拉贝洛尔联合硝苯地平治疗妊娠期高血压疾病的效果
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摘要
目的探讨拉贝洛尔联合硝苯地平治疗妊娠期高血压疾病的临床效果。方法选取2015年9月至2017年6月120例妊娠期高血压疾病患者,将其分为两组。拉贝洛尔组72例口服盐酸拉贝洛尔片治疗,联合组48例联合硝苯地平片治疗。比较两组患者的临床治疗效果。结果治疗后,观察组收缩压、舒张压等血压指标均明显低于对照组(P<0.05),剖宫产、早产及产后出血、胎儿窘迫、新生儿窒息发生率均明显低于对照组(P<0.05)。结论对妊娠期高血压疾病患者应用拉贝洛尔联合硝苯地平治疗疗效可靠,能够改善患者分娩结局及胎儿结局,对重度子痫前期患者同样具有良好的治疗效果。
Objective To investigate the effect of labetalol combined with nifedipine on patients with hypertensive disorder complicating pregnancy.Methods One hundred and twenty patients with hypertensive disorder complicating pregnancy from September 2015 to June 2017 were selected. The patients were divided into two groups, 72 patients in the labetalol group were treated with oral labetolol hydrochloride tablets, and 48 patients in the combined group were treated with nifedipine tablets. The clinical treatment effects of the two groups were compared.Results After treatment, the systolic blood pressure and diastolic blood pressure of the observation group were significantly lower than those of the control group(P<0.05). The incidence of cesarean section, premature delivery and postpartum hemorrhage, fetal distress, and neonatal asphyxia in the observation group were lower than those in the control group(P<0.05).Conclusions Therapeutic effect of the combination of labetalol and nifedipine on patients with hypertensive disorder complicating pregnancy is reliable, which can improve the outcome of childbirth and the outcome of the fetus. It also has good therapeutic effect on patients with severe pre-eclampsia.
Objective To investigate the effect of labetalol combined with nifedipine on patients with hypertensive disorder complicating pregnancy.Methods One hundred and twenty patients with hypertensive disorder complicating pregnancy from September 2015 to June 2017 were selected. The patients were divided into two groups, 72 patients in the labetalol group were treated with oral labetolol hydrochloride tablets, and 48 patients in the combined group were treated with nifedipine tablets. The clinical treatment effects of the two groups were compared.Results After treatment, the systolic blood pressure and diastolic blood pressure of the observation group were significantly lower than those of the control group(P<0.05). The incidence of cesarean section, premature delivery and postpartum hemorrhage, fetal distress, and neonatal asphyxia in the observation group were lower than those in the control group(P<0.05).Conclusions Therapeutic effect of the combination of labetalol and nifedipine on patients with hypertensive disorder complicating pregnancy is reliable, which can improve the outcome of childbirth and the outcome of the fetus. It also has good therapeutic effect on patients with severe pre-eclampsia.
引文
[1] 张大微,刘艳丽.E-钙粘蛋白在妊娠期高血压患者胎盘组织中的表达及意义[J].泰山医学院学报,2018,39(7):787-788.
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[5] 郭海峰.联用硝苯地平控释片与拉贝洛尔注射液治疗早期妊娠期高血压的效果[J].当代医药论丛,2017,15(15):153-154.DOI:10.3969/j.issn.2095-7629.2017.15.111.
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[7] 薛华平.硫酸镁联合硝苯地平对妊娠高血压综合征患者血压控制及分娩不良事件的影响[J].临床医学,2018,38(2):112-113.
[8] 盖玉娜.硫酸镁联合硝苯地平对妊娠期高血压患者血压及妊娠结局的影响[J].中国实用医刊,2018,45(7):116-118.DOI:10.3760/cma.j.issn.1674-4756.2018.07.037.
[2] 张海霞.硫酸镁分别联合硝苯地平和拉贝洛尔治疗妊娠高血压疗效对比[J].现代诊断与治疗,2018,29(8):1228-1230.
[3] 史丹丹,王勇,郭君君,等.拉贝洛尔与硝苯地平治疗重度子痫前期对血压及孕产妇和围产儿结局的影响[J].河北医药,2018,40(5):673-676,680.DOI:10.3969/j.issn.1002-7386.2018.05.007.
[4] 马永萍.探析妊娠期高血压疾病患者经拉贝洛尔与硝苯地平联用降压治疗的效果[J].海峡药学,2017,29(11):137-139.DOI:10.3969/j.issn.1006-3765.2017.11.062.
[5] 郭海峰.联用硝苯地平控释片与拉贝洛尔注射液治疗早期妊娠期高血压的效果[J].当代医药论丛,2017,15(15):153-154.DOI:10.3969/j.issn.2095-7629.2017.15.111.
[6] 曹亚磊,邢宝恒,史丹丹.硝苯地平+拉贝洛尔治疗早期妊娠合并高血压的疗效及安全性[J].中国医药导刊,2017,19(6):605,607.DOI:10.3969/j.issn.1009-0959.2017.06.034.
[7] 薛华平.硫酸镁联合硝苯地平对妊娠高血压综合征患者血压控制及分娩不良事件的影响[J].临床医学,2018,38(2):112-113.
[8] 盖玉娜.硫酸镁联合硝苯地平对妊娠期高血压患者血压及妊娠结局的影响[J].中国实用医刊,2018,45(7):116-118.DOI:10.3760/cma.j.issn.1674-4756.2018.07.037.