2种炮制工艺对远志化学成分的影响
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摘要
目的对2种远志炮制工艺进行分析、比较,考察不同炮制工艺对远志化学成分的影响。方法按照《中国药典》方法和传统经验法炮制远志,采用高效液相色谱法测定2种不同工艺有效成分细叶远志皂苷、远志■酮Ⅲ和3,6′二芥子酰基蔗糖的含量,并进行比较。结果传统经验法炮制远志中的化学成分细叶远志皂苷、远志■酮Ⅲ和3,6′二芥子酰基蔗糖的含量均符合《中国药典》规定,且传统经验法炮制工艺操作简单易行。结论此炮制方法简单可行,为甘草制远志的炮制应用提供依据。
Objective To analyze and compare two processing techniques of Polygala tenuifolia, and to investigate the effects of different processing techniques on the chemical constituents of Polygala tenuifolia. Methods Polygala tenuifolia saponins, Polygalactone Ⅲ and 3,6′ dismustard acyl sucrose were determined by high performance liquid chromatography(HPLC) in accordance with the methods of Chinese Pharmacopoeia and traditional experience. Results The contents of the chemical constituents of Polygala tenuifolia saponin, Polygalone Ⅲ and 3,6′ dismustard acyl sucrose in the traditional processing method of Polygala tenuifolia are in line with the provisions of Chinese Pharmacopoeia, and the traditional processing method is simple and feasible. Conclusion The method is simple and feasible, and provides a basis for the processing and application of Polygala tenuifolia from Glycyrrhiza uralensis.
Objective To analyze and compare two processing techniques of Polygala tenuifolia, and to investigate the effects of different processing techniques on the chemical constituents of Polygala tenuifolia. Methods Polygala tenuifolia saponins, Polygalactone Ⅲ and 3,6′ dismustard acyl sucrose were determined by high performance liquid chromatography(HPLC) in accordance with the methods of Chinese Pharmacopoeia and traditional experience. Results The contents of the chemical constituents of Polygala tenuifolia saponin, Polygalone Ⅲ and 3,6′ dismustard acyl sucrose in the traditional processing method of Polygala tenuifolia are in line with the provisions of Chinese Pharmacopoeia, and the traditional processing method is simple and feasible. Conclusion The method is simple and feasible, and provides a basis for the processing and application of Polygala tenuifolia from Glycyrrhiza uralensis.
引文
[1] 国家药典委员会.中国药典[S].1部.北京:中国医药科技出版社,2015:309-310.
[2] 徐亮亮,李创军,杨敬芝,等.远志化学成分研究[J].中药材,2014,37(9):1595-1597.
[3] 刘大伟,康利平,马百平.远志化学及药理作用研究进展[J].国际药学研究,2012,39(1):32-36.
[4] 王孝涛.历代中药炮制法汇典(古代)[M].南昌:江西科学技术出版社,1998:81.
[5] 王光志,万德光,刘友平,等.不同炮制方法对远志质量的影响[J].中成药,2009,31(2):252-255.
[6] 张介宾.景岳全书[M].上海:上海科学技术出版社,1984:1068.
[7] 孙于杰,王莹,侯林,等.超声法提取远志中细叶远志皂苷的工艺优选[J].中国实验方剂学杂志,2012,18(2):53.
[8] 张金莲,张文然,等.多指标正交法优选建昌帮炆远志炮制工艺[J].江西中医药大学学报,2018,30(2):59-62.
[9] 刘可,刘利根.HPLC-CAD法测定远志药材中细叶远志皂苷的含量[J].西北药学杂志,2016,12(12):30-31.
[10] 陈松,农璐蔚.高效液相色谱法测定桔远止咳片中细叶远志皂苷含量[J].亚太传统医药,2016,81(1):84-86.
[11] 刘艳芳,杨晓娟,田昕,等.HPLC法同时测定远志中2种活性成分的含量[J].药物分析杂志,2010,30(5):806-809.
[12] 张陶珍,荣巍巍,李清,等.远志的研究进展[J].中草药,2016,47(13):2381-2389.
[13] 林敬开,闫小平,官仕杰,等.远志不同炮制品皂苷类成分含量的比较[J] .中国实验方剂学杂志,2011,17(11):89-91.
[14] 高丽,热娜·卡斯木,木合布力·阿布力孜,等.HPLC法测定甘草抗血栓滴丸中甘草酸和甘草苷的含量[J].新疆医科大学学报,2011,34(5):470-472.
[15] 冯向东,高光伟,黄海欣.远志炮制前后质量变化的比较研究[J].中药材,2008,31(6):818-820.
[2] 徐亮亮,李创军,杨敬芝,等.远志化学成分研究[J].中药材,2014,37(9):1595-1597.
[3] 刘大伟,康利平,马百平.远志化学及药理作用研究进展[J].国际药学研究,2012,39(1):32-36.
[4] 王孝涛.历代中药炮制法汇典(古代)[M].南昌:江西科学技术出版社,1998:81.
[5] 王光志,万德光,刘友平,等.不同炮制方法对远志质量的影响[J].中成药,2009,31(2):252-255.
[6] 张介宾.景岳全书[M].上海:上海科学技术出版社,1984:1068.
[7] 孙于杰,王莹,侯林,等.超声法提取远志中细叶远志皂苷的工艺优选[J].中国实验方剂学杂志,2012,18(2):53.
[8] 张金莲,张文然,等.多指标正交法优选建昌帮炆远志炮制工艺[J].江西中医药大学学报,2018,30(2):59-62.
[9] 刘可,刘利根.HPLC-CAD法测定远志药材中细叶远志皂苷的含量[J].西北药学杂志,2016,12(12):30-31.
[10] 陈松,农璐蔚.高效液相色谱法测定桔远止咳片中细叶远志皂苷含量[J].亚太传统医药,2016,81(1):84-86.
[11] 刘艳芳,杨晓娟,田昕,等.HPLC法同时测定远志中2种活性成分的含量[J].药物分析杂志,2010,30(5):806-809.
[12] 张陶珍,荣巍巍,李清,等.远志的研究进展[J].中草药,2016,47(13):2381-2389.
[13] 林敬开,闫小平,官仕杰,等.远志不同炮制品皂苷类成分含量的比较[J] .中国实验方剂学杂志,2011,17(11):89-91.
[14] 高丽,热娜·卡斯木,木合布力·阿布力孜,等.HPLC法测定甘草抗血栓滴丸中甘草酸和甘草苷的含量[J].新疆医科大学学报,2011,34(5):470-472.
[15] 冯向东,高光伟,黄海欣.远志炮制前后质量变化的比较研究[J].中药材,2008,31(6):818-820.