血清BAFF在系统性红斑狼疮的表达及临床意义
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摘要
目的:检测系统性红斑狼疮(SLE)患者血清B细胞活化因子(BAFF)表达水平,探讨BAFF与SLE病情活动指标及临床症状的关系。方法:采用酶联免疫吸附法(ELISA)检测80例SLE患者及60例健康对照血清BAFF水平;检测SLE患者抗双链DNA(ds-DNA)抗体等指标。结果:SLE组血清BAFF水平高于健康对照组(P<0.05),活动组BAFF水平高于非活动组及健康对照组(P<0.01)。SLE患者血清中BAFF水平与SLEDAI、血沉(ESR)呈正相关(P<0.01、P<0.05);与补体C3呈负相关(P<0.05)。抗ds-DNA抗体阳性SLE患者BAFF水平高于抗ds-DNA抗体阴性SLE患者(P<0.01)。结论:SLE患者BAFF水平升高,提示BAFF参与SLE发病,且与SLE病情活动指标相关。
Objective:To investigate the levels of B cell activating factor(BAFF) in systemic lupus erythematosus(SLE),and to analysis the correlation between BAFF and SLE disease activity index,clinical symptoms.Method:Serum BAFF levels were tested by Enzyme-linked immunosorbent assay(ELISA) in 80 patients with SLE and 60 healthy controls.Anti double stranded DNA(ds-DNA) antibodies in SLE patients were detected.Result:BAFF expression in SLE group was significantly higher than that in healthy control group(P<0.05);BAFF expression in activity group higher than those in non activity group and health control group(P<0.01).Serum BAFF expression was positively correlated with SLEDAI,ESR(P<0.01,P<0.05),and negatively correlated with C3(P<0.05) in SLE patients.SLE patients with positive anti-ds DNA antibody had significantly higher expression of BAFF than that with negative anti-ds DNA antibody(P<0.01).Conclusion:BAFF may be involved in SLE development,and may affected to SLE disease activity.
Objective:To investigate the levels of B cell activating factor(BAFF) in systemic lupus erythematosus(SLE),and to analysis the correlation between BAFF and SLE disease activity index,clinical symptoms.Method:Serum BAFF levels were tested by Enzyme-linked immunosorbent assay(ELISA) in 80 patients with SLE and 60 healthy controls.Anti double stranded DNA(ds-DNA) antibodies in SLE patients were detected.Result:BAFF expression in SLE group was significantly higher than that in healthy control group(P<0.05);BAFF expression in activity group higher than those in non activity group and health control group(P<0.01).Serum BAFF expression was positively correlated with SLEDAI,ESR(P<0.01,P<0.05),and negatively correlated with C3(P<0.05) in SLE patients.SLE patients with positive anti-ds DNA antibody had significantly higher expression of BAFF than that with negative anti-ds DNA antibody(P<0.01).Conclusion:BAFF may be involved in SLE development,and may affected to SLE disease activity.
引文
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[10]葛风梅.B细胞激活因子在风湿性疾病中的研究进展[J].滨州医学院学报,2017,40(1):62-64,68.
[11]冯永民,陈秋萍,黄柳涛,等.活动性系统性红斑狼疮患者外周血嗜碱性粒细胞CD62L、BAFF和CD40L表达变化及意义[J].山东医药,2017,57(9):20-23.
[12]沈思钰,朱培元,傅晓东.系统性红斑狼疮B细胞靶向治疗研究概述[J].药物流行病学杂志,2015,24(9):554-557.
[2]王林海,刘云清.泼尼松与羟氯喹对妊娠合并系统性红斑狼疮的疗效评价[J].中外医学研究,2018,16(12):153-154.
[3]孙天水.B细胞活化因子/增殖诱导配体系统与系统性红斑狼疮的研究进展[J].中国全科医学,2017,20(14):1769-1773.
[4]俞烜华,许小玲,黄碧仙,等.系统性红斑狼疮中医证型与BAFF及疾病活动指标关系探讨[J].世界中医药,2016,11(11):2304-2307.
[5]温斯健,林有坤.B淋巴细胞刺激因子及拮抗剂与系统性红斑狼疮的研究进展[J].广西医科大学学报,2014,31(1):153-156.
[6]许小玲,俞烜华,李忆农.系统性红斑狼疮中B细胞活化因子、干扰素α的表达及临床意义[J].临床荟萃,2013,28(5):522-524,532.
[7]许小玲,李忆农.TLR9、IFN-α和BAFF水平与系统性红斑狼疮的相关性研究[J].免疫学杂志,2014,30(11):998-1002.
[8]孙明姝,王新云,张云清,等.系统性红斑狼疮病人血清BAFF及IL-17水平及意义[J].青岛大学医学院学报,2015,51(6):656-658.
[9]许鸿昌.抗核抗体、抗-ds-DNA、抗-sm、抗核小体联合检测对SLE的诊断价值[J].中国现代医生,2016,54(7):91-93,96.
[10]葛风梅.B细胞激活因子在风湿性疾病中的研究进展[J].滨州医学院学报,2017,40(1):62-64,68.
[11]冯永民,陈秋萍,黄柳涛,等.活动性系统性红斑狼疮患者外周血嗜碱性粒细胞CD62L、BAFF和CD40L表达变化及意义[J].山东医药,2017,57(9):20-23.
[12]沈思钰,朱培元,傅晓东.系统性红斑狼疮B细胞靶向治疗研究概述[J].药物流行病学杂志,2015,24(9):554-557.