四川省市售食品中双酚A和双酚S检测结果分析
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摘要
目的了解四川省区域内市售食品中双酚A(BPA)和双酚S(BPS)的浓度,为食品污染物的监测和控制提供科学依据。方法采用超高效液相色谱-四级杆串联质谱法(HPLC-MS/MS))对四川境内在售的414份食品进行BPA和BPS监测分析。样品包含罐头、鱼肉、畜禽肉、饮料、谷物(大米、小麦),共5类。结果本次检测的414份食品中295份检测出BPA,检出率71. 3%,浓度为小于检出限到173μg/kg; 98份检测出BPS,检出率23. 7%,浓度为小于检出限到54. 2μg/kg。罐头类食品是BPA检出浓度最高的食品类别(检出率99. 2%,浓度均值:34. 7μg/kg);肉类食品是BPS检出浓度最高的食品类别(检出率:44. 7%,浓度均值:2. 14μg/kg)。结论所监测的食品中大部分都已被BPA污染,罐头类食品污染最为严重;作为BPA替代品的BPS在罐头类食品和谷物中的含量很低,但其在肉类食品中的污染水平与BPA相当。
Objective To investigate the concentration of bisphenol A( BPA) and bisphenol S( BPS) in the market foodstuffs from Sichuan province,in order to provide the scientific evidence for monitoring and control of food contaminant. Methods A total of 414 samples of market foodstuffs from Sichuan province were analyzed for BPA and BPS,using high-performance liquid chromatography-tandem mass spectrometry( HPLC-MS/MS).The food samples included canned food,fish,meat&poultry,beverage and cereal( rice,wheat). Results BPA was found in 295 food samples with the detection rate of 71. 3% and the concentration was below the limit of detection( LOD) to 173 μg/kg. BPS was found in 98 food samples with the detection rate of 23. 7% and the concentration was below the limit of detection( LOD) to 54. 2 μg/kg. The highest mean concentration of BPA was found in the canned food. The detection rate and the mean concentration was 99. 2% and 34. 7 μg/kg,respectively. The highest mean concentration of BPS was found in fish and meat&poultry. The detection rate and the mean concentration was 44. 7% and 2. 14 μg/kg,respectively. Conclusion A majority of the monitored foodstuffs were contaminated with BPA,of which the canned food were the most serious polluted. BPS,as a BPA substitute,its concentration was quite low in canned food and cereal,but the level of its contamination in meat product was close to that of BPA.
Objective To investigate the concentration of bisphenol A( BPA) and bisphenol S( BPS) in the market foodstuffs from Sichuan province,in order to provide the scientific evidence for monitoring and control of food contaminant. Methods A total of 414 samples of market foodstuffs from Sichuan province were analyzed for BPA and BPS,using high-performance liquid chromatography-tandem mass spectrometry( HPLC-MS/MS).The food samples included canned food,fish,meat&poultry,beverage and cereal( rice,wheat). Results BPA was found in 295 food samples with the detection rate of 71. 3% and the concentration was below the limit of detection( LOD) to 173 μg/kg. BPS was found in 98 food samples with the detection rate of 23. 7% and the concentration was below the limit of detection( LOD) to 54. 2 μg/kg. The highest mean concentration of BPA was found in the canned food. The detection rate and the mean concentration was 99. 2% and 34. 7 μg/kg,respectively. The highest mean concentration of BPS was found in fish and meat&poultry. The detection rate and the mean concentration was 44. 7% and 2. 14 μg/kg,respectively. Conclusion A majority of the monitored foodstuffs were contaminated with BPA,of which the canned food were the most serious polluted. BPS,as a BPA substitute,its concentration was quite low in canned food and cereal,but the level of its contamination in meat product was close to that of BPA.
引文
[1]谢桂勉,杨培新,李海彬,等.食品及其包装材料中双酚A的检测研究进展[J].食品工业科技,2012,33(14):388-391.
[2]Alonso-magdalena P,Ropero AB,Soriano S,et al. Bisphenol-A acts as a potent estrogen vianon-classical estrogen triggered pathways[J]. Molecular&ellular Endocrinology,2012,355(2):201-207.
[3]吴皓,孙东,蔡卓平,等.双酚A的内分泌干扰效应研究进展[J].生态科学,2017,36(3):200-206.
[4]Gentilcore D,Porreca I,Rizzo F,et al. Bisphenol A interferes with thyroid specific gene expression[J]. Toxicology,2013,304(1):21-31.
[5]Watson CS,Jeng YJ,Guptarak J. Endocrine disruption via estrogen receptors that participateinnongenomic signaling pathways[J]. Journal of Chromatography A,2011,127(1/2):44-50.
[6]Tarapore P,Ying J,Ooyang B,et al. Exposure to Bisphenol A Correlates with Early-Onset Prostate Cancer and Promotes Centrosome Amplification and AnchorageIndependent Growth In Vitro[J]. Plos One,2014,9(3):1-11.
[7]Acevedo N,Davis B,Schaeberle CM,et al. Perinatally Administered Bisphenol A as a Potential Mammary Gland Carcinogen in Rats[J].Environmental Health Perspect,2013,121(9):1040-1046.
[8]Park MA,Choi KC. Effects of 4-nonylphenol and bisphenol A on stimulation of cell growth via disruption of the transforming growth factor-βsignaling pathway in ovarian cancer models[J]. Chemical research in toxicology,2013,27(1):119-128.
[9]European Commission. Regulation(EU)No. 10/2011 of 14 January2011 on plastic materials and articles intended to come into contact with food[S]. OJ L 12,15. 1. 2011:1-89.
[10]Liao C,Liu F,Alomirah H,et al. Bisphenol S in urine from the United States and seven Asian countries:occurrence and human exposures[J]. Environ Sci Technol,2012,46(12):6860-6866.
