经前烦躁症肝气郁证方药脑区微观干预机制初探
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摘要
经前烦躁症(PMDD)是经前期综合征(PMS)的严重类型,而PMDD肝气郁证是PMDD的重要亚型,症状广泛而复杂,发病率日渐增高,临床表现愈发严重,发病机理尚不明确,治疗效果差。然而国内外PMDD亚型的报道研究并不多,且缺乏统一的标准,探索PMDD亚型研究极为重要。目前该病的发病机制已经延伸到相关脑区,探索多种药物的作用靶点,揭示肝气郁证脑区功能变化,揭示其发病机制,更好的服务于临床。
Premenstrual irritation(PMDD) is a serious type of premenstrual syndrome(PMS),and liver Qi stagnation sydnrome is an important subtype of PMDD.The symptoms are extensive and complex.The incidence is increasing and the clinical manifestation is more serious.The pathogenesis is still not clear.However,there are few reports on PMDD subtypes at home and abroad,and there is no uniform standard.It is very important to explore PMDD subtype research.At present,the pathogenesis of the disease has been extended to the relevant brain area.Exploring the role of a variety of drug targets,revealing the liver Qi stagnation of brain function changes and its pathogenesis,can better serve the clinic.
Premenstrual irritation(PMDD) is a serious type of premenstrual syndrome(PMS),and liver Qi stagnation sydnrome is an important subtype of PMDD.The symptoms are extensive and complex.The incidence is increasing and the clinical manifestation is more serious.The pathogenesis is still not clear.However,there are few reports on PMDD subtypes at home and abroad,and there is no uniform standard.It is very important to explore PMDD subtype research.At present,the pathogenesis of the disease has been extended to the relevant brain area.Exploring the role of a variety of drug targets,revealing the liver Qi stagnation of brain function changes and its pathogenesis,can better serve the clinic.
引文
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[20] 魏盛,侯金良,巢玉彬,等.郁怒诱发经前期综合征肝气郁证猕猴模型血清单胺类神经递质含量分析[J].中西医结合学报,2012,10(8):925-930.
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[22] 葛庆芳.舒郁胶囊对大鼠海马神经元5-HT3受体表达及其介导的Ca2+-CaM通路的作用[D].济南:山东中医药大学,2012.
[23] 侯金良.择时慢性束缚应激诱导PMDD肝气郁证大鼠模型效度估计及舒郁胶囊干预机制初探[D].济南:山东中医药大学,2013.
[24] 高杰,郭英慧,张惠云. 5-HT代谢通路相关基因在PMS肝气郁证大鼠海马及下丘脑的表达[J].微循环学杂志,2011,21(2):86.
[25] 贺立娟.柴胡疏肝散对肝气郁结证模型大鼠脑局部葡萄糖代谢及多巴胺2型受体干预机制的MicroPET/CT研究[D].北京:北京中医药大学,2012.
[26] 王杰琼,张惠云.经前期综合征肝气郁证猕猴模型血清性激素检测分析[J].中国现代医药杂志,2008,10(3):1-4.
[27] 魏芳.疏肝补肾方治疗肝郁肾虚型高泌乳素血症的临床研究[D].济南:山东中医药大学,2013.
[2] 许建成,王艳丽,魏秀娟.乳腺增生病的情志影响及从肝论治初探[J].实用中医内科杂志,2011,25(11):85-87.
[3] 孙鹏,魏盛,张惠云,等.慢性束缚应激及居住入侵法制备经前期综合征肝气郁证大鼠模型的行为学观测与分析[C]//湖南省中西医结合学会肝病专业学术年会,2010:1848-1852.
[4] 金益强.中医肝脏象现代研究与临床[M].北京:人民卫生出版社,2000.
[5] 陈锦锋,王爱成,王玉来,等.肝气郁结证诊断的必备症状以及与抑郁状态的关系探讨[J].辽宁中医杂志,2005,32(1):19-22.
[6] 张惠云,乔明琦,孙丽.肝气郁证模型大鼠下丘脑单胺类神经递质分析[J].中医杂志,2008,49(2):150-152.
