啮齿动物痉挛模型常用的评定方法
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摘要
为了探讨痉挛的机制以及生理病理变化,常需要建立相应的实验动物痉挛模型。啮齿动物痉挛模型的定量评价不仅可以评价造模是否成功,还是量化干预手段效果的主要指标之一。本文就常用的啮齿动物痉挛评定方法进行综述。
In order to explore the mechanism and physiological and pathological changes of spasm, it is often necessary to establish corresponding experimental animal spasm models. The quantitative evaluation of rodent spasm model can not only evaluate the success of modeling, but also can be one of the main quantitative indicators of the effect of intervention. This paper summarized the commonly used methods of rodent spasm evaluation.
In order to explore the mechanism and physiological and pathological changes of spasm, it is often necessary to establish corresponding experimental animal spasm models. The quantitative evaluation of rodent spasm model can not only evaluate the success of modeling, but also can be one of the main quantitative indicators of the effect of intervention. This paper summarized the commonly used methods of rodent spasm evaluation.
引文
[1] Foran J R, Steinman S, Barash I, et al. Structural and mechanical alterations in spastic skeletal muscle[J]. Dev Med Child Neurol, 2005, 47(10):713-717.
[2] Mayer N H. Clinicophysiologic concepts of spasticity and motor dysfunction in adults with an upper motoneuron lesion[J].Muscle Nerve Suppl, 1997, 6(S6):S1-S13.
[3] Lance J W. Symposium synopsis[M]//Feldman R G, Young R R, Koella W P. Spasticity:Disordered Motor Control. Miami,FL:Year Book Medical Publishers, 1980:485-494.
[4] Sommerfeld D K, Eek E U, Svensson A K, et al. Spasticity after stroke:its occurrence and association with motor impairments and activity limitations[J]. Stroke, 2004, 35(1):134-139.
[5] Faherty C J, Earley B, Leonard B E. Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat[J]. J Psychopharmacol, 1997, 11(1):53-58.
[6] Watanabe F, Arnold W D, Hammer R E, et al. Pathogenesis of autosomal dominant hereditary spastic paraplegia(SPG6)revealed by a rat model[J]. J Neuropathol Exp Neurol, 2013, 72(11):1016-1028.
[7] Harris R L, Bobet J, Sanelli L, et al. Tail muscles become slow but fatigable in chronic sacral spinal rats with spasticity[J]. J Neurophysiol, 2006, 95(2):1124-1133.
[8] Bennett D J, Gorassini M, Fouad K, et al. Spasticity in rats with sacral spinal cord injury[J]. J Neurotrauma, 1999, 16(1):69-84.
[9]王杰,敖丽娟,李咏梅,等.大鼠脊髓源性痉挛模型的建立和评价[J].中国康复医学杂志, 2011, 26(6):585-587.
[10]张艳宏,刘保延,赵宏,等.脑卒中痉挛性瘫痪特点及其评定进展[J].中国康复理论与实践, 2008, 14(2):110-112.
[11] Shi G X, Yang C Y, Wu M M, et al. Muscle hypertonia after permanent focal cerebral ischemia in rats:a qualitative and quantitative behavioral and electrophysiological study[J]. Int J Neurosci, 2013, 123(8):575-581.
[12] Lee S, Toda T, Kiyama H, et al. Weakened rate-dependent depression of Hoffmann's reflex and increased motoneuron hyperactivity after motor cortical infarction in mice[J]. Cell Death Dis, 2014, 5(1):e1007.
[13] Escobar-Corona C, Torres-Castillo S, Rodriguez-Torres E E,et al. Electroacupuncture improves gait locomotion, H-reflex and ventral root potentials of spinal compression injured rats[J]. Brain Res Bull, 2017, 131:7-17.
[14] Cordero K, Coronel G G, Serrano-Illan M, et al. Effects of dietary vitamin E supplementation in bladder function and spasticity during spinal cord injury[J]. Brain Sci, 2018, 8(3):38.
[15]宗海洋,马芬芬,林耀发,等.光化学损伤单侧运动皮质致大鼠后肢痉挛性偏瘫模型的建立[J].第二军医大学学报, 2016,37(8):925-930.
[16]张京,肖娟,杨远滨.肌肉结构参数模型在中枢神经系统所致肌张力异常评价中的作用和分析[J].中国康复医学杂志,2015, 30(4):408-411.
[17]刘琦,吴长君.超声在肌肉骨骼系统中应用的研究进展[J].医学综述, 2017, 23(12):2433-2437.
[18]钟冬灵,杨璐萍,胡益娟,等.超声弹性成像在肌肉痉挛评定中的应用进展[J].中国康复理论与实践, 2018, 24(7):815-818.
[19] Johannsen S, Schick M, Roewer N, et al. Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats[J]. BMC Res Notes, 2018, 11(1):636.
[20] Wijesinghe P, McLaughlin R A, Sampson D D, et al. Parametric imaging of viscoelasticity using optical coherence elastography[J]. Phys Med Biol, 2015, 60(6):2293-2307.
