sST2与GDF-15和急性ST段抬高型心肌梗死的相关性研究
摘要
目的:探讨急性ST段抬高型心肌梗死患者血清中可溶性生长刺激表达因子2蛋白(sST2)与生长分化因子-15(GDF-15)的相关性。方法:选取心内科44例急性ST段抬高型心肌梗死患者(STEMI组)和46例稳定型心绞痛患者(SA组)使用酶联免疫吸附实验测定血清sST2、GDF-15水平,对比分析其两者与STEMI的相关性。结果:STEMI组患者血清sST2、GDF-15水平较SA组患者明显升高,且两者呈正相关;STEMI组血清sST2水平、GDF-15水平与心肌损伤标志物TnI、CK-MB、CK、LDH均呈正相关性。STEMI组中血清sST2水平与左室舒张末内径值呈正相关性;与EF值呈负相关性;GDF-15血清水平与LVIDd值呈正相关性;与EF值呈负相关性。结论:检测STEMI患者血清sST2、GDF-15水平对STEMI的早期诊断及预测左室收缩功能、心室重塑有重要的临床意义。
引文
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[3]Weir RAP,Miller AM,Murphy GEJ,et al.Serum soluble ST2:a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction[J].J Am Coll Cardiol,2010,55(3):243-250
[4]Li J,Yang L,Qin W,et al.Adaptive induction of growth differentiation factor 15 attenuates endothelial cell apop-tosis in response to high glucose stimulus[J].PLo S One,2013,8(6):65549
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