2005—2015年丹红注射液的不良反应文献分析
|
摘要
目的探讨丹红注射液致药品不良反应(ADR)的特点及相关因素,为临床合理用药提供参考。方法检索2005—2015年中国学术期刊(网络版,CNKI)、万方数字化期刊全文库、中文科技期刊全文数据库(维普)报道的丹红注射液致ADR的文献,并进行统计、分析。结果丹红注射液引发的ADR女性明显多于男性,年龄多集中在51~70岁,以全身损伤、皮肤损伤较为多见,所占构成比分别为22.6%、36.9%。在用药10~30 min出现的例数最多,占41.3%。给药途径均为注射给药,给药剂量为20 m L出现的ADR最多,占总人数的58.9%。结论临床应加强丹红注射液的合理使用,尽量避免或减少其所致ADR的发生。
Objective To investigate the characteristics and related factors of adverse drug reactions(ADR) induced by Danhong Injection, and provide reference for clinical rational use of drugs. Methods China Journal Full-text Database(CNKI), Wangfang Database, Chinese Science and Technology Journal Full-text Database(VIP), etc were retrieved from 2005 to 2015, and the documents of ADR induced by Danhong Injection were analyzed and discussed. Results Women with ADR induced by Danhong Injection were more than men, and more were focused on 51 — 70 years old. The main ADR of Danhong Injection was systemic injury(22.6%) and skin injury(36.9%). The most cases(41.3%) occured in the medication during 10 — 30 min. The administration dosage was parenteral administration. The most cases(58.9%) occured with the administration dosage of 20 m L. Conclusion The rational use of Danhong Injection should be strengthened, and to avoid or reduce the occurrence of adverse reactions.
Objective To investigate the characteristics and related factors of adverse drug reactions(ADR) induced by Danhong Injection, and provide reference for clinical rational use of drugs. Methods China Journal Full-text Database(CNKI), Wangfang Database, Chinese Science and Technology Journal Full-text Database(VIP), etc were retrieved from 2005 to 2015, and the documents of ADR induced by Danhong Injection were analyzed and discussed. Results Women with ADR induced by Danhong Injection were more than men, and more were focused on 51 — 70 years old. The main ADR of Danhong Injection was systemic injury(22.6%) and skin injury(36.9%). The most cases(41.3%) occured in the medication during 10 — 30 min. The administration dosage was parenteral administration. The most cases(58.9%) occured with the administration dosage of 20 m L. Conclusion The rational use of Danhong Injection should be strengthened, and to avoid or reduce the occurrence of adverse reactions.
引文
[1]韩素环.丹红注射液治疗脑卒中恢复期瘀血闭阻证的疗效观察[J].药物评价研究,2012,35(6):461-462.
[2]高彦,卢竞前,李易.步长丹红注射液对冠心病治疗研究进展[J].中国实用医药,2009,4(6):237-238.
[3]艾进超,何昱,杨荣兵,等.丹红注射液中主要有效成分在脑缺血大鼠体内药动学研究[J].中草药,2015,46(20):3039-3044.
[4]廉秋芳,吴朝,李晶晶,等.丹红注射液联合盐酸替罗非班治疗急性冠状动脉综合征的疗效观察[J].现代药物与临床,2015,30(12):1455-1459.
[5]胡东梅,梁小丽.64例丹红注射液不良反应报告分析[J].北方药学,2015,12(2):167-168.
[6]周福永,蔡志琴,林建群.丹红注射液不良反应文献分析与预防措施[J].中国药业,2012,21(4):62-63.
[7]栾潇潇,冯端浩,于莹莹.62例丹红注射液不良反应文献分析[J].中国医院用药评价与分析,2011,11(9):840-842.
[8]韩伟智,巩密密.丹红注射液致喉头水肿1例[J].医药导报,2011,30(9):1247.
[9]刘玉平.丹红注射液的临床不良反应监测[J].山西医药杂志,2014,43(7):820-822.
[10]俞建芬.静注丹红注射液的不良反应报告与分析[J].临床和实验医学杂志,2009,8(3):141.
[11]杨娟,计曼艳.我院丹红注射液不良反应发生情况分析[J].中国药业,2015,24(2):59-61.
[12]孙彩华,姜丽丽.丹红注射液的不良反应及防治措施[J].海峡药学,2006,06:181-182.
[13]苑冬敏,赵淑坤.丹红注射液致严重不良反应1例[J].中国药事,2009,23(10):1047-1048.
[14]李微.4例丹红注射液的不良反应报告分析[J].当代医学,2014,20(1):52.
[15]王海兵,李成建,金淑萍.丹红注射液不良反应[J].中国误诊学杂志,2009,28:7044-7045.
[16]陈集志,吴军,张增珠.丹红注射液静滴过快致不良反应1例[J].中国药师,2011,14(9):1345-1346.
[17]王亚宁,王娟,刘名一.42例丹红注射液不良反应/事件报告分析[C].2014年中国药学大会暨第十四届中国药师周论文集.北京:中国药学会,2014:7.
[18]孙志宏,闫竹琴,刁丛.丹红注射液致头痛1例[J].疑难病杂志,2010,9(6):426.
[19]吴慧轩,阎威,毛静远,等.丹红注射液静滴后致剧烈头痛1例[J].天津药学,2008,20(4):40.
