前列地尔联合硫辛酸治疗糖尿病神经病变的疗效
|
摘要
目的探讨前列地尔联合硫辛酸治疗糖尿病神经病变的疗效。方法选取本院2017年4月～2018年4月期间糖尿病神经病变患者96例,随机分为观察组与对照组,各48例。给予观察组前列地尔联合硫辛酸治疗、给予对照组仅前列地尔治疗。对比两组患者临床治疗效果,并观察组治疗前后患者神经传导速度水平以及疼痛程度。结果①观察组治疗总有效率高达97.92%,高于对照组的83.33%(χ~2=12.527,P<0.05)。②两组治疗后神经传导速度较治疗前均有所提高;且观察组治疗后神经传导速度、治疗前后传导速度差值高于对照组,差异均有统计学意义(t=13.837、15.828,P<0.05)。③两组治疗后VAS评分低于治疗前均显著;且观察组治疗后VAS评分较对照组更低,差异均有统计学意义(t=10.387,P<0.05)。结论糖尿病神经病变可采用前列地尔联合硫辛酸治疗,效果确切,可有效降低患者疼痛程度,改善神经传导速度,临床实用价值较高,可推广使用。
Objective To investigate the efficacy of alprostadil combined with lipoic acid in the treatment of diabetic neuropathy. Methods 96 patients with diabetic neuropathy received in our hospital from April 2017 to April 2018 were randomLy divided into observation group and control group, 48 cases in each group. The observation group was treated with Alprostadil Combined with lipoic acid, and the control group was treated with alprostadil only. The clinical effects of the two groups were compared, and the level of nerve conduction velocity and the degree of pain in the observation group before and after treatment were compared. Results ① The total effective rate of the observation group was97.92%, which was significantly higher than that of the control group(83.33%)(χ~2=12.527, P<0.05). ②After treatment,the nerve conduction velocity of the two groups was higher than that of the control group, and the difference of nerve conduction velocity between the two groups was higher after treatment(t=13.837, 15.828, P<0.05).③After treatment,the VAS scores of the two groups were significantly lower than those before treatment,and the VAS scores of the observation group were lower than those of the control group after treatment, the difference was statistically significant(t=10.387, P<0.05). Conclusion Alprostadil combined with lipoic acid can be used to treat diabetic neuropathy with definite effect. It can effectively reduce pain and improve nerve conduction velocity in patients with diabetic neuropathy. It has high clinical practical value and can be widely used.
Objective To investigate the efficacy of alprostadil combined with lipoic acid in the treatment of diabetic neuropathy. Methods 96 patients with diabetic neuropathy received in our hospital from April 2017 to April 2018 were randomLy divided into observation group and control group, 48 cases in each group. The observation group was treated with Alprostadil Combined with lipoic acid, and the control group was treated with alprostadil only. The clinical effects of the two groups were compared, and the level of nerve conduction velocity and the degree of pain in the observation group before and after treatment were compared. Results ① The total effective rate of the observation group was97.92%, which was significantly higher than that of the control group(83.33%)(χ~2=12.527, P<0.05). ②After treatment,the nerve conduction velocity of the two groups was higher than that of the control group, and the difference of nerve conduction velocity between the two groups was higher after treatment(t=13.837, 15.828, P<0.05).③After treatment,the VAS scores of the two groups were significantly lower than those before treatment,and the VAS scores of the observation group were lower than those of the control group after treatment, the difference was statistically significant(t=10.387, P<0.05). Conclusion Alprostadil combined with lipoic acid can be used to treat diabetic neuropathy with definite effect. It can effectively reduce pain and improve nerve conduction velocity in patients with diabetic neuropathy. It has high clinical practical value and can be widely used.
引文
[1]许延林.前列地尔注射液治疗糖尿病周围神经病变38例疗效观察[J].陕西医学杂志,2016,45(9):1233-1234.
[2]成殷勤,胡可军.气压按摩干预联合前列地尔治疗腺苷钴胺对老年2型糖尿病周围神经病变疗效[J].医学临床研究,2016,33(12):2428-2431.
[3]Sperna Weiland NH,Hermanides J,van der Ster BJP,et al.Sevoflurane based anaesthesia does not affect already impaired cerebral autoregulation in patients with type 2diabetes mellitus[J].Br J Anaesth,2018,121(6):1298-1307.
[4]张瑞,张建飞,申丽,等.活络通痹汤足浴联合前列地尔治疗糖尿病周围神经病变56例临床观察[J].中国中医药科技,2016,23(5):571-572.
[5]李惊东,雒否乐,梁崇上,等.前列地尔联合高压氧治疗糖尿病周围神经病变的临床效果观察[J].解放军医药杂志,2018,30(6):87-90.
[6]Oueslati I,Belhadj Hassen H,Ben Ahmed H,et al.Edinburgh questionnaire in the screening for peripheral artery disease in type 2 diabetic patients[J].Tunis Med,2018,96(8-9):505-509.
[7]Monteiro RL,Sartor CD,Ferreira JSSP,et al.Protocol for evaluating the effects of a foot-ankle therapeutic exercise program on daily activity,foot-ankle functionality,and biomechanics in people with diabetic polyneuropathy:A randomized controlled trial[J].BMC Musculoskelet Disord,2018,19(1):400
[8]王观华,向海霞,方鹏,等.不同剂量前列地尔治疗糖尿病痛性神经病变的疗效观察[J].中国实用神经疾病杂志,2016,19(18):106-107.
[9]李素那,钱丽旗.益气化瘀通痹汤联合前列地尔治疗糖尿病周围神经病变临床观察[J].陕西中医,2017,38(8):1056-1058.
