酒依赖患者与非饮酒健康人群甲状腺功能指标比较研究
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摘要
目的:比较酒依赖患者与非饮酒健康人群甲功指标的差异。方法:选取酒依赖患者500例设为酒依赖组,非离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平,进行统计学分析。结果:酒依赖组血清TSH水平高于对照组但差异没有达到显著水平(P> 0. 05)。酒依赖组T3与FT4水平均低于对照组但差异未达到显著水平(P>0. 05)。酒依赖组T4低于对照组且差异达到极显著水平(P <0. 01)。酒依赖组FT3低于对照组且差异达到极显著水平(P <0. 01);酒依赖组TSH与T4、TSH与FT4均呈极显著负相关关系; T3与T4、T3与FT3、T3与FT4、T4与FT3、T4与FT4、FT3与FT4均呈极显著正相关关系。饮酒时间和饮酒量分别与TSH呈极显著正相关关系、与T4呈显著负相关关系、与FT4呈极显著负相关关系。结论:酒精依赖对甲状腺有直接的毒害作用,会造成甲状腺激素的失调和甲状腺功能的紊乱。
Objective: To compare the difference of thyroid function between alcohol dependent patients and non-drinking healthy people.Methods: 500 patients with alcohol dependence were selected as alcohol dependence groups,and 500 healthy people who don't drink were selected as control group.The serum thyroid stimulating hormone( TSH),three iodine thyroid glycine( T3),thyroxine( T4),three free iodine thyroid former glycine( FT3) and free thyroxine( FT4) levels were detected,and statistical analysis were done.Results: Serum TSH level in the alcohol dependent group was higher than that in the control group,but the difference did not reach a significant level( P > 0. 05). Both T3 and FT4 levels in the alcohol dependent group were lower than those in the control group,but the difference did not reach a significant level( P > 0. 05). T4 in the alcohol dependent group was lower than that in the control group and the difference reached a very significant level( P < 0. 01). The FT3 of the alcohol dependent group was lower than that of the control group and the difference was extremely significant( P< 0. 01). TSH was negatively correlated with T4,TSH and FT4 in the alcohol dependent group. T3 and T4,T3 and FT3,T3 and FT4,T4 and FT3,T4 and FT4,T4 and FT4,FT3 and FT4 all have extremely significant positive correlation. The time and amount of drinking were positively correlated with TSH,negatively correlated with T4,and negatively correlated with FT4.Conclusion: Alcohol dependence has a direct toxic effect on the thyroid gland,causing thyroid hormone imbalance and thyroid dysfunction.
Objective: To compare the difference of thyroid function between alcohol dependent patients and non-drinking healthy people.Methods: 500 patients with alcohol dependence were selected as alcohol dependence groups,and 500 healthy people who don't drink were selected as control group.The serum thyroid stimulating hormone( TSH),three iodine thyroid glycine( T3),thyroxine( T4),three free iodine thyroid former glycine( FT3) and free thyroxine( FT4) levels were detected,and statistical analysis were done.Results: Serum TSH level in the alcohol dependent group was higher than that in the control group,but the difference did not reach a significant level( P > 0. 05). Both T3 and FT4 levels in the alcohol dependent group were lower than those in the control group,but the difference did not reach a significant level( P > 0. 05). T4 in the alcohol dependent group was lower than that in the control group and the difference reached a very significant level( P < 0. 01). The FT3 of the alcohol dependent group was lower than that of the control group and the difference was extremely significant( P< 0. 01). TSH was negatively correlated with T4,TSH and FT4 in the alcohol dependent group. T3 and T4,T3 and FT3,T3 and FT4,T4 and FT3,T4 and FT4,T4 and FT4,FT3 and FT4 all have extremely significant positive correlation. The time and amount of drinking were positively correlated with TSH,negatively correlated with T4,and negatively correlated with FT4.Conclusion: Alcohol dependence has a direct toxic effect on the thyroid gland,causing thyroid hormone imbalance and thyroid dysfunction.
引文
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[8]李书群,李晓勤,胡列鹏.长期过度饮酒导致亚临床甲状腺机能减退结果分析[J].新疆中医药,2014,32(5):36-38.
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[11]JBHonnamurthy,AR Shivashankara,SS Avinash,et al.Effect of interaction between duration of alcohol consumption and alcohol dependence on thyroid function test:cross sectional observational study[J].Indian J Clin Biochem,2017(6):1-8.
[2]刘志民,冯晓云,邹俊杰.甲亢[M].北京:中国医药科技出版社,2009:10-15.
[3]王婷婷,刘小翠,程亚玲,等.下丘脑-垂体-甲状腺轴与慢性酒依赖关系的研究进展[J].2017,17(4):299-301.
[4]Ibhazehiebo K,Koibuchi N.Impact of endocrine-disrupting chemicals on thyroid function and brain development[J].Exp Rev Endorinol Metra,2014,9(6):579-591.
[5]Pagadala MR,Zein CO,Dasarathy S,et al.Prevalence of hypothyroidism in nonalcoholic fatty liver disease[J].Dig Dis Sci,2012,57(2):528-534.
[6]Balhara YP,Deb KS.Impact of alcohol use on thyroid function[J].Indian J Endocrinol Metab,2013,17(4):580-587.
[7]钟智勇,吴小立,王继辉,等.慢性酒精中毒所致精神障碍患者甲状腺激素水平分析[J].中国药物依赖性杂志,2012,21(3):190-193.
[8]李书群,李晓勤,胡列鹏.长期过度饮酒导致亚临床甲状腺机能减退结果分析[J].新疆中医药,2014,32(5):36-38.
[9]J Li,V Nguyen,BA French,et al.Mechanism of the alcohol cyclic pattern:role of the hypothalamic-pituitary-thyroid axis[J].Am JPhysiol Gastrointest Liver Physiol,2000,279(1):118-125.
[10]Wilcoxon JS,Redei EE.Prenatal programming of adult thyroid function by alcohol and thyroid hormones[J].Am J Physiol Endocrinol Metab,2004,287(2):316-318.
[11]JBHonnamurthy,AR Shivashankara,SS Avinash,et al.Effect of interaction between duration of alcohol consumption and alcohol dependence on thyroid function test:cross sectional observational study[J].Indian J Clin Biochem,2017(6):1-8.