直肠镜下取肠液隐血检测和常规粪便隐血检测的差异分析
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摘要
目的对比评价直肠镜下取肠液检测隐血和粪便隐血检测,揭示直肠镜下取肠液检测隐血和粪便隐血检测的差异所在。方法对本院1380例健康体检人群行粪便血红蛋白测定以及直肠镜检查和肠液血红蛋白测定,并对结果进行分析。结果体检人群中粪便血红蛋白的阳性率为13.77%,肠液血红蛋白的阳性率为3.12%,查出直肠息肉的有41例。结论粪便隐血检测是消化道出血筛查的重要方法,但是容易受到肛周出血性疾病如痔疮、肛裂的影响出现假阳性。同时因为粪便隐血检查的标本依靠受检者自主排便获得,标本在肠道中存留时间过长,容易受消化酶和肠道细菌作用,或者少量消化道出血与粪便混合不匀,取样不足的情况下容易检测出现假阴性。肠液血红蛋白的检测能避免这些因素的影响,得出不一样的结论。
Objective To compare and evaluate the data of occult blood test by collecting intestinal fluid under colonoscope and stool occult blood test, and to reveal the difference between occult blood test by collecting intestinal fluid under colonoscope and stool occult blood test. Methods A total of 1380 people receiving physical examination in our hospital were given stool hemoglobin determination, and were also given colonoscopy and intestinal fluid hemoglobin determination. The results were analyzed. Results The positive rate of stool hemoglobin in the physical examination people was 13.77%, and the positive rate of intestinal fluid hemoglobin was 3.12%. There were 41 cases with rectal polyps. Conclusion Stool occult blood test is an important method of screening for gastrointestinal bleeding, but is vulnerable to perianal hemorrhagic diseases such as hemorrhoids, anal fissure and other diseases to appear false positive results. At the same time, because the specimens of stool occult blood test are obtained depending on the subjects to defecate dependently, the specimens may be susceptible to digestive enzymes and intestinal bacteria if they stay in the intestine for too long. Or there may be a small amount of gastrointestinal bleeding and uneven mixing of stools, and thus a false negative result may be obtained if the specimens are insufficient. Intestinal fluid hemoglobin test can avoid the impact of these factors, coming into a different conclusion.
Objective To compare and evaluate the data of occult blood test by collecting intestinal fluid under colonoscope and stool occult blood test, and to reveal the difference between occult blood test by collecting intestinal fluid under colonoscope and stool occult blood test. Methods A total of 1380 people receiving physical examination in our hospital were given stool hemoglobin determination, and were also given colonoscopy and intestinal fluid hemoglobin determination. The results were analyzed. Results The positive rate of stool hemoglobin in the physical examination people was 13.77%, and the positive rate of intestinal fluid hemoglobin was 3.12%. There were 41 cases with rectal polyps. Conclusion Stool occult blood test is an important method of screening for gastrointestinal bleeding, but is vulnerable to perianal hemorrhagic diseases such as hemorrhoids, anal fissure and other diseases to appear false positive results. At the same time, because the specimens of stool occult blood test are obtained depending on the subjects to defecate dependently, the specimens may be susceptible to digestive enzymes and intestinal bacteria if they stay in the intestine for too long. Or there may be a small amount of gastrointestinal bleeding and uneven mixing of stools, and thus a false negative result may be obtained if the specimens are insufficient. Intestinal fluid hemoglobin test can avoid the impact of these factors, coming into a different conclusion.
引文
[1]翟爱军,陈洪,王贵齐,等.三种结直肠癌筛查方法比较研究[J].中国全科医学,2016,9(2):170-173.
[2]黄寅,李腾庆,曹海丹,等.粪隐血试验和血清标志物检查在大肠癌早期筛查中的价值评估[J].现代医院,2017,17(2):290-291.
[3]黄珏,田相龙,宋冬霞.大便隐血与大肠疾病关系的研究[J].中国当代医药,2014,21(35):163-165.
[4]李少辉,张玉春.自动大便仪免疫胶体金法与匹拉米洞法大便隐血结果的对比分析[J].实用医技杂志,2016,23(7):728-729.
