大豆异黄酮在奶牛生产中的研究进展
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摘要
大豆异黄酮是豆科植物中存在的一类黄酮类化合物,由于其类雌激素活性而被称为植物雌激素,具有抗肿瘤、抗氧化应激、抗炎以及促进乳腺上皮细胞增殖等能力。本文主要从大豆异黄酮的主要成分、结构功能及其对奶牛瘤胃发酵、泌乳性能、抗氧化能力以及增殖性能的影响和作用机制等方面进行阐述。
Soy isoflavones are a class of flavonoids found in legumes. They are called phytoestrogens due to their estrogen-like activity and have anti-tumor,anti-oxidative stress,anti-inflammatory and mammary epithelial cells proliferation capabilities and so on. This paper mainly described the main components,structure and function of soy isoflavones and the effects and mechanisms of soy isoflavones on rumen fermentation,lactation performance,antioxidant capacity and proliferation performance of dairy cows.[Chinese Journal of Animal Nutrition,2019,31(7):2999-3003]
Soy isoflavones are a class of flavonoids found in legumes. They are called phytoestrogens due to their estrogen-like activity and have anti-tumor,anti-oxidative stress,anti-inflammatory and mammary epithelial cells proliferation capabilities and so on. This paper mainly described the main components,structure and function of soy isoflavones and the effects and mechanisms of soy isoflavones on rumen fermentation,lactation performance,antioxidant capacity and proliferation performance of dairy cows.[Chinese Journal of Animal Nutrition,2019,31(7):2999-3003]
引文
[1] TSUGAMI Y,MATSUNAGA K,SUZUKI T,et al.Isoflavones and their metabolites influence the milk component synthesis ability of mammary epithelial cells through prolactin/STAT5 signaling[J]. Molecular Nutrition&Food Research,2017,61(10):1700156.
[2]邓卉,刘进远,汪林书,等.大豆异黄酮发挥抗氧化作用的途径及机理研究[J].四川畜牧兽医,2012,39(2):32-34.
[3]方洛云,赵燕飞,金凯,等.大豆异黄酮对奶牛泌乳性能、血液免疫及抗氧化指标的影响[J].中国农学通报,2015,31(11):9-15.
[4]李延杰.大豆异黄酮的生理作用以及在畜牧生产中的应用[J].现代畜牧科技,2016(11):47.
[5]张百红,岳红云.植物雌激素的激素样作用机制研究进展[J].现代肿瘤医学,2018,26(9):1444-1446.
[6]刘春龙,李忠秋,张帆,等.大豆黄酮和染料木素对奶牛血清生化及血液流变学指标的影响[J].中国兽医学报,2009(4):460-463,467.
[7]张晓霞,刘春雪.大豆异黄酮及其在猪生产中的应用研究进展[J].粮食与饲料工业,2017(10):53-57.
[8] ASO T,UCHIYAMA S,MATSUMURA Y,et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women[J]. Journal of Women’s Health,2012,21(1):92-100.
[9] KANG H J,ANSBACHER R,HAMMOUD MM.Use of alternative and complementary medicine in menopause[J]. International Journal of Gynecology&Obstetrics,2002,79(3):195-207.
[10]程蕾,王定发,刘晓华,等.大豆异黄酮对奶牛产奶量及乳成分的影响[J].饲料博览,2009(4):5-7.
[11] RUSSO M,RUSSO G L,DAGLIA M,et al. Understanding genistein in cancer:the “good” and the“bad”effects:a review[J]. Food Chemistry,2016,196:589-600.
[12] MORTENSEN A,KULLING S E,SCHWARTZ H,et al.Analytical and compositional aspects of isoflavones in food and their biological effects[J]. Molecular Nutrition&Food Research,2009,53(Suppl 2):S266-S309.
[13]郑庆虎,周辉,陈祯祥,等.雌马酚的生物学作用及其在医学领域的研究进展[J].中国皮肤性病学杂志,2018,32(1):105-109.
[14]郑峰,崔香丹,朱洁波,等.大豆异黄酮对小鼠肝癌移植瘤血管生成的抑制作用[J].大豆科学,2018,37(1):101-104.
[15]韦习会,夏东,陈杰,等.饲喂大豆异黄酮对母猪繁殖性能及哺乳仔猪生长的影响[J].江苏农业学报,2004,20(1):51-54.
[16]卢志勇,梁代华,杨运玲,等.大豆异黄酮对奶牛乳腺上皮细胞泌乳性能及抗氧化能力的影响[J].饲料与畜牧,2013(2):25-28.
