肌氨肽苷联合丹参对脑梗死患者神经保护及相关生化指标的影响
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摘要
目的评价肌氨肽苷联合注射用丹参对脑梗死患者的神经保护作用及其对相关生化指标的影响。方法 126例脑梗死患者随机分成观察组(肌氨肽苷联合注射用丹参)与对照组(肌氨肽苷)。于治疗前及治疗后2周测定血浆高敏C-反应蛋白(hs-CRP)、血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)及纤维蛋白原(FIB)表达水平和神经功能缺损评分。结果二组治疗后血hs-CRP、TC、TG、LDL-C及FIB含量均明显降低(P<0.05),而HDL-C显著升高(P<0.05),但二组治疗后比较,各指标均差异有统计学意义(P<0.05)。同时二组治疗后神经功能缺损评分值均有所下降,以观察组为优(P<0.05)。结论肌氨肽苷、注射用丹参能减轻脑梗死患者的炎症反应,减轻对脑组织的损害,降低神经功能损伤,且肌氨肽苷联合注射用丹参疗效优于单独肌氨肽苷。
Objective To evaluate the nerve protective effect of the Muscular Amino Acids and Peptides and Nucleosides injection combination with Danshen injection power on patients with cerebral infarction and its effect on the related biochemical indicators.Methods A total of 126 cases with the cerebral infarction were divided into the treatment group(the Muscular Amino Acids and Peptides and Nucleosides injection combination with Danshen injection power)and the control group(Muscular Amino Acids and Peptides and Nucleosides injection).The expression levels of plasma high-sensitivity C-reactive protein(hs-CRP),serum total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C)and fibrinogen(FIB)and the neural function deficient scale were detected before the treatment and2 weeks after treatment.Results The contents of hs-CRP,hemorrheology and FIB in two groups decreased significantly after the treatment,and which in the treatment group decreased significantly than the control group(P<0.05),while HDL-C increased significantly(P<0.05).After treatment,the scores of the neural function deficient scale in two groups decreased and was better in the treatment group(P<0.05).ConclusionsMuscular Amino Acids and Peptides and Nucleosides injection and Danshen injection power can reduce the inflammation in ACI patients,the immune response to the brain tissue damage and the neural function damage.The treatment effect of Danshen injection power combination with Muscular Amino Acids and Peptides and Nucleosides injection is superior to the single Muscular Amino Acids and Peptides and Nucleosides injection.
Objective To evaluate the nerve protective effect of the Muscular Amino Acids and Peptides and Nucleosides injection combination with Danshen injection power on patients with cerebral infarction and its effect on the related biochemical indicators.Methods A total of 126 cases with the cerebral infarction were divided into the treatment group(the Muscular Amino Acids and Peptides and Nucleosides injection combination with Danshen injection power)and the control group(Muscular Amino Acids and Peptides and Nucleosides injection).The expression levels of plasma high-sensitivity C-reactive protein(hs-CRP),serum total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C)and fibrinogen(FIB)and the neural function deficient scale were detected before the treatment and2 weeks after treatment.Results The contents of hs-CRP,hemorrheology and FIB in two groups decreased significantly after the treatment,and which in the treatment group decreased significantly than the control group(P<0.05),while HDL-C increased significantly(P<0.05).After treatment,the scores of the neural function deficient scale in two groups decreased and was better in the treatment group(P<0.05).ConclusionsMuscular Amino Acids and Peptides and Nucleosides injection and Danshen injection power can reduce the inflammation in ACI patients,the immune response to the brain tissue damage and the neural function damage.The treatment effect of Danshen injection power combination with Muscular Amino Acids and Peptides and Nucleosides injection is superior to the single Muscular Amino Acids and Peptides and Nucleosides injection.
