硫丹暴露与人类癌症的相关性研究进展
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摘要
硫丹是一种有机氯类杀虫剂,属于持久性有机污染物(POPs)。目前已有多项研究表明硫丹具有持久性、生物富集性、高生物毒性等特性,且具有潜在的致癌性,会对环境和人类的健康产生长久的影响,因而不容忽视。总结了近年来有关硫丹的环境污染特性、暴露浓度和基于流行病学研究发现对人类健康的危害,着重对硫丹潜在的致癌性研究结果进行了归纳和分析,这将为今后揭示以硫丹为代表的农药与人类癌症发生发展的关系提供重要的参考价值。
Endosulfan is an organochlorine insecticide, classified as persistent organic pollutants(POPs). At present, a number of studies have shown that endosulfan is characterized by persistence, bioaccumulation, high toxicity and potential carcinogenicity. It can not be ignored because it will have a long-term impact on the environment and human health. The review summarizes the environmental pollution characteristics, exposure concentration and the harmful health effects of endosulfan based on epidemiological investigation, focused on the potential carcinogenicity of endosulfan, and reviewed the research findings. It will provide important reference value for revealing the relationship between exposure to pesticides represented by endosulfan and the occurrence and development of human cancer in the future.
Endosulfan is an organochlorine insecticide, classified as persistent organic pollutants(POPs). At present, a number of studies have shown that endosulfan is characterized by persistence, bioaccumulation, high toxicity and potential carcinogenicity. It can not be ignored because it will have a long-term impact on the environment and human health. The review summarizes the environmental pollution characteristics, exposure concentration and the harmful health effects of endosulfan based on epidemiological investigation, focused on the potential carcinogenicity of endosulfan, and reviewed the research findings. It will provide important reference value for revealing the relationship between exposure to pesticides represented by endosulfan and the occurrence and development of human cancer in the future.
引文
[1]TIAN Wen-jing,FU Hua-ling,XU Tuan,et al.SLC6A19 is a Novel Putative Gene,Induced by Dioxins via AhR in Human Hepatoma HepG2 Cells[J].Environmental Pollution,2018,237(6):508-514.
[2]WANG Yu-xin,WANG Ya-wen,LIU Zi-xuan,et al.Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor kappaB-Matrix Metalloproteinase Signaling[J].Chemical Research in Toxicology,2018,31(9):954-963.
[3]CHATTERJEE S,CHAKRABORTY A,SINHA S K.Spatial Distribution&Physicochemical Characterization of the Breeding Habitats of Aedes Aegypti in&Around Kolkata,West Bengal,India[J].The Indian Journal of Medical Research,2015,142(7):S79-86.
[4]LI Yuan,ZHANG Hai-bo,LI Qing-bo,et al.Characteristics of Residual Organochlorine Pesticides in Soils under Different Land-use Types on a Coastal Plain of the Yellow River Delta[J].Environmental Geochemistry and Health,2016,38(2):535-547.
[5]CANTU-SOTO E U,MEZA-MONTENEGRO M M,VALENZUELA-QUINTANAR A I,et al.Residues of Organochlorine Pesticides in Soils from the Southern Sonora,Mexico[J].Bull Environ Contam Toxicol,2011,87(5):556-60.
[6]QIU Xing-hua,ZHU Tong,WANG Feng,et al.Air-water Gas Exchange of Organochlorine Pesticides in Taihu Lake,China[J].Environmental Science&Technology,2008,42(6):1928-1932.
[7]WESTMAN DE-JONG A,ELLIOTT J,CHENG K,et al.Effects of Environmentally Relevant Concentrations of Endosulfan,Azinphosmethyl,and Diazinon on Great Basin Spadefoot(Spea intermontana)and Pacific Treefrog(Pseudacris regilla)[J].Environmental Toxicology and Chemistry,2010,29(7):1604-1612.
[8]ANTONELLA D R,ROSSINI C,RIVERSO C,et al.Endosulfan Poisoning in Canids and Felids in the Calabria Region of Southern Italy[J].Journal of Veterinary Diagnostic Investigation,2017,29(1):122-125.
[9]UNYIMADU J P,OSIBANJO O,BABAYEMI J O.Levels of Organochlorine Pesticides in Brackish Water Fish from Niger River,Nigeria[J].Journal of Environmental and Public Health,2018,28(6):2658306.