[17]赵传毅,姜宁,杨文忠,等.饲喂不同水平大豆异黄酮对泌乳中期奶牛生产性能的影响[J].黑龙江畜牧兽医,2011(17):68-69.
[18] LUNDHT.Metabolism of estrogenic isoflavones in domestic animals[J]. Experimental Biology and Medicine,1995,208(1):33-39.
[19] KASPAROVSKA J,KRIZOVA L,LOCHMAN J,et al.Soybean-derived isoflavone determination in rumen fluid and milk by LC-MS-(TOF)[J]. Journal of Chromatographic Science,2016,54(6):997-1003.
[20] KASPAROVSKA J,PECINKOVA M,DADAKOVA K,et al.Effects of isoflavone-enriched feed on the rumen microbiota in dairy cows[J].PLoS One,2016,11(4):e154642.
[21] JAMI E,ISRAEL A,KOTSER A,et al.Exploring the bovine rumen bacterial community from birth to adulthood[J].The ISME Journal,2013,7(6):1069-1079.
[22] SINGH K M,JISHA T K,REDDY B,et al.Microbial profiles of liquid and solid fraction associated biomaterial in buffalo rumen fed green and dry roughage diets by tagged 16S rRNA gene pyrosequencing[J].Molecular Biology Reports,2015,42(1):95-103.
[23] TAJIMA K,AMINOV R I,NAGAMINE T,et al.Diet-dependent shifts in the bacterial population of the rumen revealed with real-time PCR[J]. Applied and Environmental Microbiology,2001,67(6):2766-2774.
[24]杨国宇,陈伟华,陈杰,等.雄性水牛瘤胃内睾酮的检测及变化规律的研究[J].南京农业大学学报,1998,21(1):82-86.
[25]陈杰,杨国宇,韩正康.大豆黄酮对反刍动物血清睾酮和瘤胃消化代谢的影响[J].江苏农业研究,1999,20(2):17-19.
[26]朱河水,王艳玲,杨国宇,等.大豆黄酮对奶牛相关产奶性能的影响[J].华北农学报,2006,21(6):127-129.
[27]李琮,臧长江,刘亚伟,等.添喂两种植物雌激素对奶牛乳成分、血液生化指标和抗氧化性能的影响[J].中国畜牧兽医,2017,44(6):1688-1693.
[28]刘春龙,李忠秋.大豆黄酮和染料木素对奶牛瘤胃发酵水平的影响研究[C]//首届中国奶业大会论文集.青岛:中国奶业协会,2010.
[29]刘春龙,任延铭,姜文博,等.大豆异黄酮类植物雌激素对奶牛内分泌水平的影响[J].中国兽医学报,2010,30(9):1261-1264,1268.
[30] SIGL T,MEYER H H,WIEDEMANN S. Gene expression analysis of protein synthesis pathways in bovine mammary epithelial cells purified from milk during lactation and short-term restricted feeding[J].Journal of Animal Physiology and Animal Nutrition,2014,98(1):84-95.
[31]李琮,陈俊宏,刘亚伟,等.大豆黄酮、芒柄花素及其组合对奶牛产奶性能、血浆和乳中激素含量的影响[J].动物营养学报,2017,29(1):309-316.
[32]郭云,赵芳,邓海峰,等.补喂植物雌激素对泌乳期伊犁母马产奶量和乳成分的影响[J].中国饲料,2016(5):5-8.
[33]刘续航,蒋林树,王俊杰,等.大豆异黄酮对奶牛泌乳性能及乳腺主要免疫功能的影响[C]//中国畜牧兽医学会2013年学术年会论文集.北京:中国畜牧兽医学会,2013.
[34]杨建英,张勇法,王艳玲,等.大豆黄酮对奶牛产奶量和乳中常规成分的影响[J].饲料研究,2005(6):30-31.
[35]朱河水,王艳玲,杨国宇,等.大豆黄酮对泌乳后期奶牛相关乳成分的影响[J].中国农学通报,2006,22(7):27-28.
[36]孟海洋.王不留行对奶牛乳腺上皮细胞泌乳信号转导通路的影响[D].硕士学位论文.哈尔滨:东北农业大学,2013.
[37]刘春龙,李忠秋,张帆,等.大豆黄酮和染料木素对体外培养奶牛乳腺上皮细胞增殖及抗氧化水平的影响[J].畜牧兽医学报,2008,39(11):1517-1522.
[38]穆莹,江连洲.大豆异黄酮对奶牛乳腺上皮细胞增殖及泌乳性能的影响[J].中国畜牧兽医,2013(1):187-190.
