石斛化学成分及药理作用研究进展
|
摘要
石斛属(Dendrobium Sw.)是兰科重要的属之一,具有观赏价值与药用价值。近年来,对该植物的研究取得了显著的进展,本文在系统查阅相关文献的基础上,对石斛的化学成分和药理作用研究进展进行总结,为研究和合理利用提供依据。
Dendrobium represents one of the most important orchid genera with ornamental and medicinal values,and the research on this plant has made remarkable progress in recent years.In order to provide basis for research and rational utilization,on the basis of systematic review of relevant literature,the research progress of chemical constituents and pharmacological effects of Dendrobium was summarized.
Dendrobium represents one of the most important orchid genera with ornamental and medicinal values,and the research on this plant has made remarkable progress in recent years.In order to provide basis for research and rational utilization,on the basis of systematic review of relevant literature,the research progress of chemical constituents and pharmacological effects of Dendrobium was summarized.
引文
[1]Cakova V,Bonte F,Lobstein A.Dendrobium:Sources of Active Ingredients to Treat Age-Related Pathologies[J].Aging Dis,2017,8(6):827-849.
[2]马国祥,徐国钧,徐珞珊,等.商品石斛的调查及鉴定(Ⅲ)[J].中草药,1995,26(7):370-372.
[3]李桂锋,李进进,许继勇,等.铁皮石斛研究综述[J].中药材,2010,33(1):150-153.
[4]Lam Y,Ng T B,Yao R M,et al.Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology in Dendrobium Plants[J].Evidence-based Complementary and Alternative Medicine,2015(1):1-25.
[5]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015.
[6]魏刚,顺庆生,杨明志.石斛求真[M].成都:四川科学技术出版社,2014.
[7]TANG H X,ZHAO T W,SHENG Y J,et al.Dendrobium officinale Kimura et Migo:a Review on its Ethnopharmacology,Phytochemistry,and Industrialization[J].Evidence-Based Complementary and Alternative Medicine,2017:1-19.
[8]Wei W,Feng L,Bao W R,et al.Structure Characterization and Immunomodulating Effects of Polysaccharides Isolated from Dendrobium officinale[J].J Agric Food Chem,2016,64(4):881-889.
[9]王军辉,查学强,潘利华,等.金钗石斛免疫活性多糖DNP-W1B的结构特征[J].高等学校化学学报,2013,34(4):881-885.
[10]鲍素华,查学强,郝杰,等.不同分子量铁皮石斛多糖体外抗氧化活性研究[J].食品科学,2009,30(21):123-127.
[11]Zha Xueqiang,Luo jianping,Luo shizhong,et al.Structure Identification of a New Immunostimulating Polysaccharide from the Stems of Dendrobium huoshanense[J].Carbohydrate Polymers,2007,69(1):86-93.
[12]赵永灵,王世林,李晓玉,等.兜唇石斛多糖的研究[J].云南植物研究,1994,16(4):392-396.
[13]王世林,郑光植,何静波,等.黑节草多糖的研究[J].云南植物研究,1988,10(4):389-395.
[14]张雪琴,赵庭梅,刘静,等.石斛化学成分及药理作用研究进展[J].中草药,2018,49(13):3174-3181.
[15]Wang Y H,Avula B,Abe N,et al.Tandem Mass Spectrometry for Structural Identification of Sesquiterpene Alkaloids from the Stems of Dendrobium nobile using LC-QToF[J].Planta Med,2016,82(7):662-670.
[16]潘斯斯,梁贵友.金钗石斛生物碱的研究进展[J].遵义医学院学报,2018,41(1):105-107.
[17]蔡金艳,倪俊,陈天洪,等.束花石斛中1个新的菲类化合物[J].中草药,2017,48(8):1506-1508.
[18]Ye Q,Mei Y,Yang P,et al.A New 9,10-Dihydrophenanthrene Glycoside from Dendrobium primulinum[J].Chem Nat Comp,2016,52(3):381-383.
[19]Chen X J,Mei W L,Cai C H,et al.Four New Bibenzyl Derivatives from Dendrobium sinense[J].Phytochem Lett,2014.
[20]Zhou X M,Zheng C J,Gan L S,et al.Bioactive Phenanthrene and Bibenzyl Derivatives Fromthe Stems of Dendrobium nobile[J].J Nat Prod,2016,79(7):1791-1797.
[21]杨虹.鼓槌石斛和铁皮石斛化学成分的研究[D].南京:中国药科大学,2002.
[22]Fan W W,Xu F Q,Dong F W,et al.Dendrowardols A and B,two New Sesquiterpenoids from Dendrobium wardianum Warner[J].Tetrah Lett,2013,54(15):1928-1930.
[23]张冬英,范黎明,龚舒静,等.鼓槌石斛花总黄酮及挥发性成分研究[J].食品科技,2014,39(10):198-202.
