医用质子重离子加速器应用现状及发展趋势
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摘要
质子和重离子束治疗肿瘤,是当今国际社会公认的最尖端放疗技术。为促进我国高端放疗设备的发展进步,提高肿瘤患者的生活质量,对医用质子、重离子加速器及其放疗技术的应用研究具有重要的现实意义。该文在简要概述质子、重离子治癌的基础上,总结和分析了国内外医用质子加速器和医用重离子加速器相关的应用现状,并结合实际提出了医用质子、重离子加速器及其放疗技术未来的发展趋势,为我国高端放疗设备的进步和发展战略研究提供参考。
Cancer therapy with accelerated proton or heavy ion beam is the most advanced radiotherapy technology, which is recognized by the international community at present. It is of great practical significance to study the medical proton and heavy ion accelerators and the radiotherapy technology, in order to promote the development of the advanced medical radiotherapy equipments and improve the quality of life of cancer patients in China. After a brief overview of cancer therapy with proton and heavy ion beam, this paper summarized and analyzed the application status of medical proton accelerators and medical heavy ion accelerators at home and abroad, and finally put forward the future development trends of medical proton and heavy ion accelerators and the radiotherapy technology, it can provide a reference for the progress and development strategies of the advanced radiotherapy equipments in China.
Cancer therapy with accelerated proton or heavy ion beam is the most advanced radiotherapy technology, which is recognized by the international community at present. It is of great practical significance to study the medical proton and heavy ion accelerators and the radiotherapy technology, in order to promote the development of the advanced medical radiotherapy equipments and improve the quality of life of cancer patients in China. After a brief overview of cancer therapy with proton and heavy ion beam, this paper summarized and analyzed the application status of medical proton accelerators and medical heavy ion accelerators at home and abroad, and finally put forward the future development trends of medical proton and heavy ion accelerators and the radiotherapy technology, it can provide a reference for the progress and development strategies of the advanced radiotherapy equipments in China.
引文
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[19]FRIESEL D L,ANTAYA T A.Medical cyclotrons[J].Rev Acce Sci Technol,2015,2(1):133-156.
[20]SMITH A R.Present Status and Future Developments in Proton Therapy[C].AIP Conference,2009:426-437.
[21]ZHANG T,WANG C,LI M,et al.Developments for 230?MeVsuperconducting cyclotrons for proton therapy and proton irradiation[J].Nucl Instrum Methods Phys Res A,2016.
[22]马林,周桂霞,冯林春.恶性肿瘤高LET(重离子、快中子)放射治疗学[M].北京:军事医学科学出版社,2006.
[23]NODA K.Beam delivery method for carbon ion radio therapy with the heavy-ion medical accelerator in Chiba[J].Int J Part Ther,2016,2(4):481-488.
[24]OKADA T,KAMADA T,TSUJI H,et al.Carbon ion radiotherapy:clinical experiences at National Institute of Radiological Science(NIRS)[J].J Radiat Res,2010,51(4):355-364.
[25]谢修璀.医用重离子加速器HIMM注入方案的设计研究[D].兰州:中国科学院近代物理研究所,2014.
[26]叶飞,李强.重离子治癌相关研究[J].原子核物理评论,2010,27(3):309-316.
[27]WINKELMANN T,CEE R,HABERER T,et al.Experience at the ion beam therapy center(HIT)with 2 years of continuous ECR ion source operation[C].ECRIS08,Chicago,IL USA,2008,4(2):207-213.
[28]JONGEN Y,ABS M,BLONDIN A,et al.IBA-JINR400 MeV/u superconducting cyclotron for hard-on therapy[C].The 19th International Conference on Cyclotrons and their Applications,CYCLOTRONS'12.2010:328-345.
[29]肖国青,张红,李强,等.中国科学院近代物理研究所重离子束致癌进展[J].原子核物理评论,2007,24(2):85-88.
[30]陈文军,马力祯,蔡国柱,等.武威医用重离子加速器同步环的准直安装[J].原子核物理评论,2016,33(3):297.
[31]李敏.HIMM束流诊断前端控制系统的设计与实现[D].兰州:中国科学院近代物理研究所,2015.
[32]Particle Therapy Co-operative Group[R/OL].[2018-05-25].https://www.ptcog.ch/index.php/facilities-in-operation.
[33]FLANZ J,OWEN H,SCHIPPERS M.Report on workshop:modern hadron therapy gantry developments[R].Technical Report CERN-ACC-NOTE-2014-0088,CE-RN,2014.
[34]LINZ U,ALONSO J.What will it take for laser driven proton accelerators to be applied to tumor therapy?[J].Phys Rev Spec Top-AC,2007,10(10):1-8.
[35]张新民.智能材料研究进展[J].玻璃钢/复合材料,2013(Z2):57-63.
[2]陈万青,郑荣寿,曾红梅,等.2011年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2015,24(1):2.
[3]KRAFT G.Tumor therapy with ion beams[J].Nucl Instrum Methods Phys Res,2000,454(1):1-10.
[4]MOHAN R,GROSSHANS D.Proton therapy-present and future[J].Adv Drug Deliver Rev,2017,109:26-44.
