J亚群禽白血病病毒诱导免疫抑制及其相关信号通路研究进展
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摘要
J亚群禽白血病病毒(ALV-J)诱导的免疫抑制能够影响鸡的生长和繁殖,并造成其他病原的继发感染,是危害养禽业的重要病原之一。近年来,很多研究表明ALV-J感染宿主而引起的免疫抑制和致瘤是一个多因素参与的复杂过程,影响体液免疫和细胞免疫水平。论文对ALV-J病毒粒子侵入宿主及复制过程进行阐述,主要包括吸附、侵入、复制及释放等过程。论文简要探讨了ALV-J造成免疫抑制的主要原因及感染宿主后涉及的几条信号转导通路的研究状况,并对ALV-J的相关研究做了展望。
Immunosuppression induced by avian leukosis virus subgroup J(ALV-J)can affect the growth and reproduction of chickens and cause secondary infection of other pathogens,which is one of the important pathogens that endanger the poultry industry.In recent years,many studies showed that immunosuppression and tumorigenesis caused by ALV-J infection in the host are the complex multifactorial processes that affect both humoral and cellular immune responses.In the paper,ALV-J particles invading the host and replication were described,mainly divided into adsorption,invasion,replication and release processes.The main reason of ALV-J immunosuppression and several signal transduction pathways involved in host infection were briefly discussed,and the related research on ALV-J was prospected.
Immunosuppression induced by avian leukosis virus subgroup J(ALV-J)can affect the growth and reproduction of chickens and cause secondary infection of other pathogens,which is one of the important pathogens that endanger the poultry industry.In recent years,many studies showed that immunosuppression and tumorigenesis caused by ALV-J infection in the host are the complex multifactorial processes that affect both humoral and cellular immune responses.In the paper,ALV-J particles invading the host and replication were described,mainly divided into adsorption,invasion,replication and release processes.The main reason of ALV-J immunosuppression and several signal transduction pathways involved in host infection were briefly discussed,and the related research on ALV-J was prospected.
引文
[1]胡元元,刘胜宇,王冉冉.自繁自养原种鸡场禽白血病净化[J].中国畜牧兽医文摘,2017,33(2):8.
[2]王谢忠,马睿麟,张立成,等.青海省禽白血病血清学调查[J].黑龙江畜牧兽医,2016(10):136-137.
[3]张倩.我国祖代种鸡场禽白血病、禽网状内皮组织增殖症和鸡白痢的监测与分析[D].北京:中国农业大学,2017.
[4]张倩,杨卫铮,王传彬,等.禽白血病病毒抗原检测能力比对样品的制备[J].中国家禽,2016(6):25-28.
[5]杨峰,方英,白璧,等.骨髓细胞瘤禽白血病的实验室诊断[J].中国兽医杂志,2017,53(2):47-49.
[6] Meng F,Li Q,Zhang Y,et al.Characterization of subgroup J avian leukosis virus isolated from Chinese indigenous chickens[J].Virol J,2018,15(1):33.
[7]李浩然.禽白血病研究进展[J].养禽与禽病防治,2017(1):2-6.
[8]高雁怩.ALV-J感染后细胞因子变化规律及其促进IL-6产生的机制与效应研究[D].黑龙江哈尔滨:中国农业科学院,2015.
[9]王占新.针对禽白血病病毒整合酶的抗病毒机制及泛素化修饰研究[D].北京:中国农业大学,2017.
[10] Kucerova D,Plachy J,Reinisova M,et al.Nonconserved tryptophan 38of the cell surface receptorfor subgroup J avian leukosis virus discriminates sensitive from resistant avian species[J].J Virol,2013,87(15):8399-8407.
[11] Feng W,Meng W,Cai L,et al.Avian leukosis virus subgroup J induces its receptor-chNHE1up-regulation[J].Virol J,2016(13):58.
[12] Desfarges S,Ciuffi A.Retroviral integration site selection[J].Viruses,2010,2(1):111-130.
[13] Mazzeo C,Calvo V,Alonso R,et al.Protein kinase D1/2is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes[J].Cell Death Differ,2016,23(1):99-109.
[14]史若男,李婉,宋丽婷,等.动物免疫抑制研究进展[J].动物医学进展,2014,35(9):93-96.
[15]马金松,刘丽仙,豆腾飞,等.种鸡场禽白血病的综合防制[J].云南畜牧兽医,2016(3):17-19.
[16]崔治中.禽白血病病毒的亚群和准种多样性及其在不同选择压作用下的演变[J].生命科学,2016(3):283-294.
