口蹄疫表位疫苗的研究进展
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摘要
口蹄疫表位疫苗既不存在病毒复制风险,又能同时展示多个变异株的优势表位,是具有巨大发展潜力的新型疫苗。本文将从口蹄疫病毒的抗原表位,表位疫苗的设计和优化以及表位疫苗的应用等方面进行综述,为合理设计和研发有效的口蹄疫表位疫苗提供参考。
The epitope-based vaccines against foot-and-mouth disease(FMD) containing multiple topological dominant epitopes at the same time are novel vaccine with great development potential,because it does not have risk of virus replication.Here,we review the research progress of epitope-based vaccines against FMD,including the current knowledge of design and optimization of epitope-based vaccines,and their application in the control and prevent for FMD,and also raise some suggestions that would provide reference for studying more effective FMD epitope vaccines.
The epitope-based vaccines against foot-and-mouth disease(FMD) containing multiple topological dominant epitopes at the same time are novel vaccine with great development potential,because it does not have risk of virus replication.Here,we review the research progress of epitope-based vaccines against FMD,including the current knowledge of design and optimization of epitope-based vaccines,and their application in the control and prevent for FMD,and also raise some suggestions that would provide reference for studying more effective FMD epitope vaccines.
引文
[1] JAMAL S M,BELSHAM G J.Molecular epidemiology,evolution and phylogeny of foot-and-mouth disease virus[J].Infection Genetics and Evolution,2018,59:84-98.
[2] GAO Y,SUN S Q,GUO H C.Biological function of foot-and-mouth disease virus non-structural proteins and non-coding elements[J].Virolgy Journal,2016,13(1):107-133.
[3]刘在新.全球口蹄疫防控技术及病原特性研究概观[J].中国农业科学,2015,48(17):3547-3564.LIU Zai-xin.Progress and prospect of the technologies to control foot-and-mouth disease and its pathogen characteristics worldwide[J].Scientia Agricultura Sinica,2015,48(17):3547-3564.(in Chinese)
[4] CAO Y M,LI D, FU Y F,et al.Rational design and efficacy of a multi-epitope recombinant protein vaccine against foot-and-mouth disease virus serotype A in pigs[J].Antiviral Research,2017,140:133-141.
[5]文雪霞,陈化兰,熊永忠,等.抗原表位鉴定方法的研究进展[J].中国畜牧兽医,2012,39(7):66-70.WEN Xue-xia,CHEN Hua-lan,XIONG Yong-zhong,et al.Research advance in epitope identification methods[J].China Aninal Husbandry and Veterinary Medicine,2012, 39(7):66-70.(in Chinese)
[6] FRY E E,NEWMAN J W I,CURRY S,et al.Structure of foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor:receptor conservation in the face of antigenic variation[J].Journal General Virology,2005,86(Pt7):1909-1920.
[7]张中旺,张永光.抗原表位的研究方法及口蹄疫病毒抗原表位的研究进展[J].微生物学通报,2008,35(8):1302-1310.ZHANG Zhong-wang,ZHANG Yong-guang.Approaches for antigen epitope study and the development of antigen epitopes of foot-and-mouth disease virus[J].Acta Microbiologica Sinica,2008,35(8):1302-1310.(in Chinese)
[8] LIANG W F,ZHOU G H,LIU W M,et al.Identification of a conserved linear neutralizing epitope recognized by monoclonal antibody 9A9 against serotype A foot-and-mouth disease virus[J].Archives of Virology,2016,161(10):2705-2716.
[9] LUDI A B,HORTON D L,LI Y,et al.Antigenic variation of foot-and-mouth disease virus serotype A[J].Journal of General Virology,2014,95(2):384-392.
[10] SAIZ J C,GONZALEZ M J,BORCA M V,et al.Identification of neutralizing antigenic sites on VP1 and VP2 of type A5 foot-and-mouth disease virus,defined by neutralization-resistant variants[J].Journal of Virology,1991,65(5):2518-2524.
[11] MATEU M G,MART魱NEZ M A,CAPUCCI L,et al.A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C[J].Journal of General Virology,1990,71(Pt3):629-637.
[12] LEA S,HERNANDEZ J,BLAKEMORE W,et al.The structure and antigenicity of a type C foot-and-mouth disease virus[J].Structure,1994,2(2):123-139.
[13] AlAM S S,AMIN R,RAHMAN M Z,et al.Antigenic heterogeneity of capsid protein VP1 in foot-and-mouth disease virus(FMDV)serotype Asia 1[J].Advances and Applications in Bioinformatics and Chemistry,2013,6:37-46.