[5]杨琳,卢仁泉,郭林,等.胶体金法粪便隐血检测试剂的性能检测及初步临床应用评估[J].检验医学,2012,27(8):671-673.
[6]杜鹏.不同方法对大便隐血试验结果的影响[J].实用医技杂志,2015,22,(8):858-859.
[7]付明生,蔡勋全,冯洁,等.粪便隐血试验联合结肠镜序贯筛查社区结直肠癌的流行病学分析[J].胃肠病学,2016,21(9):542-544.
[8]陈耀明,顾滔,施杨丽.FOBT阳性人群结肠镜二次筛查结直肠癌的效果分析[J].实用临床医药杂志,2015,19(5):53-55.
[9]朱景新,黄文兰,徐永正.上海远郊奉贤东部地区大肠癌筛查分析[J].上海医药,2016,37(6):57-58.
[10]李静丹,贾铁钢,张景丹.胶体金法检测粪便隐血的假阴性分析[J].临床医药文献杂志,2016,3(28):5687-5690.
[11]文永,徐艳.粪便隐血试验不同检测方法的比较和应用[J].国际检验医学杂志,2015,36(21):3170-3171.
[12]王建刚.胶体金法检测粪便隐血试验假阴性的原因与应对方法的探讨[J].中国现代药物应用,2015,9(10):245.
[13]陈德林,周得维.大便潜血FOB胶体金法的检测范围及灵敏度测定[J].当代医学,2013,19(16):18-19.
[14]张朝阳.胶体金法测粪便隐血的假阴性分析[J].检验医学与临床,2012,9,(14):1762-1763.
[15]姚晓宾,王丹,马卫国,等.不同稀释液对免疫层析法粪便隐血试验的影响[J].河南大学学报(医学版),2015,34(1):40-42.
[2]黄寅,李腾庆,曹海丹,等.粪隐血试验和血清标志物检查在大肠癌早期筛查中的价值评估[J].现代医院,2017,17(2):290-291.
[3]黄珏,田相龙,宋冬霞.大便隐血与大肠疾病关系的研究[J].中国当代医药,2014,21(35):163-165.
[4]李少辉,张玉春.自动大便仪免疫胶体金法与匹拉米洞法大便隐血结果的对比分析[J].实用医技杂志,2016,23(7):728-729.
[5]杨琳,卢仁泉,郭林,等.胶体金法粪便隐血检测试剂的性能检测及初步临床应用评估[J].检验医学,2012,27(8):671-673.
[6]杜鹏.不同方法对大便隐血试验结果的影响[J].实用医技杂志,2015,22,(8):858-859.
[7]付明生,蔡勋全,冯洁,等.粪便隐血试验联合结肠镜序贯筛查社区结直肠癌的流行病学分析[J].胃肠病学,2016,21(9):542-544.
[8]陈耀明,顾滔,施杨丽.FOBT阳性人群结肠镜二次筛查结直肠癌的效果分析[J].实用临床医药杂志,2015,19(5):53-55.
[9]朱景新,黄文兰,徐永正.上海远郊奉贤东部地区大肠癌筛查分析[J].上海医药,2016,37(6):57-58.
[10]李静丹,贾铁钢,张景丹.胶体金法检测粪便隐血的假阴性分析[J].临床医药文献杂志,2016,3(28):5687-5690.
[11]文永,徐艳.粪便隐血试验不同检测方法的比较和应用[J].国际检验医学杂志,2015,36(21):3170-3171.
[12]王建刚.胶体金法检测粪便隐血试验假阴性的原因与应对方法的探讨[J].中国现代药物应用,2015,9(10):245.
[13]陈德林,周得维.大便潜血FOB胶体金法的检测范围及灵敏度测定[J].当代医学,2013,19(16):18-19.
[14]张朝阳.胶体金法测粪便隐血的假阴性分析[J].检验医学与临床,2012,9,(14):1762-1763.
[15]姚晓宾,王丹,马卫国,等.不同稀释液对免疫层析法粪便隐血试验的影响[J].河南大学学报(医学版),2015,34(1):40-42.