思密达联合重组人表皮生长因子治疗会阴部放射性皮炎的疗效
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摘要
目的:观察思密达外敷联合重组人表皮生长因子治疗宫颈癌放射治疗所导致的会阴部II级及以上放射性皮炎的效果。方法:将70例宫颈癌行放射治疗的患者出现II级及以上会阴部放射性皮炎者随机分为观察和对照两组。对照组采用常规重组人表皮生长因子涂擦治疗;观察组在常规护理基础上加思密达外敷,治疗结束后比较两组皮炎的康复情况、愈合时间和疼痛程度。结果:观察组患者疗效(88.9%)显著高于对照组(59.5%),会阴部放射性皮炎愈合时间(6.54±4.65) d短于对照组(10.80±5.60)d,疼痛程度显著低于对照组,差异均有统计学意义(P<0.05)。结论:对于放射治疗所致的宫颈癌患者会阴部皮炎,使用思密达(蒙脱石散)联合重组人表皮生长因子能够有效地提升治疗效果,缩短创面愈合时间,降低患者疼痛感,且材料便宜、易得,具有较高的普适性。
Objective: To observe the effect of external application of smecta combined with recombinant human epidermal growth factor on the treatment of radiation dermatitis of grade II or above in the perineum caused by radiation therapy of cervical cancer. Methods: Seventy patients with cervical cancer having grade II or higher perirradial radiodermatitis after radiation therapy were randomly divided into an observation group and a control group. The control group was treated with conventional recombinant human epidermal growth factor, the observation group was treated with Smecta on the basis of conventional care, and the dermatitis recovery, average recovery time,and pain degree were compared between the two groups after treatment. Results: The therapeutic effect of the observation group(88.9%) was significant higher than the control group(59.5%), the healing time [(6.54±4.65) d]was shorter than the control group [(10.80±5.60) d], the pain degree was lower than that of the control group, the differences were statistically significant(P<0.05). Conclusion: For perineal dermatitis in patients with cervical cancer due to radiotherapy, the use of smecta(montmorillonite powder) combined with recombinant human epidermal growth factor can effectively improve the therapeutic effect, shorten the healing time, reduce the pain of patients, and the medical is cheap and easy bought.
Objective: To observe the effect of external application of smecta combined with recombinant human epidermal growth factor on the treatment of radiation dermatitis of grade II or above in the perineum caused by radiation therapy of cervical cancer. Methods: Seventy patients with cervical cancer having grade II or higher perirradial radiodermatitis after radiation therapy were randomly divided into an observation group and a control group. The control group was treated with conventional recombinant human epidermal growth factor, the observation group was treated with Smecta on the basis of conventional care, and the dermatitis recovery, average recovery time,and pain degree were compared between the two groups after treatment. Results: The therapeutic effect of the observation group(88.9%) was significant higher than the control group(59.5%), the healing time [(6.54±4.65) d]was shorter than the control group [(10.80±5.60) d], the pain degree was lower than that of the control group, the differences were statistically significant(P<0.05). Conclusion: For perineal dermatitis in patients with cervical cancer due to radiotherapy, the use of smecta(montmorillonite powder) combined with recombinant human epidermal growth factor can effectively improve the therapeutic effect, shorten the healing time, reduce the pain of patients, and the medical is cheap and easy bought.
引文
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3.黄春兰.宫颈癌放射治疗副反应的护理[J].临床医学,2014,27(11):179-180.HUANG Chunlan.Nursing care of side effects of radiotherapy for cervical cancer[J].Medical Information,2014,27(11):179-180.
4.李芳,张伟华,王媛,等.宫颈癌治疗后患者生活质量的调查及影响因素分析[J].中国妇幼健康研究,2018,29(4):518-521.LI Fang,ZHANG Weihua,WANG Yuan,et al.Investigation on the quality of life of patients with cervical cancer after treatment and analysis of influencing factors[J].Chinese Journal of Woman and Child Health Research,2018,29(4):518-521.
5.陈三妹,唐四元,焦迎春.急性放射性皮炎防治的研究进展[J].中华现代护理杂志,2012,18(28):3456-3458.CHEN Sanmei,TANG Siyuan,JIAO Yingchun.Advances in the prevention and treatment of acute radiation dermatitis[J].Chinese Journal of Modern Nursing,2012,18(28):3456-3458.
6.林锦芬,马剑波,刘淑萍.苯佐卡因、思密达局部治疗复发性口腔溃疡50例[J].山东医药,2002(33):83.LIN Jinfen,MA Jianbo,LIU Shuping.Local treatment of recurrent oral ulcer by benzocaine and smecta[J].Shandong Medical Journal,2002(33):83.
