槲寄生的化学成分及药理作用研究进展
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摘要
通过查阅国内外有关文献,对槲寄生的化学成分、药理作用等进行整理、分析和归纳。槲寄生中含有黄酮、萜类、生物碱等小分子化合物,及槲寄生凝集素、壳多糖结合蛋白及槲寄生毒肽等高分子化合物;槲寄生有抗肿瘤、调节免疫、降血压、抗心律失常、抗心肌缺血等药理作用。
This article summarizes the chemical compositions and pharmacologicaleffects of Viscum coloratum( Kom.) Nakai.The main chemical constituents include small molecule compounds such as flavonoids,triterpenoids and alkaloids,and macromolecular compound such as lectin and viscotoxin.Multiplepharmacological activities have been proved,such as the anti-tumor,immune regulation,antihypertension,antiarrhythmia and anti-myocardial ischemia.The aim of this article is toprovide references for further study and the rational use through clarifying the material basis of pharmacological action.
This article summarizes the chemical compositions and pharmacologicaleffects of Viscum coloratum( Kom.) Nakai.The main chemical constituents include small molecule compounds such as flavonoids,triterpenoids and alkaloids,and macromolecular compound such as lectin and viscotoxin.Multiplepharmacological activities have been proved,such as the anti-tumor,immune regulation,antihypertension,antiarrhythmia and anti-myocardial ischemia.The aim of this article is toprovide references for further study and the rational use through clarifying the material basis of pharmacological action.
引文
[1]国家药典委员会.中华人民共和国药典(一部)[S].北京:中国医药科技出版社,2015:373.
[2]谷伟玲,张宏,张英华,等.槲寄生药材质量标准研究[J].现代养生,2014,24(12):228.
[3]中国科学院《中国植物志》编辑委员会.中国植物志[M].北京:科学出版社,1988:148.
[4]Mabberley DJ.Mabberley’s Plant Book[M].Cambridge:Cambridge University Press,2008:1021.
[5]韩兰荣,张奠湘.中国槲寄生属-分布新记录种-尼泊尔槲寄生[J].热带亚热带植物学报,2005,13(2):175-176.
[6]张水仙,刘越,孙洪波,等.槲寄生化学成分及药理作用研究进展[J].中药材,2011,12(34):1962-1967.
[7]曾广方,陈仲良.国药中黄酮类的研究(VI)桑寄生化学成分的研究(第二报)广寄生中槲寄生及其配糖体的分离[J].药学学报,1957,5(4):317-321.
[8]李超.槲寄生和扁枝槲寄生化学成分与生物活性研究[D].济南:山东大学,2014:1-77.
[9]Li RJ,Yang GE,Bai HJ,et al.A new flavonoid glycoside from mistletoe transformed by Rhodobacter sphaeroides[J].Chem Nat Compd,2012,48(5):761-764.
[10]Yang L,Zhao YL,Yang YP,et al.Chemical constituents of Viscum album var.meridianum[J].Biochem Syst Ecol,2011,39(4):849-852.
[11]Chen BN,Yang GE,Li JK,et al.Cytotoxic constituents from Viscum coloratum[J].Chem Nat Compd,2009,45(4):547-549.
[12]Han N,Huang T,Wang YC,et al.Flavanone glycosides from Viscum coloratum and their inhibitory effects on osteoclast formation[J].Chem Biodivers,2011,8(9):1682-1688.
[13]杨燕军,沙聪威,陈梅果.瘤果槲寄生化学成分的研究(Ⅱ)[J].中国药学杂志,2011,46(1):11-13.
[14]卢汝梅,邵敏敏,廖彭莹,等.柚寄生化学成分研究[J].中药材,2013,36(9):1451-1454.
[15]王俊,吴福安,王加力,等.槲寄生生物碱的系统分离及抑菌活性初探[J].食品科学,2007,28(6):63-66.
[16]Amer B,Juvik OJ,Dupont F.Novel aminoalkaloids from European mistletoe(Viscum album L.)[J].Phytochem lett,2012,5(3):677-681.
