抗心磷脂抗体和抗核抗体在宫颈机能不全孕妇中表达的临床意义
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摘要
目的探究抗心磷脂抗体(ACA)和抗核抗体(ANA)在宫颈机能不全孕妇中表达的临床意义。方法选择东莞市高埗医院妇产科于2018年1月—2018年6月收治的行产检的92例宫颈机能不全孕妇作为研究对象(实验组),选取同期与实验组相匹配的健康孕妇92例(观察组)。分析两组ACA阳性率和ANA阳性率。对实验组92例宫颈机能不全孕妇进行分组,即流产1次组(1组51例)、流产2～3次组(2组30例),流产3次以上组(3组11例),比较各组ACA阳性率和ANA阳性率。结果观察组ACA阳性率为33.70%,ANA阳性率为34.78%,ACA和ANA双阳性率为22.83%;实验组ACA阳性率为8.70%,ANA阳性率为9.78%,ACA和ANA双阳性率为2.17%,差异有统计学意义(P<0.05)。宫颈机能不全孕妇中,1组ACA阳性率为15.69%,ANA阳性率为13.73%;2组ACA阳性率为50.00%,ANA阳性率为53.33%;3组ACA阳性率为81.82%,ANA阳性率为90.91%,各组差异均有统计学意义(P<0.05)。结论宫颈机能不全孕妇存在ACA和ANA高表达,反复性流产孕妇存在ACA和ANA高表达,减少宫颈机能不全的发生,防治反复性流产,需加强对ACA和ANA水平的检测。
Objective To explore the clinical significance of anti-cardiolipin antibody(ACA) and anti-nuclear antibody(ANA)expression in pregnant women with cervical insufficiency. Methods 92 pregnant women with cervical insufficiency admitted to the Department of Obstetrics and Gynecology of the hospital from January to June,2018 were selected as the research objects and regarded as the experimental group. In addition,92 pregnant women with normal health condition matching with the experimental group during the same period were selected as the observation group. ACA and ANA positive rates were compared and analyzed between the two groups. 92 pregnant women with cervical insufficiency in the experimental group were divided into two groups: one stage abortion group,two or three abortion groups,and three or more abortion groups,which were respectively considered as the first group,the second group,and the third group,with 51,30 and 11 cases in each group. ACA positive rate and ANA positive rate were compared. Results ACA positive rate was 33.70%, ANA positive rate was 34.78%, ACA and ANA positive rate was22.83% in the observation group. ACA positive rate was 8.70%,ANA positive rate was 9.78%,ACA and ANA positive rate was2.17% in the experimental group,and the difference was statistically significant(P<0.05). Among the pregnant women with cervical insufficiency,ACA and ANA positive rates were 15.69% and 13.73% respectively in the first group. ACA and ANA positive rates were 50.00% and 53.33% respectively in the second group. ACA and ANA positive rates were 81.82% and 90.91%,respectively,in the third group,with statistically significant differences(P<0.05). Conclusion Pregnant women with cervical insufficiency have high expression of anti-cardiolipid antibody and anti-nuclear antibody,and pregnant women with recurrent abortion have high expression of anti-cardiolipid antibody and anti-nuclear antibody. So in order to reduce the occurrence of cervical insufficiency and prevent recurrent abortion,it is necessary to strengthen the detection of anti-cardiolipid antibody and anti-nuclear antibody levels.