7.Woodforde JM,Marskay H.Some relationships between subjective measures of pain[J].J Psyahosom Res,1972,16(3):173-178.
8.廖婧,张佩芳,张晓萍.1例肾移植受者并发卡波氏肉瘤的护理[J].护理研究,2008,22(5):1219-1220.LIAO Jing,ZHANG Peifang,ZHANG Xiaoping.Nursing care of 1case of kidney transplantation recipient complicated with Kaposi’s sarcoma[J].Chinese Nursing Researsh,2008,22(5):1219-1220.
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10.李惠年,刘萍,宋金梦,等.宫颈癌放疗患者的护理[J].广东医学院学报,2012,30(3):335-336.LI Huinian,LIU Pin,SONG Jinmeng,et al.Nursing care of patients with cervical cancer bychemotherapy[J].Journal of Guangdong Medical College,2012,30(3):335-336.
11.Pyun do G,Choi HJ,Yoon HS,et al.Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds:Synthesis,characterization,in vitro and in vivo studies[J].Colloids Surf BBiointerfaces,2015,135:699-706.
12.孟瑞荣.思密达在新生儿臀红中的应用效果分析与护理[J].内蒙古医科大学学报,2014,36(S1):281-283.MENG Ruirong.Application effect analysis and nursing care of smecta in neonatal red buttock[J].Journal of Inner Mongolia medical university,2014,36(S1):281-283.
13.林权,许湘萍.两种口服止血药治疗上消化道出血的疗效比较[J].海南医学,2013,24(20):3051-3052.LIN Quan,XU Xiangping.Comparison of efficacy between two oral hemostatic drugs for upper gastrointestinal hemorrhage[J].Hainan Medical Journal,2013,24(20):3051-3052.
14.党红,秦静静.思密达治疗老年患者II期压疮的效果观察[J].现代临床护理,2014,13(3):44-46.DANG Hong,QIN Jingjing.Effect of Smecta on stage II pressures ulcers of elderly patients[J].Modern Clinical Nursing,2014,13(3):44-46.
15.Kim SW,Chun M,Ryu HS,et al.Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk,early stage uterine cervical cancer patients after radical hystereclony[J].BMC Cancer,2017,17(1):297.
16.陈明华,余红春,雷丽婵,等.重组人表皮生长因子凝胶与康复新液治疗III级放射性皮炎的疗效观察[J].实用临床医药杂志,2013,17(1):95-97.CHEN Minghua,YU Hongchun,LEI Lichan,et al.Observation on efficacy of recombinant human epidermal growth factor gel and Kangfuxin liquid in treating III radiodermatitis[J].Journal of Clinical Medicine in Practice,2013,17(1):95-97.
17.梅景华.蒙脱石散治疗难治型创面20例[J].实用医药杂志,2009,26(11):60.MEI Jinghua.The therapeutic effect of Montmorillonite powder on refractory wound[J].Practical Journal of Medicine&Pharmacy,2009,26(11):60.
18.邹胜琴,杜泽秀.重组表皮生长因子促进鼻粘膜修复的临床观察[J].西部医学,2012,24(9):1760-1761.ZOU Shengqin,DU Zexiu.The clinical observation of rhEGF on repair of the nasal mucosa[J].Medical Journal of West China,2012,24(9):1760-1761.
19.薛亚妮.思密达临床应用进展[D].重庆:重庆医科大学,2015.XUE Yani.Clinical application progress of Smecta[D].Chongqing:Chongqing Medical University,2015.
2.苗政,张福泉.宫颈癌放射治疗进展[J].中国肿瘤临床,2017,44(18):899-902.MIAO Zheng,ZHANG Fuquan.Progress on radiotherapy for cervix cancer[J].Chinese Journal of Clinical Oncology,2017,44(18):899-902.
3.黄春兰.宫颈癌放射治疗副反应的护理[J].临床医学,2014,27(11):179-180.HUANG Chunlan.Nursing care of side effects of radiotherapy for cervical cancer[J].Medical Information,2014,27(11):179-180.
4.李芳,张伟华,王媛,等.宫颈癌治疗后患者生活质量的调查及影响因素分析[J].中国妇幼健康研究,2018,29(4):518-521.LI Fang,ZHANG Weihua,WANG Yuan,et al.Investigation on the quality of life of patients with cervical cancer after treatment and analysis of influencing factors[J].Chinese Journal of Woman and Child Health Research,2018,29(4):518-521.
