小剂量秋水仙碱联合依托考昔治疗急性痛风性关节炎的临床效果
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摘要
目的评价小剂量秋水仙碱联合依托考昔治疗急性痛风性关节炎的临床效果。方法选取我院风湿科2017年1月～2018年9月收治的90例急性痛风性关节炎患者作为研究对象,按照研究方法的不同分为A组、B组、C组,每组各30例。A组行小剂量秋水仙碱治疗,B组行小剂量秋水仙碱联合小剂量地塞米松治疗,C组行小剂量秋水仙碱联合依托考昔治疗。比较三组患者的实验室理化指标,包括血尿酸(UA)、红细胞沉降率(ESR)、C反应蛋白(CRP)、白细胞(WBC)、丙氨酸氨基转移酶(ALT)、肾小球滤过率(GFR)水平及疼痛评分(VAS评分)。结果 C组治疗后的UA、ESR、CRP、WBC及VAS评分低于A、B组,差异有统计学意义(P<0.05)。三组治疗前后的ALT、GFR水平及不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量秋水仙碱联合依托考昔治疗急性痛风性关节炎,患者疼痛症状显著缓解,效果显著。
Objective To evaluate the clinical effect of the combination of Colchicine with Etoricoxib in the treatment of acute gouty arthritis. Methods A total of 90 cases of acute gout arthritis treated in the department of rheumatology of our hospital from January 2017 to September 2018 were selected as the research objects. According to the different research methods, they were divided into group A, group B and group C, 30 patients in each group. Group A was treated with Colchicine in low dose. Group B was treated with Colchicine combined with Dexamethasone. Group C was treated with Colchicine combined with Etoricoxib. The laboratory physicochemical indexes including UA, ESR, CRP, WBC,ALT, GFR and VAS were compared among the three groups. Results After treatment, the level of UA, ESR, CRP, WBC and VAS scores in group C were lower than those in group A and B, with statistically significant differences(P<0.05).There was no significant difference in the level of ALT, GFR and the incidence of adverse reactions in the three groups between before and after treatment(P>0.05). Conclusion Low-dose Colchicine combined with Etoricoxib in the treatment of acute gouty arthritis, the pain symptoms of patients are significantly alleviated, the effect is significant.
Objective To evaluate the clinical effect of the combination of Colchicine with Etoricoxib in the treatment of acute gouty arthritis. Methods A total of 90 cases of acute gout arthritis treated in the department of rheumatology of our hospital from January 2017 to September 2018 were selected as the research objects. According to the different research methods, they were divided into group A, group B and group C, 30 patients in each group. Group A was treated with Colchicine in low dose. Group B was treated with Colchicine combined with Dexamethasone. Group C was treated with Colchicine combined with Etoricoxib. The laboratory physicochemical indexes including UA, ESR, CRP, WBC,ALT, GFR and VAS were compared among the three groups. Results After treatment, the level of UA, ESR, CRP, WBC and VAS scores in group C were lower than those in group A and B, with statistically significant differences(P<0.05).There was no significant difference in the level of ALT, GFR and the incidence of adverse reactions in the three groups between before and after treatment(P>0.05). Conclusion Low-dose Colchicine combined with Etoricoxib in the treatment of acute gouty arthritis, the pain symptoms of patients are significantly alleviated, the effect is significant.
引文
[1]郭迪斌,居艳娟,李荣平,等.依托考昔和美洛昔康治疗急性痛风的临床效果以及安全性分析[J].中国当代医药,2014,21(30):68-69,72.
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[9]杨彦龙,李小琴,史静,等.小剂量秋水仙碱联合得宝松治疗急性痛风性关节炎的疗效分析[J].检验医学与临床,2016,13(15):2103-2105.
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[11]黄芳.不同剂量的秋水仙碱联合地塞米松治疗急性痛风性关节炎的疗效分析[J].现代诊断与治疗,2018,29(5):714-715.
[12]徐玲玲,李琳娜,薛耀明.依托考昔治疗急性重度痛风性关节炎的疗效及影响因素[J].医学研究杂志,2015,44(2):108-112.
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[14]李学峰,霍艳蕊,尹磊,等.依托考昔联合祛湿化瘀解毒定痛汤治疗急性痛风性关节炎疗效观察及对炎性因子的影响[J].河北医药,2017,39(3):353-357.
[15]杨晓燕.依托考昔治疗急性痛风性关节炎疗效及安全性的meta分析[D].石家庄:河北医科大学,2016.
[2]李丹,张剑勇.痛风现代流行病学及降尿酸药物研究进展[J].风湿病与关节炎,2016,5(4):73-76.
[3]刘颖,李志琛,陈建斌,等.小剂量秋水仙碱联合糖皮质激素治疗急性痛风性关节炎的疗效观察[J].解放军医学杂志,2015,40(8):652-655.
[4]王珉,何雅楠,仝磊.依托考昔片治疗痛风性关节炎59例疗效评价[J].新疆医学,2015,45(8):1128-1130.
[5]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志,2011,15(6):410-413.
[6]严广斌.视觉模拟评分法[J].中华关节外科杂志(电子版),2014,8(2):273.
[7]于一云,薛愉,朱小霞,等.急性痛风性关节炎的药物治疗及选择[J].上海医药,2015,36(11):14-18.
[8]蒙龙,李娟,龙锐,等.小剂量与常规剂量秋水仙碱治疗急性痛风性关节炎的系统评价[J].中国临床药理学与治疗学,2014,19(6):655-656.
[9]杨彦龙,李小琴,史静,等.小剂量秋水仙碱联合得宝松治疗急性痛风性关节炎的疗效分析[J].检验医学与临床,2016,13(15):2103-2105.
[10]柯渠青,邱晓堂,黄妮.小剂量秋水仙碱联合依托考昔治疗急性痛风性关节炎的临床观察[J].中国医药导报,2016,13(33):129-132.
[11]黄芳.不同剂量的秋水仙碱联合地塞米松治疗急性痛风性关节炎的疗效分析[J].现代诊断与治疗,2018,29(5):714-715.
[12]徐玲玲,李琳娜,薛耀明.依托考昔治疗急性重度痛风性关节炎的疗效及影响因素[J].医学研究杂志,2015,44(2):108-112.
[13]郭敏,成志锋,胡玉华,等.依托考昔在急性痛风性关节炎应用中的疗效观察[J].现代生物医学进展,2014,14(29):5747-5750.
[14]李学峰,霍艳蕊,尹磊,等.依托考昔联合祛湿化瘀解毒定痛汤治疗急性痛风性关节炎疗效观察及对炎性因子的影响[J].河北医药,2017,39(3):353-357.
[15]杨晓燕.依托考昔治疗急性痛风性关节炎疗效及安全性的meta分析[D].石家庄:河北医科大学,2016.