307例吸毒者尿蛋白检测结果分析
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摘要
目的通过检测吸毒者尿液总蛋白(TP)、微量白蛋白(mAlb)、α1-微球蛋白(α1-MG)水平,评估吸毒者的肾功能状况。方法检测307例吸毒者和201名体检健康者(正常对照组)尿液TP、mAlb、α1-MG水平。根据吸毒者吸食毒品的种类分为冰毒组(213例)、吗啡组(30例)、混吸组(36例)和其他组(28例),比较各组各项目的检测结果。结果吸毒组尿TP、mAlb、α1-MG水平均明显高于正常对照组(P<0.000 1)。冰毒组mAlb水平高于吗啡组(P<0.05),而尿TP和α1-MG水平低于吗啡组(P<0.05)。吗啡组尿mAlb水平低于混吸组(P<0.05)。混吸组尿α1-MG水平高于其他组(P<0.05)。男性吸毒者尿TP及α1-MG水平明显高于女性(P<0.05、P<0.001),而mAlb差异无统计学意义(P>0.05)。结论冰毒对肾小球的损伤更为严重,吗啡对肾小管的损伤更为严重。应高度重视并加强对吸毒者的健康干预,有效地控制毒品危害。
Objective To assess the status of renal function of cases with drug addicts by determining urinary total protein(TP),microalbumin(m Alb) and alpha 1-microglobulin(α1-MG) levels. Methods Urinary TP,m Alb and α1-MG levels were determined in 307 cases with drug addicts and 201 healthy subjects(healthy control group). According to the types of drugs taken by the cases with drug addicts,they were classified into methamphetamine group(213 cases),morphine group(30 cases),mixed group(36 cases) and the other group(28 cases). Their results were compared. Results The TP,mAlb and α1-MG levels in drug addict group were higher than those in healthy control group(P<0.000 1). The mAlb level in methamphetamine group was higher than that in morphine group(P<0.05),but the TP and α1-MG levels were lower(P<0.05). The mAlb level in morphine group was lower than that in mixed group(P<0.05). The α1-MG level in mixed group was higher than that in the other group(P<0.05). The urinary TP and α1-MG levels of male drug addicts were higher than those of female drug addicts(P<0.05,P<0.001),and mAlb had no statistical significance(P>0.05). Conclusions Methamphetamine tends to cause serious damage to glomerulus,while morphine tends to cause serious damage to renal tubule. It should pay attention to strength the health intervention for drug addicts and control the harm of drugs.
Objective To assess the status of renal function of cases with drug addicts by determining urinary total protein(TP),microalbumin(m Alb) and alpha 1-microglobulin(α1-MG) levels. Methods Urinary TP,m Alb and α1-MG levels were determined in 307 cases with drug addicts and 201 healthy subjects(healthy control group). According to the types of drugs taken by the cases with drug addicts,they were classified into methamphetamine group(213 cases),morphine group(30 cases),mixed group(36 cases) and the other group(28 cases). Their results were compared. Results The TP,mAlb and α1-MG levels in drug addict group were higher than those in healthy control group(P<0.000 1). The mAlb level in methamphetamine group was higher than that in morphine group(P<0.05),but the TP and α1-MG levels were lower(P<0.05). The mAlb level in morphine group was lower than that in mixed group(P<0.05). The α1-MG level in mixed group was higher than that in the other group(P<0.05). The urinary TP and α1-MG levels of male drug addicts were higher than those of female drug addicts(P<0.05,P<0.001),and mAlb had no statistical significance(P>0.05). Conclusions Methamphetamine tends to cause serious damage to glomerulus,while morphine tends to cause serious damage to renal tubule. It should pay attention to strength the health intervention for drug addicts and control the harm of drugs.
引文
[1]朱莉莉,施苗盛,赵印敏.吸毒者免疫功能改变的检测及分析[J].检验医学,2013,28(12):1144-1146.
[2]陈骋,陈剑珩,沈洁,等.传统毒品向新型毒品滥用转变的现状及原因分析[J].中国药物滥用防治杂志,2017,23(3):143-145.
[3]徐友辉.新型胺类毒品的种类、危害及发展趋势[J].四川职业技术学院学报,2017,27(2):155-158.
[4]游青青,罗庆新,谢筱颖,等.吸毒患者对肾功能损害的分析[J].医学检验与临床,2013,24(5):67-68.
[5]王雪,黄明生,李静,等.甲基苯丙胺的机体毒性研究[J].中国药物滥用防治杂志,2003,9(3):43-45.
[6]MAXWELL J C.A new survey of methamphetamine users in treatment:who they are,why they like“meth”,and why they need additional services[J].Subst Use Misuse,2014,49(6):639-644.
[7]TATEYAMA M,OHTA S,NAGAO T,et al.Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat[J].Neuropharmacology,1993,32(8):761-766.
[8]郭东文,郑继旺.大鼠腹腔注射甲基苯丙胺的条件性位置偏爱效应及其受体机制[J].北京医科大学学报,1999,31(3):235-238.
[9]张倩倩,王爱平,靳洪涛.中药肾毒性的研究进展[J].解放军药学学报,2013,29(6):558-561.
[2]陈骋,陈剑珩,沈洁,等.传统毒品向新型毒品滥用转变的现状及原因分析[J].中国药物滥用防治杂志,2017,23(3):143-145.
[3]徐友辉.新型胺类毒品的种类、危害及发展趋势[J].四川职业技术学院学报,2017,27(2):155-158.
[4]游青青,罗庆新,谢筱颖,等.吸毒患者对肾功能损害的分析[J].医学检验与临床,2013,24(5):67-68.
[5]王雪,黄明生,李静,等.甲基苯丙胺的机体毒性研究[J].中国药物滥用防治杂志,2003,9(3):43-45.
[6]MAXWELL J C.A new survey of methamphetamine users in treatment:who they are,why they like“meth”,and why they need additional services[J].Subst Use Misuse,2014,49(6):639-644.
[7]TATEYAMA M,OHTA S,NAGAO T,et al.Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat[J].Neuropharmacology,1993,32(8):761-766.
[8]郭东文,郑继旺.大鼠腹腔注射甲基苯丙胺的条件性位置偏爱效应及其受体机制[J].北京医科大学学报,1999,31(3):235-238.
[9]张倩倩,王爱平,靳洪涛.中药肾毒性的研究进展[J].解放军药学学报,2013,29(6):558-561.