自血疗法治疗常见皮肤病的疗效与安全性系统评价
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摘要
目的:系统评价自血疗法治疗常见皮肤疾患的疗效与安全性。方法:检索中国知网(CNKI)、万方、SinoMed、维普、SCI、PubMed等数据库中关于自血疗法治疗常见皮肤疾患的随机对照试验(RCT),采用RevMan 5.2软件评价文献质量,进行Meta分析。结果:纳入23篇RCT共1980位患者,结果显示,自血疗法治疗痤疮、荨麻疹、银屑病的治愈率优于对照组,而治疗慢性湿疹的治愈率与对照组比较无统计学差异。自血疗法改善痤疮、荨麻疹患者皮损积分优于对照组;而治疗寻常型银屑病在改善皮肤积分方面与对照组比较无统计学差异。自血疗法在降低皮肤病治愈复发率方面优于对照组。且无严重不良反应,安全性较好。结论:自血疗法治疗痤疮、荨麻疹、银屑病疗效优于常规疗法,且安全性较好。但由于缺乏高质量文献,结论尚需谨慎,期待未来更多高质量文献増强研究结果的可靠性。
Objective:To evaluate the efficacy and safety of autohemotherapy on treatment of common skin diseases through Meta-analysis.Methods:We searched CNKI,Wanfang,SinoMed,VIP,SCI,PubMed for random controlled trials of autohemotherapy on the treatment of common skin diseases.Revman 5.0 was used for evaluating literature quality and Meta-analysis.Results:Twenty-three randomized controlled clinical trials involved 1980 patients were included in the Meta-analysis.It showed that curative rates of acne,urticaria and psoriasis vulgaris in treatment group were higher than those of the control group.Autotherapy had an advantage of improving skin damage scores on acne and urticaria patients.While there was no statistical difference between treatment group and control group on psoriasis vulgaris.The recurrence rate of autohemotherapy was lower than that of the control group and it showed no sign of severe adverse reaction.Conclusion:Autohemotherapy is a more effective and safe therapy on treatment of acne,urticaria and psoriasis vulgaris than routine therapy.While due to the low quality of inclusive articles,we should be more prudent to reach conclusion.So we are expecting more high-grade literature to increase the reliability of outcomes.
Objective:To evaluate the efficacy and safety of autohemotherapy on treatment of common skin diseases through Meta-analysis.Methods:We searched CNKI,Wanfang,SinoMed,VIP,SCI,PubMed for random controlled trials of autohemotherapy on the treatment of common skin diseases.Revman 5.0 was used for evaluating literature quality and Meta-analysis.Results:Twenty-three randomized controlled clinical trials involved 1980 patients were included in the Meta-analysis.It showed that curative rates of acne,urticaria and psoriasis vulgaris in treatment group were higher than those of the control group.Autotherapy had an advantage of improving skin damage scores on acne and urticaria patients.While there was no statistical difference between treatment group and control group on psoriasis vulgaris.The recurrence rate of autohemotherapy was lower than that of the control group and it showed no sign of severe adverse reaction.Conclusion:Autohemotherapy is a more effective and safe therapy on treatment of acne,urticaria and psoriasis vulgaris than routine therapy.While due to the low quality of inclusive articles,we should be more prudent to reach conclusion.So we are expecting more high-grade literature to increase the reliability of outcomes.
引文
[1] 李阳雪,高子平,赵凤娇,等.自血疗法联合多种方式治疗慢性荨麻疹的现状及研究进展[J].世界最新医学信息文摘,2016(A0):84-85.
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[3] 张春萍,张议文,王俐钧,等.自血穴注疗法现代临床文献研究[J].针灸临床杂志,2015,31(11):56-58.
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[6] 吴潇雅.自血穴位注射疗法治疗寻常痤疮的临床疗效评价及其对TLR2表达的影响[D].南京:南京中医药大学,2016.
