低频重复经颅磁刺激治疗精神分裂症的效果及对患者认知功能的影响
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摘要
目的探讨低频重复经颅磁刺激对精神分裂症患者的效果及患者认知功能的影响。方法选取2017年1月～2018年6月通过我院治疗的62例精神分裂症患者,随机分为对照组和研究组,对照组应用药物治疗,研究组联合应用低频重复经颅磁刺激治疗。比较两组患者PANSS评分、认知功能评分和有效率。结果研究组患者治疗后的PANSS评分较治疗前明显下降,且与对照组比较差异有统计学意义(P<0.05)。研究组患者治疗后的认知功能评分(包括即刻记忆、延时记忆、语言功能)较治疗前有一定提高,且与对照组比较差异有统计学意义(P<0.05)。研究组的治疗总有效率明显优于对照组(P<0.05)。结论精神分裂症患者治疗过程中,低频重复经颅磁刺激的治疗效果理想,临床上应当进一步推广应用。
Objective To investigate the effect of low frequency repetitive transcranial magnetic stimulation on the patients with schizophrenia and the patients' cognitive function. Methods 62 patients with schizophrenia who were treated in our hospital from January 2017 to June 2018 were selected and randomly divided into the control group and the study group. The control group was treated with drugs. The study group was combined with low frequency repetitive transcranial magnetic stimulation. PANSS scores, cognitive function scores, and effectiveness were compared between the two groups. Results The PANSS scores after treatment in the study group were significantly lower than those before treatment, and the differences were statistically significant compared with the control group(P<0.05). Cognitive function scores in the patients in the study group after treatment(including immediate memory, delayed memory, language function) were improved compared with those before treatment, and the differences were statistically significant compared with the control group(P<0.05). The total effective rate in the study group was significantly better than that in the control group(P<0.05). Conclusion During the treatment of patients with schizophrenia, low frequency repetitive transcranial magnetic stimulation is ideal, and should be further promoted and applied clinically.
Objective To investigate the effect of low frequency repetitive transcranial magnetic stimulation on the patients with schizophrenia and the patients' cognitive function. Methods 62 patients with schizophrenia who were treated in our hospital from January 2017 to June 2018 were selected and randomly divided into the control group and the study group. The control group was treated with drugs. The study group was combined with low frequency repetitive transcranial magnetic stimulation. PANSS scores, cognitive function scores, and effectiveness were compared between the two groups. Results The PANSS scores after treatment in the study group were significantly lower than those before treatment, and the differences were statistically significant compared with the control group(P<0.05). Cognitive function scores in the patients in the study group after treatment(including immediate memory, delayed memory, language function) were improved compared with those before treatment, and the differences were statistically significant compared with the control group(P<0.05). The total effective rate in the study group was significantly better than that in the control group(P<0.05). Conclusion During the treatment of patients with schizophrenia, low frequency repetitive transcranial magnetic stimulation is ideal, and should be further promoted and applied clinically.
引文
[1]关晨霞,郭钢花,李哲.不同频率低频重复经颅磁刺激对有癫痫发作史的颅脑损伤患者认知功能的影响[J].中华物理医学与康复杂志,2016,38(5):349-352.
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[12]廖亮华,黄东,江兴妹,等.高频与低频重复经颅磁刺激对脑梗死患者认知功能的影响[J].中华物理医学与康复杂志,2017,39(1):56-58.
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[15]扈罗曼,朱其秀,刘云霞,等.重复经颅磁刺激联合康复训练治疗非痴呆型血管性认知障碍的疗效观察[J].中华物理医学与康复杂志,2016,38(4):278-282.
[16]Deng ZD,Davis S,Asturias G,et al.Effect of repetitive transcranial magnetic stimulation on the structural connectome in patients with major depression[J].Clinical Neurophysiology,2017,128(3):e144-e145.
[17]蒲丽,向波,梁雪梅,等.低频重复经颅磁刺激与无抽搐电休克治疗精神分裂症患者的疗效及白质完整性分析[J].实用医学杂志,2017,33(19):3243-3247.
[18]崔文辉,周千,王菲,等.静息状态下精神分裂症与双相障碍患者脑功能磁共振低频振幅的比较研究[J].中国医科大学学报,2016,45(11):977-981.
[19]Xia X,Liu Y,Bai Y,et al.Long-lasting repetitive transcranial magnetic stimulation modulates electroencephalography oscillation in patients with disorders of consciousness[J].Neuroreport,2017,28(15):1022-1029.
[20]谭志,陈武标,庞燕华,等.低频振幅f MRI联合基于体素的形态学分析在精神分裂症中的应用[J].实用医学杂志,2017,33(14):2380-2385.
