白术饮片质量分析报告
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摘要
目的:评价白术饮片的总体质量状况。方法:采用法定标准检验与探索性研究相结合的方法对白术质量进行评价和分析。结果:共抽取248批次白术饮片,按法定标准检验,合格率为96.0%,不合格率为4.0%;不合格项目为二氧化硫残留量和色度,不合格原因为过度硫熏和炮制过度。按探索性研究方法检验,合格率为37.1%,不合格率高达62.9%,不合格原因主要是各产地白术一致性差、指标成分不达标、滥用植物生长调节剂、杀菌剂、杀虫剂农药以及重金属超标等。结论:综合法定检验和探索性研究结果,白术饮片总体质量状况评价为"一般",建议对白术进行规范化种植,完善提高白术饮片现行质量标准,并加强监管。
Objective: To evaluate the overall quality of prepared slices of Atractylodes macrocephala. Methods:The quality of Atractylodes macrocephala was evaluated and analyzed by statutory standard testing combined with exploratory research. Results: 248 batches of Atractylodes macrocephala were sampled. The qualified rate was 96.0% and the unqualified rate was 4.0% according to the legal standards. The unqualified items were sulfur dioxide residues and chromaticity, and the reasons for disqualification were excessive sulfur and overcooking. The qualified rate was 37.1% and the unqualified rate was as high as 62.9% according to exploratory research testing. The reasons for disqualification were mainly poor consistency of Atractylodes macrocephala in various places, substandard composition, abuse of regulators, fungicides, pesticides for plant growth and excessive heavy metals. Conclusion: Based on the results of statutory standard testing and exploratory research, the overall quality status of Atractylodes macrocephala was evaluated as average. Therefore, it is recommended to standardize the planting of Atractylodes macrocephala, improve the current quality standards of prepared slices of Atractylodes macrocephala, and strengthen supervision.
Objective: To evaluate the overall quality of prepared slices of Atractylodes macrocephala. Methods:The quality of Atractylodes macrocephala was evaluated and analyzed by statutory standard testing combined with exploratory research. Results: 248 batches of Atractylodes macrocephala were sampled. The qualified rate was 96.0% and the unqualified rate was 4.0% according to the legal standards. The unqualified items were sulfur dioxide residues and chromaticity, and the reasons for disqualification were excessive sulfur and overcooking. The qualified rate was 37.1% and the unqualified rate was as high as 62.9% according to exploratory research testing. The reasons for disqualification were mainly poor consistency of Atractylodes macrocephala in various places, substandard composition, abuse of regulators, fungicides, pesticides for plant growth and excessive heavy metals. Conclusion: Based on the results of statutory standard testing and exploratory research, the overall quality status of Atractylodes macrocephala was evaluated as average. Therefore, it is recommended to standardize the planting of Atractylodes macrocephala, improve the current quality standards of prepared slices of Atractylodes macrocephala, and strengthen supervision.
引文
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[2]徐超.白术饮片质量标准和高速逆流色谱分离纯化技术的研究[D].上海:华东理工大学,2005.
[3]王琳,赵国先,冯志华,等.白术多糖、枯草芽孢杆菌对育成期蛋鸡生长性能和血清免疫指标的影响[J].中国家禽,2017,39(16):31-35.
[4]方成武,彭华胜,杨洁,等.白术资源现状调查及保护对策[C].安徽中医药继承与创新博士科技论坛论文集,2008:372-374.
[5]王宁.安徽省白术资源及其开发对策[J].安徽农业科学,2012,40(14):8157-8158.
[6]彭华胜,王德群.白术道地药材的形成与变迁[J].中国中药杂志,2004,29(12):1133-1135.
[7]杨舒婷,龚华栋,赵云鹏,等.产地与种源对白术药材质量的影响[J].中药材,2013,36(6):890-892.
[8]田颖,刘志刚,孟庆莉.不同产地白术药材中白术内酯Ⅱ和Ⅲ的含量测定[J].海峡药学,2012,24(8):65-68.
[9]吴慧,赵文龙,单国顺,等. HPLC波长切换法同时测定白术及其不同麸制品中白术内酯Ⅰ、Ⅱ、Ⅲ[J].中成药,2013,35(11):2484-2487.
[10]阎克里,朱秀卿,赵丽. HPLC法同时测定白术挥发油中5种抗肿瘤成分含量[J].药物分析杂志,2011,31(6):1106-1110.
[11]段启,许冬谨,谢晨. HPLC法测定白术不同炮制品中白术内酯Ⅰ、Ⅱ、Ⅲ[J].中草药,2008,39(9):1343-1345.
[12]沈建涛,张振凌.白术炮制品中白术内酯Ⅰ、Ⅲ含量随放置时间变化的研究[J].时珍国医国药,2014,25(8):1873-1875.
[13]张金莲,谢日健,刘明贵,等.不同炮制方法对白术中白术内酯Ⅰ,Ⅱ,Ⅲ含量的影响[J].中国实验方剂学杂志,2016,22(21):15-18.
[14]朱国琼,高岚.白术古今炮制述要[J].基层中药杂志,1998,12(3):17.
[15]李钊,李维聪.浅析白术不同炮制的临床应用[J].四川中医,2015,33(2):189-191.
[16]费莹,王娜妮,李洪玉,等.炮制工艺对白术挥发油组成及3种白术内酯含量的影响研究[J].中华中医药学刊,2016,34(2):418-421.
[17]李庆.白术的不同炮制法对临床作用的影响[J].中国医药指南,2013,11(19):302-303.
[18]王文明,夏黎,段启,等.清炒白术高效液相色谱指纹图谱研究[J].现代医药卫生,2013,29(17):2582-2583.
[19]段启,许冬谨,刘传祥,等.白术的研究进展[J].中草药,2008,39(5):附4-6.
[20]王琦,陈鸿平,刘友平,等.土炒对白术挥发油含量及组成的影响[J].中国药业,2014,23(14):17-19.