建立实验性家兔高镁血症模型的研究
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摘要
目的研究探讨实验性家兔高镁血症模型的建造方法。方法健康实验家兔随机分为对照组和实验组,实验组家兔采用不同的给药速度,观察家兔呼吸、血压和心电的变化。通过统计计算来确定高镁血症造模的最佳速度。结果给药速度约为0.38mmol/kg.min造模成功率高于其他组别。结论造模采用1.9ml/kg的10%MgCl2溶液5min内注入成功率最高。
Objective To establish the method of building the model of hypermagnesemia in experimental rabbits.Methods The healthy experimental rabbits were divided randomly in to the control group and the experimental group.Different injection speed was performed in different experimental group.The changes of blood pressure,respiration and ECG were observed,and the optimal injection speed of building hypermagnesemia model was obtained.Results 0.38mmol/kg.min was the best injection speed which have higher success rate of building hypermagnesemia model than that of other speed.Conclusion Injecting 1.9ml/kg of 10% MgCl2 solution via vein in 5 min could have the highest success rate in building hypermagnesemia model.
Objective To establish the method of building the model of hypermagnesemia in experimental rabbits.Methods The healthy experimental rabbits were divided randomly in to the control group and the experimental group.Different injection speed was performed in different experimental group.The changes of blood pressure,respiration and ECG were observed,and the optimal injection speed of building hypermagnesemia model was obtained.Results 0.38mmol/kg.min was the best injection speed which have higher success rate of building hypermagnesemia model than that of other speed.Conclusion Injecting 1.9ml/kg of 10% MgCl2 solution via vein in 5 min could have the highest success rate in building hypermagnesemia model.
引文
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[2]王玉柱,明英姿,万齐全.连续型血液过滤致高镁血症一例报告[J].透析与人工器官,2007,18(1):7-8.
[3]赵贵卿,王化洲,高东明,等.氯化镁对正常兔血流动力学的影响[J].中国药学杂志,1999,34(2):109.
[4]杨正望,周芳,谈珍瑜,等.不同造模方法对大鼠多囊卵巢综合征模型的影响[J].中国实验动物学报,2010,18(1):13-14.
[5]金惠明,王建枝.病理生理学[M].第7版.北京:人民卫生出版社,2010:39-40.
[6]黄泽炳,肖剑锋,沈建新.镁对心肌细胞钾通道和钙通道的调节[J].医学综述,2010,16(1):19-22.
[7]宋文慧.酶法测定镁离子的方法学研究[J].实验与检验医学,2008,26(3):293-294.
[8]钟月华.血糖、血镁指标对颅脑损伤预后的分析[J].实验与检验医学,2010,28(4):414.