[21] Jiang L, Wang Y J, Wang Q Y, et al. Correlation between pathological characteristics and Young's modulus value of spastic gastrocnemius in a spinal cord injury rat model[J]. 2017,2017:5387948.
[22] Thompson F J, Browd C R, Carvalho P M, et al. Velocity-dependent ankle torque in the normal rat[J]. Neuroreport, 1996, 7(14):2273-2276.
[23] van Gorp S, Deumens R, Leerink M, et al. Translation of the rat thoracic contusion model; part 1-supraspinally versus spinally mediated pain-like responses and spasticity[J]. Spinal Cord,2014, 52(7):524-528.
[24] Wang D C, Bose P, Parmer R, et al. Chronic intrathecal baclofen treatment and withdrawal:I. Changes in ankle torque and hind limb posture in normal rats[J]. J Neurotrauma, 2002,19(7):875-886.
[25] Bose P, Parmer R, Thompson F J. Velocity-dependent ankle torque in rats after contusion injury of the midthoracic spinal cord:time course[J]. J Neurotrauma, 2002, 19(10):1231-1249.
[26] van Gorp S, Leerink M, Kakinohana O, et al. Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation[J]. Stem Cell Res Ther, 2013, 4(3):57.
[27] Chen Y J, Cheng F C, Sheu M L, et al. Detection of subtle neurological alterations by the Catwalk XT gait analysis system[J]. J Neuroeng Rehabil, 2014, 11(1):62.
[28] Beare J E, Morehouse J R, DeVries W H, et al. Gait analysis in normal and spinal contused mice using the TreadScan system[J]. J Neurotrauma, 2009, 26(11):2045-2056.
[29]汤浩,项永生,郭阳,等. CatWalk步态分析系统分析大鼠大脑中动脉阻塞模型的行为学特征[J].中华神经医学杂志,2011, 10(12):1243-1249.
[30] Harada S, Yamazaki Y, Nishioka H, et al. Neuroprotective effect through the cerebral sodium-glucose transporter on the development of ischemic damage in global ischemia[J]. Brain Res, 2013, 1541:61-68.
[31] Meier C, Middelanis J, Wasielewski B, et al. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells[J]. Pediatr Res, 2006, 59(2):244-249.
[32] Zong H, Ma F, Zhang L, et al. Hindlimb spasticity after unilateral motor cortex lesion in rats is reduced by contralateral nerve root transfer[J]. Biosci Rep, 2016, 36(6):e00430.
[33] Smith R R, Burke D A, Baldini A D, et al. The Louisville Swim Scale:a novel assessment of hindlimb function following spinal cord injury in adult rats[J]. J Neurotrauma, 2006, 23(11):1654-1670.
[34] Ryu Y, Ogata T, Nagao M, et al. The swimming test is effective for evaluating spasticity after contusive spinal cord injury[J]. PLoS One, 2017, 12(2):e0171937.
[35] Thibaut F A, Chatelle C, Wannez S, et al. Spasticity in disorders of consciousness:a behavioral study[J]. Eur J Phys Rehabil Med, 2015, 51(4):389-397.
[2] Mayer N H. Clinicophysiologic concepts of spasticity and motor dysfunction in adults with an upper motoneuron lesion[J].Muscle Nerve Suppl, 1997, 6(S6):S1-S13.
[3] Lance J W. Symposium synopsis[M]//Feldman R G, Young R R, Koella W P. Spasticity:Disordered Motor Control. Miami,FL:Year Book Medical Publishers, 1980:485-494.
[4] Sommerfeld D K, Eek E U, Svensson A K, et al. Spasticity after stroke:its occurrence and association with motor impairments and activity limitations[J]. Stroke, 2004, 35(1):134-139.
[5] Faherty C J, Earley B, Leonard B E. Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat[J]. J Psychopharmacol, 1997, 11(1):53-58.
[6] Watanabe F, Arnold W D, Hammer R E, et al. Pathogenesis of autosomal dominant hereditary spastic paraplegia(SPG6)revealed by a rat model[J]. J Neuropathol Exp Neurol, 2013, 72(11):1016-1028.
[7] Harris R L, Bobet J, Sanelli L, et al. Tail muscles become slow but fatigable in chronic sacral spinal rats with spasticity[J]. J Neurophysiol, 2006, 95(2):1124-1133.
[8] Bennett D J, Gorassini M, Fouad K, et al. Spasticity in rats with sacral spinal cord injury[J]. J Neurotrauma, 1999, 16(1):69-84.
[9]王杰,敖丽娟,李咏梅,等.大鼠脊髓源性痉挛模型的建立和评价[J].中国康复医学杂志, 2011, 26(6):585-587.
[10]张艳宏,刘保延,赵宏,等.脑卒中痉挛性瘫痪特点及其评定进展[J].中国康复理论与实践, 2008, 14(2):110-112.
[11] Shi G X, Yang C Y, Wu M M, et al. Muscle hypertonia after permanent focal cerebral ischemia in rats:a qualitative and quantitative behavioral and electrophysiological study[J]. Int J Neurosci, 2013, 123(8):575-581.