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[11] 陈云龙,袁福宁,杨庆镗,等.自血穴位注射治疗慢性湿疹及对T淋巴细胞的影响[J].中国中医药,2013,11(12):160-161.
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[14] 陈云龙,陈文峰,林阿丰,等.自血疗法辨证治疗慢性荨麻疹的疗效观察及对T淋巴细胞亚群的影响[J].甘肃中医学院学报,2011,28(5):49-51.
[15] 高敏坚,黄成川,罗颖兴.自血疗法联合盐酸依匹斯汀治疗慢性荨麻疹的疗效探讨[J].中外医疗,2014(23):95-96.
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[17] 李小莎.自血穴位注射联合盐酸奥洛他定治疗慢性荨麻疹48例临床疗效及安全性评价[J].湖南中医药大学学报,2016(9):75-78.
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[19] 汤勇,卢正文.自血疗法联合枸地氯雷他定治疗慢性荨麻疹临床疗效及其对外周血的影响[J].湖北中医杂志,2017(3):12-14.
[20] 吴钱红,阳媚.穴位自血疗法治疗慢性荨麻疹40例疗效观察[J].广西中医药,2016(1):14-16.
[21] 向联飞.足三里自血穴位注射联合药物治疗慢性荨麻疹的临床观察[D].成都:成都中医药大学,2016.
[22] 杨庆镗,陈云龙,张永平,等.自血穴位注射治疗慢性荨麻疹疗效观察及对外周血IgE、IL-4与IFN-γ的影响[J].光明中医,2011,26 (12):2482-2483.
[23] 由丽娜,陈丽蓉,宋国宏,等.足三里穴位自血疗法联合地氯雷他定治疗胆碱能性荨麻疹的临床观察[J].中国现代医学杂志,2016,26(17):72-74.
[24]陈云龙,林研研,陈珊珊,等.自血穴位注射治疗寻常型银屑病多中心疗效观察及对外周血IL-8、TNF-α的影响[J].甘肃中医学院学报,2011,28(3):48-50.
[25]陈云龙,杨庆镗,林研研,等.自血穴位注射治疗银屑病118例[J].中国中医药,2011,9(10):41-42.
[26]张敏,李艳玲,张枫,等.自血疗法联合窄谱中波紫外线治疗寻常型银屑病临床疗效观察[J].世界最新医学信息文摘,2015,15(14):37-38.
[27]彭昆,张敏,赵敏. NB_UVB联合自血疗法治疗寻常性银屑病疗效观察[J].齐齐哈尔医学院学报,2012,13(14):1864.
[28] Li XX,Han M,Wang YY,et al. Chinese herbal medicine for gout:a systematic review of randomized clinical trials[J]. Clin Rheumatol,2013,32(7):943-959.
[29] Adetugbo K,Williams H. How well are randomized controlled trials reported in the dermatology literature?[J]. Arch Dermatol,2000,136(3):381-385.
[2] Sheikhi A,Azarbeig M,Karimi H.Autohemotherapy in chronic urticaria:what could be the autoreactive factors and curative mechanisms[J].Ann Dermatol,2014,26(4):526.
[3] 张春萍,张议文,王俐钧,等.自血穴注疗法现代临床文献研究[J].针灸临床杂志,2015,31(11):56-58.
[4] Higgins J,Green S.Cochrane Collaboration:Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011][M].Chichester:John Wiley & Sons Ltd and The Cochrane Collaboration,2011.
[5] 杜淑佳.腧穴自血疗法治疗痤疮的临床研究[D].广州:广州中医药大学,2009.
[6] 吴潇雅.自血穴位注射疗法治疗寻常痤疮的临床疗效评价及其对TLR2表达的影响[D].南京:南京中医药大学,2016.
[7] 严迩晗.自血穴位注射治疗寻常痤疮的临床观察[D].南京:南京中医药大学,2014.
[8] 杨巧菊.自体血穴位注射治疗痤疮36例[J].中国民间疗法,2008(7):11.
