免疫治疗联合抗病毒治疗对于病毒性脑炎患者临床效果观察
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摘要
目的总结免疫治疗与常规抗病毒治疗联合应用治疗患者病毒性脑炎临床疗效。方法选取2016年5月至2017年5月笔者所在医院神经内科患者100例,采用随机法,分为两组,每组有患者50例。对照组患者给予的是常规的抗病毒治疗方式,实验组结合丙种球蛋白治疗方法进行辅助治疗,对两组实验结果进行评估。结果实验组的患者有效率达到了94.00%,而对照组仅有对照组74.00%,实验组显著优于对照组,有统计学差异(P<0.05)。干预前两组患者的MESSS评分对比无显著差异,干预后观察组患者的MESSS评分显著低于对照组患者,观察组患者MESSS评分均优于对照组(P<0.05)。结论对患者病毒性脑炎的治疗,可以使用丙种球蛋白联合常规抗病毒方法进行,治疗效果更有效。
Objective To summarize the clinical efficacy of immunotherapy combined with conventional antiviral therapy in the treatment of viral encephalitis. Methods 100 patients in neurology department of our hospital from May 2016 to May-2017 were randomLy divided into two groups with 50 patients in each group. The patients in the control group were given conventional antiviral therapy, and the experimental group was treated with the therapy of gamma globulin, and the results of the two groups were evaluated.Results The effective rate of the patients in the experimental group reached 94%, while the control group was only 74% of the control group, and the experimental group was significantly better than the control group, with a statistically significant difference(P<0.05).There was no significant difference in the MESSS score of the two groups before the intervention, and the MESSS score of the patients in the observation group was significantly lower than that of the control group, and the MESSS score of the observation group was better than that of the control group(P<0.05). Conclusion The treatment of patients with viral encephalitis can be treated with gamma globulin combined with conventional antiviral therapy, and the treatment effect is more effective.
Objective To summarize the clinical efficacy of immunotherapy combined with conventional antiviral therapy in the treatment of viral encephalitis. Methods 100 patients in neurology department of our hospital from May 2016 to May-2017 were randomLy divided into two groups with 50 patients in each group. The patients in the control group were given conventional antiviral therapy, and the experimental group was treated with the therapy of gamma globulin, and the results of the two groups were evaluated.Results The effective rate of the patients in the experimental group reached 94%, while the control group was only 74% of the control group, and the experimental group was significantly better than the control group, with a statistically significant difference(P<0.05).There was no significant difference in the MESSS score of the two groups before the intervention, and the MESSS score of the patients in the observation group was significantly lower than that of the control group, and the MESSS score of the observation group was better than that of the control group(P<0.05). Conclusion The treatment of patients with viral encephalitis can be treated with gamma globulin combined with conventional antiviral therapy, and the treatment effect is more effective.
引文
[1]刘建平,王士列,刘煜帆.30例成人病毒性脑炎临床治疗疗效观察与分析[J].中国医学创新,2014,11(03):109-110.
[2]邹雪,王滨.更昔洛韦治疗成人病毒性脑炎患者的疗效及其对CPR,IL-6和TNF-α的影响[J].中南药学,2016,14(01):82-84.
[3]张金躯.更昔洛韦对病毒性脑炎患者抗病毒治疗的疗效及其对CPR、IL-6、TNF-α指标的影响[J].抗感染药学,2017,14(01):177-178.
[4]张跃军,张立梅,焦春发,等.高压氧辅助阿昔洛韦联合炎琥宁治疗病毒性脑炎临床效果[J].临床误诊误治,2016,29(S1):86-88.
[5]刘朝锋.依达拉奉对病毒性脑炎患者血清蛋白代谢的影响[J].四川生理科学杂志,2017,39(01):26-28.
[6]田盼,欧阳敏,范学文,等.成人颅内感染患者的临床资料分析[J].宁夏医学杂志,2017,39(04):320-323.
[7]王明,邹乐乐,赵晓玲,等.亚低温治疗成人病毒性脑炎疗效观察[J].中国实用神经疾病杂志,2016,19(22):78-79.
[8]康传铭.阿昔洛韦联合炎琥宁治疗成人病毒性脑炎的临床观察[J].中国医药指南,2016,14(18):73.
[9]张跃军,张立梅,焦春发,等.高压氧辅助阿昔洛韦联合炎琥宁治疗小儿和成人病毒性脑炎的血清学研究[J].解放军医药杂志,2016,28(S1):1-3.
[2]邹雪,王滨.更昔洛韦治疗成人病毒性脑炎患者的疗效及其对CPR,IL-6和TNF-α的影响[J].中南药学,2016,14(01):82-84.
[3]张金躯.更昔洛韦对病毒性脑炎患者抗病毒治疗的疗效及其对CPR、IL-6、TNF-α指标的影响[J].抗感染药学,2017,14(01):177-178.
[4]张跃军,张立梅,焦春发,等.高压氧辅助阿昔洛韦联合炎琥宁治疗病毒性脑炎临床效果[J].临床误诊误治,2016,29(S1):86-88.
[5]刘朝锋.依达拉奉对病毒性脑炎患者血清蛋白代谢的影响[J].四川生理科学杂志,2017,39(01):26-28.
[6]田盼,欧阳敏,范学文,等.成人颅内感染患者的临床资料分析[J].宁夏医学杂志,2017,39(04):320-323.
[7]王明,邹乐乐,赵晓玲,等.亚低温治疗成人病毒性脑炎疗效观察[J].中国实用神经疾病杂志,2016,19(22):78-79.
[8]康传铭.阿昔洛韦联合炎琥宁治疗成人病毒性脑炎的临床观察[J].中国医药指南,2016,14(18):73.
[9]张跃军,张立梅,焦春发,等.高压氧辅助阿昔洛韦联合炎琥宁治疗小儿和成人病毒性脑炎的血清学研究[J].解放军医药杂志,2016,28(S1):1-3.