放疗联合替莫唑胺治疗老年高级别脑胶质瘤术后患者临床观察
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摘要
目的观察放疗联合替莫唑胺治疗老年高级别脑胶质瘤术后患者的远期疗效和安全性。方法 56例老年高级别脑胶质瘤术后患者分为2组。观察组29例采用调强放疗联合替莫唑胺治疗。对照组27例单纯采用调强放疗。比较2组的远期疗效和不良反应。结果观察组疾病无进展生存时间为(18.48±5.12)个月,高于对照组的(12.93±3.93)个月,差异有统计学意义(t=4.53,P<0.05)。观察组总生存时间为(20.69±4.62)个月,对照组为(18.63±3.70)个月,差异无统计学意义(t=1.83,P>0.05)。2组恶心呕吐、骨髓抑制、放射性脑损伤发生率比较差异均无统计学意义(χ~2=2.18、1.82、0.60,P均>0.05)。结论放疗联合替莫唑胺治疗老年高级别脑胶质瘤术后患者具有一定生存优势,且安全性良好。
Objective To observe the long-term efficacy and safety of radiotherapy combined with temozolomide in the treatment of postoperative patients with highly malignant brain glioma. Methods Fifty-six postoperative patients with highly malignant brain glioma were divided into two groups. Twenty-nine patients in the observation group received the intensity modulated radiotherapy combined with temozolomide, and 27 patients in the control group received the intensity modulated radiotherapy. The long-term efficacy and toxicities were compared between two groups.Results The disease progression-free survival time in the observation group was(18.48±5.12) months, and was(12.93±3.93) months in the control group(t=4.53, P<0.05). The disease progression-free survival time in the observation group was(20.69±4.62) months,and was(18.63±3.70) months in the control group(t=1.83, P>0.05). There was no statistically significant differences in the nausea and vomiting, bone marrow suppression, radiation brain damage incidences between the two groups(χ~2=2.18,1.82,0.60;P>0.05).Conclusion Radiotherapy combined with temozolomide is safe and effect in the treatment of postoperative patients with highly malignant brain glioma.
Objective To observe the long-term efficacy and safety of radiotherapy combined with temozolomide in the treatment of postoperative patients with highly malignant brain glioma. Methods Fifty-six postoperative patients with highly malignant brain glioma were divided into two groups. Twenty-nine patients in the observation group received the intensity modulated radiotherapy combined with temozolomide, and 27 patients in the control group received the intensity modulated radiotherapy. The long-term efficacy and toxicities were compared between two groups.Results The disease progression-free survival time in the observation group was(18.48±5.12) months, and was(12.93±3.93) months in the control group(t=4.53, P<0.05). The disease progression-free survival time in the observation group was(20.69±4.62) months,and was(18.63±3.70) months in the control group(t=1.83, P>0.05). There was no statistically significant differences in the nausea and vomiting, bone marrow suppression, radiation brain damage incidences between the two groups(χ~2=2.18,1.82,0.60;P>0.05).Conclusion Radiotherapy combined with temozolomide is safe and effect in the treatment of postoperative patients with highly malignant brain glioma.
引文
[1] 刘京.恶性脑胶质瘤术后放疗联合替莫唑胺化疗同步的疗效观察[J].中国实用神经疾病杂志,2017,20(9):79-81.
[2] PERRY JR,LAPERRIERE N,O’CALLAGHAN CJ,et al.Short-course radiation plus temozolomide in elderly patients with glioblastoma [J].N Engl J Med,2017,376(11):1027-1037.
[3] 吴劲松,周良辅.脑胶质瘤的外科手术近代观点[J].复旦学报(医学版),2017,44(6):724-732.
[4] 孙涛,董莹,张矛.老年多形性胶质母细胞瘤术后替莫唑胺同步放疗临床观察[J].中华肿瘤防治杂志,2015,22(18):1466-1469.
[5] 李浩诣,汪云,黄科.联合用药靶向胶质母细胞瘤样干细胞的治疗进展[J].肿瘤基础与临床,2017,30(1):88-93.
[6] 黄仁华,侯艳丽,徐欣,等.脑胶质瘤术后三维适形放疗联合替莫唑胺疗效分析[J].肿瘤学杂志,2015,21(3):219-222.
[7] 牛瑞芳,杨静,窦长武,等.替莫唑胺联合调强放疗对恶性脑胶质瘤患者术后残留病灶的疗效分析[J].肿瘤药学,2017,7(2):200-203.
[8] 夏璐,周强,刘黎.恶性脑胶质瘤术后替莫唑胺同步放化疗的疗效观察[J].中国实用神经疾病杂志,2016,19(4):3-5.
[9] 陈伟,齐珺,王茂德,等.高分级脑胶质瘤术后同步放化疗联合辅助化疗与单纯放疗治疗的疗效对比[J].中国实用神经疾病杂志,2016,19(20):37-39.
[10] BRZOZOWSKA A,TORUN A,MAZURKIEWICZ M.The impact of surgery on the efficacy of adjuvant therapy in glioblastomamultiforme [J].Adv Clin Exp Med,2015,24(2) :279-287.
[11] ABOZIADA MA,ABO-KRESHA AE.Hypofractionated conformal irradiation of patients with malignant glioma[J].J Egypt Natl Canc Inst,2012,24 (3) :139-143.
[12] 罗伟明,王洪林.高分级脑胶质瘤术后同步放化疗联合辅助化疗的临床观察[J].肿瘤,2014,34(4):357-360.
[2] PERRY JR,LAPERRIERE N,O’CALLAGHAN CJ,et al.Short-course radiation plus temozolomide in elderly patients with glioblastoma [J].N Engl J Med,2017,376(11):1027-1037.
[3] 吴劲松,周良辅.脑胶质瘤的外科手术近代观点[J].复旦学报(医学版),2017,44(6):724-732.
[4] 孙涛,董莹,张矛.老年多形性胶质母细胞瘤术后替莫唑胺同步放疗临床观察[J].中华肿瘤防治杂志,2015,22(18):1466-1469.
[5] 李浩诣,汪云,黄科.联合用药靶向胶质母细胞瘤样干细胞的治疗进展[J].肿瘤基础与临床,2017,30(1):88-93.
[6] 黄仁华,侯艳丽,徐欣,等.脑胶质瘤术后三维适形放疗联合替莫唑胺疗效分析[J].肿瘤学杂志,2015,21(3):219-222.
[7] 牛瑞芳,杨静,窦长武,等.替莫唑胺联合调强放疗对恶性脑胶质瘤患者术后残留病灶的疗效分析[J].肿瘤药学,2017,7(2):200-203.
[8] 夏璐,周强,刘黎.恶性脑胶质瘤术后替莫唑胺同步放化疗的疗效观察[J].中国实用神经疾病杂志,2016,19(4):3-5.
[9] 陈伟,齐珺,王茂德,等.高分级脑胶质瘤术后同步放化疗联合辅助化疗与单纯放疗治疗的疗效对比[J].中国实用神经疾病杂志,2016,19(20):37-39.
[10] BRZOZOWSKA A,TORUN A,MAZURKIEWICZ M.The impact of surgery on the efficacy of adjuvant therapy in glioblastomamultiforme [J].Adv Clin Exp Med,2015,24(2) :279-287.
[11] ABOZIADA MA,ABO-KRESHA AE.Hypofractionated conformal irradiation of patients with malignant glioma[J].J Egypt Natl Canc Inst,2012,24 (3) :139-143.
[12] 罗伟明,王洪林.高分级脑胶质瘤术后同步放化疗联合辅助化疗的临床观察[J].肿瘤,2014,34(4):357-360.