复方中药治疗糖尿病的研究进展
|
摘要
糖尿病是以血糖水平升高为主要特征的糖代谢紊乱慢性疾病。随着国民生活水平提高和生活方式改变,糖尿病发病率及并发症逐年升高,带来了严重公共健康问题。近年来糖尿病药物研发领域进展迅速,1型糖尿病药物以研发长效缓释胰岛素制剂为主,2型糖尿病药物多针对单靶点进行研发,但是长期服用易引发酮酸中毒、肥胖、心脑血管等副作用。考虑到对复杂慢性疾病的长期治疗,目前降糖西药研发加强多靶点复方制剂开发,不断有新的西药降糖复方制剂获批上市,这提示复方制剂在糖尿病治疗上的合理性和必要性。基于多活性成分的中药复方制剂具有多成分单靶点的加合作用,多成分多靶点的协同作用及毒性分散效应,有助于恢复机体血糖稳态,且作用温和副作用小,在糖尿病长期治疗中取得不错的临床疗效。该文主要从近年来复方中药治疗糖尿病的临床进展为主线,以经典复方、现代复方和中西药复方干预途径及靶点为切入点,强调机制互补和强强组合来减毒增效的作用机制研究进展进行综述,为合理利用复方中药治疗糖尿病提供理论依据,并有效指导新型复方降糖中药研发。
Diabetes is a chronic disorder of glucose metabolism characterized by elevated blood glucose levels. With the improvement in living standards and the changes in lifestyle,T2 DM incidence has a dramatic increase in the past decades,bringing a series of public health problems. In the research and development field of diabetic drugs,T1 DM drugs are mainly long-acting sustained-release insulin preparations,whereas T2 DM drugs mainly are based on single target. T2 DM drugs usually have a good anti-hyperglycemic effect,but with side effects for long-term administration. Therefore,the research and development of hypoglycemic drugs focus on formula drugs with multi-component,multi-target and multi-pathway effects. In the similar principle of action,traditional Chinese medicine formula has achieved a good efficacy in the treatment of diabetes,with mild anti-hyperglycemic effects and multiple-component synergistic effects in intervening the pathogenesis of diabetes,including additive effect,synergy effect and toxicity scattering effect. This article mainly reviews clinical trials and mechanisms of action of traditional Chinese medicine formula for the treatment of diabetes,so as to provide a reference to the rational and effective clinical application of traditional Chinese medicine formula in treating diabetes.
Diabetes is a chronic disorder of glucose metabolism characterized by elevated blood glucose levels. With the improvement in living standards and the changes in lifestyle,T2 DM incidence has a dramatic increase in the past decades,bringing a series of public health problems. In the research and development field of diabetic drugs,T1 DM drugs are mainly long-acting sustained-release insulin preparations,whereas T2 DM drugs mainly are based on single target. T2 DM drugs usually have a good anti-hyperglycemic effect,but with side effects for long-term administration. Therefore,the research and development of hypoglycemic drugs focus on formula drugs with multi-component,multi-target and multi-pathway effects. In the similar principle of action,traditional Chinese medicine formula has achieved a good efficacy in the treatment of diabetes,with mild anti-hyperglycemic effects and multiple-component synergistic effects in intervening the pathogenesis of diabetes,including additive effect,synergy effect and toxicity scattering effect. This article mainly reviews clinical trials and mechanisms of action of traditional Chinese medicine formula for the treatment of diabetes,so as to provide a reference to the rational and effective clinical application of traditional Chinese medicine formula in treating diabetes.
引文
[1] Cho N H,Shaw J E,Karuranga S,et al.IDF diabetes atlas:global estimates of diabetes prevalence for 2017 and projections for 2045[J].Diabetes Res Clin Pract,2018,138:271.
[2] Ashcroft F M,Rorsman P. Diabetes mellitus and theβcell:the last ten years[J]. Cell,2012,148(6):1160.
[3]徐风,杨东辉,尚明英,等.中药药效物质的“显效形式”、“叠加作用”和“毒性分散效应”———由中药体内代谢研究引发的思考[J].世界科学技术———中医药现代化,2014,16(4):688.
