长链非编码RNA参与心肌缺血再灌注损伤的研究进展
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摘要
心肌梗死后的再灌注治疗有效保护了心肌,却造成了心肌缺血再灌注损伤。近来大量的研究证实,长链非编码RNA参与了心肌缺血再灌注损伤的病理过程,长链非编码RNA可以通过调节基因表达调节心肌细胞坏死、凋亡、自噬,长链非编码RNA可以调节心肌梗死后心律失常,长链非编码RNA也可以作为心肌梗死的临床诊断标志物及治疗靶点。本文将对长链非编码RNA参与心肌缺血再灌注损伤的研究进展作一综述。
Reperfusion therapy after myocardial infarction effectively protects the myocardium,but it causes myocardial ischemia-reperfusion injury.A large number of recent studies have confirmed that long non-coding RNA is involved in the pathological process of myocardial ischemia-reperfusion injury,long non-coding RNA can regulate cardiomyocyte necrosis,apoptosis,autophagy by regulating gene expression.Long non-coding RNA can regulate arrhythmia after myocardial infarction.Long non-coding RNA can also be used as a clinical diagnostic marker and therapeutic target for myocardial infarction.This article will review the research progress of long non-coding RNA involved in myocardial ischemia-reperfusion injury.
Reperfusion therapy after myocardial infarction effectively protects the myocardium,but it causes myocardial ischemia-reperfusion injury.A large number of recent studies have confirmed that long non-coding RNA is involved in the pathological process of myocardial ischemia-reperfusion injury,long non-coding RNA can regulate cardiomyocyte necrosis,apoptosis,autophagy by regulating gene expression.Long non-coding RNA can regulate arrhythmia after myocardial infarction.Long non-coding RNA can also be used as a clinical diagnostic marker and therapeutic target for myocardial infarction.This article will review the research progress of long non-coding RNA involved in myocardial ischemia-reperfusion injury.
引文
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[4] 刘德敏,贾宏宇,柴文静,等.自噬与氧化应激在心血管疾病中的研究进展[J].临床心血管病杂志,2018,34(4):402-407.
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[6] Ma L,Bajic VB,Zhang Z.On the classification of long non-coding RNAs[J].RNA Biol,2013,10(6):925-933.
[7] Wu X,Zhu H,Zhu S,et al.lncRNA expression character associated with ischemic reperfusion injury[J].Mol Med Rep,2017,16(4):3745-3752.
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[9] Djebali S,Davis CA,Merkel A,et al.Landscape of transcription in human cells[J].Nature,2012,489(7414):101-108.
[10] Rinn JL,Chang HY.Genome regulation by long noncoding RNAs[J].Annu Rev Biochem,2012,81:145-166.
[11] Bar C,Chatterjee S,Thum T.Long noncoding RNAs in cardiovascular pathology,diagnosis,and therapy[J].Circulation,2016,134(19):1484-1499.
[12] Carrieri C,Cimatti L,Biagioli M,et al.Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat[J].Nature,2012,491(7424):454-457.
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[16] Wu X,Zhu H,Zhu S,et al.lncRNA expression character associated with ischemic reperfusion injury[J].Mol Med Rep,2017,16(4):3745-3752.
[17] Gu Y,Yang F,Xu R-m,et al.Differential expression profile of long non-coding RNA in cardiomyocytes autophagy induced by angiotensin II[J].Cell Biol Int,2017,41(10):1076-1082.
[18] Wu T,Wu H-d,Xu Z-x,et al.Abnormal expression of long non-coding RNAs in myocardial infarction[J].Heart And Vessels,2017,32(10):1253-1261.
[19] Liu Y,Li G,Lu H,et al.Expression profiling and ontology analysis of long noncoding RNAs in post-ischemic heart and their implied roles in ischemia/reperfusion injury[J].Gene,2014,543(1):15-21.