[17]朱丽君,董雯雯,马宁宁,等.ALV-J不同接种途径诱导SPF鸡免疫抑制状况的比较分析[J].中国兽医学报,2017,37(11):2068-2075.
[18] Chen G,Li Z,Su S,et al.Identification of key genes fluctuated induced by avian leukemia virus(ALV-J)infection in chicken cells[J].In Vitro Cell Dev Biol Anim,2018,54(1):41-51.
[19] Hu X,Chen S,Jia C,et al.Gene expression profile and long non-coding RNA analysis,using RNA-Seq,in chicken embryonic fibroblast cells infected by avian leukosis virus J[J].Arch Virol,2018,163(3):639-647.
[20]唐敬洁,刘玉芬,吴迪.禽类Toll样受体研究进展[J].动物医学进展,2017,38(1):86-89.
[21] Feng M,Dai M,Xie T,et al.Innate immune responses in ALV-J infected chicks and chickens with Hemangioma in vivo[J].Front Microbiol,2016(7):786.
[22] Dai M,Wu S,Feng M,et al.Recombinant chicken interferonalpha inhibits the replication of exogenous avian leukosis virus(ALV)in DF-1cells[J].Mol Immunol,2016,(76):62-69.
[23] Liu D,Qiu Q,Zhang X,et al.Infection of chicken bone marrow mononuclear cells with subgroup J avian leukosis virus inhibits dendritic cell differentiation and alters cytokine expression[J].Infect Genet Evol,2016(44):130-136.
[24] Qiu L L,Xu L,Guo X M,et al.Gene expression changes in chicken NLRC5signal pathway associated with in vitro avian leukosis virus subgroup J infection[J].Genet Mol Res,2016,15(1):1-7.
[25] Dai M,Feng M,Liao M,et al.Inhibition of ERK/MAPK suppresses avian leukosis virus subgroup A and B replication[J].Microb Pathog,2017(102):29-35.
[26] Dai M,Feng M,Ye Y,et al.Exogenous avian leukosis virusinduced activation of the ERK/AP1pathway is required for virus replication and correlates with virus-induced tumorigenesis[J].Sci Rep,2016(6):19226.
[27] Wang Q,Gao Y,Ji X,et al.Differential expression of microRNAs in avian leukosis virus subgroup J-induced tumors[J].Vet Microbiol,2013,162(1):232-238.
[28] Feng W,Zhou D,Meng W,et al.Growth retardation induced by avian leukosis virus subgroup J associated with down-regulated Wnt/beta-catenin pathway[J].Microb Pathog,2017(104):48-55.
[29] Hang B,Sang J,Qin A,et al.Transcription analysis of the response of chicken bursa of Fabricius to avian leukosis virus subgroup J strain JS09GY3[J].Virus Res,2014,188:8-14.
[30] Zhang X,Yan Y,Lei X,et al.Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens[J].Oncotarget,2017,8(21):34961-34970.
[31] Wang G,Wang Z,Zhuang P,et al.Exosomes carring gag/env of ALV-J possess negative effect on immunocytes[J].Microb Pathog,2017(112):142-147.
[32]杜建中.我国禽类养殖的现状与对策思考[J].南方农业,2015,9(16):80-81.
[33] Choi K M,Johnson E S.Occupational exposure assessment using antibody levels:exposure to avian leukosis/sarcoma viruses in the poultry industry[J].Int J Environ Health Res,2011,21(4):306-316.
[2]王谢忠,马睿麟,张立成,等.青海省禽白血病血清学调查[J].黑龙江畜牧兽医,2016(10):136-137.
[3]张倩.我国祖代种鸡场禽白血病、禽网状内皮组织增殖症和鸡白痢的监测与分析[D].北京:中国农业大学,2017.
[4]张倩,杨卫铮,王传彬,等.禽白血病病毒抗原检测能力比对样品的制备[J].中国家禽,2016(6):25-28.
[5]杨峰,方英,白璧,等.骨髓细胞瘤禽白血病的实验室诊断[J].中国兽医杂志,2017,53(2):47-49.
[6] Meng F,Li Q,Zhang Y,et al.Characterization of subgroup J avian leukosis virus isolated from Chinese indigenous chickens[J].Virol J,2018,15(1):33.
[7]李浩然.禽白血病研究进展[J].养禽与禽病防治,2017(1):2-6.
[8]高雁怩.ALV-J感染后细胞因子变化规律及其促进IL-6产生的机制与效应研究[D].黑龙江哈尔滨:中国农业科学院,2015.
[9]王占新.针对禽白血病病毒整合酶的抗病毒机制及泛素化修饰研究[D].北京:中国农业大学,2017.
