野鸡尾研究进展
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摘要
该文通过查阅相关文献,对民间常用草药野鸡尾的资源分布、形态特征、化学成分、药理作用及主要活性成分金粉蕨素的药理作用等的研究进展进行分类整理和综述。目前,从该植物中分离得到35种化合物,主要为黄酮类、香豆素类以及茚酮类等。药理作用研究表明,野鸡尾具有抗炎镇痛、解毒、解痉及抗肿瘤等作用,其主要活性成分金粉蕨素具有保护内皮细胞、抗动脉粥样硬化以及抗癌作用。
To classify and describe the resource distribution,morphological characteristics,chemical constituents,pharmacological effects and main active ingredient onychin from the literatures of Onychium japonicum.Thirty-five compounds have been isolated from this plant,including flavonoids,coumarins,and indene ketone.Pharmacological research showed that Onychium japonicum has anti-inflammatory,analgesic,detoxifying,spasmolytic,and antitumor effects. Onychin is the main active ingredient,and it has endothelial cells protection,anti-atherosclerosis and anti-tumor effects.
To classify and describe the resource distribution,morphological characteristics,chemical constituents,pharmacological effects and main active ingredient onychin from the literatures of Onychium japonicum.Thirty-five compounds have been isolated from this plant,including flavonoids,coumarins,and indene ketone.Pharmacological research showed that Onychium japonicum has anti-inflammatory,analgesic,detoxifying,spasmolytic,and antitumor effects. Onychin is the main active ingredient,and it has endothelial cells protection,anti-atherosclerosis and anti-tumor effects.
引文
[1]湖北省农科院中药材研究所.湖北恩施药用植物志(上册)[M].武汉:湖北科学技术出版社,2006:51-52.
[2]中国科学院中国植物志编辑委员会.中国植物志[M].北京:科学出版社,1990:108.
[3]高成芝,袁阿兴,覃凌.野鸡尾的生药鉴定[J].广西医学,1988,10(3):131.
[4]邓晰朝.野雉尾金粉蕨配子体发育及其系统学意义[J].广西植物,2016,36(1):96-100.
[5]于晶,王全喜,包文美.中国金粉蕨属孢子形态的研究[J].植物研究,2001,21(2):227-230.
[6]XU Y L,KUBO I,MA Y B.A cytotoxic flavanone glycoside from Onychium japonicum:srructure of onychin[J].Phytochemistry,1993,33(2):510.
[7]李明潺.野雉尾金粉蕨的化学成分研究[D].天津:天津医科大学,2007:24-58.
[8]李明潺.两种土家族药用植物化学成分及其生物活性研究[D].天津:天津医科大学,2013:10-40.
[9]HASEGAWA M,AKABORI Y,AKABORI S.New indanone compounds from Onychium joponieum[J].Phytochemistry,1974,13(2):509-511.
[10]HSUE T H,WANG J L,TANG C P.The structure of onychiol B,[las,3as-(1β,1aα,3aβ,5α,5aα,6α,10aβ)l-1-[l-(hydroxymethyl)vinyl]-3a,5a,8-trimethyl-2,3,3a,4,5,5a,9,10,10a,10b-decahydro-1H,6H-cyclohept[e]indene-5,6-diol:a diterpene alco-hol from Onychium joponieum(Thunb.)Kunze[J].Cta Cryst,1980,36:2802.
[11]HASEGAWA M,TANEYAMA M.Chicoric acid from Onychium japonicum and its distribution in the ferns[J].Shokubutsugaku Zasshi,1973,86(4):315-317.
[12]冯艺萍,李彬,郭力城,等.小叶金华草抗炎镇痛作用[J].中国实验方剂学杂志,2011,17(12):197-199.
[13]HO S T,YANG M S,TSAI S P,et al.Studies on the Taiwan folk medicine.II.pharmacological properties of Onychium japonicum(Thunb.)Kunze[J].Taiwan Yaoxue Zazhi,1980,32(1):29.
[14]YANG L L,YEN K Y,KISO Y,et al.Antihepatotoxic actions of Formosan plant drugs[J].J Ethnopharm,1987,19(1):103-110.
[15]杨德胜,罗鹤辉.土家解毒药的临床应用[J].湖南中医杂志,2010,26(6):101-102.