[39]欧阳五庆,邹思湘,林成招.大豆黄酮对RMEC增殖的影响[C]//全国反刍动物营养生理生化第三次学术会议论文摘要汇编.长春:中国畜牧兽医学会,2004.
[40] ARORA A,NAIR MG,STRASBURG G M.Antioxidant activities of isoflavones and their biological metabolites in a liposomal system[J]. Archives of Biochemistry and Biophysics,1998,356(2):133-141.
[41]林厦菁,蒋守群,林哲敏,等.大豆异黄酮和抗生素对文昌鸡生长性能、肉品质和血浆抗氧化指标的影响[J].华南农业大学学报,2018,39(1):1-6.
[42]刘德义,周玉传,陆天水,等.大豆异黄酮对奶牛产奶量和乳脂率及饲料转化率的影响[J].中国畜牧杂志,2004,40(4):31-32,55.
[2]邓卉,刘进远,汪林书,等.大豆异黄酮发挥抗氧化作用的途径及机理研究[J].四川畜牧兽医,2012,39(2):32-34.
[3]方洛云,赵燕飞,金凯,等.大豆异黄酮对奶牛泌乳性能、血液免疫及抗氧化指标的影响[J].中国农学通报,2015,31(11):9-15.
[4]李延杰.大豆异黄酮的生理作用以及在畜牧生产中的应用[J].现代畜牧科技,2016(11):47.
[5]张百红,岳红云.植物雌激素的激素样作用机制研究进展[J].现代肿瘤医学,2018,26(9):1444-1446.
[6]刘春龙,李忠秋,张帆,等.大豆黄酮和染料木素对奶牛血清生化及血液流变学指标的影响[J].中国兽医学报,2009(4):460-463,467.
[7]张晓霞,刘春雪.大豆异黄酮及其在猪生产中的应用研究进展[J].粮食与饲料工业,2017(10):53-57.
[8] ASO T,UCHIYAMA S,MATSUMURA Y,et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women[J]. Journal of Women’s Health,2012,21(1):92-100.
[9] KANG H J,ANSBACHER R,HAMMOUD MM.Use of alternative and complementary medicine in menopause[J]. International Journal of Gynecology&Obstetrics,2002,79(3):195-207.
[10]程蕾,王定发,刘晓华,等.大豆异黄酮对奶牛产奶量及乳成分的影响[J].饲料博览,2009(4):5-7.
[11] RUSSO M,RUSSO G L,DAGLIA M,et al. Understanding genistein in cancer:the “good” and the“bad”effects:a review[J]. Food Chemistry,2016,196:589-600.
[12] MORTENSEN A,KULLING S E,SCHWARTZ H,et al.Analytical and compositional aspects of isoflavones in food and their biological effects[J]. Molecular Nutrition&Food Research,2009,53(Suppl 2):S266-S309.
[13]郑庆虎,周辉,陈祯祥,等.雌马酚的生物学作用及其在医学领域的研究进展[J].中国皮肤性病学杂志,2018,32(1):105-109.
[14]郑峰,崔香丹,朱洁波,等.大豆异黄酮对小鼠肝癌移植瘤血管生成的抑制作用[J].大豆科学,2018,37(1):101-104.
[15]韦习会,夏东,陈杰,等.饲喂大豆异黄酮对母猪繁殖性能及哺乳仔猪生长的影响[J].江苏农业学报,2004,20(1):51-54.
[16]卢志勇,梁代华,杨运玲,等.大豆异黄酮对奶牛乳腺上皮细胞泌乳性能及抗氧化能力的影响[J].饲料与畜牧,2013(2):25-28.
[17]赵传毅,姜宁,杨文忠,等.饲喂不同水平大豆异黄酮对泌乳中期奶牛生产性能的影响[J].黑龙江畜牧兽医,2011(17):68-69.
[18] LUNDHT.Metabolism of estrogenic isoflavones in domestic animals[J]. Experimental Biology and Medicine,1995,208(1):33-39.
[19] KASPAROVSKA J,KRIZOVA L,LOCHMAN J,et al.Soybean-derived isoflavone determination in rumen fluid and milk by LC-MS-(TOF)[J]. Journal of Chromatographic Science,2016,54(6):997-1003.
[20] KASPAROVSKA J,PECINKOVA M,DADAKOVA K,et al.Effects of isoflavone-enriched feed on the rumen microbiota in dairy cows[J].PLoS One,2016,11(4):e154642.