[4]仝小林.黄连为主药系列经方在糖尿病辨治中的运用[J].中医杂志,2013,54(3):209.
[5]林菁.黄连解毒汤治疗肥胖2型糖尿病73例临床观察[J].中国民族民间医药,2015,24(3):70.
[6]陈一君,吴庆光,刘颖,等.黄连解毒汤单独用药及联合用药对2型糖尿病治疗效果的Meta分析[J].中国实验方剂学杂志,2018,24(10):212.
[7]李松,韩景辉,孟长海.黄连解毒汤联合复方丹参滴丸对初诊2型糖尿病患者胰岛β细胞功能及血清CRP、ICAM-1水平的影响[J].中医学报,2018,33(4):560.
[8]丁香.中药黄连解毒汤治疗2型糖尿病患者的临床效果[J].中国药物经济学,2018,13(8):62.
[9]张森乐.黄连解毒汤加味对肥胖2型糖尿病患者血糖、血脂及胰岛β细胞功能的影响[J].实用糖尿病杂志,2018,14(1):54.
[10]王艺萍,张丽艳,王意忠,等.黄连解毒汤对2型糖尿病肾病大鼠肾脏的保护作用及其机制探讨[J].现代生物医学进展,2018,18(5):858.
[11]杨永霞,王琳琳,郑凌云,等.基于核磁共振氢谱代谢组学研究黄连解毒汤对胰岛素抵抗大鼠棕色脂肪组织代谢组的影响[J].高等学校化学学报,2014,35(9):1883.
[12] Zhang X J,Deng Y X,Shi Q Z,et al. Hypolipidemic effect of the Chinese polyherbal HuanglianJiedu decoction in type 2diabetic rats and its possible mechanism[J]. Phytomedicine,2014,21(5):615.
[13]苏虹霞,段玉红.基于分子对接技术研究黄连解毒汤治疗糖尿病的物质基础[J].中医药信息,2018(5):13.
[14]衡霞,朱宝杰,孙莉敏,等.基于网络药理学的黄连解毒汤调节巨噬细胞炎症反应和代谢的作用机制研究[J].药学学报,2018,53(9):1449.
[15]涂珺,罗新新,李冰涛,等.小檗碱对脂肪胰岛素抵抗细胞PPARγ及脂肪分泌因子表达的影响[J].中国中药杂志,2016,41(11):1983.
[16]朱水兰,雷婷,高旭,等.药根碱多重调控脂肪胰岛素抵抗细胞葡萄糖转运蛋白的降糖效应研究[J].中国中药杂志,2018,43(6):1215.
[17] Xu J,Lian F,Zhao L,et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula[J]. ISME J,2015,9(3):552.
[18]冯新格,严育忠,曾艺鹏,等.葛根芩连汤对2型糖尿病湿热证肠道菌群的影响[J].世界中西医结合杂志,2016,11(8):1110.
[19]张颖,蔡春沉.葛根芩连汤饮片治疗2型糖尿病的疗效观察[J].辽宁中医杂志,2016,43(4):783.
[20]朱亚歌.葛根芩连汤治疗2型糖尿病60例临床观察[J].中国民族民间医药,2018,27(1):114.
[21]单思,涂珺,严小军,等.基于IPA探析葛根芩连汤治疗2型糖尿病分子机制的研究[J].中华中医药杂志,2017,32(12):5342.
[22]罗新新,朱水兰,李冰涛,等.葛根芩连汤激活PPARγ上调脂联素和GLUT4表达改善脂肪胰岛素抵抗[J].中国中药杂志,2017,42(23):4641.
[23]王烨,周琦,朱向东,等.葛根芩连汤对自发肥胖型2型糖尿病ZDF大鼠FFA及NF-κB/IRS2通路的影响[J].上海中医药大学学报,2017,31(6):65.
[24]周琦,朱向东,仝小林,等.葛根芩连汤对2型糖尿病模型大鼠胰岛细胞IRS-2/PI3K-Akt通路的影响[J].中医杂志,2018,59(11):973.
