非小细胞肺癌中miRNAs的表达水平及作用机制研究进展
摘要
<正>肺癌在世界范围内的患病率与死亡率增长迅速,对人类的健康造成了严重影响。大部分(80%)肺癌发病者是患非小细胞肺癌(Non-Small Cell Lung Cancer,NSCLC),通常检查出患有NSCLC时癌症已经发展至中期或晚期,这是因为目前NSCLC诊断方式精确度有待提高以及缺少相关诊断标志物,如此使治疗康复难度大大提高,预后复发率高。miRNA是一类内生非编码RNA,长度约22个核苷酸,在生物细胞中可以
引文
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2别志欣,李琳.miRNA在非小细胞肺癌中的研究进展[J].肿瘤防治研究,2012,39(6):739-743.
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11丁莎莎,陈晓丽,陈子兴,等.miRNA-106a在非小细胞肺癌中的表达及意义[J].现代肿瘤医学,2015,23(16):2289-2291.
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16王琳,娄加陶.miRNA-128a对非小细胞肺癌细胞增殖和迁移的影响[J].上海交通大学学报(医学版),2014,34(3):268-273,278.
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24张海涛,王翠翠,任凌燕,等.miRNA-130a在非小细胞肺癌中的表达和功能[J].现代肿瘤医学,2015,23(13):1838-1841.
25王思念,吕进,江其生.miRNA-130a与非小细胞肺癌侵袭转移相关研究进展[J].现代肿瘤医学,2013,21(4):903-905.
26矫爱红.miRNA-200c靶向上皮间质转化调节因子ZEB2抑制非小细胞肺癌的转移[D].济南:山东大学,2017.
27 Ling H,Pickard K,Ivan C,et al.The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis[J].Gut,2016,65(6):977-989.
28魏晨晨,姜黎黎,陈沁楠,等.miRNA-224通过调节Bim影响人非小细胞肺癌的增殖与凋亡[J].南京医科大学学报(自然科学版),2016,36(8):942-946.
29 Vickers MM,Bar J,Gorn-Hondermann I,et al.Stage-dependent differential expression of microRNAs in colorectal cancer:potential role as markers of metastatic disease[J].Clin Exp Metastasis,2012,29(2):123-132.
30 Luo XQ,Xu L,Ke ZY,et al.miRNA expression in childhood acute granulocytic leukemia and its subtypes[J].Zhonghua Zhong Liu Za Zhi,2011,33(11):831-835.
31 M Shu,X Zheng,S Wu,et al.Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells.Molecular Cancer,2011,10(1):59-59.
32 Wang R,Wang ZX,Yang JS,et al.miRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14(RAB14)[J].Oncogene,2011,30(23):2644-2658.
33王鹤,刘志利,德伟,等.miRNA-335对人非小细胞肺癌细胞迁移、侵袭及增殖能力的影响[J].南京医科大学学报(自然科学版),2012,32(6):795-799.
34 Herbst RS,Heymach JV,Lippman SM.Lung cancer[J].N Engl JMed,2008,359(13):1367-1380.
2别志欣,李琳.miRNA在非小细胞肺癌中的研究进展[J].肿瘤防治研究,2012,39(6):739-743.
3姜荣华,徐艳珺.miRNA在非小细胞肺癌中的研究进展[J].肿瘤学杂志,2011,17(7):494-497.
4 Chen Y,Zhu XD,Zhang XJ,et al.Nanoparticles modified with tumortargeting sc Fv deliver siRNA and miRNA for cancer therapy[J].Mol T-her,2010,18(9):1650-1656.
5 Bommer GT,Gerin I,Feng Y,et al.P53-mediated activation of miR-NA34 candidate tumor-suppressor genes[J].Curr Biol,2007,17(15):1298-1307.
6曾婷,郝丽,谢逸欣,等.miRNA-34a与非小细胞肺癌的关系及其可能调节机制[J].中国医药导报,2012,9(23):5-7.
7 Xiao BX,Guo JM,Miao Y,et al.Detection of miR-106a in gastric carcinoma and its clinical significance[J].Clin Chim Acta,2009,400(1/2):97-102.
8 Catela Ivkovic T,Aralica G,Cacev T,et al.miR-106a overexpression and pRB downregulation in sporadic colorectal cancer[J].Exp Mol Pathol,2013,94(1):148-154.
9 Li P,Xu QH,Zhang D,et al.Upregulated miR-106a plays an oncogenic role in pancreatic cancer[J].FEBS Lett,2014,588(5):705-712.