[17]孙永慧,郎悦,张颖.HPLC法测定槲寄生中N-桂皮酰基丁二胺[J].哈尔滨商业大学学报:自然科学版,2015,31(5):530-532.
[18]廖彭莹,卢汝梅,邵敏敏,等.水蒸气蒸馏法和二氧化碳超临界流体萃取法提取柚寄生的挥发性成分[J].时珍国医国药,2013,24(5):1274-1276.
[19]Ibrahime EI,Hekal IA.Misletoe extract,as an adjuvant therapy after resection of superficial bladder cancer:prospective clinical randomized study[J].J Urol,2009,181(4):640-645.
[20]杨学良.重组槲寄生凝集素抗肝癌细胞SMMC7721的实验研究[D].长春:吉林大学,2013,1-93.
[21]廖彭莹,邱志彬,卓生华.柚寄生多糖的提取与含量的测定[J].食品研究与开发,2014,35(22):74-77.
[22]刘石磊,杜秀宝,范崇旭,等.槲寄生毒素研究进展[J].中草药,2006,37(4):619-622.
[23]孔凡青,吕学谦,杨艳红.槲寄生抗肿瘤作用研究[J].科技信息,2010(19):820-821.
[24]Kim JJ,Hwang YH,Kang KY,et al.Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin(KML-B),a novel TLR4 agonist[J].Int Immunopharmacol,2014,21(2):309-319.
[25]孔凡青,丁海麦,杨艳红,等.槲寄生碱对人肝癌细胞株SMMC-7721 bcl-2mRNA表达的影响[J].天津农业科学,2010,16(6):8-9.
[26]孙莉,姚俊涛,王一羽,等.槲寄生碱抑制肺癌细胞增殖作用初步观察[J].中华肿瘤防治杂志,2013,20(21):1653-1656.
[27]邱心如,周洪澜,李亚娟,等.槲寄生碱体外通过激活Caspase8诱导ACC细胞的凋亡[J].中国实验诊断学,2012,16(1):27-28.
[28]孙景临,刘威,穆晞惠,等.槲寄生蛋白抗癌活性研究及新成分鉴定[J].医学分子生物学杂志,2012,9(1):49-52.
[29]Trger W,Galun D,Reif M,et al.Viscum album[L.]extract therapy in patients with locally advanced or metastatic pancreatic cancer:a randomised clinical trial on overall survival[J].Eur J Cancer,2013,49(18):3788-3797.
[30]Eisenbraun J,Scheer R,Krz M,et al.Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract[J].Phytomedicine,2011,18(2):151-157.
[31]Werthmann P G,Strter G,Friesland H,et al.Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts-A case report[J].Phytomedicine,2013,20(3):324-327.
[32]曲义坤,丁隆,刘伟新,等.槲寄生生物碱抗胃癌的作用[J].中国老年学杂志,2013,33(1):103-104
[33]李丽,梁再赋,姜弈.槲寄生提取物的免疫调节作用[J].国外医药:植物药分册,2003,18(1):12-15.
[34]刘武青,李晓莉,王睿睿,等.卵叶槲寄生化学成分体外抗HIV活性的初步研究[J].中国新药杂志,2010,19(12):1017-1025.
[35]王晓妍.益肾降压颗粒治疗老年人高血压病的临床研究及其对性激素的影响[D].济南:山东中医药大学,2008:34.
[36]蔡欣蕊.槲寄生在常见心血管系统疾病中的应用[J].云南中医药杂志,2011,32(12):69-70.
[37]Radenkovic M,Ivetic V,Popovic M,et al.Effects of mistletoe(Viscum album L.,Loranthaceae)extracts on arterial blood pressure in rats treated with atropine sulfate and hexocycline[J].Clin Exp Hypertens,2009,31(1):11-19.
[38]吴金义,张爽,张秀梅,等.槲寄生抗实验性心律失常的作用[J].中国老年学杂志,2011,15(31):2933-2935.
[39]张荣沭,沈雅香,苗术,等.槲寄生黄酮苷对大鼠心肌缺血再灌注损伤保护作用[J].中国医院药学杂志,2010,30(12):999-1001.