[24]陆礼和,杜艳妮,张艳,等.金钗石斛营养成分分析研究[J].云南师范大学学报(自然科学版),2013,33(1):60-63.
[25]曲继旭,贺雨馨,陈龙,等.3种石斛氢基酸组成及营养评价[J].辽宁中医药大学学报,2018,20(2):60-62.
[26]谢唐贵,陈敬民,李燕婧.不同产地铁皮石斛水提物的免疫调节作用研究[J].云南中医中药杂志,2018,39(4):80-81.
[27]余琪,毛培江,姜建民,等.4种药用石斛对增强小鼠免疫功能效果的比较研究[J].中国现代应用药学,2017,34(2):191-195.
[28]陈星星,李焰,杨小燕,等.铁皮石斛对免疫抑制模型小鼠脾脏淋巴细胞体外增殖的影响[J].中国兽医杂志,2018,54(4):100-103.
[29]宋美芳,李光,陈曦,等.两种石斛多糖提高小鼠免疫活性的初步研究[J].中国药学杂志,2013,48(6):428-431.
[30]Pan L H,Wang J,Ye X Q,et al.Enzyme-Assisted Extraction of Polysaccharides from Dendrobium chrysotoxum,and its Functional Properties and Immunomodulatory Activity[J].LWT-Food Sci Technol,2015,60(2):1149-1154.
[31]刘庆春.金钗石斛对糖尿病大鼠肾组织PKC和TGF-BI表达的影响[J].光明中医,2017,32(7):957-958.
[32]黎同明,邓敏贞.石斛合剂对2型糖尿病模型大鼠的降糖作用及其对胰岛细胞凋亡的影响[J].中药材,2012,35(5):765-769.
[33]宓文佳,陈素红,吕圭源,等.铁皮石斛根提取物对2型糖尿病模型小鼠的降糖作用研究[J].中药药理与临床,2015,31(1):125-129.
[34]安祯祥,何远利,陈昱江,等.金钗石斛多糖对肝纤维化大鼠肝功能损伤治疗作用及机制探讨[J].时珍国医国药,2016,27(8):1865-1867.
[35]谢庆芬,谢鲁灵枫,贡小辉,等.霍山铁皮石斛提取物不同极性部位抗氧化活性研究[J].食品科技,2018,9(43):275-278.
[36]唐汉庆,韦祎,卢兰,等.铁皮石斛对小鼠抗氧化能力影响的实验研究[J].中国卫生检验杂志,2014,(21):3082-3084.
[37]KIM J H,OH S Y,HAN S B,et a1.Anti-Inflammatory Effects of Dendrobium nohile derived Phenanthrenes in LPS-stimulated Murine Macrophages[J].Archives of Pharmacal Research,2015,38(6):1117-1126.
[38]周威,曾庆芳,夏杰,等.金钗石斛的菲类抗肿瘤活性成分研究[J].中国药学杂志,2018(20):1722-1725.
[39]谢唐贵,陈敬民,李燕婧.不同产地铁皮石斛水提物的抗疲劳作用研究[J].云南中医中药杂志,2018,8(2):66-67.
[2]马国祥,徐国钧,徐珞珊,等.商品石斛的调查及鉴定(Ⅲ)[J].中草药,1995,26(7):370-372.
[3]李桂锋,李进进,许继勇,等.铁皮石斛研究综述[J].中药材,2010,33(1):150-153.
[4]Lam Y,Ng T B,Yao R M,et al.Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology in Dendrobium Plants[J].Evidence-based Complementary and Alternative Medicine,2015(1):1-25.
[5]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015.
[6]魏刚,顺庆生,杨明志.石斛求真[M].成都:四川科学技术出版社,2014.
[7]TANG H X,ZHAO T W,SHENG Y J,et al.Dendrobium officinale Kimura et Migo:a Review on its Ethnopharmacology,Phytochemistry,and Industrialization[J].Evidence-Based Complementary and Alternative Medicine,2017:1-19.
[8]Wei W,Feng L,Bao W R,et al.Structure Characterization and Immunomodulating Effects of Polysaccharides Isolated from Dendrobium officinale[J].J Agric Food Chem,2016,64(4):881-889.
[9]王军辉,查学强,潘利华,等.金钗石斛免疫活性多糖DNP-W1B的结构特征[J].高等学校化学学报,2013,34(4):881-885.
[10]鲍素华,查学强,郝杰,等.不同分子量铁皮石斛多糖体外抗氧化活性研究[J].食品科学,2009,30(21):123-127.
[11]Zha Xueqiang,Luo jianping,Luo shizhong,et al.Structure Identification of a New Immunostimulating Polysaccharide from the Stems of Dendrobium huoshanense[J].Carbohydrate Polymers,2007,69(1):86-93.
[12]赵永灵,王世林,李晓玉,等.兜唇石斛多糖的研究[J].云南植物研究,1994,16(4):392-396.
[13]王世林,郑光植,何静波,等.黑节草多糖的研究[J].云南植物研究,1988,10(4):389-395.