[5]SCHULZERTNER D,TSUJII H.Particle radiation therapy using proton and heavier ion beams[J].J Clin Oncol,2007,25(8):954.
[6]胡逸民.肿瘤放射物理学[M].北京:原子能出版社,2003.
[7]SCHULZ-ERTNER D,TSUJII H.Particle ra-diation therapy using proton and heavier ion beams[J].J Clin Oncol,2007,25:953-964.
[8]ANTONOVIC L,BRAHME A,FURUSAWA Y,et al.Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions[J].JRadiat Res,2013,54(1):18-26.
[9]李文建.质子与重离子肿瘤治疗的进展[J].原子核物理评论,2005,22(1):39-43.
[10]AMALDI U,BONOMI R,BRACCINI S,et al.Accelerators for hadrontherapy:from Lawrence cyclotrons to linacs[J].Nucl Instrum Methods Phys Res,2010,620(2):563-577.
[11]MOHAN R,BORTFELD T.Proton therapy:clinical gains through current and future treatment programs[J].Front Radiat Ther Oncol,2011,43(43):440-464.
[12]王彤,肖平,贾少微,等.重离子肿瘤治疗装置的基本构成[J].中国医疗器械杂志,2014,38(6):427-438.
[13]OWEN H,LOMAX A,JOLLY S.Currentand future accelerator technologies for charged particle therapy[J].Nucl Instrum Methods Phys Res.A,2016,809:96-104.
[14]郝焕锋.7 MeV/U重离子回旋加速器设计与研制[D].兰州:中国科学院近代物理研究所,2014.
[15]OWEN H,HOLDER D,ALONSO J,et al.Technologies for delivery of proton and ion beams for radiotherapy[J].Int J Mod Phys A,2014,29(14):81.
[16]CHAO A W,CHOU W.Reviews of accelerator science and technology[M].Singapore:World Scientific,2008.
[17]ProteusPlus picture gallery[R/OL].[2018-05-25].https://ibaworldwide.com/proton-therapy.
[18]SCHIPPERS J M,D?LLING R,DUPPICH J,et al.The SCcyclotron and beam lines of PSI’s new proton therapy facility PROSCAN[J].Nucl Instrum Meth Phys Res A,2007,261(1-2):773-776.
[19]FRIESEL D L,ANTAYA T A.Medical cyclotrons[J].Rev Acce Sci Technol,2015,2(1):133-156.
[20]SMITH A R.Present Status and Future Developments in Proton Therapy[C].AIP Conference,2009:426-437.
[21]ZHANG T,WANG C,LI M,et al.Developments for 230?MeVsuperconducting cyclotrons for proton therapy and proton irradiation[J].Nucl Instrum Methods Phys Res A,2016.
[22]马林,周桂霞,冯林春.恶性肿瘤高LET(重离子、快中子)放射治疗学[M].北京:军事医学科学出版社,2006.
[23]NODA K.Beam delivery method for carbon ion radio therapy with the heavy-ion medical accelerator in Chiba[J].Int J Part Ther,2016,2(4):481-488.
[24]OKADA T,KAMADA T,TSUJI H,et al.Carbon ion radiotherapy:clinical experiences at National Institute of Radiological Science(NIRS)[J].J Radiat Res,2010,51(4):355-364.
[25]谢修璀.医用重离子加速器HIMM注入方案的设计研究[D].兰州:中国科学院近代物理研究所,2014.
[26]叶飞,李强.重离子治癌相关研究[J].原子核物理评论,2010,27(3):309-316.
[27]WINKELMANN T,CEE R,HABERER T,et al.Experience at the ion beam therapy center(HIT)with 2 years of continuous ECR ion source operation[C].ECRIS08,Chicago,IL USA,2008,4(2):207-213.
[28]JONGEN Y,ABS M,BLONDIN A,et al.IBA-JINR400 MeV/u superconducting cyclotron for hard-on therapy[C].The 19th International Conference on Cyclotrons and their Applications,CYCLOTRONS'12.2010:328-345.
[29]肖国青,张红,李强,等.中国科学院近代物理研究所重离子束致癌进展[J].原子核物理评论,2007,24(2):85-88.
[30]陈文军,马力祯,蔡国柱,等.武威医用重离子加速器同步环的准直安装[J].原子核物理评论,2016,33(3):297.
[31]李敏.HIMM束流诊断前端控制系统的设计与实现[D].兰州:中国科学院近代物理研究所,2015.
[32]Particle Therapy Co-operative Group[R/OL].[2018-05-25].https://www.ptcog.ch/index.php/facilities-in-operation.
[33]FLANZ J,OWEN H,SCHIPPERS M.Report on workshop:modern hadron therapy gantry developments[R].Technical Report CERN-ACC-NOTE-2014-0088,CE-RN,2014.
[34]LINZ U,ALONSO J.What will it take for laser driven proton accelerators to be applied to tumor therapy?[J].Phys Rev Spec Top-AC,2007,10(10):1-8.
[35]张新民.智能材料研究进展[J].玻璃钢/复合材料,2013(Z2):57-63.