[21] JAMI E,ISRAEL A,KOTSER A,et al.Exploring the bovine rumen bacterial community from birth to adulthood[J].The ISME Journal,2013,7(6):1069-1079.
[22] SINGH K M,JISHA T K,REDDY B,et al.Microbial profiles of liquid and solid fraction associated biomaterial in buffalo rumen fed green and dry roughage diets by tagged 16S rRNA gene pyrosequencing[J].Molecular Biology Reports,2015,42(1):95-103.
[23] TAJIMA K,AMINOV R I,NAGAMINE T,et al.Diet-dependent shifts in the bacterial population of the rumen revealed with real-time PCR[J]. Applied and Environmental Microbiology,2001,67(6):2766-2774.
[24]杨国宇,陈伟华,陈杰,等.雄性水牛瘤胃内睾酮的检测及变化规律的研究[J].南京农业大学学报,1998,21(1):82-86.
[25]陈杰,杨国宇,韩正康.大豆黄酮对反刍动物血清睾酮和瘤胃消化代谢的影响[J].江苏农业研究,1999,20(2):17-19.
[26]朱河水,王艳玲,杨国宇,等.大豆黄酮对奶牛相关产奶性能的影响[J].华北农学报,2006,21(6):127-129.
[27]李琮,臧长江,刘亚伟,等.添喂两种植物雌激素对奶牛乳成分、血液生化指标和抗氧化性能的影响[J].中国畜牧兽医,2017,44(6):1688-1693.
[28]刘春龙,李忠秋.大豆黄酮和染料木素对奶牛瘤胃发酵水平的影响研究[C]//首届中国奶业大会论文集.青岛:中国奶业协会,2010.
[29]刘春龙,任延铭,姜文博,等.大豆异黄酮类植物雌激素对奶牛内分泌水平的影响[J].中国兽医学报,2010,30(9):1261-1264,1268.
[30] SIGL T,MEYER H H,WIEDEMANN S. Gene expression analysis of protein synthesis pathways in bovine mammary epithelial cells purified from milk during lactation and short-term restricted feeding[J].Journal of Animal Physiology and Animal Nutrition,2014,98(1):84-95.
[31]李琮,陈俊宏,刘亚伟,等.大豆黄酮、芒柄花素及其组合对奶牛产奶性能、血浆和乳中激素含量的影响[J].动物营养学报,2017,29(1):309-316.
[32]郭云,赵芳,邓海峰,等.补喂植物雌激素对泌乳期伊犁母马产奶量和乳成分的影响[J].中国饲料,2016(5):5-8.
[33]刘续航,蒋林树,王俊杰,等.大豆异黄酮对奶牛泌乳性能及乳腺主要免疫功能的影响[C]//中国畜牧兽医学会2013年学术年会论文集.北京:中国畜牧兽医学会,2013.
[34]杨建英,张勇法,王艳玲,等.大豆黄酮对奶牛产奶量和乳中常规成分的影响[J].饲料研究,2005(6):30-31.
[35]朱河水,王艳玲,杨国宇,等.大豆黄酮对泌乳后期奶牛相关乳成分的影响[J].中国农学通报,2006,22(7):27-28.
[36]孟海洋.王不留行对奶牛乳腺上皮细胞泌乳信号转导通路的影响[D].硕士学位论文.哈尔滨:东北农业大学,2013.
[37]刘春龙,李忠秋,张帆,等.大豆黄酮和染料木素对体外培养奶牛乳腺上皮细胞增殖及抗氧化水平的影响[J].畜牧兽医学报,2008,39(11):1517-1522.
[38]穆莹,江连洲.大豆异黄酮对奶牛乳腺上皮细胞增殖及泌乳性能的影响[J].中国畜牧兽医,2013(1):187-190.
[39]欧阳五庆,邹思湘,林成招.大豆黄酮对RMEC增殖的影响[C]//全国反刍动物营养生理生化第三次学术会议论文摘要汇编.长春:中国畜牧兽医学会,2004.
[40] ARORA A,NAIR MG,STRASBURG G M.Antioxidant activities of isoflavones and their biological metabolites in a liposomal system[J]. Archives of Biochemistry and Biophysics,1998,356(2):133-141.
[41]林厦菁,蒋守群,林哲敏,等.大豆异黄酮和抗生素对文昌鸡生长性能、肉品质和血浆抗氧化指标的影响[J].华南农业大学学报,2018,39(1):1-6.
[42]刘德义,周玉传,陆天水,等.大豆异黄酮对奶牛产奶量和乳脂率及饲料转化率的影响[J].中国畜牧杂志,2004,40(4):31-32,55.