阻抑溴酸钾氧化茜素红褪色动力学光度法测定药物中水杨酸
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摘要
在稀盐酸介质中,水杨酸的存在对溴酸钾氧化茜素红褪色反应有很强的阻抑作用,利用光度法监测反应过程中茜素红浓度的变化,建立了水杨酸-溴酸钾-茜素红体系阻抑动力学光度法测定水杨酸含量的方法。在选定条件下,方法的线性范围是0.008μg·m L~(-1)-1.2μg·m L~(-1),检出限为0.0017μg·m L~(-1)。
In a dilute hydrochloric acid medium,salicylic acid showed strong inhibitory effect on the fading reaction of alizarin red oxidized by potassium bromate.In this paper,the change of alizarin red concentration in inhibitory reaction was monitored by sepctrophotometry.and based on this,a new method for the determination of salicylic acid by inhibitory kinetics spectrophotometry in salicylic acid-KBr O_3-alizarin red system was established.The detection limit was 0.0017μg·m L~(-1)and the linear range was 0.008~1.2μg·m L~(-1).
In a dilute hydrochloric acid medium,salicylic acid showed strong inhibitory effect on the fading reaction of alizarin red oxidized by potassium bromate.In this paper,the change of alizarin red concentration in inhibitory reaction was monitored by sepctrophotometry.and based on this,a new method for the determination of salicylic acid by inhibitory kinetics spectrophotometry in salicylic acid-KBr O_3-alizarin red system was established.The detection limit was 0.0017μg·m L~(-1)and the linear range was 0.008~1.2μg·m L~(-1).
引文
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[11]樊雪梅,王书民,苏智魁.流动注射化学发光法测定水杨酸[J].分析化学,2010,38(12):1839.
[12]谢成根,李淮芬.流动注射化学发光法测定水杨酸[J].分析试验室,2004,23(7):61-62.
[13]曹金秀,蔡文开,梁晶晶,等.阻抑动力学光度法测定痕量水杨酸[J].中国卫生检验杂志,2009,19(8):1725-1727.
[14]李利军,何品刚,方禹之.水杨酸抑制亚硝酸根催化鸡冠花红褪色反应的伏安法研究及其应用[J].分析化学,2000,28(5):534.
[2]邱新华,吴美珠,刘燕.紫外分光光度法测定复方三酸粉中水杨酸的含量[J].中国实用医药,2011,6(10):38-39.
[3]Parham H,Rahbar N.Solid phase extraction spectrophotometric determination of salicylic acid using magnetic iron oxide nanopart icles as extractor[J].J Pharmaceut Biomed,2009,50(4):58-63.
[4]钱啸.紫外分光光度法测定阿司匹林咀嚼片中游离水杨酸含量[J].中国实用医药,2009,4(7):146-147.
[5]李利军,陈其锋,程昊,等.流动注射不可逆双安培法测定水杨酸的研究[J].化学通报,2006,10:785-188.
[6]罗红梅,廖钫,谭宝玉,等.水杨酸在多壁碳纳米管修饰电极上的电化学行为及其测定[J].分析科学学报,2009,25(6):665-668.
[7]段沅杏,王璐,贺兵,等.高效液相色谱法测定食品添加剂中水杨酸[J].理化检验:化学分册,2012,48(2):152-154.
[8]鲍峰伟,郝红玲,何爱民,等.高效液相色谱内标法测定香精香料中的水杨酸[J].化学工程师,2010,181,(10):17-19.
[9]董影杰,于泓,黄旭,等.离子液体作高效液相色谱流动相添加剂测定水杨酸[J].分析测试学报,2011,30(3):302-306.
[10]Algar S O,Martos N R,Diaz A M.Fast and single solid phase fluorescence spectroscopic batch procedure for(acetyl)salicylic acid determination in drug formulations[J].J Pharmaceut Biomed,2003,31(3):439-446.
[11]樊雪梅,王书民,苏智魁.流动注射化学发光法测定水杨酸[J].分析化学,2010,38(12):1839.
[12]谢成根,李淮芬.流动注射化学发光法测定水杨酸[J].分析试验室,2004,23(7):61-62.
[13]曹金秀,蔡文开,梁晶晶,等.阻抑动力学光度法测定痕量水杨酸[J].中国卫生检验杂志,2009,19(8):1725-1727.
[14]李利军,何品刚,方禹之.水杨酸抑制亚硝酸根催化鸡冠花红褪色反应的伏安法研究及其应用[J].分析化学,2000,28(5):534.