成人语后聋听觉皮层静息态fMRI成像特点的初步研究
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摘要
目的:了解成人语后聋静息态听觉皮层功能磁共振成像(fMRI)的特点。方法:选取8例重度以上感音神经性语后聋患者,分别以双侧初级听觉皮层(A1)为种子点作静息态fMRI功能连接分析,另选取8例听力正常者做对照组,对比2组间差异。结果:以左侧A1区为种子点(ROI),正常听力者主要激活区域为双侧颞上回(STG),语后聋患者主要激活的区域有双侧STG、中央前回,左侧颞横回(TTG)、中央后回,右侧颞中回(MTG)(P<0.01);以右侧A1区为种子点时,正常听力者主要激活区域为双侧STG,语后聋患者激活的脑区主要有双侧STG、右侧中央前回和中央后回(P<0.01),2组间差异有统计学意义(P<0.05)。结论:语后聋患者大脑发生功能性重组,这种改变可能使其在听力剥夺后增强视觉、触觉等其他感觉功能,进而对日常生活中的信息获取进行有效的补偿。
Objective:To understand the auditory cortex resting-state fMRI features for adult post-lingual deafness.Method:The author performed functional connectivity analysis on the study subjects with resting-state fMRI,the region of interest(ROI)of which were based separately on the left and right sides of primary auditory cortex.The data were collected from 8 cases with severe or above sensorineurally post-lingual deafness,compared to a control group of 8 cases with normal hearing.Result:When ROI were based on the left A1 areas of all subjects,the main activating area in the control group was bilateral superior temporal gyrus(STG),while the postlingual deafness group included the bilateral STG,pre-central gyri,left Transverse temporal gyrus(TTG),postcentral gyri and right TTG(P<0.01);when ROI were based on the right A1 areas of all subjects,the main activating area in the control group was the bilateral STG,while the post-lingual deafness group included the bilateral STG,right pre-central gyri and post-central gyri(P<0.01).The data showed statistical significance(P<0.05).Conclusion:After hearing loss functional reorganization takes place in the brains of adults with post-lingual deafness,resulting in possible enhancement of visual sense,tactile sense and other sensory systems in order to compensate information acquisition in daily life.
Objective:To understand the auditory cortex resting-state fMRI features for adult post-lingual deafness.Method:The author performed functional connectivity analysis on the study subjects with resting-state fMRI,the region of interest(ROI)of which were based separately on the left and right sides of primary auditory cortex.The data were collected from 8 cases with severe or above sensorineurally post-lingual deafness,compared to a control group of 8 cases with normal hearing.Result:When ROI were based on the left A1 areas of all subjects,the main activating area in the control group was bilateral superior temporal gyrus(STG),while the postlingual deafness group included the bilateral STG,pre-central gyri,left Transverse temporal gyrus(TTG),postcentral gyri and right TTG(P<0.01);when ROI were based on the right A1 areas of all subjects,the main activating area in the control group was the bilateral STG,while the post-lingual deafness group included the bilateral STG,right pre-central gyri and post-central gyri(P<0.01).The data showed statistical significance(P<0.05).Conclusion:After hearing loss functional reorganization takes place in the brains of adults with post-lingual deafness,resulting in possible enhancement of visual sense,tactile sense and other sensory systems in order to compensate information acquisition in daily life.
引文
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[2]耿左军,张云亭,张权,等.感音神经性聋人和正常人纯音刺激脑功能区BOLD-fMRI研究[J].中华耳科学杂志,2005,3(3):165-169.
[3] BUSHARA K O,GRAFMAN J,HALLETT M.Neural correlates of auditory-visual stimulus onsetasynchronydetection[J].J Neurosci,2001,21:300-304.
[4] BUSHARA KO,HANAKAWA T,IMMISCH I,et al.Neural correlates of cross-modalbinding[J].Nat Neurosci,2003,6:190-195.
[5] WU C T,WEISSMAN D H,ROBERTS K C,et al.The neural circuitry underlying the executive control of auditory spatialattention[J].Brain Res,2007,1134:187-198.
[6] FINNEY E M,FINE I,DOBKINS K R.Visual stimuli activate auditory cortex in thedeaf[J].Nat Neurosci,2001,4:1171-1173.
[7] KARNS C M,DOW M W,NEVILLE H J.Altered cross-modal processing in the primary auditory cortex of congenitally deaf adults:a visual-somatosensory fMRI study with a double-flash illusion[J].J Neurosci,2012,32:9626-9638.