[14] XUE M,WANG H W,LI W,et al.Effects of amino acid substitutions in the VP2 B-C loop on antigenicity and pathogenicity of serotype Asia1 foot-andmouth disease virus[J].Virology Journal,2012,9(1):191.
[15] CARR B V,LEFEVRE E A,WINDSOR M A,et al.CD4+T-cell responses to foot-and-mouth disease virus in vaccinated cattle[J].Journal General Virology,2013,94(Pt1):97-107.
[16] HABIELA M,SEAGO J,PEREZ-MARTIN E,et al.Laboratory animal models to study foot-and-mouth disease:a review with emphasis on natural and vaccine-induced immunity[J].Journal of General Virology,2014,95(Pt11):2329-2345.
[17] DIMARCHI R,BROOKE G,GALE C,et al.Protection of cattle against foot-and-mouth disease by a synthetic peptide[J].Science,1986,232(4750):639-641.
[18] BLANCO E,GARCIA-BRIONES M,SANZ-PARRA A,et al.Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus[J].Journal of Virology,2001,75(7):3164-3174.
[19] BLANCO E,CUBILLOS C,MORENO N,et al.B epitope multiplicity and B/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines[J].Clinical and Developmental Immunology,2013,12:475960-475969.
[20] CUBILLOS C,DE LA TORRE B G,BRCENA J,et al.Inclusion of a specific T cell epitope increases the protection conferred against foot-and-mouth disease virus in pigs by a linear peptide containing an immunodominant B cell site[J].Virology Journal,2012,9(1):66-76.
[21]韩小艳,赵娜,王永祥.接头序列及其在融合蛋白构建中的应用[J].河北医科大学学报,2007(3):224-227.HAN Xiao-yan,ZHAO Na,WANG Yong-xiang.Application of linker sequences in construction of fusion proteins[J].Journal of Hebei Medical University,2007(3):224-227.(in Chinese)
[22] REDDY CHICHILI V P,KUMAR V,SIVARAMAN J.Linkers in the structural biology of protein-protein interactions[J].The Protein Society,2012,22(2):153-167.
[23] FANG M L,LI J L,WANG H,et al.Correlation between efficacy and structure of recombinant epitope vaccines against bovine type O foot-and-mouth disease virus[J].Biotechnology Letters,2012,34(5):839-847.
[24] ZHANG C R,XU W,CHEN J,et al.Soybean oil containing ginseng saponins as adjuvants promotes production of cytokines and enhances immune responses to foot-and-mouth disease vaccine[J].Microbiology and Immunology,2018,62(3):187-194.
[25] REN J L,YANG L,XU H F,et al.CpG oligodeoxynucleotide and montanide ISA 206 adjuvant combination augments the immune responses of a recombinant FMDV vaccine in cattle[J].Vaccine,2011,29(45):7960-7965.
[26] GRUBMAN M J,BAXT B.Foot-and-mouth disease[J].Clinical Microbiology Reviews,2004,17(2):465-493.
[27] WANG C Y,CHANG T Y,WALFIELD A M,et al.Effective synthetic peptide vaccine for foot-and-mouth disease in swine[J].Vaccine,2002,20(19-20):2603-2610.
[28] SORIA I,QUATTROCCHI V,LANGELLOTTI C,et al.Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle[J].Plos One,2017,12(9):e0185184.
[29] SHAO J J,WANG J F,CHANG H Y,et al.Immune potential of a novel multiple-epitope vaccine to FMDV type Asia 1 in guinea pigs and sheep[J].Virologica Sinica,2011,26(3):190-197.
[30] CAO Y M,LU Z J,LI P H,et al.Improved neutralising antibody response against foot-and-mouth disease virus in mice inoculated with a multi-epitope peptide vaccine using polyinosinic and poly-cytidylic acid as an adjuvant[J].Journal Virological Methods,2012,185(1):124-128.
[31] CAO Y M,LU Z J, LI Y L,et al.Poly(I:C)combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs[J].Antiviral Research,2013,97(2):145-153.
[32] CHAI Z,WANG H W,ZHOU G H,et al.Adenovirus-vectored type Asia 1 foot-and-mouth disease virus(FMDV)capsid proteins as a vehicle to display a conserved, neutralising epitope of type O FMDV[J].Jounal of Virological Methods,2013,188(1-2):175-182.