[10] Kucerova D,Plachy J,Reinisova M,et al.Nonconserved tryptophan 38of the cell surface receptorfor subgroup J avian leukosis virus discriminates sensitive from resistant avian species[J].J Virol,2013,87(15):8399-8407.
[11] Feng W,Meng W,Cai L,et al.Avian leukosis virus subgroup J induces its receptor-chNHE1up-regulation[J].Virol J,2016(13):58.
[12] Desfarges S,Ciuffi A.Retroviral integration site selection[J].Viruses,2010,2(1):111-130.
[13] Mazzeo C,Calvo V,Alonso R,et al.Protein kinase D1/2is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes[J].Cell Death Differ,2016,23(1):99-109.
[14]史若男,李婉,宋丽婷,等.动物免疫抑制研究进展[J].动物医学进展,2014,35(9):93-96.
[15]马金松,刘丽仙,豆腾飞,等.种鸡场禽白血病的综合防制[J].云南畜牧兽医,2016(3):17-19.
[16]崔治中.禽白血病病毒的亚群和准种多样性及其在不同选择压作用下的演变[J].生命科学,2016(3):283-294.
[17]朱丽君,董雯雯,马宁宁,等.ALV-J不同接种途径诱导SPF鸡免疫抑制状况的比较分析[J].中国兽医学报,2017,37(11):2068-2075.
[18] Chen G,Li Z,Su S,et al.Identification of key genes fluctuated induced by avian leukemia virus(ALV-J)infection in chicken cells[J].In Vitro Cell Dev Biol Anim,2018,54(1):41-51.
[19] Hu X,Chen S,Jia C,et al.Gene expression profile and long non-coding RNA analysis,using RNA-Seq,in chicken embryonic fibroblast cells infected by avian leukosis virus J[J].Arch Virol,2018,163(3):639-647.
[20]唐敬洁,刘玉芬,吴迪.禽类Toll样受体研究进展[J].动物医学进展,2017,38(1):86-89.
[21] Feng M,Dai M,Xie T,et al.Innate immune responses in ALV-J infected chicks and chickens with Hemangioma in vivo[J].Front Microbiol,2016(7):786.
[22] Dai M,Wu S,Feng M,et al.Recombinant chicken interferonalpha inhibits the replication of exogenous avian leukosis virus(ALV)in DF-1cells[J].Mol Immunol,2016,(76):62-69.
[23] Liu D,Qiu Q,Zhang X,et al.Infection of chicken bone marrow mononuclear cells with subgroup J avian leukosis virus inhibits dendritic cell differentiation and alters cytokine expression[J].Infect Genet Evol,2016(44):130-136.
[24] Qiu L L,Xu L,Guo X M,et al.Gene expression changes in chicken NLRC5signal pathway associated with in vitro avian leukosis virus subgroup J infection[J].Genet Mol Res,2016,15(1):1-7.
[25] Dai M,Feng M,Liao M,et al.Inhibition of ERK/MAPK suppresses avian leukosis virus subgroup A and B replication[J].Microb Pathog,2017(102):29-35.
[26] Dai M,Feng M,Ye Y,et al.Exogenous avian leukosis virusinduced activation of the ERK/AP1pathway is required for virus replication and correlates with virus-induced tumorigenesis[J].Sci Rep,2016(6):19226.
[27] Wang Q,Gao Y,Ji X,et al.Differential expression of microRNAs in avian leukosis virus subgroup J-induced tumors[J].Vet Microbiol,2013,162(1):232-238.
[28] Feng W,Zhou D,Meng W,et al.Growth retardation induced by avian leukosis virus subgroup J associated with down-regulated Wnt/beta-catenin pathway[J].Microb Pathog,2017(104):48-55.
[29] Hang B,Sang J,Qin A,et al.Transcription analysis of the response of chicken bursa of Fabricius to avian leukosis virus subgroup J strain JS09GY3[J].Virus Res,2014,188:8-14.
[30] Zhang X,Yan Y,Lei X,et al.Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens[J].Oncotarget,2017,8(21):34961-34970.
[31] Wang G,Wang Z,Zhuang P,et al.Exosomes carring gag/env of ALV-J possess negative effect on immunocytes[J].Microb Pathog,2017(112):142-147.
[32]杜建中.我国禽类养殖的现状与对策思考[J].南方农业,2015,9(16):80-81.
[33] Choi K M,Johnson E S.Occupational exposure assessment using antibody levels:exposure to avian leukosis/sarcoma viruses in the poultry industry[J].Int J Environ Health Res,2011,21(4):306-316.