5.陈三妹,唐四元,焦迎春.急性放射性皮炎防治的研究进展[J].中华现代护理杂志,2012,18(28):3456-3458.CHEN Sanmei,TANG Siyuan,JIAO Yingchun.Advances in the prevention and treatment of acute radiation dermatitis[J].Chinese Journal of Modern Nursing,2012,18(28):3456-3458.
6.林锦芬,马剑波,刘淑萍.苯佐卡因、思密达局部治疗复发性口腔溃疡50例[J].山东医药,2002(33):83.LIN Jinfen,MA Jianbo,LIU Shuping.Local treatment of recurrent oral ulcer by benzocaine and smecta[J].Shandong Medical Journal,2002(33):83.
7.Woodforde JM,Marskay H.Some relationships between subjective measures of pain[J].J Psyahosom Res,1972,16(3):173-178.
8.廖婧,张佩芳,张晓萍.1例肾移植受者并发卡波氏肉瘤的护理[J].护理研究,2008,22(5):1219-1220.LIAO Jing,ZHANG Peifang,ZHANG Xiaoping.Nursing care of 1case of kidney transplantation recipient complicated with Kaposi’s sarcoma[J].Chinese Nursing Researsh,2008,22(5):1219-1220.
9.Cox JD,Stetz J,Pajak TF.Toxicity criteria of the radiation therapy oncology group(RTOG)and the European Organization for research and treatment of cancer(EORTC)[J].Int J Radiat Oncol Biol Phys,1995,31(5):1341-1346.
10.李惠年,刘萍,宋金梦,等.宫颈癌放疗患者的护理[J].广东医学院学报,2012,30(3):335-336.LI Huinian,LIU Pin,SONG Jinmeng,et al.Nursing care of patients with cervical cancer bychemotherapy[J].Journal of Guangdong Medical College,2012,30(3):335-336.
11.Pyun do G,Choi HJ,Yoon HS,et al.Polyurethane foam containing rhEGF as a dressing material for healing diabetic wounds:Synthesis,characterization,in vitro and in vivo studies[J].Colloids Surf BBiointerfaces,2015,135:699-706.
12.孟瑞荣.思密达在新生儿臀红中的应用效果分析与护理[J].内蒙古医科大学学报,2014,36(S1):281-283.MENG Ruirong.Application effect analysis and nursing care of smecta in neonatal red buttock[J].Journal of Inner Mongolia medical university,2014,36(S1):281-283.
13.林权,许湘萍.两种口服止血药治疗上消化道出血的疗效比较[J].海南医学,2013,24(20):3051-3052.LIN Quan,XU Xiangping.Comparison of efficacy between two oral hemostatic drugs for upper gastrointestinal hemorrhage[J].Hainan Medical Journal,2013,24(20):3051-3052.
14.党红,秦静静.思密达治疗老年患者II期压疮的效果观察[J].现代临床护理,2014,13(3):44-46.DANG Hong,QIN Jingjing.Effect of Smecta on stage II pressures ulcers of elderly patients[J].Modern Clinical Nursing,2014,13(3):44-46.
15.Kim SW,Chun M,Ryu HS,et al.Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk,early stage uterine cervical cancer patients after radical hystereclony[J].BMC Cancer,2017,17(1):297.
16.陈明华,余红春,雷丽婵,等.重组人表皮生长因子凝胶与康复新液治疗III级放射性皮炎的疗效观察[J].实用临床医药杂志,2013,17(1):95-97.CHEN Minghua,YU Hongchun,LEI Lichan,et al.Observation on efficacy of recombinant human epidermal growth factor gel and Kangfuxin liquid in treating III radiodermatitis[J].Journal of Clinical Medicine in Practice,2013,17(1):95-97.
17.梅景华.蒙脱石散治疗难治型创面20例[J].实用医药杂志,2009,26(11):60.MEI Jinghua.The therapeutic effect of Montmorillonite powder on refractory wound[J].Practical Journal of Medicine&Pharmacy,2009,26(11):60.
18.邹胜琴,杜泽秀.重组表皮生长因子促进鼻粘膜修复的临床观察[J].西部医学,2012,24(9):1760-1761.ZOU Shengqin,DU Zexiu.The clinical observation of rhEGF on repair of the nasal mucosa[J].Medical Journal of West China,2012,24(9):1760-1761.
19.薛亚妮.思密达临床应用进展[D].重庆:重庆医科大学,2015.XUE Yani.Clinical application progress of Smecta[D].Chongqing:Chongqing Medical University,2015.