[25]章常华,孙军,肖琴,等.葛根芩连汤含药血清对L6肌细胞胰岛素抵抗模型中PI3K、Akt、GLUT4、AMPK蛋白的影响[J].时珍国医国药,2018(7):1537.
[26] Li J,Xu J,Hou R,et al. Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice[J]. Biomed Pharmacother,2017,89:10.
[27] Huang Z Q,Fan X M,Wang Y M,et al. A new method to evaluate the dose-effect relationship of a TCM formula Gegen Qinlian Decoction:"focus"mode of integrated biomarkers[J]. Acta Pharmacol Sin,2017,38(8):1141.
[28]涂珺,李冰涛,张启云,等.基于均匀设计的葛根芩连汤降血糖作用的量效关系研究[C].保定:世界中医药联合会内分泌暨方药量效研究专业委员会第二届学术年会,2015.
[29]罗新新,徐国良,黎宇,等.葛根调节脂肪细胞糖脂代谢改善胰岛素抵抗的研究[J].中国中药杂志,2016,41(14):2687.
[30]黎宇,罗新新,严奉东,等.葛根上调肝胰岛素抵抗HepG2细胞OB-R,IRS2,GLUT1和GLUT2蛋白调节糖代谢的研究[J].中国中药杂志,2017,42(10):1939.
[31]涂珺,朱水兰,周小妹.黄芩苷、小檗碱和葛根素体外胰岛素抵抗细胞差异化降糖作用研究[J].中国中药杂志,2018,43(20):409.
[32]牟健,庄贵华,尚红利.加味补阳还五汤对糖尿病大鼠血糖的影响及其抗氧化活性[J].中成药,2017,39(8):1561.
[33] Lin L,Wu S Y,Wang G F,et al. Effect of astragalosideⅣon hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin[J]. Phytother Res,2010,24(2):219.
[34]赵胜,毛奇.补阳还五汤合八珍汤治疗糖尿病肌萎缩的疗效及其对患者血糖、胰岛功能、神经传导功能、血清相关因子的影响[J].中国实验方剂学杂志,2018,24(22):175.
[35]王涓涓,邵岩,韩向莉,等.小陷胸汤合补阳还五汤治疗早期糖尿病肾病临床观察[J].中国实验方剂学杂志,2016,22(21):152.
[36]孙伯欣,李羚青.补阳还五汤治疗糖尿病周围神经病变的临床疗效观察[J].基因组学与应用生物学,2017,36(8):3398.
[37]张宏艳.补阳还五汤加减治疗2型糖尿病肾病30例[J].中国中医药现代远程教育,2017,15(8):99.
[38]潘莉,张建新,陈玲燕,等.补阳还五汤对2型糖尿病大鼠模型血清TNF-α及肾脏VCAM-1表达的影响[J].中国老年学杂志,2011,31(23):4632.
[39]李阳,徐洁,王芳,等.补阳还五汤对糖尿病大鼠主动脉PPAR-γ表达的影响[J].中国中医急症,2012,21(1):62.
[40]贲莹,张凤华,梁文杰,等.不同黄芪剂量补阳还五汤对糖尿病大鼠周围神经功能及氧化应激的作用[J].中成药,2015,37(1):199.
[41] Hu H,Zhu Q,Su J,et al. Effects of an enriched extract of paeoniflorin,a monoterpene glycoside used in Chinese herbal medicine,on cholesterol metabolism in a hyperlipidemic rat model[J].Med Sci Monit,2017,23:3412.
[42] Li Y C,Qiao J Y,Wang B,et al. Paeoniflorin ameliorates fructose-induced insulin resistance and hepatic steatosis by activating LKB1/AMPK and AKT pathways[J]. Nutrients,2018,10(8):1024.
[43]杨凤艳,于敬,罗刚,等.新工艺金芪降糖片对糖尿病小鼠血糖血脂的影响[J].时珍国医国药,2012,23(3):677.
[44]朱磊.金芪降糖片在2型糖尿病患者临床治疗中的意义[J].中国处方药,2016,14(11):87.