[9] 杨杨.自血疗法配合阿达帕林外用治疗风热型寻常性痤疮的临床研究[D].广州:广州中医药大学,2016.
[10] 张东淑,方茜,柳涛,等.靳氏经络注血疗法治疗痤疮临床研究[J].中医学报,2014,29(12):1835-1837.
[11] 陈云龙,袁福宁,杨庆镗,等.自血穴位注射治疗慢性湿疹及对T淋巴细胞的影响[J].中国中医药,2013,11(12):160-161.
[12] 范葵.自血疗法治疗慢性湿疹30例[J].中国中医药,2013,11(23):19-20.
[13] 陈云龙,陈文峰,林阿丰,等.自血疗法治疗慢性荨麻疹疗效观察及对B淋巴细胞的影响[J].甘肃中医学院学报,2012,29(3):61-62.
[14] 陈云龙,陈文峰,林阿丰,等.自血疗法辨证治疗慢性荨麻疹的疗效观察及对T淋巴细胞亚群的影响[J].甘肃中医学院学报,2011,28(5):49-51.
[15] 高敏坚,黄成川,罗颖兴.自血疗法联合盐酸依匹斯汀治疗慢性荨麻疹的疗效探讨[J].中外医疗,2014(23):95-96.
[16] 李素丹.腧穴自血疗法治疗血虚风燥型慢性荨麻疹临床研究[D].广州:广州中医药大学,2011.
[17] 李小莎.自血穴位注射联合盐酸奥洛他定治疗慢性荨麻疹48例临床疗效及安全性评价[J].湖南中医药大学学报,2016(9):75-78.
[18] 刘炫斯,谢玲玲,杨晓宇.自血穴位注射治疗慢性荨麻疹40例疗效观察[J].甘肃中医学院学报,2012,29(3):63-64.
[19] 汤勇,卢正文.自血疗法联合枸地氯雷他定治疗慢性荨麻疹临床疗效及其对外周血的影响[J].湖北中医杂志,2017(3):12-14.
[20] 吴钱红,阳媚.穴位自血疗法治疗慢性荨麻疹40例疗效观察[J].广西中医药,2016(1):14-16.
[21] 向联飞.足三里自血穴位注射联合药物治疗慢性荨麻疹的临床观察[D].成都:成都中医药大学,2016.
[22] 杨庆镗,陈云龙,张永平,等.自血穴位注射治疗慢性荨麻疹疗效观察及对外周血IgE、IL-4与IFN-γ的影响[J].光明中医,2011,26 (12):2482-2483.
[23] 由丽娜,陈丽蓉,宋国宏,等.足三里穴位自血疗法联合地氯雷他定治疗胆碱能性荨麻疹的临床观察[J].中国现代医学杂志,2016,26(17):72-74.
[24]陈云龙,林研研,陈珊珊,等.自血穴位注射治疗寻常型银屑病多中心疗效观察及对外周血IL-8、TNF-α的影响[J].甘肃中医学院学报,2011,28(3):48-50.
[25]陈云龙,杨庆镗,林研研,等.自血穴位注射治疗银屑病118例[J].中国中医药,2011,9(10):41-42.
[26]张敏,李艳玲,张枫,等.自血疗法联合窄谱中波紫外线治疗寻常型银屑病临床疗效观察[J].世界最新医学信息文摘,2015,15(14):37-38.
[27]彭昆,张敏,赵敏. NB_UVB联合自血疗法治疗寻常性银屑病疗效观察[J].齐齐哈尔医学院学报,2012,13(14):1864.
[28] Li XX,Han M,Wang YY,et al. Chinese herbal medicine for gout:a systematic review of randomized clinical trials[J]. Clin Rheumatol,2013,32(7):943-959.
[29] Adetugbo K,Williams H. How well are randomized controlled trials reported in the dermatology literature?[J]. Arch Dermatol,2000,136(3):381-385.