[14]张雪琴,赵庭梅,刘静,等.石斛化学成分及药理作用研究进展[J].中草药,2018,49(13):3174-3181.
[15]Wang Y H,Avula B,Abe N,et al.Tandem Mass Spectrometry for Structural Identification of Sesquiterpene Alkaloids from the Stems of Dendrobium nobile using LC-QToF[J].Planta Med,2016,82(7):662-670.
[16]潘斯斯,梁贵友.金钗石斛生物碱的研究进展[J].遵义医学院学报,2018,41(1):105-107.
[17]蔡金艳,倪俊,陈天洪,等.束花石斛中1个新的菲类化合物[J].中草药,2017,48(8):1506-1508.
[18]Ye Q,Mei Y,Yang P,et al.A New 9,10-Dihydrophenanthrene Glycoside from Dendrobium primulinum[J].Chem Nat Comp,2016,52(3):381-383.
[19]Chen X J,Mei W L,Cai C H,et al.Four New Bibenzyl Derivatives from Dendrobium sinense[J].Phytochem Lett,2014.
[20]Zhou X M,Zheng C J,Gan L S,et al.Bioactive Phenanthrene and Bibenzyl Derivatives Fromthe Stems of Dendrobium nobile[J].J Nat Prod,2016,79(7):1791-1797.
[21]杨虹.鼓槌石斛和铁皮石斛化学成分的研究[D].南京:中国药科大学,2002.
[22]Fan W W,Xu F Q,Dong F W,et al.Dendrowardols A and B,two New Sesquiterpenoids from Dendrobium wardianum Warner[J].Tetrah Lett,2013,54(15):1928-1930.
[23]张冬英,范黎明,龚舒静,等.鼓槌石斛花总黄酮及挥发性成分研究[J].食品科技,2014,39(10):198-202.
[24]陆礼和,杜艳妮,张艳,等.金钗石斛营养成分分析研究[J].云南师范大学学报(自然科学版),2013,33(1):60-63.
[25]曲继旭,贺雨馨,陈龙,等.3种石斛氢基酸组成及营养评价[J].辽宁中医药大学学报,2018,20(2):60-62.
[26]谢唐贵,陈敬民,李燕婧.不同产地铁皮石斛水提物的免疫调节作用研究[J].云南中医中药杂志,2018,39(4):80-81.
[27]余琪,毛培江,姜建民,等.4种药用石斛对增强小鼠免疫功能效果的比较研究[J].中国现代应用药学,2017,34(2):191-195.
[28]陈星星,李焰,杨小燕,等.铁皮石斛对免疫抑制模型小鼠脾脏淋巴细胞体外增殖的影响[J].中国兽医杂志,2018,54(4):100-103.
[29]宋美芳,李光,陈曦,等.两种石斛多糖提高小鼠免疫活性的初步研究[J].中国药学杂志,2013,48(6):428-431.
[30]Pan L H,Wang J,Ye X Q,et al.Enzyme-Assisted Extraction of Polysaccharides from Dendrobium chrysotoxum,and its Functional Properties and Immunomodulatory Activity[J].LWT-Food Sci Technol,2015,60(2):1149-1154.
[31]刘庆春.金钗石斛对糖尿病大鼠肾组织PKC和TGF-BI表达的影响[J].光明中医,2017,32(7):957-958.
[32]黎同明,邓敏贞.石斛合剂对2型糖尿病模型大鼠的降糖作用及其对胰岛细胞凋亡的影响[J].中药材,2012,35(5):765-769.
[33]宓文佳,陈素红,吕圭源,等.铁皮石斛根提取物对2型糖尿病模型小鼠的降糖作用研究[J].中药药理与临床,2015,31(1):125-129.
[34]安祯祥,何远利,陈昱江,等.金钗石斛多糖对肝纤维化大鼠肝功能损伤治疗作用及机制探讨[J].时珍国医国药,2016,27(8):1865-1867.
[35]谢庆芬,谢鲁灵枫,贡小辉,等.霍山铁皮石斛提取物不同极性部位抗氧化活性研究[J].食品科技,2018,9(43):275-278.
[36]唐汉庆,韦祎,卢兰,等.铁皮石斛对小鼠抗氧化能力影响的实验研究[J].中国卫生检验杂志,2014,(21):3082-3084.
[37]KIM J H,OH S Y,HAN S B,et a1.Anti-Inflammatory Effects of Dendrobium nohile derived Phenanthrenes in LPS-stimulated Murine Macrophages[J].Archives of Pharmacal Research,2015,38(6):1117-1126.
[38]周威,曾庆芳,夏杰,等.金钗石斛的菲类抗肿瘤活性成分研究[J].中国药学杂志,2018(20):1722-1725.
[39]谢唐贵,陈敬民,李燕婧.不同产地铁皮石斛水提物的抗疲劳作用研究[J].云南中医中药杂志,2018,8(2):66-67.