[33] BISWAL J K,RANJAN R,PATTNAIK B.Chimeric foot-andmouth disease virus serotype O displaying a serotype Asia1 antigenic epitope at the surface[J].Biotechnology Letters,2016,38(9):1509-1517.
[34] WONG C L,YONG C Y,MUHAMAD A,et al.A 12-residue epitope displayed on phage T7 reacts strongly with antibodies against foot-and-mouth disease virus[J].Applied Microbiology and Biotechnology,2018,102(9):4131-4142.
[35] LEE H B,PIAO D C,LEE J Y,et al.Artificially designed recombinant protein composed of multiple epitopes of foot-and-mouth disease virus as a vaccine candidate[J].Microbial Cell Factories,2017,16(1):33-42.
[2] GAO Y,SUN S Q,GUO H C.Biological function of foot-and-mouth disease virus non-structural proteins and non-coding elements[J].Virolgy Journal,2016,13(1):107-133.
[3]刘在新.全球口蹄疫防控技术及病原特性研究概观[J].中国农业科学,2015,48(17):3547-3564.LIU Zai-xin.Progress and prospect of the technologies to control foot-and-mouth disease and its pathogen characteristics worldwide[J].Scientia Agricultura Sinica,2015,48(17):3547-3564.(in Chinese)
[4] CAO Y M,LI D, FU Y F,et al.Rational design and efficacy of a multi-epitope recombinant protein vaccine against foot-and-mouth disease virus serotype A in pigs[J].Antiviral Research,2017,140:133-141.
[5]文雪霞,陈化兰,熊永忠,等.抗原表位鉴定方法的研究进展[J].中国畜牧兽医,2012,39(7):66-70.WEN Xue-xia,CHEN Hua-lan,XIONG Yong-zhong,et al.Research advance in epitope identification methods[J].China Aninal Husbandry and Veterinary Medicine,2012, 39(7):66-70.(in Chinese)
[6] FRY E E,NEWMAN J W I,CURRY S,et al.Structure of foot-and-mouth disease virus serotype A1061 alone and complexed with oligosaccharide receptor:receptor conservation in the face of antigenic variation[J].Journal General Virology,2005,86(Pt7):1909-1920.
[7]张中旺,张永光.抗原表位的研究方法及口蹄疫病毒抗原表位的研究进展[J].微生物学通报,2008,35(8):1302-1310.ZHANG Zhong-wang,ZHANG Yong-guang.Approaches for antigen epitope study and the development of antigen epitopes of foot-and-mouth disease virus[J].Acta Microbiologica Sinica,2008,35(8):1302-1310.(in Chinese)
[8] LIANG W F,ZHOU G H,LIU W M,et al.Identification of a conserved linear neutralizing epitope recognized by monoclonal antibody 9A9 against serotype A foot-and-mouth disease virus[J].Archives of Virology,2016,161(10):2705-2716.
[9] LUDI A B,HORTON D L,LI Y,et al.Antigenic variation of foot-and-mouth disease virus serotype A[J].Journal of General Virology,2014,95(2):384-392.
[10] SAIZ J C,GONZALEZ M J,BORCA M V,et al.Identification of neutralizing antigenic sites on VP1 and VP2 of type A5 foot-and-mouth disease virus,defined by neutralization-resistant variants[J].Journal of Virology,1991,65(5):2518-2524.
[11] MATEU M G,MART魱NEZ M A,CAPUCCI L,et al.A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C[J].Journal of General Virology,1990,71(Pt3):629-637.
[12] LEA S,HERNANDEZ J,BLAKEMORE W,et al.The structure and antigenicity of a type C foot-and-mouth disease virus[J].Structure,1994,2(2):123-139.
[13] AlAM S S,AMIN R,RAHMAN M Z,et al.Antigenic heterogeneity of capsid protein VP1 in foot-and-mouth disease virus(FMDV)serotype Asia 1[J].Advances and Applications in Bioinformatics and Chemistry,2013,6:37-46.
[14] XUE M,WANG H W,LI W,et al.Effects of amino acid substitutions in the VP2 B-C loop on antigenicity and pathogenicity of serotype Asia1 foot-andmouth disease virus[J].Virology Journal,2012,9(1):191.
[15] CARR B V,LEFEVRE E A,WINDSOR M A,et al.CD4+T-cell responses to foot-and-mouth disease virus in vaccinated cattle[J].Journal General Virology,2013,94(Pt1):97-107.