[45]白蓉蓉,李志军.金芪降糖片联合替米沙坦治疗早期糖尿病肾病的疗效观察[J].现代药物与临床,2015,30(11):1382.
[46]李慧卉.金芪降糖片联合那格列奈治疗2型糖尿病的临床研究[J].现代药物与临床,2018,33(8):2001.
[47] Liu Q, Liu S, Gao L, et al. Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAymice[J]. Acta Pharm Sin B,2017,7(4):461.
[48] Gao L H,Liu Q,Liu S N,et al. A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice[J]. J Ethnopharmacol,2014,151(1):675.
[49]吕元军,李长平,谭效锋,等.金芪降糖片对糖尿病大鼠肾脏IL-17和IL-23表达的影响[J].天津医药,2017,45(3):249.
[50]尹清晟,范姗姗,陈瑞,等.金芪降糖片联合胰岛素激活PPAR-α/FGF21信号改善2型糖尿病大鼠胰岛素抵抗[J].药物评价研究,2018,41(8):1425.
[51]陈瑞,马宁宁,范姗姗,等.基于代谢组学分析金芪降糖片改善2型糖尿病大鼠脂代谢紊乱的作用机制[J].中国实验方剂学杂志,2018,24(20):102.
[52]姜晖,李开智,王绍志,等.高效液相色谱法测定养阴降糖片4种成分的含量[J].中国药业,2017,26(7):32.
[53]杨丽华,吕维斌.养阴降糖片干预糖尿病前期患者60例临床观察[J].云南中医中药杂志,2014,35(7):49.
[54]王敬民,徐青,陈菊仙,等.养阴降糖片联合银杏叶片对早期2型糖尿病氧化应激与胰岛素抵抗的干预[J].中华中医药学刊,2013(8):1677.
[55]詹锐文.养阴降糖片联合二甲双胍治疗2型糖尿病120例疗效观察[J].河北中医,2004,26(10):748.
[56]黄平.养阴降糖片对糖尿病大鼠IGF-Ⅱ的影响[J].浙江中医学院学报,2000,24(5):49.
[57] Gong W,Li J,Chen Z,et al. Polydatin promotes Nrf2-ARE antioxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys[J]. Free Radic Biol Med,2017,106:393.
[58] Roy S,Metya S K,Sannigrahi S,et al. Treatment with ferulic acid to rats with streptozotocin-induced diabetes:effects on oxidative stress,pro-inflammatory cytokines,and apoptosis in the pancreaticβ-cell[J]. Endocrine,2013,44(2):369.
[59] Roy S,Metya S K,Rahaman N,et al. Ferulic acid in the treatment of post-diabetes testicular damage:relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF-β1,IL-1β,and Akt signalling[J]. Cell Biochem Funct,2014,32(1):115.
[60]钱瑾,黎明,吴嘉瑞,等.消渴丸中药成分对α-葡萄糖苷酶抑制作用的研究[J].中国实验方剂学杂志,2012,18(7):173.
[61]王旭,陈军,周云庆,等.消渴丸治疗2型糖尿病患者105例临床疗效及安全性观察[J].世界中西医结合杂志,2015,10(2):223.
[62]秦蕊,朱新建,董月华.消渴丸联合盐酸二甲双胍治疗2型糖尿病临床观察[J].辽宁中医杂志,2017,44(4):759.
[63]钟慧玲,谢琼,吴坚,等.消渴丸联合二甲双胍治疗老年2型糖尿病临床研究[J].亚太传统医药,2017,13(19):143.
[64]耿春贤,刘菊妍,邹琦,等.消渴丸中药组分对GK大鼠血脂、胰岛素和胰腺影响的实验研究[J].世界中西医结合杂志,2014,9(8):822.
[65]邓慧敏,刘菊妍,周杰,等.消渴丸对GK大鼠糖尿病心肌病的作用及机理初探[J].实用糖尿病杂志,2014,10(1):31.
[2] Ashcroft F M,Rorsman P. Diabetes mellitus and theβcell:the last ten years[J]. Cell,2012,148(6):1160.
