强.干扰素在临床应用中的副作用[J].广西医学,2003,25(4):572-574
[42]Rinehart JJ,Malspeis L,Young D,et al.Phase I/II trial of human recombinant interferon gamma in renal cell carcinoma[J].J Boil Response Mod,1986,5(4):300-308