[20] Huang Z,Ye B,Wang Z,et al.Inhibition of LncRNA-HRIM Increases Cell Viability by Regulating Autophagy Levels During Hypoxia/Reoxygenation in Myocytes[J].Cell Physiol Biochem,2018,46(4):1341-1351.
[21] Zheng C,Wu Z,Tian L,et al.Long Noncoding RNA AK12348 is Involved in the regulation of myocardial ischaemia-reperfusion injury by targeting PARP and caspase-3[J].Heart Lung Circ,2018,27(5):e51-e58.
[22] Wang JX,Zhang XJ,Li Q,et al.MicroRNA-103/107 regulate programmed necrosis and myocardial ischemia/reperfusion injury through targeting FADD[J].Circ Res,2015,117(4):352-363.
[23] Wang K,Long B,Zhou LY,et al.CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation[J].Nat Commun,2014,5:3596.
[24] Wang K,Sun T,Li N,et al.MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361[J].PLoS Genet,2014,10(7):e1004467.
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[26] Zhang H,Li H,Ge A,et al.Long non-coding RNA TUG1 inhibits apoptosis and inflammatory response in LPS-treated H9c2 cells by down-regulation of miR-29b[J].Biomed Pharmacother,2018,101:663-669.
[27] Li L,Zhang M,Chen W,et al.LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125[J].Acta Biochim Biophys Sin (Shanghai),2018,50(10):996-1006.
[28] Luo H,Wang J,Liu D,et al.The lncRNA H19/miR-675 axis regulates myocardial ischemic and reperfusion injury by targeting PPARalpha[J].Mol Immunol,2019,105:46-54.
[29] Kong F,Jin J,Lv X,et al.Long noncoding RNA RMRP upregulation aggravates myocardial ischemia-reperfusion injury by sponging miR-206 to target ATG3 expression[J].Biomed Pharmacother,2019,109:716-725.
[30] Zhang X,Sha M,Yao Y,et al.Increased B-type-natriuretic peptide promotes myocardial cell apoptosis via the B-type-natriuretic peptide/long non-coding RNA LSINCT5/caspase-1/interleukin 1 beta signaling pathway[J].Mol Med Rep,2015,12(5):6761-6767.
[31] Liu Y,Zhou D,Li G,et al.Long non coding RNA-UCA1 contributes to cardiomyocyte apoptosis by suppression of p27 expression[J].Cell Physiol Biochem,2015,35(5):1986-1998.
[32] Zhao R,Wang X,Wang H,et al.Inhibition of long noncoding RNA BDNF-AS rescues cell death and apoptosis in hypoxia/reoxygenation damaged murine cardiomyocyte[J].Biochimie,2017,138:43-49.
[33] Li X,Dai Y,Yan S,et al.Down-regulation of lncRNA KCNQ1OT1 protects against myocardial ischemia/reperfusion injury following acute myocardial infarction[J].Biochem Biophys Res Commun,2017,491(4):1026-1033.
[34] Zhang W,Li Y,Wang P.Long non-coding RNA-ROR aggravates myocardial ischemia/reperfusion injury[J].Braz J Med Biol Res,2018,51(6):e6555.
[35] Zhang SB,Liu TJ,Pu GH,et al.Suppression of long non-coding RNA LINC00652 restores sevoflurane-induced cardioprotection against myocardial ischemia-reperfusion injury by targeting GLP-1R through the cAMP/PKA pathway in mice[J].Cell Physiol Biochem,2018,49(4):1476-1491.
[36] Liu Y,Wang T,Zhang M,et al.Down-regulation of myocardial infarction associated transcript 1 improves myocardial ischemia-reperfusion injury in aged diabetic rats by inhibition of activation of NF-kappaB signaling pathway[J].Chem Biol Interact,2019,300:111-122.
[37] Wang K,Liu F,Liu CY,et al.The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873[J].Cell Death Differ,2016,23(8):1394-1405.