[16] HABIELA M,SEAGO J,PEREZ-MARTIN E,et al.Laboratory animal models to study foot-and-mouth disease:a review with emphasis on natural and vaccine-induced immunity[J].Journal of General Virology,2014,95(Pt11):2329-2345.
[17] DIMARCHI R,BROOKE G,GALE C,et al.Protection of cattle against foot-and-mouth disease by a synthetic peptide[J].Science,1986,232(4750):639-641.
[18] BLANCO E,GARCIA-BRIONES M,SANZ-PARRA A,et al.Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus[J].Journal of Virology,2001,75(7):3164-3174.
[19] BLANCO E,CUBILLOS C,MORENO N,et al.B epitope multiplicity and B/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines[J].Clinical and Developmental Immunology,2013,12:475960-475969.
[20] CUBILLOS C,DE LA TORRE B G,BRCENA J,et al.Inclusion of a specific T cell epitope increases the protection conferred against foot-and-mouth disease virus in pigs by a linear peptide containing an immunodominant B cell site[J].Virology Journal,2012,9(1):66-76.
[21]韩小艳,赵娜,王永祥.接头序列及其在融合蛋白构建中的应用[J].河北医科大学学报,2007(3):224-227.HAN Xiao-yan,ZHAO Na,WANG Yong-xiang.Application of linker sequences in construction of fusion proteins[J].Journal of Hebei Medical University,2007(3):224-227.(in Chinese)
[22] REDDY CHICHILI V P,KUMAR V,SIVARAMAN J.Linkers in the structural biology of protein-protein interactions[J].The Protein Society,2012,22(2):153-167.
[23] FANG M L,LI J L,WANG H,et al.Correlation between efficacy and structure of recombinant epitope vaccines against bovine type O foot-and-mouth disease virus[J].Biotechnology Letters,2012,34(5):839-847.
[24] ZHANG C R,XU W,CHEN J,et al.Soybean oil containing ginseng saponins as adjuvants promotes production of cytokines and enhances immune responses to foot-and-mouth disease vaccine[J].Microbiology and Immunology,2018,62(3):187-194.
[25] REN J L,YANG L,XU H F,et al.CpG oligodeoxynucleotide and montanide ISA 206 adjuvant combination augments the immune responses of a recombinant FMDV vaccine in cattle[J].Vaccine,2011,29(45):7960-7965.
[26] GRUBMAN M J,BAXT B.Foot-and-mouth disease[J].Clinical Microbiology Reviews,2004,17(2):465-493.
[27] WANG C Y,CHANG T Y,WALFIELD A M,et al.Effective synthetic peptide vaccine for foot-and-mouth disease in swine[J].Vaccine,2002,20(19-20):2603-2610.
[28] SORIA I,QUATTROCCHI V,LANGELLOTTI C,et al.Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle[J].Plos One,2017,12(9):e0185184.
[29] SHAO J J,WANG J F,CHANG H Y,et al.Immune potential of a novel multiple-epitope vaccine to FMDV type Asia 1 in guinea pigs and sheep[J].Virologica Sinica,2011,26(3):190-197.
[30] CAO Y M,LU Z J,LI P H,et al.Improved neutralising antibody response against foot-and-mouth disease virus in mice inoculated with a multi-epitope peptide vaccine using polyinosinic and poly-cytidylic acid as an adjuvant[J].Journal Virological Methods,2012,185(1):124-128.
[31] CAO Y M,LU Z J, LI Y L,et al.Poly(I:C)combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs[J].Antiviral Research,2013,97(2):145-153.
[32] CHAI Z,WANG H W,ZHOU G H,et al.Adenovirus-vectored type Asia 1 foot-and-mouth disease virus(FMDV)capsid proteins as a vehicle to display a conserved, neutralising epitope of type O FMDV[J].Jounal of Virological Methods,2013,188(1-2):175-182.
[33] BISWAL J K,RANJAN R,PATTNAIK B.Chimeric foot-andmouth disease virus serotype O displaying a serotype Asia1 antigenic epitope at the surface[J].Biotechnology Letters,2016,38(9):1509-1517.
[34] WONG C L,YONG C Y,MUHAMAD A,et al.A 12-residue epitope displayed on phage T7 reacts strongly with antibodies against foot-and-mouth disease virus[J].Applied Microbiology and Biotechnology,2018,102(9):4131-4142.
[35] LEE H B,PIAO D C,LEE J Y,et al.Artificially designed recombinant protein composed of multiple epitopes of foot-and-mouth disease virus as a vaccine candidate[J].Microbial Cell Factories,2017,16(1):33-42.