[3]徐风,杨东辉,尚明英,等.中药药效物质的“显效形式”、“叠加作用”和“毒性分散效应”———由中药体内代谢研究引发的思考[J].世界科学技术———中医药现代化,2014,16(4):688.
[4]仝小林.黄连为主药系列经方在糖尿病辨治中的运用[J].中医杂志,2013,54(3):209.
[5]林菁.黄连解毒汤治疗肥胖2型糖尿病73例临床观察[J].中国民族民间医药,2015,24(3):70.
[6]陈一君,吴庆光,刘颖,等.黄连解毒汤单独用药及联合用药对2型糖尿病治疗效果的Meta分析[J].中国实验方剂学杂志,2018,24(10):212.
[7]李松,韩景辉,孟长海.黄连解毒汤联合复方丹参滴丸对初诊2型糖尿病患者胰岛β细胞功能及血清CRP、ICAM-1水平的影响[J].中医学报,2018,33(4):560.
[8]丁香.中药黄连解毒汤治疗2型糖尿病患者的临床效果[J].中国药物经济学,2018,13(8):62.
[9]张森乐.黄连解毒汤加味对肥胖2型糖尿病患者血糖、血脂及胰岛β细胞功能的影响[J].实用糖尿病杂志,2018,14(1):54.
[10]王艺萍,张丽艳,王意忠,等.黄连解毒汤对2型糖尿病肾病大鼠肾脏的保护作用及其机制探讨[J].现代生物医学进展,2018,18(5):858.
[11]杨永霞,王琳琳,郑凌云,等.基于核磁共振氢谱代谢组学研究黄连解毒汤对胰岛素抵抗大鼠棕色脂肪组织代谢组的影响[J].高等学校化学学报,2014,35(9):1883.
[12] Zhang X J,Deng Y X,Shi Q Z,et al. Hypolipidemic effect of the Chinese polyherbal HuanglianJiedu decoction in type 2diabetic rats and its possible mechanism[J]. Phytomedicine,2014,21(5):615.
[13]苏虹霞,段玉红.基于分子对接技术研究黄连解毒汤治疗糖尿病的物质基础[J].中医药信息,2018(5):13.
[14]衡霞,朱宝杰,孙莉敏,等.基于网络药理学的黄连解毒汤调节巨噬细胞炎症反应和代谢的作用机制研究[J].药学学报,2018,53(9):1449.
[15]涂珺,罗新新,李冰涛,等.小檗碱对脂肪胰岛素抵抗细胞PPARγ及脂肪分泌因子表达的影响[J].中国中药杂志,2016,41(11):1983.
[16]朱水兰,雷婷,高旭,等.药根碱多重调控脂肪胰岛素抵抗细胞葡萄糖转运蛋白的降糖效应研究[J].中国中药杂志,2018,43(6):1215.
[17] Xu J,Lian F,Zhao L,et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula[J]. ISME J,2015,9(3):552.
[18]冯新格,严育忠,曾艺鹏,等.葛根芩连汤对2型糖尿病湿热证肠道菌群的影响[J].世界中西医结合杂志,2016,11(8):1110.
[19]张颖,蔡春沉.葛根芩连汤饮片治疗2型糖尿病的疗效观察[J].辽宁中医杂志,2016,43(4):783.
[20]朱亚歌.葛根芩连汤治疗2型糖尿病60例临床观察[J].中国民族民间医药,2018,27(1):114.
[21]单思,涂珺,严小军,等.基于IPA探析葛根芩连汤治疗2型糖尿病分子机制的研究[J].中华中医药杂志,2017,32(12):5342.
[22]罗新新,朱水兰,李冰涛,等.葛根芩连汤激活PPARγ上调脂联素和GLUT4表达改善脂肪胰岛素抵抗[J].中国中药杂志,2017,42(23):4641.
[23]王烨,周琦,朱向东,等.葛根芩连汤对自发肥胖型2型糖尿病ZDF大鼠FFA及NF-κB/IRS2通路的影响[J].上海中医药大学学报,2017,31(6):65.
