棉尾兔乳头瘤病毒(CRPV)蛋白质组学及相关肿瘤发生的研究（英文）
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摘要
棉尾兔乳头瘤病毒(CRPV)是由Shope RE.在1933发现的首个哺乳动物DNA肿瘤病毒.CRPV感染会引起棉尾兔头颈部腺瘤,使之成为欧美传说"勇士兔"的原型.本篇综述讨论了CRPV的蛋白质组学,以及相关蛋白在肿瘤发生中的作用.CRPV属于乳头瘤病毒家族,与人类乳头瘤病毒(HPV)存在同源性.CRPV不具封套,由7868个碱基对形成环状双股脱氧核糖核酸,并由衣壳包裹.蛋白质组由非结构性早期调节蛋白和结构性后期蛋白组成,其中早期调节蛋白E7和E2在肿瘤形成和发展中起到关键作用.由于其与HPV的同源性,CRPV在研究乳头瘤病毒感染以及病毒相关的肿瘤学中有广泛应用.
Cottontail Rabbit Papillomavirus(CRPV)is the first mammalian DNA tumor virus discovered in 1933 by Shope RE.CRPV-infection symptoms include head-neck carcinogenesis in sulvilagus,which became the prototype of the Jackalope fairy tale.In this paper,the proteome of CRPV and its roles in related tumorigenesis are discussed.CRPV belongs to the papillomaviridae family and has homology with Human Papillomavirus(HPV).It is non-enveloped and has a circular dsDNA of 7868 base pairs wrapped up by capsid.Its genome yields two classes of proteins,the non-structural regulatory early proteins and the structural late proteins,among which the E7 and E2 proteins are essential for papilloma development and tumorigenesis.CRPV infection is a widely used model to study the papillomavirus infection and virus-mediate carcinoma progress for its homology with HPV.
Cottontail Rabbit Papillomavirus(CRPV)is the first mammalian DNA tumor virus discovered in 1933 by Shope RE.CRPV-infection symptoms include head-neck carcinogenesis in sulvilagus,which became the prototype of the Jackalope fairy tale.In this paper,the proteome of CRPV and its roles in related tumorigenesis are discussed.CRPV belongs to the papillomaviridae family and has homology with Human Papillomavirus(HPV).It is non-enveloped and has a circular dsDNA of 7868 base pairs wrapped up by capsid.Its genome yields two classes of proteins,the non-structural regulatory early proteins and the structural late proteins,among which the E7 and E2 proteins are essential for papilloma development and tumorigenesis.CRPV infection is a widely used model to study the papillomavirus infection and virus-mediate carcinoma progress for its homology with HPV.
引文
[1]Escudero Duch,C.,Williams,R.A.,Timm,R.M.,Perez-Tris,J.,and Benitez,L.A Century of Shope Papillomavirus in Museum Rabbit Specimens[J].PloSone2015,(07).
[2]Shope,R.E.,and Hurst,E.W.INFECTIOUS PAP-ILLOMATOSIS OF RABBITS:WITH A NOTE ON THEHISTOPATHOLOGY[J].The Journal of experimental medicine 1933,(58):607-624.
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[4]Giri,I.,Danos,O.,and Yaniv,M.Genomic structure of the cottontail rabbit(Shope)papillomavirus[J].Proceedings of the National Academy of Sciences of the U-nited States of America,1985,(82):1580-1584.
[5]Peh,W.L.,Brandsma,J.L.,Christensen,N.D.,Cladel,N.M.,Wu,X.,and Doorbar,J.The viral E4protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo[J].Journal of virology,2004,(78):2142-2151.
[6]Jeckel,S.,Loetzsch,E.,Huber,E.,Stubenrauch,F.,and Iftner,T.Identification of the E9/E2CcDNAand functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus[J].Journal of virology,2003,(77):8736-8744.
[7]Jeckel,S.,Huber,E.,Stubenrauch,F.,and Iftner,T.(2002)A transactivator function of cottontail rabbit papillomavirus e2is essential for tumor induction in rabbits[J].Journal of virology,2002,(76):11209-11215.
[8]Brandsma,J.L.,Yang,Z.H.,Barthold,S.W.,and Johnson,E.A.Use of a rapid,efficient inoculation method to induce papillomas by cottontail rabbit papillomavirus DNA shows that the E7gene is required[J].Proceedings of the National Academy of Sciences of the United States of America,1991,(88):4816-4820.
[9]Hu,J.,Budgeon,L.R.,Balogh,K.K.,Peng,X.,Cladel,N.M.,and Christensen,N.D.Longpeptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1transgenic rabbits[J].Trials in vaccinology,2014,(3):134-142.
[10]Kalnin,K.,Tibbitts,T.,Yan,Y.,Stegalkina,S.,Shen,L.,Costa,V.,Sabharwal,R.,Anderson,S.F.,Day,P.M.,Christensen,N.,Schiller,J.T.,Jagu,S.,Roden,R.B.,Almond,J.,and Kleanthous,H.Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes[J].Vaccine,2014,(32):3540-3547.
[11]Wurdak,M.,Schneider,M.,Iftner,T.,and Stubenrauch,F.The contribution of SP100to cottontail rabbit papillomavirus transcription and replication[J].The Journal of general virology,2018,(99):344-345.