[11]Kinch CD,Ibhazehiebo K,Jeong JH,et al. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish[J].Proceedings of the National Academy of Sciences of the United states of Amevica,2015,112(5):1475-1480
[12]Ji K,Hong S,Kho Y,et al. Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish[J]. Environ. Sci.Technol,2013,47(15):8793-8800.
[17]Wenhui Qiu,Yali Zhao,Ming Yang,et al. Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish[J]. Endocrinology,2016,157(2):636-647.
[18]国先芬,王贻鑫,耿存珍,等.环境激素双酚A的毒理学研究进展[J].环境科学与技术,2013,36(2):86-92.
[20]韩灏,邵兵,马亚鲁,等.高效液相色谱法测定饮料类食品中的类雌激素[J].色谱,2005,23(2):176-179.
[21]Khim Js,Lee KT,Kannan K,et al. Trace orgamic contaminants in sediment and water from Ulsan Bay and its vicinity,Korea[J]. Arch Environ Contam Toxicol,2001,40:141-150.
[22]Liao C,Kannan K. Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the United States and their implications for human exposure[J]. J Agric Food Chem,2013,61(19):4655-4662.
[23]Heemken OP,Reincke H,Stachel B,et al. The occurrence of xenoestrogens in the Elbe riverand the North Sea[J]. Chermosphere,2001,45:245-259.
[24]Cao X L,Perez-Locas C,Dufresne G,et al. Concentrations of bisphenol A in the composite food samples from the 2008 Canadian total diet study in Quebec City and dietary intake estimates[J]. Food Addit Contam,2011,28(6):791-798.
[25]姚卫蓉,俞晔.食品包装容器中双酚A含量的调查和迁移研究[C].第二届国际食品安全高峰论坛论文集,2009.
[2]Alonso-magdalena P,Ropero AB,Soriano S,et al. Bisphenol-A acts as a potent estrogen vianon-classical estrogen triggered pathways[J]. Molecular&ellular Endocrinology,2012,355(2):201-207.
[3]吴皓,孙东,蔡卓平,等.双酚A的内分泌干扰效应研究进展[J].生态科学,2017,36(3):200-206.
[4]Gentilcore D,Porreca I,Rizzo F,et al. Bisphenol A interferes with thyroid specific gene expression[J]. Toxicology,2013,304(1):21-31.
[5]Watson CS,Jeng YJ,Guptarak J. Endocrine disruption via estrogen receptors that participateinnongenomic signaling pathways[J]. Journal of Chromatography A,2011,127(1/2):44-50.
[6]Tarapore P,Ying J,Ooyang B,et al. Exposure to Bisphenol A Correlates with Early-Onset Prostate Cancer and Promotes Centrosome Amplification and AnchorageIndependent Growth In Vitro[J]. Plos One,2014,9(3):1-11.
[7]Acevedo N,Davis B,Schaeberle CM,et al. Perinatally Administered Bisphenol A as a Potential Mammary Gland Carcinogen in Rats[J].Environmental Health Perspect,2013,121(9):1040-1046.
[8]Park MA,Choi KC. Effects of 4-nonylphenol and bisphenol A on stimulation of cell growth via disruption of the transforming growth factor-βsignaling pathway in ovarian cancer models[J]. Chemical research in toxicology,2013,27(1):119-128.
[9]European Commission. Regulation(EU)No. 10/2011 of 14 January2011 on plastic materials and articles intended to come into contact with food[S]. OJ L 12,15. 1. 2011:1-89.
[10]Liao C,Liu F,Alomirah H,et al. Bisphenol S in urine from the United States and seven Asian countries:occurrence and human exposures[J]. Environ Sci Technol,2012,46(12):6860-6866.
[11]Kinch CD,Ibhazehiebo K,Jeong JH,et al. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish[J].Proceedings of the National Academy of Sciences of the United states of Amevica,2015,112(5):1475-1480
[12]Ji K,Hong S,Kho Y,et al. Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish[J]. Environ. Sci.Technol,2013,47(15):8793-8800.
[17]Wenhui Qiu,Yali Zhao,Ming Yang,et al. Actions of Bisphenol A and Bisphenol S on the Reproductive Neuroendocrine System During Early Development in Zebrafish[J]. Endocrinology,2016,157(2):636-647.
[18]国先芬,王贻鑫,耿存珍,等.环境激素双酚A的毒理学研究进展[J].环境科学与技术,2013,36(2):86-92.
[20]韩灏,邵兵,马亚鲁,等.高效液相色谱法测定饮料类食品中的类雌激素[J].色谱,2005,23(2):176-179.
[21]Khim Js,Lee KT,Kannan K,et al. Trace orgamic contaminants in sediment and water from Ulsan Bay and its vicinity,Korea[J]. Arch Environ Contam Toxicol,2001,40:141-150.
[22]Liao C,Kannan K. Concentrations and profiles of bisphenol A and other bisphenol analogues in foodstuffs from the United States and their implications for human exposure[J]. J Agric Food Chem,2013,61(19):4655-4662.
[23]Heemken OP,Reincke H,Stachel B,et al. The occurrence of xenoestrogens in the Elbe riverand the North Sea[J]. Chermosphere,2001,45:245-259.
[24]Cao X L,Perez-Locas C,Dufresne G,et al. Concentrations of bisphenol A in the composite food samples from the 2008 Canadian total diet study in Quebec City and dietary intake estimates[J]. Food Addit Contam,2011,28(6):791-798.
[25]姚卫蓉,俞晔.食品包装容器中双酚A含量的调查和迁移研究[C].第二届国际食品安全高峰论坛论文集,2009.