探讨结核感染T细胞斑点试验诊断老年人肺结核的应用价值
摘要
目的探讨结核感染T细胞斑点试验诊断老年人肺结核的应用价值。方法选取2016年6月—2018年6月期间河南理工大学第一附属医院收治的老年肺结核患者48例,设为观察组,同期选取48例老年健康体检者为对照组,分别对两组实施结核抗体测定、红细胞沉降率检查、痰结核菌涂片检查及结核感染T细胞斑点试验,比较其诊断结果。结果结核感染T细胞斑点试验诊断老年人肺结核的阳性检出率显著高于结核抗体测定、红细胞沉降率检查及痰结核菌涂片检查(P<0.05);结核感染T细胞斑点试验的特异性为97.92%,敏感性为100.00%,检测效果比其他诊断方法明显更优(P<0.05)。结论临床诊断老年人肺结核采用结核感染T细胞斑点试验诊断具有更高的诊断价值,能够使诊断准确度显著提高,值得推广。
引文
[1] 严松盛.结核感染T细胞斑点试验检测对老年活动性肺结核的诊断价值[J].中国继续医学教育,2017,9(28):19-21.
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[3] 丁宏辉,刘时憧.结核感染 T 细胞斑点试验在老年人慢性阻塞性肺疾病合并肺结核诊断中的应用[J].中国基层医药,2015,21(10):1505-1507.
[4] Sultan,B.Benn,P.Mahungu,T.et al.Comparison of two interferon-gamma release assays (QuantiFERON-TB Gold In-Tube and T-SPOT.TB) in testing for latent tuberculosis infection among HIV-infected adults[J].International journal of STD &AIDS,2013,24(10):775-779.
[5] Kobashi,Y.Abe,M.Mouri,K.et al.Usefulness of tuberculin skin test and three interferon-gamma release assays for the differential diagnosis of pulmonary tuberculosis[J].Internal medicine,2012,51(10):1199-1205.
[6] 郭新美,尹丽霞,寇昌伟,等.结核感染T细胞斑点试验诊断老年患者肺结核的应用研究[J].中华医院感染学杂志,2015,16(12):2647-2648,2660.
[7] Yoshihiro Kobashi,Masaaki Abe,Keiji Mouri et al.Discussion Regarding Tuberculin Skin Tests and Interferon-gamma Release Assays for the Differential Diagnosis of Pulmonary Tuberculosis[J].Internal medicine.2013,51(20):2999-2999.
[8] 万荣,李明武,赖明红,等.结核感染T细胞斑点试验在老年肺结核中的诊断价值[J].中国防痨杂志,2015,37(4):348-352.
[2] Yan,Liping,Xiao,Heping,Han,Minet al.Diagnostic value of T-SPOT.TB interferon- release assays for active tuberculosis[J].Experimental and therapeutic medicine,2015,10(1):345-351.
[3] 丁宏辉,刘时憧.结核感染 T 细胞斑点试验在老年人慢性阻塞性肺疾病合并肺结核诊断中的应用[J].中国基层医药,2015,21(10):1505-1507.
[4] Sultan,B.Benn,P.Mahungu,T.et al.Comparison of two interferon-gamma release assays (QuantiFERON-TB Gold In-Tube and T-SPOT.TB) in testing for latent tuberculosis infection among HIV-infected adults[J].International journal of STD &AIDS,2013,24(10):775-779.
[5] Kobashi,Y.Abe,M.Mouri,K.et al.Usefulness of tuberculin skin test and three interferon-gamma release assays for the differential diagnosis of pulmonary tuberculosis[J].Internal medicine,2012,51(10):1199-1205.
[6] 郭新美,尹丽霞,寇昌伟,等.结核感染T细胞斑点试验诊断老年患者肺结核的应用研究[J].中华医院感染学杂志,2015,16(12):2647-2648,2660.
[7] Yoshihiro Kobashi,Masaaki Abe,Keiji Mouri et al.Discussion Regarding Tuberculin Skin Tests and Interferon-gamma Release Assays for the Differential Diagnosis of Pulmonary Tuberculosis[J].Internal medicine.2013,51(20):2999-2999.
[8] 万荣,李明武,赖明红,等.结核感染T细胞斑点试验在老年肺结核中的诊断价值[J].中国防痨杂志,2015,37(4):348-352.