[21]蔡广超,关勇,齐明,等.高频重复经颅磁刺激对精神分裂症患者阴性症状改善作用持续性的随访研究[J].中国当代医药,2018,(16):12-15.
[2]Liu P,Gao J,Pan S,et al.Effects of high-frequency repetitive transcranial magnetic stimulation on cerebral hemodynamics in patients with disorders of consciousness:A sham-controlled study[J].European Neurology,2016,76(1-2):1-7.
[3]陈峰,姚乾坤,占达飞,等.精神分裂症首次发病未用药患者药物治疗前后静息态脑功能低频振幅的变化特征[J].中华精神科杂志,2017,50(2):133-138.
[4]宋煜青,谭云龙,双梅,等.基于重复性成套神经心理状态测验比较抑郁症和精神分裂症患者认知功能的差异[J].安徽医科大学学报,2018,53(4):610-613.
[5]Shin HW,Youn YC,Chung SJ,et al.Effect of high-frequency repetitive transcranial magnetic stimulation on major depressive disorder in patients with Parkinson's disease[J].Journal of Neurology,2016,263(7):1442-1448.
[6]李新剑,宋伟,仇爱珍,等.经颅磁刺激术联合康复训练对脑性瘫痪患儿日常精细动作及认知功能发育的影响[J].中国全科医学,2016,19(18):2184-2187.
[7]Pelissolo A,Harikagermaneau G,Rachid F,et al.Repetitive transcranial magnetic stimulation to supplementary motor area in refractory obsessive-com pulsive disorder treatment:A sham-controlled trial[J].International Journal of Neuropsychopharmacology,2016,19(8):pyw025.
[8]徐清,程灶火,刘晓伟,等.重复经颅磁刺激对慢性精神分裂症患者认知功能和血清脑源性神经营养因子水平的影响研究[J].中国全科医学,2017,20(25):3171-3177.
[9]Ambriz-Tututi M,Alvarado-Reynoso B,Drucker-Colín R.Analgesic effect of repetitive transcranial magnetic stimulation(r TMS)in patients with chronic low back pain[J].Bioelectromagnetics,2016,37(8):527-535.
[10]李大奇,吕臻,况利,等.MECT联合r TMS治疗对偏执型精神分裂症患者认知功能的影响[J].重庆医学,2016,45(26):3631-3633.
[11]Sasaki N,Hara T,Yamada N,et al.The efficacy of highfrequency repetitive transcranial magnetic stimulation for improving apathy in chronic stroke patients[J].European Neurology,2017,78(1-2):28.
[12]廖亮华,黄东,江兴妹,等.高频与低频重复经颅磁刺激对脑梗死患者认知功能的影响[J].中华物理医学与康复杂志,2017,39(1):56-58.
[13]Rousseau E,Melo-Silva CA,Gakwaya S,et al.Effects of repetitive transcranial magnetic stimulation of upper airway muscles during sleep in obstructive sleep apnea patients[J].Journal of Applied Physiology,2016,121(5):487.
[14]吴越,徐文炜,刘晓伟,等.重复经颅磁刺激对阿尔茨海默病患者精神行为症状及认知功能的影响[J].中华物理医学与康复杂志,2017,39(2):131-135.
[15]扈罗曼,朱其秀,刘云霞,等.重复经颅磁刺激联合康复训练治疗非痴呆型血管性认知障碍的疗效观察[J].中华物理医学与康复杂志,2016,38(4):278-282.
[16]Deng ZD,Davis S,Asturias G,et al.Effect of repetitive transcranial magnetic stimulation on the structural connectome in patients with major depression[J].Clinical Neurophysiology,2017,128(3):e144-e145.
[17]蒲丽,向波,梁雪梅,等.低频重复经颅磁刺激与无抽搐电休克治疗精神分裂症患者的疗效及白质完整性分析[J].实用医学杂志,2017,33(19):3243-3247.
[18]崔文辉,周千,王菲,等.静息状态下精神分裂症与双相障碍患者脑功能磁共振低频振幅的比较研究[J].中国医科大学学报,2016,45(11):977-981.
[19]Xia X,Liu Y,Bai Y,et al.Long-lasting repetitive transcranial magnetic stimulation modulates electroencephalography oscillation in patients with disorders of consciousness[J].Neuroreport,2017,28(15):1022-1029.
[20]谭志,陈武标,庞燕华,等.低频振幅f MRI联合基于体素的形态学分析在精神分裂症中的应用[J].实用医学杂志,2017,33(14):2380-2385.
[21]蔡广超,关勇,齐明,等.高频重复经颅磁刺激对精神分裂症患者阴性症状改善作用持续性的随访研究[J].中国当代医药,2018,(16):12-15.