[38] 安军钰,黄晏,李万鹏.PAR-2对自噬介导的心肌缺血/再灌注损伤的研究进展[J].临床心血管病杂志,2018,34(5):527-530.
[39] Wang K,Liu CY,Zhou LY,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].Nat Commun,2015,6:6779-6779.
[40] Yu SY,Dong B,Fang ZF,et al.Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy[J].J Cell Mol Med,2018,22(10):4886-4898.
[41] Wang JJ,Bie ZD,Sun CF.Long noncoding RNA AK088388 regulates autophagy through miR-30a to affect cardiomyocyte injury[J].J Cell Biochem,2019,120(6):10155-10163.
[42] Ma M,Hui J,Zhang QY,et al.Long non-coding RNA nuclear-enriched abundant transcript 1 inhibition blunts myocardial ischemia reperfusion injury via autophagic flux arrest and apoptosis in streptozotocin-induced diabetic rats[J].Atherosclerosis,2018,277:113-122.
[43] Liu CY,Zhang YH,Li RB,et al.LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription[J].Nat Commun,2018,9(1):29-29.
[44] Zhu P,Yang M,Ren H,et al.Long noncoding RNA MALAT1 downregulates cardiac transient outward potassium current by regulating miR-200c/HMGB1 pathway[J].J Cell Biochem,2018,119(12):10239-10249.
[45] Vausort M,Wagner DR,Devaux Y.Long noncoding RNAs in patients with acute myocardial infarction[J].Circ Res,2014,115(7):668-677.
[46] Gao W,Zhu M,Wang H,et al.Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population[J].Mutat Res,2015,772:15-22.
[47] Yan Y,Zhang B,Liu N,et al.Circulating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction[J].Biomed Res Int,2016,2016:8079372.
[48] Zhang Y,Sun L,Xuan L,et al.Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction[J].Sci Rep,2016,6:22384.
[49] Saddic LA,Sigurdsson MI,Chang TW,et al.The long noncoding RNA landscape of the ischemic human left ventricle[J].Circ Cardiovasc Genet,2017,10(1):e001534.
[50] Zhang Z,Gao W,Long QQ,et al.Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population[J].Sci Rep,2017,7(1):7491-7491.
[2] Hausenloy DJ,Yellon DM.Myocardial ischemia-reperfusion injury:a neglected therapeutic target[J].J Clin Invest,2013,123(1):92-100.
[3] Wu MY,Yiang GT,Liao WT,et al.Current mechanistic concepts in ischemia and reperfusion injury[J].Cell Physiol Biochem,2018,46(4):1650-1667.
[4] 刘德敏,贾宏宇,柴文静,等.自噬与氧化应激在心血管疾病中的研究进展[J].临床心血管病杂志,2018,34(4):402-407.
[5] Ponting CP,Oliver PL,Reik W.Evolution and functions of long noncoding RNAs[J].Cell,2009,136(4):629-641.
[6] Ma L,Bajic VB,Zhang Z.On the classification of long non-coding RNAs[J].RNA Biol,2013,10(6):925-933.
[7] Wu X,Zhu H,Zhu S,et al.lncRNA expression character associated with ischemic reperfusion injury[J].Mol Med Rep,2017,16(4):3745-3752.
[8] Pei Y,Zhang H,Chen B,et al.Altered long noncoding RNA profiles in rat ischemia-reperfusion injury after IONPs administration[J].Int J ClinExp Med,2017,10(8):12112-12122.
[9] Djebali S,Davis CA,Merkel A,et al.Landscape of transcription in human cells[J].Nature,2012,489(7414):101-108.
[10] Rinn JL,Chang HY.Genome regulation by long noncoding RNAs[J].Annu Rev Biochem,2012,81:145-166.
[11] Bar C,Chatterjee S,Thum T.Long noncoding RNAs in cardiovascular pathology,diagnosis,and therapy[J].Circulation,2016,134(19):1484-1499.
