基于“毒邪”与神经毒性的关系论治帕金森病
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摘要
分析神经毒性导致帕金森病发生的机制及中医学对于"毒邪"的认识,中医学所谓的"毒邪"分为外毒与内毒,外毒与内毒均可导致帕金森病。探讨帕金森病中医学"毒邪"理论与神经毒性的关系,并总结归纳出中西医病因病机的相关性,即神经系统老化为中医学中的肝肾气血亏虚(本虚),环境、职业暴露及药物依赖等多因素交互作用所致的帕金森病神经毒性为中医学中的内、外毒,即"痰浊、瘀血"等病理产物(标实),黑质-纹状体多巴胺能神经通路变性丢失则为脑络受损。提出"毒邪"为帕金森病重要的病因,在今后防治帕金森病时可从毒论治,治以解毒、祛毒,排毒之法。
To analyze the mechanism of neurotoxicity leading to the occurrence of Parkinson's disease and the understanding of "toxin factor" in traditional Chinese medicine. The so-called "toxin factor" in traditional Chinese medicine is divided into external and internal toxin. Both external and internal toxin can cause Parkinson's disease. To explore the relationship between the theory of "toxin factor" in Chinese medicine and neurotoxicity in Parkinson's disease, and to summarize the correlation between pathogenesis of Chinese and Western medicine.So the aging of nervous system is the de ciency of liver and kidney in traditional Chinese medicine(de ciency syndrome). Parkinson's disease neurotoxicity caused by multi-factor interactions such as environment, occupational exposure and drug dependence is internal and external toxicity in traditional Chinese medicine, namely pathological products such as "turbidity and blood stasis"(excessive syndrome), substantia nigra-striatum loss of denaturation of the dopaminergic neuropathy is impaired in the brain. It is proposed that "toxin factor" is an important cause of Parkinson's disease. In the future, when it is used to prevent Parkinson's disease, it can be treated from toxin, and it is treated with detoxi cation, scorpion venom and elimination of toxicant.
To analyze the mechanism of neurotoxicity leading to the occurrence of Parkinson's disease and the understanding of "toxin factor" in traditional Chinese medicine. The so-called "toxin factor" in traditional Chinese medicine is divided into external and internal toxin. Both external and internal toxin can cause Parkinson's disease. To explore the relationship between the theory of "toxin factor" in Chinese medicine and neurotoxicity in Parkinson's disease, and to summarize the correlation between pathogenesis of Chinese and Western medicine.So the aging of nervous system is the de ciency of liver and kidney in traditional Chinese medicine(de ciency syndrome). Parkinson's disease neurotoxicity caused by multi-factor interactions such as environment, occupational exposure and drug dependence is internal and external toxicity in traditional Chinese medicine, namely pathological products such as "turbidity and blood stasis"(excessive syndrome), substantia nigra-striatum loss of denaturation of the dopaminergic neuropathy is impaired in the brain. It is proposed that "toxin factor" is an important cause of Parkinson's disease. In the future, when it is used to prevent Parkinson's disease, it can be treated from toxin, and it is treated with detoxi cation, scorpion venom and elimination of toxicant.
引文
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[16] RECASENS A, DEHAY B, BOVE J, et al. Lewy body extracts from Parkinson disease brains triggera-synuclein pathology and neurodegeneration in mice and monkeys[J].Ann Neurol, 2014(75):351-362.
[17]张顺宵,刘毅,孙艳,等.从毒论治神经系统疑难病症的思路及应用[J].山东中医药大学学报, 2016, 40(5):461-463.
[18]魏媛.滋补肝肾,通络解毒法治疗帕金森病46例的临床疗效分析[J].世界最新医学信息文摘, 2016, 16(49):275-278.
[19]卢晨.川芎嗪对MPTP诱导大鼠中脑多巴胺神经元所伤所致帕金森病的脑神经保护机制研究[D].西安:第四军医大学, 2015.
[20]万明珠,于嵩,陈亚丽,等.“脑肾相济”针刺疗法治疗帕金森病理论探讨[J].辽宁中医药大学学报, 2018, 20(2):150-152.