[12] Lee S, Toda T, Kiyama H, et al. Weakened rate-dependent depression of Hoffmann's reflex and increased motoneuron hyperactivity after motor cortical infarction in mice[J]. Cell Death Dis, 2014, 5(1):e1007.
[13] Escobar-Corona C, Torres-Castillo S, Rodriguez-Torres E E,et al. Electroacupuncture improves gait locomotion, H-reflex and ventral root potentials of spinal compression injured rats[J]. Brain Res Bull, 2017, 131:7-17.
[14] Cordero K, Coronel G G, Serrano-Illan M, et al. Effects of dietary vitamin E supplementation in bladder function and spasticity during spinal cord injury[J]. Brain Sci, 2018, 8(3):38.
[15]宗海洋,马芬芬,林耀发,等.光化学损伤单侧运动皮质致大鼠后肢痉挛性偏瘫模型的建立[J].第二军医大学学报, 2016,37(8):925-930.
[16]张京,肖娟,杨远滨.肌肉结构参数模型在中枢神经系统所致肌张力异常评价中的作用和分析[J].中国康复医学杂志,2015, 30(4):408-411.
[17]刘琦,吴长君.超声在肌肉骨骼系统中应用的研究进展[J].医学综述, 2017, 23(12):2433-2437.
[18]钟冬灵,杨璐萍,胡益娟,等.超声弹性成像在肌肉痉挛评定中的应用进展[J].中国康复理论与实践, 2018, 24(7):815-818.
[19] Johannsen S, Schick M, Roewer N, et al. Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats[J]. BMC Res Notes, 2018, 11(1):636.
[20] Wijesinghe P, McLaughlin R A, Sampson D D, et al. Parametric imaging of viscoelasticity using optical coherence elastography[J]. Phys Med Biol, 2015, 60(6):2293-2307.
[21] Jiang L, Wang Y J, Wang Q Y, et al. Correlation between pathological characteristics and Young's modulus value of spastic gastrocnemius in a spinal cord injury rat model[J]. 2017,2017:5387948.
[22] Thompson F J, Browd C R, Carvalho P M, et al. Velocity-dependent ankle torque in the normal rat[J]. Neuroreport, 1996, 7(14):2273-2276.
[23] van Gorp S, Deumens R, Leerink M, et al. Translation of the rat thoracic contusion model; part 1-supraspinally versus spinally mediated pain-like responses and spasticity[J]. Spinal Cord,2014, 52(7):524-528.
[24] Wang D C, Bose P, Parmer R, et al. Chronic intrathecal baclofen treatment and withdrawal:I. Changes in ankle torque and hind limb posture in normal rats[J]. J Neurotrauma, 2002,19(7):875-886.
[25] Bose P, Parmer R, Thompson F J. Velocity-dependent ankle torque in rats after contusion injury of the midthoracic spinal cord:time course[J]. J Neurotrauma, 2002, 19(10):1231-1249.
[26] van Gorp S, Leerink M, Kakinohana O, et al. Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation[J]. Stem Cell Res Ther, 2013, 4(3):57.
[27] Chen Y J, Cheng F C, Sheu M L, et al. Detection of subtle neurological alterations by the Catwalk XT gait analysis system[J]. J Neuroeng Rehabil, 2014, 11(1):62.
[28] Beare J E, Morehouse J R, DeVries W H, et al. Gait analysis in normal and spinal contused mice using the TreadScan system[J]. J Neurotrauma, 2009, 26(11):2045-2056.
[29]汤浩,项永生,郭阳,等. CatWalk步态分析系统分析大鼠大脑中动脉阻塞模型的行为学特征[J].中华神经医学杂志,2011, 10(12):1243-1249.
[30] Harada S, Yamazaki Y, Nishioka H, et al. Neuroprotective effect through the cerebral sodium-glucose transporter on the development of ischemic damage in global ischemia[J]. Brain Res, 2013, 1541:61-68.
[31] Meier C, Middelanis J, Wasielewski B, et al. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells[J]. Pediatr Res, 2006, 59(2):244-249.
[32] Zong H, Ma F, Zhang L, et al. Hindlimb spasticity after unilateral motor cortex lesion in rats is reduced by contralateral nerve root transfer[J]. Biosci Rep, 2016, 36(6):e00430.
[33] Smith R R, Burke D A, Baldini A D, et al. The Louisville Swim Scale:a novel assessment of hindlimb function following spinal cord injury in adult rats[J]. J Neurotrauma, 2006, 23(11):1654-1670.
[34] Ryu Y, Ogata T, Nagao M, et al. The swimming test is effective for evaluating spasticity after contusive spinal cord injury[J]. PLoS One, 2017, 12(2):e0171937.
[35] Thibaut F A, Chatelle C, Wannez S, et al. Spasticity in disorders of consciousness:a behavioral study[J]. Eur J Phys Rehabil Med, 2015, 51(4):389-397.