系统性疾病患者角膜神经丛和郎格汉斯细胞的共聚焦显微镜观察
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摘要
角膜共聚焦显微镜(corneal confocal microscope,CCM)是一种非侵入性、用于研究活体角膜的方法,其越来越多地被用以评估角膜神经丛和郎格汉斯细胞病变。本文对应用CCM研究糖尿病、干燥综合征、多发性硬化、甲状腺相关性眼病、纤维肌痛、慢性偏头痛、帕金森病等系统性疾病中的角膜神经丛和郎格汉斯细胞病变的新进展进行综述。
Corneal confocal microscope(CCM) is a non-invasive instrument for the study of living cornea and is increasingly being used to evaluate corneal nerve plexus and Langerhans cell lesions.This paper reviews the recent advances in corneal nerve plexus and Langerhans cell lesions from the perspective of the use of CCM in the study of systemic diseases such as diabetes mellitus,Sjogren's syndrome, multiple sclerosis, thyroid-associated ophthalmopathy, fibromyalgia, chronic migraine and Parkinson's disease.
Corneal confocal microscope(CCM) is a non-invasive instrument for the study of living cornea and is increasingly being used to evaluate corneal nerve plexus and Langerhans cell lesions.This paper reviews the recent advances in corneal nerve plexus and Langerhans cell lesions from the perspective of the use of CCM in the study of systemic diseases such as diabetes mellitus,Sjogren's syndrome, multiple sclerosis, thyroid-associated ophthalmopathy, fibromyalgia, chronic migraine and Parkinson's disease.
引文
1 Papanas N,Ziegler D.Corneal confocal microscopy:Recent progress in the evaluation of diabetic neuropathy.J Diabetes Investig 2015;6(4):381-389
2阳雪,李莹.角膜朗格汉斯细胞在干眼发病机制中作用的研究进展.中华眼科杂志 2018;54(2):149-153
3 Stern ME,Schaumburg CS,Pflugfelder SC.Dry eye as a mucosal autoimmune disease.Int Rev Immunol 2013;32(1):19-41
4 Resch MD,Marsovszky L,Németh J,et al.Dry eye and corneal langerhans cells in systemic lupus erythematosus.J Ophthalmol 2015;2015:543835
5 Xiong Q,Lu B,Ye HY,et al.Coneal confocal microscopy as a non-invasive test to assess diabetic peripheral neuropathy.Diabetes Res Clin Pract 2018;136:85-92
6 Khan A,Petropoulos IN,Ponirakis G,et al.Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy.J Diabetes Investig 2018;9(5):1167-1172
7陆炯,李函,邢茜,等.基于角膜共焦激光显微镜检测的角膜基底神经变化与2型糖尿病视网膜微血管病变的相关性研究.眼科新进展 2017;37(9):863-866
8韩治华,杨淑焕,郭卫民,等.糖尿病患者角膜朗格汉斯细胞与神经纤维病理改变的研究.国际眼科杂志2016;16(2):343-345
9赵雪松,樊永平,杨涛.补肾益髓法对复发缓解型多发性硬化患者认知功能的影响.中华中医药杂志 2018;33(11):4903-4905
10 Mikolajczak J,Zimmermann H,Kheirkhah A,et al.Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density.Mult Scler 2017;14(23):1847-1853
11 Bitirgen G,Akpinar Z,Malik RA,et al.Use of Corneal Confocal Microscopy to Detect Corneal Nerve Loss and Increased Dendritic Cells in Patients With Multiple Sclerosis.JAMA Ophthalmol 2017;135(7):777-782
12朱明娟,邢凯,亢泽峰,等.甲状腺相关性眼病的诊断及治疗进展.山东大学耳鼻喉眼学报 2018;32(5):110-116
13 Kocabeyoglu S,Moca MC,Cevik Y,et al.Ocular Surface Alterations and In Vivo Confocal Microscopic Features of Corneas in Patients With Newly Diagnosed Graves' Disease.Cornea 2015;34(7):745-749
14 Wu LQ,Cheng JW,Cai JP,et al.Observation of Corneal Langerhans Cells by In Vivo Confocal Microscopy in Thyroid-Associated Ophthalmopathy.Curr Eye Res 2016;41(7):927-932
15 Heidari F,Afshari M,Moosazadeh M.Prevalence of fibromyalgia in general population and patients,a systematic review and meta-analysis.Rheumatol Int 2017;37(9):1527-1539
16 Oudejans L,He X,Niesters M,et al.Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia.Sci Rep 2016;6:23573
17 Erkan Turan K,Kocabeyoglu S,Unal-Cevik I,et al.Ocular Surface Alterations in the Context of Corneal In Vivo Confocal Microscopic Characteristics in Patients With Fibromyalgia.Cornea 2018;37(2):205-210
18 Semeraro F,Forbice E,Nascimbeni G,et al.Effect of Autologous Serum Eye Drops in Patients with Sjogren Syndrome-related Dry Eye:Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface.In Vivo 2016;30(6):931-938
19 Tepelus TC,Chiu GB,Huang J,et al.Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes:a preliminary study.Graefes Arch Clin Exp Ophthalmol 2017;255(9):1771-1778
20 Machetta F,Fea AM,Actis AG,et al.In vivo confocal microscopic evaluation of corneal langerhans cells in dry eye patients.Open Ophthalmol J 2014;8:51-59
21 Choi EY,Kang HG,Lee CH,et al.Langerhans cells prevent subbasal nerve damage and upregulate neurotrophic factors in dry eye disease.PLoS One 2017;12(4):e0176153