[12]Christensen,N.D.,Budgeon,L.R.,Cladel,N.M.,and Hu,J.Recent advances in preclinical model systems for papillomaviruses[J].Virus research,2017,(231):108-118.
[13]Jagu,S.,Karanam,B.,Wang,J.W.,Zayed,H.,Weghofer,M.,Brendle,S.A.,Balogh,K.K.,Tossi,K.P.,Roden,R.B.S.,and Christensen,N.D.Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adenoassociated virus-like particle immunogen displaying L2 17-36epitopes[J].Vaccine,2015,(33):5553-5563.
[14]Probst-Hunczek,S.,Jager,G.,Schneider,M.,Notz,E.,Stubenrauch,F.,and Iftner,T.RNA sequencing analysis identifies novel spliced transcripts but does not indicate quantitative or qualitative changes of viral transcripts during progression of cottontail rabbit papillomavirus-induced tumours[J].The Journal of general virology,2015,(96):3083-3089.
[15]Schneider,M.,Yigitliler,A.,Stubenrauch,F.,and Iftner,T.Cottontail Rabbit Papillomavirus E1and E2Proteins Mutually Influence Their Subcellular Localizations[J].Journal of virology,2018,(92).
[2]Shope,R.E.,and Hurst,E.W.INFECTIOUS PAP-ILLOMATOSIS OF RABBITS:WITH A NOTE ON THEHISTOPATHOLOGY[J].The Journal of experimental medicine 1933,(58):607-624.
[3]Rous,P.,and Beard,J.W.THE PROGRESSIONTO CARCINOMA OF VIRUS-INDUCED RABBITPAPILLOMAS(SHOPE)[J].The Journal of experimental medicine,1935.(62):523-548.
[4]Giri,I.,Danos,O.,and Yaniv,M.Genomic structure of the cottontail rabbit(Shope)papillomavirus[J].Proceedings of the National Academy of Sciences of the U-nited States of America,1985,(82):1580-1584.
[5]Peh,W.L.,Brandsma,J.L.,Christensen,N.D.,Cladel,N.M.,Wu,X.,and Doorbar,J.The viral E4protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo[J].Journal of virology,2004,(78):2142-2151.
[6]Jeckel,S.,Loetzsch,E.,Huber,E.,Stubenrauch,F.,and Iftner,T.Identification of the E9/E2CcDNAand functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus[J].Journal of virology,2003,(77):8736-8744.
[7]Jeckel,S.,Huber,E.,Stubenrauch,F.,and Iftner,T.(2002)A transactivator function of cottontail rabbit papillomavirus e2is essential for tumor induction in rabbits[J].Journal of virology,2002,(76):11209-11215.
[8]Brandsma,J.L.,Yang,Z.H.,Barthold,S.W.,and Johnson,E.A.Use of a rapid,efficient inoculation method to induce papillomas by cottontail rabbit papillomavirus DNA shows that the E7gene is required[J].Proceedings of the National Academy of Sciences of the United States of America,1991,(88):4816-4820.
[9]Hu,J.,Budgeon,L.R.,Balogh,K.K.,Peng,X.,Cladel,N.M.,and Christensen,N.D.Longpeptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1transgenic rabbits[J].Trials in vaccinology,2014,(3):134-142.
[10]Kalnin,K.,Tibbitts,T.,Yan,Y.,Stegalkina,S.,Shen,L.,Costa,V.,Sabharwal,R.,Anderson,S.F.,Day,P.M.,Christensen,N.,Schiller,J.T.,Jagu,S.,Roden,R.B.,Almond,J.,and Kleanthous,H.Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes[J].Vaccine,2014,(32):3540-3547.
[11]Wurdak,M.,Schneider,M.,Iftner,T.,and Stubenrauch,F.The contribution of SP100to cottontail rabbit papillomavirus transcription and replication[J].The Journal of general virology,2018,(99):344-345.
[12]Christensen,N.D.,Budgeon,L.R.,Cladel,N.M.,and Hu,J.Recent advances in preclinical model systems for papillomaviruses[J].Virus research,2017,(231):108-118.
[13]Jagu,S.,Karanam,B.,Wang,J.W.,Zayed,H.,Weghofer,M.,Brendle,S.A.,Balogh,K.K.,Tossi,K.P.,Roden,R.B.S.,and Christensen,N.D.Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adenoassociated virus-like particle immunogen displaying L2 17-36epitopes[J].Vaccine,2015,(33):5553-5563.
[14]Probst-Hunczek,S.,Jager,G.,Schneider,M.,Notz,E.,Stubenrauch,F.,and Iftner,T.RNA sequencing analysis identifies novel spliced transcripts but does not indicate quantitative or qualitative changes of viral transcripts during progression of cottontail rabbit papillomavirus-induced tumours[J].The Journal of general virology,2015,(96):3083-3089.
[15]Schneider,M.,Yigitliler,A.,Stubenrauch,F.,and Iftner,T.Cottontail Rabbit Papillomavirus E1and E2Proteins Mutually Influence Their Subcellular Localizations[J].Journal of virology,2018,(92).