[40]Jiang Y,Wang C,Li YY,et al.Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference[J].J Ethnopharmacol,2014,158(Pt A):230-238.
[41]张兴梅,薛桥丽,肖蓉,等.扁枝槲寄生提取物对金黄色葡萄球菌抑菌机理的研究[J].现代食品科技,2016(1):1-9.
[42]Abdel-Sattar EA,Elberry AA,Harraz FM,et al.Antihyperglycemic and hypolipidaemic effects of the methanolic extract of Saudi mistletoe(Viscum schimperi Engl.)[J].JAR,2011,2(2):171-177.
[43]Yin J,Han N,Xu XY,et al.Inhibitory activity of the ethyl acetate fraction from viscum coloratum on bone resorption[J].Planta Med,2008,74(2):120-125.
[2]谷伟玲,张宏,张英华,等.槲寄生药材质量标准研究[J].现代养生,2014,24(12):228.
[3]中国科学院《中国植物志》编辑委员会.中国植物志[M].北京:科学出版社,1988:148.
[4]Mabberley DJ.Mabberley’s Plant Book[M].Cambridge:Cambridge University Press,2008:1021.
[5]韩兰荣,张奠湘.中国槲寄生属-分布新记录种-尼泊尔槲寄生[J].热带亚热带植物学报,2005,13(2):175-176.
[6]张水仙,刘越,孙洪波,等.槲寄生化学成分及药理作用研究进展[J].中药材,2011,12(34):1962-1967.
[7]曾广方,陈仲良.国药中黄酮类的研究(VI)桑寄生化学成分的研究(第二报)广寄生中槲寄生及其配糖体的分离[J].药学学报,1957,5(4):317-321.
[8]李超.槲寄生和扁枝槲寄生化学成分与生物活性研究[D].济南:山东大学,2014:1-77.
[9]Li RJ,Yang GE,Bai HJ,et al.A new flavonoid glycoside from mistletoe transformed by Rhodobacter sphaeroides[J].Chem Nat Compd,2012,48(5):761-764.
[10]Yang L,Zhao YL,Yang YP,et al.Chemical constituents of Viscum album var.meridianum[J].Biochem Syst Ecol,2011,39(4):849-852.
[11]Chen BN,Yang GE,Li JK,et al.Cytotoxic constituents from Viscum coloratum[J].Chem Nat Compd,2009,45(4):547-549.
[12]Han N,Huang T,Wang YC,et al.Flavanone glycosides from Viscum coloratum and their inhibitory effects on osteoclast formation[J].Chem Biodivers,2011,8(9):1682-1688.
[13]杨燕军,沙聪威,陈梅果.瘤果槲寄生化学成分的研究(Ⅱ)[J].中国药学杂志,2011,46(1):11-13.
[14]卢汝梅,邵敏敏,廖彭莹,等.柚寄生化学成分研究[J].中药材,2013,36(9):1451-1454.
[15]王俊,吴福安,王加力,等.槲寄生生物碱的系统分离及抑菌活性初探[J].食品科学,2007,28(6):63-66.
[16]Amer B,Juvik OJ,Dupont F.Novel aminoalkaloids from European mistletoe(Viscum album L.)[J].Phytochem lett,2012,5(3):677-681.
[17]孙永慧,郎悦,张颖.HPLC法测定槲寄生中N-桂皮酰基丁二胺[J].哈尔滨商业大学学报:自然科学版,2015,31(5):530-532.
[18]廖彭莹,卢汝梅,邵敏敏,等.水蒸气蒸馏法和二氧化碳超临界流体萃取法提取柚寄生的挥发性成分[J].时珍国医国药,2013,24(5):1274-1276.
[19]Ibrahime EI,Hekal IA.Misletoe extract,as an adjuvant therapy after resection of superficial bladder cancer:prospective clinical randomized study[J].J Urol,2009,181(4):640-645.
[20]杨学良.重组槲寄生凝集素抗肝癌细胞SMMC7721的实验研究[D].长春:吉林大学,2013,1-93.
[21]廖彭莹,邱志彬,卓生华.柚寄生多糖的提取与含量的测定[J].食品研究与开发,2014,35(22):74-77.