[10]GHOSH R,SIDDHARTH M,SINGH N,et al.Organochlorine Pesticide-Mediated Induction of NADPH Oxidase and NitricOxide Synthase in Endothelial Cell[J].Journal of Clinical and Diagnostic Research,2017,11(1):Bc09-bc12.
[11]SINGH N D,SHARMA A K,DWIVEDI P,et al.Citrinin and Endosulfan Induced Teratogenic Effects in Wistar Rats[J].Journal of Applied Toxicology,2007,27(2):143-151.
[12]US EPA.EPA 738-R-02-013.Reregistration Eligibility Decision for Endosulfan Archived 2006-10-06 at the Wayback Machine[S].United States:2002.
[13]POLANCO R A,RIBA L M,DELVALLS C T,et al.Monitoring of Organochlorine Pesticides in Blood of Women with Uterine Cervix Cancer[J].Environmental Pollution,2017,220(Pt B):853-862.
[14]RAU A T,COUTINHO A,AVABRATHA K S,et al.Pesticide(Endosulfan)Levels in the Bone Marrow of Children with Hematological Malignancies[J].Indian Pediatrics,2012,49(2):113-117.
[15]BAND P R,ABANTO Z,BERT J,et al.Prostate Cancer Risk and Exposure to Pesticides in British Columbia Farmers[J].The Prostate,2011,71(2):168-183.
[16]GHOSH K,CHATTERIEE B,JAYAPRASAD A G,et al.The Persistent Organochlorine Pesticide Endosulfan Modulates Multiple Epigenetic Regulators with Oncogenic Potential in MCF-7Cells[J].The Science of the Total Environment,2018,624(10):1612-1622.
[17]XU Dan,LI Shuai,LIN Li-mei,et al.Gene Expression Profiling to Identify the Toxicities and Potentially Relevant Disease Outcomes due to Endosulfan Exposure[J].Toxicology Research,2016,5(2):621-632.
[18]LU Yu-quan,MORIMOTO K,TAKESHITA T,et al.Genotoxic Effects of Alpha-endosulfan and Beta-endosulfan on Human Hep G2 Cells[J].Environmental Health Perspectives,2000,108(6):559-561.
[19]PEYRE L,ZUCCHINI-PASCAL N,DE SOUSA G,et al.Effects of Endosulfan on Hepatoma Cell Adhesion:Epithelial-mesenchymal Transition and Anoikis Resistance[J].Toxicology,2012,300(1/2):19-30.
[20]PEYRE L,ZUCCHINI-PASCAL N,DE SOUSA G,et al.Potential Involvement of Chemicals in Liver Cancer Progression:an Alternative Toxicological Approach Combining Biomarkers and Innovative Technologies[J].Toxicology in vitro,2014,28(8):1507-1520.
[21]SEBASTIAN R,RAGHAVAN S.Induction of DNA Damage and Erroneous Repair can Explain Genomic Instability Caused by Endosulfan[J].Carcinogenesis,2016,37(10):929-940.
[22]XU Dan,LIANG Dong,GUO Yu-bing,et al.Endosulfan Causes the Alterations of DNA Damage Response through ATM-p53Signaling Pathway in Human Leukemia Cells[J].Environmental Pollution,2018,238(6):1048-1055.
[2]WANG Yu-xin,WANG Ya-wen,LIU Zi-xuan,et al.Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor kappaB-Matrix Metalloproteinase Signaling[J].Chemical Research in Toxicology,2018,31(9):954-963.
[3]CHATTERJEE S,CHAKRABORTY A,SINHA S K.Spatial Distribution&Physicochemical Characterization of the Breeding Habitats of Aedes Aegypti in&Around Kolkata,West Bengal,India[J].The Indian Journal of Medical Research,2015,142(7):S79-86.
[4]LI Yuan,ZHANG Hai-bo,LI Qing-bo,et al.Characteristics of Residual Organochlorine Pesticides in Soils under Different Land-use Types on a Coastal Plain of the Yellow River Delta[J].Environmental Geochemistry and Health,2016,38(2):535-547.
[5]CANTU-SOTO E U,MEZA-MONTENEGRO M M,VALENZUELA-QUINTANAR A I,et al.Residues of Organochlorine Pesticides in Soils from the Southern Sonora,Mexico[J].Bull Environ Contam Toxicol,2011,87(5):556-60.