[20]王宏蕾,范峥,郭桂明.丹红注射液致药物性肝损害1例[J].中国医院药学杂志,2015,35(16):1527-1528.
[21]陈燕丽,黎铁华.我院29例丹红注射液不良反应综合分析[J].当代医学,2011,17(29):130.
[22]南玲,廖淑梅.丹红注射液致发热及伤口出血[J].药物不良反应杂志,2009,11(5):378-379.
[23]曹胜,李君,李王芳.丹红注射液的不良反应及合理应用[J].哈尔滨医药,2014,34(6):386-387.
[24]景浩然,胡利民,王少峡,等.丹红注射液及其活性组分对脂多糖诱导的小胶质细胞NO分泌的抑制作用[J].现代药物与临床,2013,28(3):285-287.
[25]黄承杰.丹红注射液不良反应分析[J].交通医学,2009,23(2):165-167.
[26]柳青,雷招宝.丹红注射液的不良反应及合理应用[J].中成药,2010,32(11):1964-1966.
[27]王建青,李俊,吕雄文,等.109例药品不良反应报告回顾性分析[J].安徽医药,2013,17(11):1993-1995.
[28]吴丽云.丹红红注射液不良反应45例分析[J].中国基层医药,2013,20(10):1560-1561.
[29]刘美虹.丹红注射液不良反应风险因素研究[J].中西医结合心血管病电子杂志,2014(5):98.
[2]高彦,卢竞前,李易.步长丹红注射液对冠心病治疗研究进展[J].中国实用医药,2009,4(6):237-238.
[3]艾进超,何昱,杨荣兵,等.丹红注射液中主要有效成分在脑缺血大鼠体内药动学研究[J].中草药,2015,46(20):3039-3044.
[4]廉秋芳,吴朝,李晶晶,等.丹红注射液联合盐酸替罗非班治疗急性冠状动脉综合征的疗效观察[J].现代药物与临床,2015,30(12):1455-1459.
[5]胡东梅,梁小丽.64例丹红注射液不良反应报告分析[J].北方药学,2015,12(2):167-168.
[6]周福永,蔡志琴,林建群.丹红注射液不良反应文献分析与预防措施[J].中国药业,2012,21(4):62-63.
[7]栾潇潇,冯端浩,于莹莹.62例丹红注射液不良反应文献分析[J].中国医院用药评价与分析,2011,11(9):840-842.
[8]韩伟智,巩密密.丹红注射液致喉头水肿1例[J].医药导报,2011,30(9):1247.
[9]刘玉平.丹红注射液的临床不良反应监测[J].山西医药杂志,2014,43(7):820-822.
[10]俞建芬.静注丹红注射液的不良反应报告与分析[J].临床和实验医学杂志,2009,8(3):141.
[11]杨娟,计曼艳.我院丹红注射液不良反应发生情况分析[J].中国药业,2015,24(2):59-61.
[12]孙彩华,姜丽丽.丹红注射液的不良反应及防治措施[J].海峡药学,2006,06:181-182.
[13]苑冬敏,赵淑坤.丹红注射液致严重不良反应1例[J].中国药事,2009,23(10):1047-1048.
[14]李微.4例丹红注射液的不良反应报告分析[J].当代医学,2014,20(1):52.
[15]王海兵,李成建,金淑萍.丹红注射液不良反应[J].中国误诊学杂志,2009,28:7044-7045.
[16]陈集志,吴军,张增珠.丹红注射液静滴过快致不良反应1例[J].中国药师,2011,14(9):1345-1346.
[17]王亚宁,王娟,刘名一.42例丹红注射液不良反应/事件报告分析[C].2014年中国药学大会暨第十四届中国药师周论文集.北京:中国药学会,2014:7.
[18]孙志宏,闫竹琴,刁丛.丹红注射液致头痛1例[J].疑难病杂志,2010,9(6):426.
[19]吴慧轩,阎威,毛静远,等.丹红注射液静滴后致剧烈头痛1例[J].天津药学,2008,20(4):40.
[20]王宏蕾,范峥,郭桂明.丹红注射液致药物性肝损害1例[J].中国医院药学杂志,2015,35(16):1527-1528.
[21]陈燕丽,黎铁华.我院29例丹红注射液不良反应综合分析[J].当代医学,2011,17(29):130.
[22]南玲,廖淑梅.丹红注射液致发热及伤口出血[J].药物不良反应杂志,2009,11(5):378-379.
[23]曹胜,李君,李王芳.丹红注射液的不良反应及合理应用[J].哈尔滨医药,2014,34(6):386-387.
[24]景浩然,胡利民,王少峡,等.丹红注射液及其活性组分对脂多糖诱导的小胶质细胞NO分泌的抑制作用[J].现代药物与临床,2013,28(3):285-287.
[25]黄承杰.丹红注射液不良反应分析[J].交通医学,2009,23(2):165-167.
[26]柳青,雷招宝.丹红注射液的不良反应及合理应用[J].中成药,2010,32(11):1964-1966.
[27]王建青,李俊,吕雄文,等.109例药品不良反应报告回顾性分析[J].安徽医药,2013,17(11):1993-1995.
[28]吴丽云.丹红红注射液不良反应45例分析[J].中国基层医药,2013,20(10):1560-1561.
[29]刘美虹.丹红注射液不良反应风险因素研究[J].中西医结合心血管病电子杂志,2014(5):98.