[7] 陶蓉.雌激素与经前焦虑性障碍的相关性研究[J].南京中医药大学学报,2009,29(11):18-19.
[8] Hays J,Ockene JK,Brunner RL,et al.Effects of estrogen plus progestin on health-related quality of life[J].New England Journal of Medicine,2003,348(19):1839-1854.
[9] 刘子旺,王玉来,郭蓉娟,等.利用脑电非线性分析关联维数对肝气郁结证患者的研究[J].北京中医药大学学报,2007,30(4):271-273.
[10] 陈锦锋.肝气郁结证患者PET脑功能成像研究及中医神经信息学研究探讨[D].北京:北京中医药大学,2005.
[11] 朱清静,罗欣拉,熊振芳.柴胡疏肝散对慢性束缚应激性肝郁证大鼠下丘脑-垂体-肾上腺轴的调节作用[J].湖北中医杂志,2003,25(11):7-8.
[12] 严灿,张斩春,邓中炎.肝主疏泄免疫学机制的临床与实验研究[J].中国中医基础医学志,1995,1(3):36-38.
[13] Wang F R,Qiao M Q,Xue L,et al.Possible Involvement of μ Opioid Receptor in the Antidepressant-Like Effect of Shuyu Formula in Restraint Stress-Induced Depression-Like Rats[J].Evidence-based Complementary and Alternative Medicine,2015,2015:1-11.
[14] 刘文琼.疏肝清热法治疗经前期紧张综合征肝经郁热型100例[J].上海中医药杂志,2008,42(1):46-47.
[15] 周睿,杨丽洁,史艳,等.安神调肝针法治疗肝郁气滞型经前期紧张综合征焦虑状态46例疗效观察[J].云南中医中药杂志,2010,31(8):54-55.
[16] 李艳彦,谢鸣,陈禹,等.肝郁脾虚证模型大鼠下丘脑-垂体-肾上腺皮质的变化[J].现代生物医学进展,2006,6(4):10-12.
[17] 林耀平,陈明钟,陈明森.舒肝解郁胶囊治疗轻中度肝气郁结型抑郁症40例[J].福建中医药,2010,41(6):18-19.
[18] 乔明琦,张惠云.治疗经前期综合征的中药五类复方新药及其制备方法,中国:CN1596941[P].2005-03-23.
[19] 金光亮,南睿,郭霞珍.慢性应激肝郁证大鼠模型的建立[J].北京中医药大学学报,2003,26(2):18-21.
[20] 魏盛,侯金良,巢玉彬,等.郁怒诱发经前期综合征肝气郁证猕猴模型血清单胺类神经递质含量分析[J].中西医结合学报,2012,10(8):925-930.
[21] Lucassen PJ,Muner MB,Holsboer F,et al.Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure[J].Am J Pathol,2001,158(2):453-468.
[22] 葛庆芳.舒郁胶囊对大鼠海马神经元5-HT3受体表达及其介导的Ca2+-CaM通路的作用[D].济南:山东中医药大学,2012.
[23] 侯金良.择时慢性束缚应激诱导PMDD肝气郁证大鼠模型效度估计及舒郁胶囊干预机制初探[D].济南:山东中医药大学,2013.
[24] 高杰,郭英慧,张惠云. 5-HT代谢通路相关基因在PMS肝气郁证大鼠海马及下丘脑的表达[J].微循环学杂志,2011,21(2):86.
[25] 贺立娟.柴胡疏肝散对肝气郁结证模型大鼠脑局部葡萄糖代谢及多巴胺2型受体干预机制的MicroPET/CT研究[D].北京:北京中医药大学,2012.
[26] 王杰琼,张惠云.经前期综合征肝气郁证猕猴模型血清性激素检测分析[J].中国现代医药杂志,2008,10(3):1-4.
[27] 魏芳.疏肝补肾方治疗肝郁肾虚型高泌乳素血症的临床研究[D].济南:山东中医药大学,2013.