[16]殷帅文,黄风春,张圆圆,等.不同蕨类植物提取物乙酰胆碱酯酶抑制活性的评价[J].天然产物研究与开发,2009,21(5):854-857.
[17]黄红林,朱炳阳,郑兴,等.金粉蕨素急性毒性实验[J].南华大学学报(医学版),2001,29(6):539-541.
[18]郭玉.金粉蕨素对脂质过氧化内皮细胞的保护作用[J].中国临床药理学与治疗学,2004,9(6):612-614.
[19]严奉祥,朱炳阳,郑兴,等.金粉蕨素对小白鼠实验性肝损伤脂质过氧化的保护作用[J].南华大学学报(医学版),2002,30(1):4-6.
[20]郭玉,朱炳阳,严奉祥,等.金粉蕨素对甲萘醌损伤人脐静脉内皮细胞的保护作用[J].中国病理生理杂志,2003,19(1):10-13.
[21]庹勤慧,黄红林,谢志忠,等.金粉蕨素对溶血性磷脂酰胆碱损伤血管内皮依赖性舒张功能的保护作用及机制[J].中国动脉硬化杂志,2001,9(1):27-30.
[22]郭玉,朱炳阳,严奉祥,等.金粉蕨素拮抗氧化损伤所抑制的内皮细胞增殖的作用及其机制[J].中国药理学通报,2003,19(4):401-403.
[23]杨茗,廖端芳,朱炳阳,等.金粉蕨素抑制大鼠主动脉平滑肌增殖作用及机制[J].中国临床药理学与治疗学,2003,8(1):11-14.
[24]YANG M,HUANG H L,ZHU B Y,et al.Onychin inhibits proliferation of vascular smooth muscle cells by regulating cell cycle[J].Acta Pharmacol Sin,2005,26(2):205-211.
[25]庹勤慧,朱炳阳.金粉蕨素抑制氧化应激诱导的血管内皮细胞凋亡[J].中国动脉硬化杂志,2004,12(3):283.
[26]TUO Q H,WANG C,YAN F X,et al.MAPK pathway mediates the protective effects of onychin on oxidative stress-induced apoptosis in ECV304 endothelial cells[J].Life Sci,2004,76(5):487-497.
[27]庹勤慧,廖端芳,朱炳阳,等.金粉蕨素拮抗血管内皮细胞氧化应激损伤及机制[J].中国临床药理学与治疗学,2003,8(4):381-384.
[28]林江虹.金粉蕨素对动脉粥样硬化兔血脂的影响[J].中国医药科学,2011,14(1):37-38.
[29]白军,杨春,唐敏,等.金粉蕨素体外诱导人宫颈癌He La细胞凋亡的机制[J].肿瘤药学,2014,4(3):176-181.
[30]唐华贵,谢宛玉,曹建国,等.金粉蕨素体外抗人卵巢癌作用研究[J].医药论坛杂志,2008,29(15):4-6.
[31]NING Y X,BAI J.Mechanism of induction apoptosis of onychin in ovarian cells in vitro[J].Chin Germ J Clin Oncol,2013,12(8):389-392.
[2]中国科学院中国植物志编辑委员会.中国植物志[M].北京:科学出版社,1990:108.
[3]高成芝,袁阿兴,覃凌.野鸡尾的生药鉴定[J].广西医学,1988,10(3):131.
[4]邓晰朝.野雉尾金粉蕨配子体发育及其系统学意义[J].广西植物,2016,36(1):96-100.
[5]于晶,王全喜,包文美.中国金粉蕨属孢子形态的研究[J].植物研究,2001,21(2):227-230.
[6]XU Y L,KUBO I,MA Y B.A cytotoxic flavanone glycoside from Onychium japonicum:srructure of onychin[J].Phytochemistry,1993,33(2):510.
[7]李明潺.野雉尾金粉蕨的化学成分研究[D].天津:天津医科大学,2007:24-58.
[8]李明潺.两种土家族药用植物化学成分及其生物活性研究[D].天津:天津医科大学,2013:10-40.
[9]HASEGAWA M,AKABORI Y,AKABORI S.New indanone compounds from Onychium joponieum[J].Phytochemistry,1974,13(2):509-511.