[12] Carrieri C,Cimatti L,Biagioli M,et al.Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat[J].Nature,2012,491(7424):454-457.
[13] Yoon JH,Abdelmohsen K,Srikantan S,et al.LincRNA-p21 suppresses target mRNA translation[J].Mol Cell,2012,47(4):648-655.
[14] Ebert MS,Sharp PA.Emerging roles for natural microRNA sponges[J].Curr Biol,2010,20(19):R858-861.
[15] Lorenzen JM,Martino F,Thum T.Epigenetic modifications in cardiovascular disease[J].Basic Res Cardiol,2012,107(2):245-245.
[16] Wu X,Zhu H,Zhu S,et al.lncRNA expression character associated with ischemic reperfusion injury[J].Mol Med Rep,2017,16(4):3745-3752.
[17] Gu Y,Yang F,Xu R-m,et al.Differential expression profile of long non-coding RNA in cardiomyocytes autophagy induced by angiotensin II[J].Cell Biol Int,2017,41(10):1076-1082.
[18] Wu T,Wu H-d,Xu Z-x,et al.Abnormal expression of long non-coding RNAs in myocardial infarction[J].Heart And Vessels,2017,32(10):1253-1261.
[19] Liu Y,Li G,Lu H,et al.Expression profiling and ontology analysis of long noncoding RNAs in post-ischemic heart and their implied roles in ischemia/reperfusion injury[J].Gene,2014,543(1):15-21.
[20] Huang Z,Ye B,Wang Z,et al.Inhibition of LncRNA-HRIM Increases Cell Viability by Regulating Autophagy Levels During Hypoxia/Reoxygenation in Myocytes[J].Cell Physiol Biochem,2018,46(4):1341-1351.
[21] Zheng C,Wu Z,Tian L,et al.Long Noncoding RNA AK12348 is Involved in the regulation of myocardial ischaemia-reperfusion injury by targeting PARP and caspase-3[J].Heart Lung Circ,2018,27(5):e51-e58.
[22] Wang JX,Zhang XJ,Li Q,et al.MicroRNA-103/107 regulate programmed necrosis and myocardial ischemia/reperfusion injury through targeting FADD[J].Circ Res,2015,117(4):352-363.
[23] Wang K,Long B,Zhou LY,et al.CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation[J].Nat Commun,2014,5:3596.
[24] Wang K,Sun T,Li N,et al.MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361[J].PLoS Genet,2014,10(7):e1004467.
[25] Zhao ZH,Hao W,Meng QT,et al.Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury[J].Cell Biol Int,2017,41(1):62-70.
[26] Zhang H,Li H,Ge A,et al.Long non-coding RNA TUG1 inhibits apoptosis and inflammatory response in LPS-treated H9c2 cells by down-regulation of miR-29b[J].Biomed Pharmacother,2018,101:663-669.
[27] Li L,Zhang M,Chen W,et al.LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125[J].Acta Biochim Biophys Sin (Shanghai),2018,50(10):996-1006.
[28] Luo H,Wang J,Liu D,et al.The lncRNA H19/miR-675 axis regulates myocardial ischemic and reperfusion injury by targeting PPARalpha[J].Mol Immunol,2019,105:46-54.
[29] Kong F,Jin J,Lv X,et al.Long noncoding RNA RMRP upregulation aggravates myocardial ischemia-reperfusion injury by sponging miR-206 to target ATG3 expression[J].Biomed Pharmacother,2019,109:716-725.
[30] Zhang X,Sha M,Yao Y,et al.Increased B-type-natriuretic peptide promotes myocardial cell apoptosis via the B-type-natriuretic peptide/long non-coding RNA LSINCT5/caspase-1/interleukin 1 beta signaling pathway[J].Mol Med Rep,2015,12(5):6761-6767.
