用星点设计-效应面法优化聚乙烯醇-盐酸普萘洛尔多孔水凝胶处方
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摘要
目的采用星点设计-效应面法优化聚乙烯醇-盐酸普萘洛尔多孔水凝胶的处方。方法以聚乙烯醇和壳聚糖的用量为考察因素,12 h体外经皮累积渗透量为评价指标,分别用多元线性模型、非线性模型描述考察因素和评价指标之间的关系。根据最佳数学模型绘制效应面和等高线图,确定最优处方。结果非线性模型中二次多项式拟合的相关系数较高,r=0.970 2,按最佳处方制备的多孔水凝胶12 h累积渗透量预测值与理论值偏差为4.32%,模型具有良好的预测性。结论该处方应用本设计方法能实现多指标的同步优化,所建立的模型具有良好的预测性,可用于处方优化。
Objective To optimize the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method.Methods The amount of polyvinyl alcohol and chitosan were taken as the investigation factors,the percutaneous cumulative permeation amount in vitro was used as the evaluation index,and the relationship between the investigation index and the investigation factor were described by the multivariate linear model and the nonlinear model.The optimal formulation was determined by plotting the effect surface and the contour map according to the model.Results The quadratic polynomial fitting in the nonlinear model had a higher complex correlation coefficient,r=0.970 2.The porous hydrogel's 12 h cumulative permeation deviation between the predicted value and the theoretical value was 4.32% which was prepared by optimal formulation,and the model had good predictability.Conclusion The central composite design-response surface method was used to optimize the polyvinyl alcohol-propranolol hydrogel formulation,which could realize the simultaneous optimization of multiple indicators.The established model had good predictability and could be used for formulation optimization.
Objective To optimize the formulation of polyvinyl alcohol-propranolol hydrochloride porous hydrogel by central composite design-response surface method.Methods The amount of polyvinyl alcohol and chitosan were taken as the investigation factors,the percutaneous cumulative permeation amount in vitro was used as the evaluation index,and the relationship between the investigation index and the investigation factor were described by the multivariate linear model and the nonlinear model.The optimal formulation was determined by plotting the effect surface and the contour map according to the model.Results The quadratic polynomial fitting in the nonlinear model had a higher complex correlation coefficient,r=0.970 2.The porous hydrogel's 12 h cumulative permeation deviation between the predicted value and the theoretical value was 4.32% which was prepared by optimal formulation,and the model had good predictability.Conclusion The central composite design-response surface method was used to optimize the polyvinyl alcohol-propranolol hydrogel formulation,which could realize the simultaneous optimization of multiple indicators.The established model had good predictability and could be used for formulation optimization.
引文
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[11] 陈欢欢,昝佳,林莹,等.壳聚糖/聚乙烯醇温敏水凝胶的制备及性质研究[J].清华大学学报(自然科学版),2006,46(6):843-846.
[2] 郑家伟,王绪凯,秦中平,等.口服普萘洛尔治疗婴幼儿血管瘤中国专家共识[J].上海口腔医学,2016,25(3):257-260.
[3] 王琨,陈涛,张雷.普萘洛尔不同使用途径治疗婴幼儿血管瘤疗效对比观察[J].中国卫生标准管理,2015,6(32):129-130.
[4] 陈丽萍.壳聚糖/PVA/明胶复合膜的制备及性能优化[D].哈尔滨:哈尔滨工业大学,2011.
[5] 黄梅.冷冻解冻法聚乙烯醇凝胶体系研究[D].苏州:苏州大学,2012.
[6] PEPPAS N A,STAUFFER S R.Reinforced uncrosslinked poly(vinyl alcohol) gels produced by cyclic freezing-thawing processes:a short review[J].J Control Rel,1991,16(3):305-310.
[7] 李希明.高含水聚乙烯醇弹性体[J].高分子学报,1989,1(5):519-523.
[8] YAO L,SWORDS G A.Hydrogels and methods of making and using same[P].USA:6268405.
[9] ZHANG X,YANG D,NIE J.Chitosan/polyethylene glycol diacrylate films as potential wound dressing material [J].Int J Biol Macromol,2008,43(5):456-462.
[10] 张步宁,崔英德,陈循军,等.甲壳素/壳聚糖医用敷料研究进展[J].化工进展,2008,27(4):520-526.
[11] 陈欢欢,昝佳,林莹,等.壳聚糖/聚乙烯醇温敏水凝胶的制备及性质研究[J].清华大学学报(自然科学版),2006,46(6):843-846.