[24]周琦,朱向东,仝小林,等.葛根芩连汤对2型糖尿病模型大鼠胰岛细胞IRS-2/PI3K-Akt通路的影响[J].中医杂志,2018,59(11):973.
[25]章常华,孙军,肖琴,等.葛根芩连汤含药血清对L6肌细胞胰岛素抵抗模型中PI3K、Akt、GLUT4、AMPK蛋白的影响[J].时珍国医国药,2018(7):1537.
[26] Li J,Xu J,Hou R,et al. Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice[J]. Biomed Pharmacother,2017,89:10.
[27] Huang Z Q,Fan X M,Wang Y M,et al. A new method to evaluate the dose-effect relationship of a TCM formula Gegen Qinlian Decoction:"focus"mode of integrated biomarkers[J]. Acta Pharmacol Sin,2017,38(8):1141.
[28]涂珺,李冰涛,张启云,等.基于均匀设计的葛根芩连汤降血糖作用的量效关系研究[C].保定:世界中医药联合会内分泌暨方药量效研究专业委员会第二届学术年会,2015.
[29]罗新新,徐国良,黎宇,等.葛根调节脂肪细胞糖脂代谢改善胰岛素抵抗的研究[J].中国中药杂志,2016,41(14):2687.
[30]黎宇,罗新新,严奉东,等.葛根上调肝胰岛素抵抗HepG2细胞OB-R,IRS2,GLUT1和GLUT2蛋白调节糖代谢的研究[J].中国中药杂志,2017,42(10):1939.
[31]涂珺,朱水兰,周小妹.黄芩苷、小檗碱和葛根素体外胰岛素抵抗细胞差异化降糖作用研究[J].中国中药杂志,2018,43(20):409.
[32]牟健,庄贵华,尚红利.加味补阳还五汤对糖尿病大鼠血糖的影响及其抗氧化活性[J].中成药,2017,39(8):1561.
[33] Lin L,Wu S Y,Wang G F,et al. Effect of astragalosideⅣon hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin[J]. Phytother Res,2010,24(2):219.
[34]赵胜,毛奇.补阳还五汤合八珍汤治疗糖尿病肌萎缩的疗效及其对患者血糖、胰岛功能、神经传导功能、血清相关因子的影响[J].中国实验方剂学杂志,2018,24(22):175.
[35]王涓涓,邵岩,韩向莉,等.小陷胸汤合补阳还五汤治疗早期糖尿病肾病临床观察[J].中国实验方剂学杂志,2016,22(21):152.
[36]孙伯欣,李羚青.补阳还五汤治疗糖尿病周围神经病变的临床疗效观察[J].基因组学与应用生物学,2017,36(8):3398.
[37]张宏艳.补阳还五汤加减治疗2型糖尿病肾病30例[J].中国中医药现代远程教育,2017,15(8):99.
[38]潘莉,张建新,陈玲燕,等.补阳还五汤对2型糖尿病大鼠模型血清TNF-α及肾脏VCAM-1表达的影响[J].中国老年学杂志,2011,31(23):4632.
[39]李阳,徐洁,王芳,等.补阳还五汤对糖尿病大鼠主动脉PPAR-γ表达的影响[J].中国中医急症,2012,21(1):62.
[40]贲莹,张凤华,梁文杰,等.不同黄芪剂量补阳还五汤对糖尿病大鼠周围神经功能及氧化应激的作用[J].中成药,2015,37(1):199.
[41] Hu H,Zhu Q,Su J,et al. Effects of an enriched extract of paeoniflorin,a monoterpene glycoside used in Chinese herbal medicine,on cholesterol metabolism in a hyperlipidemic rat model[J].Med Sci Monit,2017,23:3412.
[42] Li Y C,Qiao J Y,Wang B,et al. Paeoniflorin ameliorates fructose-induced insulin resistance and hepatic steatosis by activating LKB1/AMPK and AKT pathways[J]. Nutrients,2018,10(8):1024.
[43]杨凤艳,于敬,罗刚,等.新工艺金芪降糖片对糖尿病小鼠血糖血脂的影响[J].时珍国医国药,2012,23(3):677.