Objective To explore the clinical significance of anti-cardiolipin antibody(ACA) and anti-nuclear antibody(ANA)expression in pregnant women with cervical insufficiency. Methods 92 pregnant women with cervical insufficiency admitted to the Department of Obstetrics and Gynecology of the hospital from January to June,2018 were selected as the research objects and regarded as the experimental group. In addition,92 pregnant women with normal health condition matching with the experimental group during the same period were selected as the observation group. ACA and ANA positive rates were compared and analyzed between the two groups. 92 pregnant women with cervical insufficiency in the experimental group were divided into two groups: one stage abortion group,two or three abortion groups,and three or more abortion groups,which were respectively considered as the first group,the second group,and the third group,with 51,30 and 11 cases in each group. ACA positive rate and ANA positive rate were compared. Results ACA positive rate was 33.70%, ANA positive rate was 34.78%, ACA and ANA positive rate was22.83% in the observation group. ACA positive rate was 8.70%,ANA positive rate was 9.78%,ACA and ANA positive rate was2.17% in the experimental group,and the difference was statistically significant(P<0.05). Among the pregnant women with cervical insufficiency,ACA and ANA positive rates were 15.69% and 13.73% respectively in the first group. ACA and ANA positive rates were 50.00% and 53.33% respectively in the second group. ACA and ANA positive rates were 81.82% and 90.91%,respectively,in the third group,with statistically significant differences(P<0.05). Conclusion Pregnant women with cervical insufficiency have high expression of anti-cardiolipid antibody and anti-nuclear antibody,and pregnant women with recurrent abortion have high expression of anti-cardiolipid antibody and anti-nuclear antibody. So in order to reduce the occurrence of cervical insufficiency and prevent recurrent abortion,it is necessary to strengthen the detection of anti-cardiolipid antibody and anti-nuclear antibody levels.
引文
[1]周佳任,尚涛,张丹.宫颈机能不全患者妊娠期血清抗心磷脂抗体及抗核抗体的阳性率及其临床意义[J].中华围产医学杂志,2013,16(6):213-214.
[2]陈芯仪,陈月红,孙瑞雪,等. 694例抗心磷脂抗体阳性病例病因构成和临床特点分析[J].血栓与止血学,2015,10(2):65-69.
[3]高琳,徐友文,王佐君.抗核抗体和抗心磷脂抗体对宫颈机能不全孕妇的临床意义[J].中国卫生检验杂志,2016,15(9):1285-1287.
[4]曾勇,梁佩燕,刁梁辉,等.不明原因不孕患者血清中抗核抗体、抗心磷脂抗体和抗β_2糖蛋白I抗体的检测价值[J].生殖医学杂志,2015,24(12):998-1002.
[5]张雅西,覃永亮,骆慧莎,等.特发性血小板减少性紫癜与抗核抗体和抗心磷脂抗体的关系探讨[J].血栓与止血学,2014,20(5):232-234.
[6]陈芳,方杰,王婷,等.稽留流产患者抗心磷脂抗体和抗β2糖蛋白Ⅰ抗体的检测及临床意义[J].中国综合临床,2016,32(4):304-307.
[7]马开慧,陈婷婷,应菲菲.抗心磷脂抗体与抗子宫内膜抗体在反复自然流产中的诊断分析[J].检验医学与临床,2017,14(20):3086-3088.
[8]徐海英,胡君华.宫颈机能不全孕妇抗核抗体和抗心磷脂抗体表达的临床意义[J].中国卫生检验杂志,2017,10(1):71-73.
[2]陈芯仪,陈月红,孙瑞雪,等. 694例抗心磷脂抗体阳性病例病因构成和临床特点分析[J].血栓与止血学,2015,10(2):65-69.
[3]高琳,徐友文,王佐君.抗核抗体和抗心磷脂抗体对宫颈机能不全孕妇的临床意义[J].中国卫生检验杂志,2016,15(9):1285-1287.
[4]曾勇,梁佩燕,刁梁辉,等.不明原因不孕患者血清中抗核抗体、抗心磷脂抗体和抗β_2糖蛋白I抗体的检测价值[J].生殖医学杂志,2015,24(12):998-1002.
[5]张雅西,覃永亮,骆慧莎,等.特发性血小板减少性紫癜与抗核抗体和抗心磷脂抗体的关系探讨[J].血栓与止血学,2014,20(5):232-234.
[6]陈芳,方杰,王婷,等.稽留流产患者抗心磷脂抗体和抗β2糖蛋白Ⅰ抗体的检测及临床意义[J].中国综合临床,2016,32(4):304-307.
[7]马开慧,陈婷婷,应菲菲.抗心磷脂抗体与抗子宫内膜抗体在反复自然流产中的诊断分析[J].检验医学与临床,2017,14(20):3086-3088.
[8]徐海英,胡君华.宫颈机能不全孕妇抗核抗体和抗心磷脂抗体表达的临床意义[J].中国卫生检验杂志,2017,10(1):71-73.