吸入布地奈德治疗哮喘患儿及对血清TGF-β1与PAF水平的影响
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摘要
目的研究吸入布地奈德治疗哮喘患儿及对血清TGF-β1与PAF水平的影响。方法选择2014年3月-2015年2月在本院进行治疗的哮喘患儿102例,根据随机数字表分为观察组和对照组,观察组采用吸入器吸入布地奈德治疗,对照组采用吸入器吸入特布他林治疗。对两组患者呼吸功能,临床疗效,VAS评分以及TGF-β1与PAF水平进行比较。结果观察组的有效率显著高于对照组的有效率(χ~2=8.251,P <0.05)。治疗后,观察组患者用力呼气量(FEV1.0)、最大呼气流速(PEF)及用力FEF25%、FEF50%、FEF75%和FEF25-75%与对照组比较均明显降低(P <0.05)。治疗后4周和12周时观察组VAS评分均显著低于对照组(P <0.05)。治疗后观察组TGF-β1和PAF水平均显著低于对照组(P <0.05)。结论吸入布地奈德治疗患儿哮喘具有确切的临床疗效,能够显著改善患儿哮喘症状和受损的肺功能,同时其治疗作用的发挥可能与其能够降低血清TGF-β1与PAF水平密切相关。
Objective To study the effects of inhaled budesonide in the treatment of children with asthma and its effect on serum TGF-beta 1 and PAF level. Methods 103 cases of children with asthma cured in our hospital from 2014 March to 2015 were divided into observation group and the control group according to the random number table. The observation group were treated with inhaled budesonide and the control group was given terbutaline inhaler. Respiratory function, clinical efficacy, VAS score, TGF-beta 1 and PAF levels in the two groups were compared. Results The effective rate of the observation group was significantly higher than that of the control group(χ~2 = 8.251, P < 0.05). After treatment, the forced expiratory volume(FEV1.0), maximal expiratory flow rate(PEF)and forced FEF25%, FEF75%, FEF50% and FEF25-75% in observation group were significantly lower than those in the control group(P <0.05). The VAS score of the observation group was significantly lower than that of the control group(P <0.05)after 4 weeks and 12 weeks.The levels of PAF beta 1 and TGF-in the observation group were significantly lower than those in the control group(P <0.05).Conclusion Inhalation Budesonide in the treatment of children with asthma has exact clinical curative effect, and it can significantly improve asthma symptoms and lung function, and its therapeutic effect may be related to that it can reduce the serum levels of TGF-β1 and PAF.
Objective To study the effects of inhaled budesonide in the treatment of children with asthma and its effect on serum TGF-beta 1 and PAF level. Methods 103 cases of children with asthma cured in our hospital from 2014 March to 2015 were divided into observation group and the control group according to the random number table. The observation group were treated with inhaled budesonide and the control group was given terbutaline inhaler. Respiratory function, clinical efficacy, VAS score, TGF-beta 1 and PAF levels in the two groups were compared. Results The effective rate of the observation group was significantly higher than that of the control group(χ~2 = 8.251, P < 0.05). After treatment, the forced expiratory volume(FEV1.0), maximal expiratory flow rate(PEF)and forced FEF25%, FEF75%, FEF50% and FEF25-75% in observation group were significantly lower than those in the control group(P <0.05). The VAS score of the observation group was significantly lower than that of the control group(P <0.05)after 4 weeks and 12 weeks.The levels of PAF beta 1 and TGF-in the observation group were significantly lower than those in the control group(P <0.05).Conclusion Inhalation Budesonide in the treatment of children with asthma has exact clinical curative effect, and it can significantly improve asthma symptoms and lung function, and its therapeutic effect may be related to that it can reduce the serum levels of TGF-β1 and PAF.
引文
[1]苏楠,林江涛,刘国梁等.我国八省市支气管哮喘患者对疾病管理与认知现状调查[J].中华内科杂志,2015,54(8):680-683.
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[7]张丽,胡红,王晓芝等.变应性鼻炎对支气管哮喘患者临床控制和肺通气功能的影响[J].国际呼吸杂志,2013,33(11):801-803.
[8]王雯,黄克武,刘秋云等.支气管哮喘规范化管理与教育对哮喘控制的效果评析[J].中华哮喘杂志(电子版),2011,05(6):415-419.
[9]励爱,贺登科.布地奈德联合肺力咳治疗小儿哮喘[J].中国实验方剂学杂志,2014,20(24):207-209.
[10]邓虎,王晓旭,毛相裕等.TGF-β1/Smads信号转导通路在慢性阻塞性肺疾病中的研究进展[J].世界中西医结合杂志,2014,9(12):1350-1354.
[11]Marrache AM,Gobeil F Jr,Bernier SG,et a1.Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor[J].JImmunol,2010,169(1 1):6474-6481.
[2]刘文,赵霞.从影响小儿体质形成的相关因素探讨哮喘患儿的日常调护[J].中医药信息,2010,27(4):1-3.
[3]田福玲,李旗,崔建美等.小儿推拿疗法在小儿支气管哮喘慢性持续期的作用机制和治疗效果研究[J].中国全科医学,2015,(1):105-108.
[4]林江涛,苏楠,农英等.中国哮喘患者402例现状调查及与亚太地区的比较[J].中华结核和呼吸杂志,2015,38(2):136-137.
[5]中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(支气管哮喘的定义、诊断、治疗和管理方案)[J].中华结核和呼吸杂志,2008,31(3):177-185.
[6]沙莉,刘传合.2014年全球哮喘防治创议委员会儿童支气管哮喘最新修订指南解读[J].中国医刊,2015,(7):16-18,19.
[7]张丽,胡红,王晓芝等.变应性鼻炎对支气管哮喘患者临床控制和肺通气功能的影响[J].国际呼吸杂志,2013,33(11):801-803.
[8]王雯,黄克武,刘秋云等.支气管哮喘规范化管理与教育对哮喘控制的效果评析[J].中华哮喘杂志(电子版),2011,05(6):415-419.
[9]励爱,贺登科.布地奈德联合肺力咳治疗小儿哮喘[J].中国实验方剂学杂志,2014,20(24):207-209.
[10]邓虎,王晓旭,毛相裕等.TGF-β1/Smads信号转导通路在慢性阻塞性肺疾病中的研究进展[J].世界中西医结合杂志,2014,9(12):1350-1354.
[11]Marrache AM,Gobeil F Jr,Bernier SG,et a1.Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor[J].JImmunol,2010,169(1 1):6474-6481.