[44]朱磊.金芪降糖片在2型糖尿病患者临床治疗中的意义[J].中国处方药,2016,14(11):87.
[45]白蓉蓉,李志军.金芪降糖片联合替米沙坦治疗早期糖尿病肾病的疗效观察[J].现代药物与临床,2015,30(11):1382.
[46]李慧卉.金芪降糖片联合那格列奈治疗2型糖尿病的临床研究[J].现代药物与临床,2018,33(8):2001.
[47] Liu Q, Liu S, Gao L, et al. Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAymice[J]. Acta Pharm Sin B,2017,7(4):461.
[48] Gao L H,Liu Q,Liu S N,et al. A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice[J]. J Ethnopharmacol,2014,151(1):675.
[49]吕元军,李长平,谭效锋,等.金芪降糖片对糖尿病大鼠肾脏IL-17和IL-23表达的影响[J].天津医药,2017,45(3):249.
[50]尹清晟,范姗姗,陈瑞,等.金芪降糖片联合胰岛素激活PPAR-α/FGF21信号改善2型糖尿病大鼠胰岛素抵抗[J].药物评价研究,2018,41(8):1425.
[51]陈瑞,马宁宁,范姗姗,等.基于代谢组学分析金芪降糖片改善2型糖尿病大鼠脂代谢紊乱的作用机制[J].中国实验方剂学杂志,2018,24(20):102.
[52]姜晖,李开智,王绍志,等.高效液相色谱法测定养阴降糖片4种成分的含量[J].中国药业,2017,26(7):32.
[53]杨丽华,吕维斌.养阴降糖片干预糖尿病前期患者60例临床观察[J].云南中医中药杂志,2014,35(7):49.
[54]王敬民,徐青,陈菊仙,等.养阴降糖片联合银杏叶片对早期2型糖尿病氧化应激与胰岛素抵抗的干预[J].中华中医药学刊,2013(8):1677.
[55]詹锐文.养阴降糖片联合二甲双胍治疗2型糖尿病120例疗效观察[J].河北中医,2004,26(10):748.
[56]黄平.养阴降糖片对糖尿病大鼠IGF-Ⅱ的影响[J].浙江中医学院学报,2000,24(5):49.
[57] Gong W,Li J,Chen Z,et al. Polydatin promotes Nrf2-ARE antioxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys[J]. Free Radic Biol Med,2017,106:393.
[58] Roy S,Metya S K,Sannigrahi S,et al. Treatment with ferulic acid to rats with streptozotocin-induced diabetes:effects on oxidative stress,pro-inflammatory cytokines,and apoptosis in the pancreaticβ-cell[J]. Endocrine,2013,44(2):369.
[59] Roy S,Metya S K,Rahaman N,et al. Ferulic acid in the treatment of post-diabetes testicular damage:relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF-β1,IL-1β,and Akt signalling[J]. Cell Biochem Funct,2014,32(1):115.
[60]钱瑾,黎明,吴嘉瑞,等.消渴丸中药成分对α-葡萄糖苷酶抑制作用的研究[J].中国实验方剂学杂志,2012,18(7):173.
[61]王旭,陈军,周云庆,等.消渴丸治疗2型糖尿病患者105例临床疗效及安全性观察[J].世界中西医结合杂志,2015,10(2):223.
[62]秦蕊,朱新建,董月华.消渴丸联合盐酸二甲双胍治疗2型糖尿病临床观察[J].辽宁中医杂志,2017,44(4):759.
[63]钟慧玲,谢琼,吴坚,等.消渴丸联合二甲双胍治疗老年2型糖尿病临床研究[J].亚太传统医药,2017,13(19):143.
[64]耿春贤,刘菊妍,邹琦,等.消渴丸中药组分对GK大鼠血脂、胰岛素和胰腺影响的实验研究[J].世界中西医结合杂志,2014,9(8):822.
[65]邓慧敏,刘菊妍,周杰,等.消渴丸对GK大鼠糖尿病心肌病的作用及机理初探[J].实用糖尿病杂志,2014,10(1):31.