[21]卓鹰,黄泳,姜雪梅,等.头针对帕金森病患者脑葡萄糖代谢的影响[J].中国中医基础医学杂志, 2006, 12(1):33-34.
[22]姜雪梅,黄泳,李东江.头电计对帕金森病患者纹状体区显像影响[J].中国针灸, 2006, 26(6):427-430.
[2]CHUANGCS,SUHL,LINCL.RiskofParkinson disease after organophosphate or carbamate Poisoning[M].Neurologica, 2016:1-9.
[3] KLODOWSKA D G, JASINSKA M B, SAFRANOW K. et al. The role of environmental factors in Parkinson’s disease may on disease onset age[J]. Neurol Neurochir Pol, 2005,39(6):445-450.
[4]颜凡莉,陈明苍,季宇彬.帕金森模型及评价方法研究进展[J].亚太传统医药, 2014, 10(6):55-57.
[5] KAREN D J, LI W, HARP P R, et al. Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos[J]. Neurotoxicology, 2001, 22(6):811-817.
[6]张洁.亚中毒阈剂量毒死蜱脑发育期暴露对大鼠黑质多巴胺能神经元的远期影响及机制[D].长沙:中南大学, 2012.
[7] DONAIRE V, NISO M, MORAN J M. et al. Heat shock proteins protect both MPP+and paraquat neurotoxicity[J].Brain Res Bull, 2005, 67(6):509-514.
[8]和青.铁导致a-突触核蛋白聚集在帕金森病中的作用研究[D].青岛:青岛大学, 2010.
[9]Centers for disease control(CDC).Street-drug contaminant causing parkinsonism[M]. MMWR Morb Mortal Wkly Rep,1984(33):351-352.
[10]张锦,张允玲,郭蓉娟,等.从“毒损脑络”到“毒损络脉”的理论探讨[J].北京中医药, 2013, 32(7):483-486.
[11]王永炎.关于提高脑血管疾病疗效难点的思考[J].中国中西医结合杂志, 1997, 17(2):195-196.
[12]高颖,谢颖桢.试论浊毒在血管性痴呆发病中的作用[J].中国中医急症, 2000, 9(6):266-267.
[13]王健,赵建军,任吉祥,等.髓虚毒损脑病病机关键的提出及在出血性中风的应用[J].长春中医药大学学报,2013, 29(4):15-717.
[14] HUANG D Y, YE M. Microglia and Parkinson’s disease[J].ChineseJournalof TissueEngineeringResearch,2012,16(24):4549-4554.
[15]DAMIERP,HIRSCHEC,ZHANGP,etal.Glutatilione peroxidase,glialcellsandPark inson’sdisease[J].Neuroseience, 1993(52):1-6
[16] RECASENS A, DEHAY B, BOVE J, et al. Lewy body extracts from Parkinson disease brains triggera-synuclein pathology and neurodegeneration in mice and monkeys[J].Ann Neurol, 2014(75):351-362.
[17]张顺宵,刘毅,孙艳,等.从毒论治神经系统疑难病症的思路及应用[J].山东中医药大学学报, 2016, 40(5):461-463.
[18]魏媛.滋补肝肾,通络解毒法治疗帕金森病46例的临床疗效分析[J].世界最新医学信息文摘, 2016, 16(49):275-278.
[19]卢晨.川芎嗪对MPTP诱导大鼠中脑多巴胺神经元所伤所致帕金森病的脑神经保护机制研究[D].西安:第四军医大学, 2015.
[20]万明珠,于嵩,陈亚丽,等.“脑肾相济”针刺疗法治疗帕金森病理论探讨[J].辽宁中医药大学学报, 2018, 20(2):150-152.
[21]卓鹰,黄泳,姜雪梅,等.头针对帕金森病患者脑葡萄糖代谢的影响[J].中国中医基础医学杂志, 2006, 12(1):33-34.
[22]姜雪梅,黄泳,李东江.头电计对帕金森病患者纹状体区显像影响[J].中国针灸, 2006, 26(6):427-430.