10 Zhao SG,Yang G,Mu YL,et al.miR-106a is an independent prognostic marker in patients with glioblastoma[J].Neuro-oncology,2013,15(6):707-717.
11丁莎莎,陈晓丽,陈子兴,等.miRNA-106a在非小细胞肺癌中的表达及意义[J].现代肿瘤医学,2015,23(16):2289-2291.
12 Lukiw WJ.Micro-RNA speciation in fetal,adult and Alzheimer’s disease hippocampus[J].Neuroreport,2007,18(3):297-300.
13 Lages E,Guttin A,El Atifi M,et al.miRNA and target protein patterns reveal physiopathological features of glioma subtypes[J].PLo S One,2011,6(5):e20600.
14 Zhu YH,Yu FY,Jiao Y,et al.Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5[J].Clin Cancer Res,2011,17(22):7105-7115.
15 Wuchty S,Arjona D,Li AG,et al.Prediction of associations between microRNAs and gene expression in glioma biology[J].PLo S One,2011,6(2):e14681.
16王琳,娄加陶.miRNA-128a对非小细胞肺癌细胞增殖和迁移的影响[J].上海交通大学学报(医学版),2014,34(3):268-273,278.
17 Li BK,Huang PZ,Qiu JL,et al.miRNA-130a is down-regulated in hepatocellular carcinoma and associates with poor prognosis[J].Med Oncol,2014,31(10):230.
18 L He,HY Wang,L Zhang,L Huang,JD Li.Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer.Cell Death&Disease,2014,5(5):e1205.
19 Zhang X,Huang LN,Zhao YL,et al.Downregulation of miR-130a contributes to cisplatin resistance in ovarian cancer cells by targeting X-linked inhibitor of apoptosis(XIAP)directly[J].Acta Biochim Biophys Sin(Shanghai),2013,45(12):995-1001.
20 Liu L,Nie J,Chen L,et al.The oncogenic role of miRNA-130a/301a/454 in human colorectal cancer via targeting Smad4 expression[J].PLo S One,2013,8(2):e55532.
21 Shuwei Qiu,Sheng Lin,Dan Hu,Yimin Feng,Yang Tan.Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients.Journal of Translational Medicine,2013,11(1):10-10.
22 Boll K,Reiche K,Kasack K,et al.miR-130a,miR-203 and miR-205jointly repress key oncogenic pathways and are downregulated in prostate carcinoma[J].Oncogene,2013,32(3):277-285.
23 Kovaleva V,Mora R,Park YJ,et al.miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells[J].Cancer Res,2012,72(7):1763-1772.
24张海涛,王翠翠,任凌燕,等.miRNA-130a在非小细胞肺癌中的表达和功能[J].现代肿瘤医学,2015,23(13):1838-1841.
25王思念,吕进,江其生.miRNA-130a与非小细胞肺癌侵袭转移相关研究进展[J].现代肿瘤医学,2013,21(4):903-905.
26矫爱红.miRNA-200c靶向上皮间质转化调节因子ZEB2抑制非小细胞肺癌的转移[D].济南:山东大学,2017.
27 Ling H,Pickard K,Ivan C,et al.The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis[J].Gut,2016,65(6):977-989.
28魏晨晨,姜黎黎,陈沁楠,等.miRNA-224通过调节Bim影响人非小细胞肺癌的增殖与凋亡[J].南京医科大学学报(自然科学版),2016,36(8):942-946.
29 Vickers MM,Bar J,Gorn-Hondermann I,et al.Stage-dependent differential expression of microRNAs in colorectal cancer:potential role as markers of metastatic disease[J].Clin Exp Metastasis,2012,29(2):123-132.
30 Luo XQ,Xu L,Ke ZY,et al.miRNA expression in childhood acute granulocytic leukemia and its subtypes[J].Zhonghua Zhong Liu Za Zhi,2011,33(11):831-835.
31 M Shu,X Zheng,S Wu,et al.Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells.Molecular Cancer,2011,10(1):59-59.
32 Wang R,Wang ZX,Yang JS,et al.miRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14(RAB14)[J].Oncogene,2011,30(23):2644-2658.
33王鹤,刘志利,德伟,等.miRNA-335对人非小细胞肺癌细胞迁移、侵袭及增殖能力的影响[J].南京医科大学学报(自然科学版),2012,32(6):795-799.
34 Herbst RS,Heymach JV,Lippman SM.Lung cancer[J].N Engl JMed,2008,359(13):1367-1380.