[10]吴志英.硫辛酸联合前列地尔治疗糖尿病周围神经病变的疗效观察[J].中国医院用药评价与分析,2016,16(6):788-790.
[11]Lee HJ,Seo HI,Cha HY,et al.Diabetes and Alzheimer's disease:Mechanisms and nutritional aspects[J].Clin Nutr Res,2018,7(4):229-240.
[12]Da Costa R,Doctor P,Mahajan K,et al.Bilateral phrenic nerve palsy in a diabetic causing respiratory failure[J].Indian J Crit Care Med,2018,22(10):737-739.
[13]Ghavami H,Radfar M,Soheily S,et al.Effect of lifestyle interventions on diabetic peripheral neuropathy in patients with type 2 diabetes,result of a randomized clinical trial[J].Agri,2018,30(4):165-170.
[14]王艳红,岳宗相,黄荣利,前列地尔联合α-硫辛酸治疗糖尿病周围神经病变的临床研究[J].检验医学与临床,2016,13(15):2097-2099.
[15]张瑶,胡军,许腾.前列地尔与α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的疗效观察[J].临床内科杂志,2017,34(7):496-497.
[16]Neagu C,Buzea A,Agache A,et al.Surgical revascularization in chronic limb-threatening ischemia in diabetic patients[J].Chirurgia(Bucur),2018,113(5):668-677.
[17]褚莉茗,ChuLiming.α-硫辛酸联合前列地尔治疗糖尿病周围神经病变的效果分析[J].中国综合临床,2016,32(1):57-60.
[18]张丰姣,赵艳利,任健,等.前列地尔与硫辛酸治疗糖尿病神经病变效果观察[J].中国实用神经疾病杂志,2018,21(8):857-860.
[19]胡爱平.前列地尔联合硫辛酸治疗糖尿病神经病变的疗效[J].糖尿病新世界,2017,20(5):161-162.
[2]成殷勤,胡可军.气压按摩干预联合前列地尔治疗腺苷钴胺对老年2型糖尿病周围神经病变疗效[J].医学临床研究,2016,33(12):2428-2431.
[3]Sperna Weiland NH,Hermanides J,van der Ster BJP,et al.Sevoflurane based anaesthesia does not affect already impaired cerebral autoregulation in patients with type 2diabetes mellitus[J].Br J Anaesth,2018,121(6):1298-1307.
[4]张瑞,张建飞,申丽,等.活络通痹汤足浴联合前列地尔治疗糖尿病周围神经病变56例临床观察[J].中国中医药科技,2016,23(5):571-572.
[5]李惊东,雒否乐,梁崇上,等.前列地尔联合高压氧治疗糖尿病周围神经病变的临床效果观察[J].解放军医药杂志,2018,30(6):87-90.
[6]Oueslati I,Belhadj Hassen H,Ben Ahmed H,et al.Edinburgh questionnaire in the screening for peripheral artery disease in type 2 diabetic patients[J].Tunis Med,2018,96(8-9):505-509.
[7]Monteiro RL,Sartor CD,Ferreira JSSP,et al.Protocol for evaluating the effects of a foot-ankle therapeutic exercise program on daily activity,foot-ankle functionality,and biomechanics in people with diabetic polyneuropathy:A randomized controlled trial[J].BMC Musculoskelet Disord,2018,19(1):400
[8]王观华,向海霞,方鹏,等.不同剂量前列地尔治疗糖尿病痛性神经病变的疗效观察[J].中国实用神经疾病杂志,2016,19(18):106-107.
[9]李素那,钱丽旗.益气化瘀通痹汤联合前列地尔治疗糖尿病周围神经病变临床观察[J].陕西中医,2017,38(8):1056-1058.
[10]吴志英.硫辛酸联合前列地尔治疗糖尿病周围神经病变的疗效观察[J].中国医院用药评价与分析,2016,16(6):788-790.
[11]Lee HJ,Seo HI,Cha HY,et al.Diabetes and Alzheimer's disease:Mechanisms and nutritional aspects[J].Clin Nutr Res,2018,7(4):229-240.
[12]Da Costa R,Doctor P,Mahajan K,et al.Bilateral phrenic nerve palsy in a diabetic causing respiratory failure[J].Indian J Crit Care Med,2018,22(10):737-739.
[13]Ghavami H,Radfar M,Soheily S,et al.Effect of lifestyle interventions on diabetic peripheral neuropathy in patients with type 2 diabetes,result of a randomized clinical trial[J].Agri,2018,30(4):165-170.
[14]王艳红,岳宗相,黄荣利,前列地尔联合α-硫辛酸治疗糖尿病周围神经病变的临床研究[J].检验医学与临床,2016,13(15):2097-2099.
[15]张瑶,胡军,许腾.前列地尔与α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的疗效观察[J].临床内科杂志,2017,34(7):496-497.
[16]Neagu C,Buzea A,Agache A,et al.Surgical revascularization in chronic limb-threatening ischemia in diabetic patients[J].Chirurgia(Bucur),2018,113(5):668-677.
[17]褚莉茗,ChuLiming.α-硫辛酸联合前列地尔治疗糖尿病周围神经病变的效果分析[J].中国综合临床,2016,32(1):57-60.
[18]张丰姣,赵艳利,任健,等.前列地尔与硫辛酸治疗糖尿病神经病变效果观察[J].中国实用神经疾病杂志,2018,21(8):857-860.
[19]胡爱平.前列地尔联合硫辛酸治疗糖尿病神经病变的疗效[J].糖尿病新世界,2017,20(5):161-162.