参芪扶正注射液对卵巢癌化疗后免疫功能及生活质量的影响
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摘要
目的探讨参芪扶正注射液对卵巢癌化疗后免疫功能及生活质量的影响。方法回顾性分析卵巢癌患者105例,按照治疗方式不同分为参芪扶正组(n=55)和单纯化疗组(n=50),单纯化疗组给予TC化疗方案,参芪扶正组在TC化疗方案上给予参芪扶正注射液治疗,比较两组治疗前后T淋巴细胞亚群水平和生活质量的变化。结果参芪扶正组总有效率明显高于单纯化疗组,差异有统计学意义;参芪扶正组化疗后的CD3~+、CD4~+和CD4~+/CD8~+水平明显高于单纯化疗组,差异有统计学意义;参芪扶正组化疗后的生活质量评分明显高于单纯化疗组,差异有统计学意义。结论参芪扶正注射液可有效提高卵巢癌患者的化疗疗效,同时改善患者的免疫功能,提升生活质量。
Objective To investigate the influence of the life quality of Shengqi Fuzheng injection on the immune function of ovarian cancer after chemotherapy. Methods 105 cases of patients with ovarian cancer was selected as a retrospective analysis. According to different treatment,all patients were divided into Shengqi Fuzheng group(n=55) and chemotherapy group(n=50),chemotherapy group was given the TC chemotherapy regimens,Shengqi Fuzheng group was given Shengqi Fuzheng injection basis on TC chemotherapy regimens. Compared the level of T lymphocyte subsets and the change of quality of life in 2 groups before and after treatment. Results The total effective rate of Shengqi Fuzheng group was obviously higher than that of chemotherapy group,the difference was statistically significant; The CD3~+、CD4~+ and CD4~+/CD8~+ in Shengqi Fuzheng group group after chemotherapy were significantly higher than those of chemotherapy group,the difference was statistically significant;The quality of life score in Shengqi Fuzheng group after chemotherapy was significantly higher than that of chemotherapy group,the difference was statistically significant. Conclusion Shengqi Fuzheng injection can effectively improve the ovarian cancer patients with chemotherapy curative effect,improve the patient's immune function,improve the quality of life.
Objective To investigate the influence of the life quality of Shengqi Fuzheng injection on the immune function of ovarian cancer after chemotherapy. Methods 105 cases of patients with ovarian cancer was selected as a retrospective analysis. According to different treatment,all patients were divided into Shengqi Fuzheng group(n=55) and chemotherapy group(n=50),chemotherapy group was given the TC chemotherapy regimens,Shengqi Fuzheng group was given Shengqi Fuzheng injection basis on TC chemotherapy regimens. Compared the level of T lymphocyte subsets and the change of quality of life in 2 groups before and after treatment. Results The total effective rate of Shengqi Fuzheng group was obviously higher than that of chemotherapy group,the difference was statistically significant; The CD3~+、CD4~+ and CD4~+/CD8~+ in Shengqi Fuzheng group group after chemotherapy were significantly higher than those of chemotherapy group,the difference was statistically significant;The quality of life score in Shengqi Fuzheng group after chemotherapy was significantly higher than that of chemotherapy group,the difference was statistically significant. Conclusion Shengqi Fuzheng injection can effectively improve the ovarian cancer patients with chemotherapy curative effect,improve the patient's immune function,improve the quality of life.
引文
[1]冯晓燕,何琳,孙志茹.KLF9在上皮性卵巢癌组织中的表达及其临床意义[J].中国现代医学杂志,2017,27(20):40-45.
[2]李楠,杨亮,孙亚楠,等.腹腔热灌注联合多西他赛、奥沙利铂静脉化疗治疗晚期卵巢癌疗效观察[J].现代妇产科进展,2017,26(7):493-496.
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[7]李好山,王军海,田君.紫杉醇联合卡铂化疗方案对中晚期宫颈癌患者免疫功能及血清SCC-Ag、TSGF水平的影响[J].实用癌症杂志,2018,33(4):556-560.
[8]赵云,于法明,姜东亮,等.参芪扶正注射液联合艾迪注射液治疗晚期非小细胞肺癌的临床意义[J].实用癌症杂志,2017,32(6):959-962.
[9]文柳静,王晨,任丽.参芪扶正注射液对胰腺癌多药耐药逆转作用研究[J].中国药学杂志,2017,52(13):1147-1151.
[10]常青.黄芪扶正汤对甲状腺癌术后免疫功能及生活质量的影响[J].中华中医药学刊,2018,36(3):691-693.
[11]王必铭.不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和IL-2水平的影响[J].中国现代医学杂志,2017,27(26):87-91.
[2]李楠,杨亮,孙亚楠,等.腹腔热灌注联合多西他赛、奥沙利铂静脉化疗治疗晚期卵巢癌疗效观察[J].现代妇产科进展,2017,26(7):493-496.
[3]陈丽佳,渠红,武珊珊,等.康艾注射液联合DC化疗方案对卵巢癌晚期患者疾病控制率及中位生存期的影响[J].中国地方病防治杂志,2018,33(1):101.
[4]李宁,田永巍,高岭.卵巢癌恶性腹腔积液TP方案静脉联合循环热灌注化疗临床疗效分析[J].中华肿瘤防治杂志,2017,24(2):119-123.
[5]王成双,郑翠玲.叶酸联合甲钴胺预防卵巢癌患者紫杉醇化疗外周神经毒性的观察[J].实用医学杂志,2016,32(14):2421-2422.
[6]喻晶,张慧峰,雷旦生.卵巢癌化疗患者紫杉醇血药浓度监测的临床价值[J].肿瘤防治研究,2017,44(4):268-271.
[7]李好山,王军海,田君.紫杉醇联合卡铂化疗方案对中晚期宫颈癌患者免疫功能及血清SCC-Ag、TSGF水平的影响[J].实用癌症杂志,2018,33(4):556-560.
[8]赵云,于法明,姜东亮,等.参芪扶正注射液联合艾迪注射液治疗晚期非小细胞肺癌的临床意义[J].实用癌症杂志,2017,32(6):959-962.
[9]文柳静,王晨,任丽.参芪扶正注射液对胰腺癌多药耐药逆转作用研究[J].中国药学杂志,2017,52(13):1147-1151.
[10]常青.黄芪扶正汤对甲状腺癌术后免疫功能及生活质量的影响[J].中华中医药学刊,2018,36(3):691-693.
[11]王必铭.不同麻醉方法对卵巢癌患者围手术期T淋巴细胞亚群含量和IL-2水平的影响[J].中国现代医学杂志,2017,27(26):87-91.