[10]HSUE T H,WANG J L,TANG C P.The structure of onychiol B,[las,3as-(1β,1aα,3aβ,5α,5aα,6α,10aβ)l-1-[l-(hydroxymethyl)vinyl]-3a,5a,8-trimethyl-2,3,3a,4,5,5a,9,10,10a,10b-decahydro-1H,6H-cyclohept[e]indene-5,6-diol:a diterpene alco-hol from Onychium joponieum(Thunb.)Kunze[J].Cta Cryst,1980,36:2802.
[11]HASEGAWA M,TANEYAMA M.Chicoric acid from Onychium japonicum and its distribution in the ferns[J].Shokubutsugaku Zasshi,1973,86(4):315-317.
[12]冯艺萍,李彬,郭力城,等.小叶金华草抗炎镇痛作用[J].中国实验方剂学杂志,2011,17(12):197-199.
[13]HO S T,YANG M S,TSAI S P,et al.Studies on the Taiwan folk medicine.II.pharmacological properties of Onychium japonicum(Thunb.)Kunze[J].Taiwan Yaoxue Zazhi,1980,32(1):29.
[14]YANG L L,YEN K Y,KISO Y,et al.Antihepatotoxic actions of Formosan plant drugs[J].J Ethnopharm,1987,19(1):103-110.
[15]杨德胜,罗鹤辉.土家解毒药的临床应用[J].湖南中医杂志,2010,26(6):101-102.
[16]殷帅文,黄风春,张圆圆,等.不同蕨类植物提取物乙酰胆碱酯酶抑制活性的评价[J].天然产物研究与开发,2009,21(5):854-857.
[17]黄红林,朱炳阳,郑兴,等.金粉蕨素急性毒性实验[J].南华大学学报(医学版),2001,29(6):539-541.
[18]郭玉.金粉蕨素对脂质过氧化内皮细胞的保护作用[J].中国临床药理学与治疗学,2004,9(6):612-614.
[19]严奉祥,朱炳阳,郑兴,等.金粉蕨素对小白鼠实验性肝损伤脂质过氧化的保护作用[J].南华大学学报(医学版),2002,30(1):4-6.
[20]郭玉,朱炳阳,严奉祥,等.金粉蕨素对甲萘醌损伤人脐静脉内皮细胞的保护作用[J].中国病理生理杂志,2003,19(1):10-13.
[21]庹勤慧,黄红林,谢志忠,等.金粉蕨素对溶血性磷脂酰胆碱损伤血管内皮依赖性舒张功能的保护作用及机制[J].中国动脉硬化杂志,2001,9(1):27-30.
[22]郭玉,朱炳阳,严奉祥,等.金粉蕨素拮抗氧化损伤所抑制的内皮细胞增殖的作用及其机制[J].中国药理学通报,2003,19(4):401-403.
[23]杨茗,廖端芳,朱炳阳,等.金粉蕨素抑制大鼠主动脉平滑肌增殖作用及机制[J].中国临床药理学与治疗学,2003,8(1):11-14.
[24]YANG M,HUANG H L,ZHU B Y,et al.Onychin inhibits proliferation of vascular smooth muscle cells by regulating cell cycle[J].Acta Pharmacol Sin,2005,26(2):205-211.
[25]庹勤慧,朱炳阳.金粉蕨素抑制氧化应激诱导的血管内皮细胞凋亡[J].中国动脉硬化杂志,2004,12(3):283.
[26]TUO Q H,WANG C,YAN F X,et al.MAPK pathway mediates the protective effects of onychin on oxidative stress-induced apoptosis in ECV304 endothelial cells[J].Life Sci,2004,76(5):487-497.
[27]庹勤慧,廖端芳,朱炳阳,等.金粉蕨素拮抗血管内皮细胞氧化应激损伤及机制[J].中国临床药理学与治疗学,2003,8(4):381-384.
[28]林江虹.金粉蕨素对动脉粥样硬化兔血脂的影响[J].中国医药科学,2011,14(1):37-38.
[29]白军,杨春,唐敏,等.金粉蕨素体外诱导人宫颈癌He La细胞凋亡的机制[J].肿瘤药学,2014,4(3):176-181.
[30]唐华贵,谢宛玉,曹建国,等.金粉蕨素体外抗人卵巢癌作用研究[J].医药论坛杂志,2008,29(15):4-6.
[31]NING Y X,BAI J.Mechanism of induction apoptosis of onychin in ovarian cells in vitro[J].Chin Germ J Clin Oncol,2013,12(8):389-392.