引文
[1]江伟,何武,辛敏,等.三七总皂苷对脑梗死患者的神经保护作用及高敏C-反应蛋白的影响[J].中西医结合心脑血管病杂志,2013,11(5):553-554
[2]中华神经科学会、中华神经外科学会.各类脑血管疾病的诊断要点[J].中华神经科杂志,1996,29(6):379-380
[3]全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383
[4]程华英.丹参川芎嗪注射液治疗腔隙性脑梗死临床体会[J].中华全科医学,2010,8(9):1146-1147
[5]徐也鲁.动脉粥样硬化,一种慢性炎症过程[J].中国动脉硬化杂志,2001,9(2):93-95
[6]Glickman SW,Phillips S,Anstrom KJ,et al.Discriminative capacity of biomarkers for acute stroke in the emergency department[J].J Emerg Med,2011,41(3):333-339
[7]詹建梅,俎德玲.急性脑梗死患者血清超敏C反应蛋白与神经功能缺损的关系[J].心脑血管病防治,2007,7(5):334-335
[8]黄澄,刘裕英,吕艳.心肌酶谱联合纤维蛋白原和-二聚体在脑梗死患者检测中的意义[J].中国医药导报,2013,10(16):100-101
[9]文治成,鲁远君.中老年人TC、LDL-C、HDL-C与复发性脑梗死的关系[J].中国老年学杂志,2011,31(13):2580-2581
[10]王德江,朱育昌,李传彪.高脂血症、颈动脉粥样硬化与脑梗死的相关性研究[J].中国医药指南,2013,11(21):467-468
[11]赵宁,陆琳,杨万章,等.丹参注射液对急性脑梗死大鼠脑组织VEGF表达的影响[J].中西医结合心脑血管病杂志,2013;11(5):584-585
[12]邓英光,张荣萍,余卫.丹参注射液联合骨髓干细胞移植治疗脑梗死肢体截瘫的临床研究[J].实用心脑肺血血管病杂志,2012,20(3):424-425
[13]张琳,李琳.丹参芎嗪注射液联合血栓通注射液治疗急性脑梗死的临床观察[J].中国疗养医学,2013,22(6):528-529
[2]中华神经科学会、中华神经外科学会.各类脑血管疾病的诊断要点[J].中华神经科杂志,1996,29(6):379-380
[3]全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383
[4]程华英.丹参川芎嗪注射液治疗腔隙性脑梗死临床体会[J].中华全科医学,2010,8(9):1146-1147
[5]徐也鲁.动脉粥样硬化,一种慢性炎症过程[J].中国动脉硬化杂志,2001,9(2):93-95
[6]Glickman SW,Phillips S,Anstrom KJ,et al.Discriminative capacity of biomarkers for acute stroke in the emergency department[J].J Emerg Med,2011,41(3):333-339
[7]詹建梅,俎德玲.急性脑梗死患者血清超敏C反应蛋白与神经功能缺损的关系[J].心脑血管病防治,2007,7(5):334-335
[8]黄澄,刘裕英,吕艳.心肌酶谱联合纤维蛋白原和-二聚体在脑梗死患者检测中的意义[J].中国医药导报,2013,10(16):100-101
[9]文治成,鲁远君.中老年人TC、LDL-C、HDL-C与复发性脑梗死的关系[J].中国老年学杂志,2011,31(13):2580-2581
[10]王德江,朱育昌,李传彪.高脂血症、颈动脉粥样硬化与脑梗死的相关性研究[J].中国医药指南,2013,11(21):467-468
[11]赵宁,陆琳,杨万章,等.丹参注射液对急性脑梗死大鼠脑组织VEGF表达的影响[J].中西医结合心脑血管病杂志,2013;11(5):584-585
[12]邓英光,张荣萍,余卫.丹参注射液联合骨髓干细胞移植治疗脑梗死肢体截瘫的临床研究[J].实用心脑肺血血管病杂志,2012,20(3):424-425
[13]张琳,李琳.丹参芎嗪注射液联合血栓通注射液治疗急性脑梗死的临床观察[J].中国疗养医学,2013,22(6):528-529