[6]QIU Xing-hua,ZHU Tong,WANG Feng,et al.Air-water Gas Exchange of Organochlorine Pesticides in Taihu Lake,China[J].Environmental Science&Technology,2008,42(6):1928-1932.
[7]WESTMAN DE-JONG A,ELLIOTT J,CHENG K,et al.Effects of Environmentally Relevant Concentrations of Endosulfan,Azinphosmethyl,and Diazinon on Great Basin Spadefoot(Spea intermontana)and Pacific Treefrog(Pseudacris regilla)[J].Environmental Toxicology and Chemistry,2010,29(7):1604-1612.
[8]ANTONELLA D R,ROSSINI C,RIVERSO C,et al.Endosulfan Poisoning in Canids and Felids in the Calabria Region of Southern Italy[J].Journal of Veterinary Diagnostic Investigation,2017,29(1):122-125.
[9]UNYIMADU J P,OSIBANJO O,BABAYEMI J O.Levels of Organochlorine Pesticides in Brackish Water Fish from Niger River,Nigeria[J].Journal of Environmental and Public Health,2018,28(6):2658306.
[10]GHOSH R,SIDDHARTH M,SINGH N,et al.Organochlorine Pesticide-Mediated Induction of NADPH Oxidase and NitricOxide Synthase in Endothelial Cell[J].Journal of Clinical and Diagnostic Research,2017,11(1):Bc09-bc12.
[11]SINGH N D,SHARMA A K,DWIVEDI P,et al.Citrinin and Endosulfan Induced Teratogenic Effects in Wistar Rats[J].Journal of Applied Toxicology,2007,27(2):143-151.
[12]US EPA.EPA 738-R-02-013.Reregistration Eligibility Decision for Endosulfan Archived 2006-10-06 at the Wayback Machine[S].United States:2002.
[13]POLANCO R A,RIBA L M,DELVALLS C T,et al.Monitoring of Organochlorine Pesticides in Blood of Women with Uterine Cervix Cancer[J].Environmental Pollution,2017,220(Pt B):853-862.
[14]RAU A T,COUTINHO A,AVABRATHA K S,et al.Pesticide(Endosulfan)Levels in the Bone Marrow of Children with Hematological Malignancies[J].Indian Pediatrics,2012,49(2):113-117.
[15]BAND P R,ABANTO Z,BERT J,et al.Prostate Cancer Risk and Exposure to Pesticides in British Columbia Farmers[J].The Prostate,2011,71(2):168-183.
[16]GHOSH K,CHATTERIEE B,JAYAPRASAD A G,et al.The Persistent Organochlorine Pesticide Endosulfan Modulates Multiple Epigenetic Regulators with Oncogenic Potential in MCF-7Cells[J].The Science of the Total Environment,2018,624(10):1612-1622.
[17]XU Dan,LI Shuai,LIN Li-mei,et al.Gene Expression Profiling to Identify the Toxicities and Potentially Relevant Disease Outcomes due to Endosulfan Exposure[J].Toxicology Research,2016,5(2):621-632.
[18]LU Yu-quan,MORIMOTO K,TAKESHITA T,et al.Genotoxic Effects of Alpha-endosulfan and Beta-endosulfan on Human Hep G2 Cells[J].Environmental Health Perspectives,2000,108(6):559-561.
[19]PEYRE L,ZUCCHINI-PASCAL N,DE SOUSA G,et al.Effects of Endosulfan on Hepatoma Cell Adhesion:Epithelial-mesenchymal Transition and Anoikis Resistance[J].Toxicology,2012,300(1/2):19-30.
[20]PEYRE L,ZUCCHINI-PASCAL N,DE SOUSA G,et al.Potential Involvement of Chemicals in Liver Cancer Progression:an Alternative Toxicological Approach Combining Biomarkers and Innovative Technologies[J].Toxicology in vitro,2014,28(8):1507-1520.
[21]SEBASTIAN R,RAGHAVAN S.Induction of DNA Damage and Erroneous Repair can Explain Genomic Instability Caused by Endosulfan[J].Carcinogenesis,2016,37(10):929-940.
[22]XU Dan,LIANG Dong,GUO Yu-bing,et al.Endosulfan Causes the Alterations of DNA Damage Response through ATM-p53Signaling Pathway in Human Leukemia Cells[J].Environmental Pollution,2018,238(6):1048-1055.