[31] Liu Y,Zhou D,Li G,et al.Long non coding RNA-UCA1 contributes to cardiomyocyte apoptosis by suppression of p27 expression[J].Cell Physiol Biochem,2015,35(5):1986-1998.
[32] Zhao R,Wang X,Wang H,et al.Inhibition of long noncoding RNA BDNF-AS rescues cell death and apoptosis in hypoxia/reoxygenation damaged murine cardiomyocyte[J].Biochimie,2017,138:43-49.
[33] Li X,Dai Y,Yan S,et al.Down-regulation of lncRNA KCNQ1OT1 protects against myocardial ischemia/reperfusion injury following acute myocardial infarction[J].Biochem Biophys Res Commun,2017,491(4):1026-1033.
[34] Zhang W,Li Y,Wang P.Long non-coding RNA-ROR aggravates myocardial ischemia/reperfusion injury[J].Braz J Med Biol Res,2018,51(6):e6555.
[35] Zhang SB,Liu TJ,Pu GH,et al.Suppression of long non-coding RNA LINC00652 restores sevoflurane-induced cardioprotection against myocardial ischemia-reperfusion injury by targeting GLP-1R through the cAMP/PKA pathway in mice[J].Cell Physiol Biochem,2018,49(4):1476-1491.
[36] Liu Y,Wang T,Zhang M,et al.Down-regulation of myocardial infarction associated transcript 1 improves myocardial ischemia-reperfusion injury in aged diabetic rats by inhibition of activation of NF-kappaB signaling pathway[J].Chem Biol Interact,2019,300:111-122.
[37] Wang K,Liu F,Liu CY,et al.The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873[J].Cell Death Differ,2016,23(8):1394-1405.
[38] 安军钰,黄晏,李万鹏.PAR-2对自噬介导的心肌缺血/再灌注损伤的研究进展[J].临床心血管病杂志,2018,34(5):527-530.
[39] Wang K,Liu CY,Zhou LY,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].Nat Commun,2015,6:6779-6779.
[40] Yu SY,Dong B,Fang ZF,et al.Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy[J].J Cell Mol Med,2018,22(10):4886-4898.
[41] Wang JJ,Bie ZD,Sun CF.Long noncoding RNA AK088388 regulates autophagy through miR-30a to affect cardiomyocyte injury[J].J Cell Biochem,2019,120(6):10155-10163.
[42] Ma M,Hui J,Zhang QY,et al.Long non-coding RNA nuclear-enriched abundant transcript 1 inhibition blunts myocardial ischemia reperfusion injury via autophagic flux arrest and apoptosis in streptozotocin-induced diabetic rats[J].Atherosclerosis,2018,277:113-122.
[43] Liu CY,Zhang YH,Li RB,et al.LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription[J].Nat Commun,2018,9(1):29-29.
[44] Zhu P,Yang M,Ren H,et al.Long noncoding RNA MALAT1 downregulates cardiac transient outward potassium current by regulating miR-200c/HMGB1 pathway[J].J Cell Biochem,2018,119(12):10239-10249.
[45] Vausort M,Wagner DR,Devaux Y.Long noncoding RNAs in patients with acute myocardial infarction[J].Circ Res,2014,115(7):668-677.
[46] Gao W,Zhu M,Wang H,et al.Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population[J].Mutat Res,2015,772:15-22.
[47] Yan Y,Zhang B,Liu N,et al.Circulating Long Noncoding RNA UCA1 as a Novel Biomarker of Acute Myocardial Infarction[J].Biomed Res Int,2016,2016:8079372.
[48] Zhang Y,Sun L,Xuan L,et al.Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction[J].Sci Rep,2016,6:22384.
[49] Saddic LA,Sigurdsson MI,Chang TW,et al.The long noncoding RNA landscape of the ischemic human left ventricle[J].Circ Cardiovasc Genet,2017,10(1):e001534.
[50] Zhang Z,Gao W,Long QQ,et al.Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population[J].Sci Rep,2017,7(1):7491-7491.