22 Shetty R,Deshmukh R,Shroff R,et al.Subbasal Nerve Plexus Changes in Chronic Migraine.Cornea 2018;37(1):72-75
23 Kinard KI,Smith AG,Singleton JR,et al.Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eye.Headache 2015;55(4):543-549
24 Demirci S,Gunes A,Koyuncuoglu HR,et al.Evaluation of corneal parameters in patients with Parkinson's disease.Neurol Sci 2016;37(8):1247-1252
25 Arrigo A,Rania L,Calamuneri A,et al.Early Corneal Innervation and Trigeminal Alterations in Parkinson Disease:A Pilot Study.Cornea 2018;37(4):448-454
26 Misra SL,Kersten HM,Roxburgh RH,et al.Corneal nerve microstructure in Parkinson's disease.J Clin Neurosci 2017;39:53-58
2阳雪,李莹.角膜朗格汉斯细胞在干眼发病机制中作用的研究进展.中华眼科杂志 2018;54(2):149-153
3 Stern ME,Schaumburg CS,Pflugfelder SC.Dry eye as a mucosal autoimmune disease.Int Rev Immunol 2013;32(1):19-41
4 Resch MD,Marsovszky L,Németh J,et al.Dry eye and corneal langerhans cells in systemic lupus erythematosus.J Ophthalmol 2015;2015:543835
5 Xiong Q,Lu B,Ye HY,et al.Coneal confocal microscopy as a non-invasive test to assess diabetic peripheral neuropathy.Diabetes Res Clin Pract 2018;136:85-92
6 Khan A,Petropoulos IN,Ponirakis G,et al.Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy.J Diabetes Investig 2018;9(5):1167-1172
7陆炯,李函,邢茜,等.基于角膜共焦激光显微镜检测的角膜基底神经变化与2型糖尿病视网膜微血管病变的相关性研究.眼科新进展 2017;37(9):863-866
8韩治华,杨淑焕,郭卫民,等.糖尿病患者角膜朗格汉斯细胞与神经纤维病理改变的研究.国际眼科杂志2016;16(2):343-345
9赵雪松,樊永平,杨涛.补肾益髓法对复发缓解型多发性硬化患者认知功能的影响.中华中医药杂志 2018;33(11):4903-4905
10 Mikolajczak J,Zimmermann H,Kheirkhah A,et al.Patients with multiple sclerosis demonstrate reduced subbasal corneal nerve fibre density.Mult Scler 2017;14(23):1847-1853
11 Bitirgen G,Akpinar Z,Malik RA,et al.Use of Corneal Confocal Microscopy to Detect Corneal Nerve Loss and Increased Dendritic Cells in Patients With Multiple Sclerosis.JAMA Ophthalmol 2017;135(7):777-782
12朱明娟,邢凯,亢泽峰,等.甲状腺相关性眼病的诊断及治疗进展.山东大学耳鼻喉眼学报 2018;32(5):110-116
13 Kocabeyoglu S,Moca MC,Cevik Y,et al.Ocular Surface Alterations and In Vivo Confocal Microscopic Features of Corneas in Patients With Newly Diagnosed Graves' Disease.Cornea 2015;34(7):745-749
14 Wu LQ,Cheng JW,Cai JP,et al.Observation of Corneal Langerhans Cells by In Vivo Confocal Microscopy in Thyroid-Associated Ophthalmopathy.Curr Eye Res 2016;41(7):927-932
15 Heidari F,Afshari M,Moosazadeh M.Prevalence of fibromyalgia in general population and patients,a systematic review and meta-analysis.Rheumatol Int 2017;37(9):1527-1539
16 Oudejans L,He X,Niesters M,et al.Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia.Sci Rep 2016;6:23573
17 Erkan Turan K,Kocabeyoglu S,Unal-Cevik I,et al.Ocular Surface Alterations in the Context of Corneal In Vivo Confocal Microscopic Characteristics in Patients With Fibromyalgia.Cornea 2018;37(2):205-210
18 Semeraro F,Forbice E,Nascimbeni G,et al.Effect of Autologous Serum Eye Drops in Patients with Sjogren Syndrome-related Dry Eye:Clinical and In Vivo Confocal Microscopy Evaluation of the Ocular Surface.In Vivo 2016;30(6):931-938
19 Tepelus TC,Chiu GB,Huang J,et al.Correlation between corneal innervation and inflammation evaluated with confocal microscopy and symptomatology in patients with dry eye syndromes:a preliminary study.Graefes Arch Clin Exp Ophthalmol 2017;255(9):1771-1778
20 Machetta F,Fea AM,Actis AG,et al.In vivo confocal microscopic evaluation of corneal langerhans cells in dry eye patients.Open Ophthalmol J 2014;8:51-59
21 Choi EY,Kang HG,Lee CH,et al.Langerhans cells prevent subbasal nerve damage and upregulate neurotrophic factors in dry eye disease.PLoS One 2017;12(4):e0176153
22 Shetty R,Deshmukh R,Shroff R,et al.Subbasal Nerve Plexus Changes in Chronic Migraine.Cornea 2018;37(1):72-75
23 Kinard KI,Smith AG,Singleton JR,et al.Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eye.Headache 2015;55(4):543-549
24 Demirci S,Gunes A,Koyuncuoglu HR,et al.Evaluation of corneal parameters in patients with Parkinson's disease.Neurol Sci 2016;37(8):1247-1252
25 Arrigo A,Rania L,Calamuneri A,et al.Early Corneal Innervation and Trigeminal Alterations in Parkinson Disease:A Pilot Study.Cornea 2018;37(4):448-454
26 Misra SL,Kersten HM,Roxburgh RH,et al.Corneal nerve microstructure in Parkinson's disease.J Clin Neurosci 2017;39:53-58