[22]刘石磊,杜秀宝,范崇旭,等.槲寄生毒素研究进展[J].中草药,2006,37(4):619-622.
[23]孔凡青,吕学谦,杨艳红.槲寄生抗肿瘤作用研究[J].科技信息,2010(19):820-821.
[24]Kim JJ,Hwang YH,Kang KY,et al.Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin(KML-B),a novel TLR4 agonist[J].Int Immunopharmacol,2014,21(2):309-319.
[25]孔凡青,丁海麦,杨艳红,等.槲寄生碱对人肝癌细胞株SMMC-7721 bcl-2mRNA表达的影响[J].天津农业科学,2010,16(6):8-9.
[26]孙莉,姚俊涛,王一羽,等.槲寄生碱抑制肺癌细胞增殖作用初步观察[J].中华肿瘤防治杂志,2013,20(21):1653-1656.
[27]邱心如,周洪澜,李亚娟,等.槲寄生碱体外通过激活Caspase8诱导ACC细胞的凋亡[J].中国实验诊断学,2012,16(1):27-28.
[28]孙景临,刘威,穆晞惠,等.槲寄生蛋白抗癌活性研究及新成分鉴定[J].医学分子生物学杂志,2012,9(1):49-52.
[29]Trger W,Galun D,Reif M,et al.Viscum album[L.]extract therapy in patients with locally advanced or metastatic pancreatic cancer:a randomised clinical trial on overall survival[J].Eur J Cancer,2013,49(18):3788-3797.
[30]Eisenbraun J,Scheer R,Krz M,et al.Quality of life in breast cancer patients during chemotherapy and concurrent therapy with a mistletoe extract[J].Phytomedicine,2011,18(2):151-157.
[31]Werthmann P G,Strter G,Friesland H,et al.Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts-A case report[J].Phytomedicine,2013,20(3):324-327.
[32]曲义坤,丁隆,刘伟新,等.槲寄生生物碱抗胃癌的作用[J].中国老年学杂志,2013,33(1):103-104
[33]李丽,梁再赋,姜弈.槲寄生提取物的免疫调节作用[J].国外医药:植物药分册,2003,18(1):12-15.
[34]刘武青,李晓莉,王睿睿,等.卵叶槲寄生化学成分体外抗HIV活性的初步研究[J].中国新药杂志,2010,19(12):1017-1025.
[35]王晓妍.益肾降压颗粒治疗老年人高血压病的临床研究及其对性激素的影响[D].济南:山东中医药大学,2008:34.
[36]蔡欣蕊.槲寄生在常见心血管系统疾病中的应用[J].云南中医药杂志,2011,32(12):69-70.
[37]Radenkovic M,Ivetic V,Popovic M,et al.Effects of mistletoe(Viscum album L.,Loranthaceae)extracts on arterial blood pressure in rats treated with atropine sulfate and hexocycline[J].Clin Exp Hypertens,2009,31(1):11-19.
[38]吴金义,张爽,张秀梅,等.槲寄生抗实验性心律失常的作用[J].中国老年学杂志,2011,15(31):2933-2935.
[39]张荣沭,沈雅香,苗术,等.槲寄生黄酮苷对大鼠心肌缺血再灌注损伤保护作用[J].中国医院药学杂志,2010,30(12):999-1001.
[40]Jiang Y,Wang C,Li YY,et al.Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference[J].J Ethnopharmacol,2014,158(Pt A):230-238.
[41]张兴梅,薛桥丽,肖蓉,等.扁枝槲寄生提取物对金黄色葡萄球菌抑菌机理的研究[J].现代食品科技,2016(1):1-9.
[42]Abdel-Sattar EA,Elberry AA,Harraz FM,et al.Antihyperglycemic and hypolipidaemic effects of the methanolic extract of Saudi mistletoe(Viscum schimperi Engl.)[J].JAR,2011,2(2):171-177.
[43]Yin J,Han N,Xu XY,et al.Inhibitory activity of the ethyl acetate fraction from viscum coloratum on bone resorption[J].Planta Med,2008,74(2):120-125.