食源性生物活性肽制备工艺、功能特性及应用研究进展
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摘要
食源性生物活性肽因具有原料广泛、安全性高、效果明显等特点,已成为研究热点。文中重点综述了食源性生物活性肽的制备工艺及功能特性,同时简述了食源性生物活性肽在食品、养殖业及其他领域的应用,并对其发展前景进行了展望。
Food-derived bioactive peptides have become the focus of the research because of its wide source,highly safe and efficiency. This paper reviewed the preparation process and functional characteristics of food-derived bioactive peptides. Meanwhile,applications in food,farming industry and other fields were briefly reviewed. Finally,the development of the prospect of food-derived peptides was also discussed.
Food-derived bioactive peptides have become the focus of the research because of its wide source,highly safe and efficiency. This paper reviewed the preparation process and functional characteristics of food-derived bioactive peptides. Meanwhile,applications in food,farming industry and other fields were briefly reviewed. Finally,the development of the prospect of food-derived peptides was also discussed.
引文
[1]SINGH B P,VIJ S,HATI S.Functional significance of bioactive peptides derived from soybean[J].Peptides,2014,54(2):171-179.
[2]章少在,张少斌.植物源活性肽的研究进展及其吸收机制[J].中国酿造,2011,30(5):1-4.
[3]NONGONIERMA A B,FITZGERALD R J.Biofunctional properties of caseinophosphopeptides in the oral Cavity[J].Caries Research,2012,46(3):234-267.
[4]POWER O,JAKEMAN P,FITZGERALD R J.Antioxidative peptides:enzymatic production,in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides[J].Amino Acids,2013,44(3):797-820.
[5]葛平珍,周才琼.源性活性肽制备与分离纯化的研究进展[J].食品工业科技,2014,35(4):363-368.
[6]UDENIGWE C C,ALUKO R E.Food protein-derived bioactive peptides:production,processing,and potential health benefits[J].Journal of Food Science,2012,77(1):R11-R24.
[7]王丙莲,孟庆军,张利群,等.HPLC-MS/MS在活性多肽检测中的应用[J].食品研究与开发,2007,28(6):159-161.
[8]李建杰,叶磊,荣瑞芬.生物活性肽的酶法制备及分离鉴定研究进展[J].食品研究与开发,2012,33(2):195-199.
[9]BYUN T,KOFOD L,BLINKOVSKY A.Synergistic action of an X-prolyl dipeptidyl aminopeptidase and a non-specific aminopeptidase in protein hydrolysis[J].Journal of Agricultural and Food Chemistry,2001,49(4):2 061-2 063.
[10]程小飞,肖通虎,章表明,等.酶膜反应器及其在生物催化领域的应用[J].高分子通报,2011(8):60-65.
[11]顾浩峰,张富新,张怡,等.乳制品中生物活性肽的研究进展[J].食品工业科技,2013,34(2):370-375+381.
[12]WANG H K,CUI L M,CHEN W,et al.An application in Gouda cheese manufacture for a strain of Lactobacillus helveticus ND01[J].International Journal of Dairy Technology,2011,64(3):386-393.
[13]迟晓星,张涛,王楠.微生物发酵法制备大豆多肽的研究[J].食品科技,2012(2):69-72.
[14]DZIUBA B,DZIUBA M.Milk proteins-derived bioactive peptides in dairy products:molecular,biological and methodological aspects[J].Acta Sci Pol Technol Aliment,2014,13(1):5-25.
[15]孔令明,李芳,陶永霞,等.多肽的功能活性与研究进展[J].中国食品添加剂,2009(3):71-73,67.
[16]KORHONEN H,PIHLANTO A.Food-derived bioactive peptides opportunities for designing future foods[J].Current Pharmaceutical Design,2003,9(16):1 297-1 308.
[17]LUNA-VITAL D A,MOJICA L,GONZALEZ DE MEJIA E,et al.Biological potential of protein hydrolysates and peptides from common bean(Phaseolus vulgaris L.):A review[J].Food Research International,2015,76:39-50.
[18]OSHIMA G,SHIMABUKURO H,NAGASAWA K.Peptide inhibitors of angiotensin converting enzyme in digests of gelation by bacterial collagenase[J].Biochimica Biophysica acta,1979,566(1):128-137.
[19]BALTI R,BOUGATEF A,SILA A,et al.Nine novel angiotensin I-converting enzyme(ACE)inhibitory peptides from cuttlefish(Sepia officinalis)muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats[J].Food chemistry,2015,170:519-525.
[20]GIRGIH A T,UDENIGWE C C,LI H,et al.Kinetics of enzyme inhibition and antihypertensive effects of hemp seed(Cannabis sativa L.)protein hydrolysates[J].Journal of the American Oil Chemists'Society,2011,88(11):1 767-1 774.
[21]SARMADI B H,ISMAIL A.Antioxidative peptides from food proteins:A review[J].Peptides,2010,31(10):1 949-1 956.
[22]张晖,唐文婷,王立,等.抗氧化肽的构效关系研究进展[J].食品与生物技术学报,2013,32(7):673-679.
[23]徐力,李相鲁,吴晓霞,等.一种新的玉米抗氧化肽的制备与结构表征[J].高等学校化学学报,2004,25(3):466-469.
[24]QIAN Z J,JUNG W K,KIM S K.Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin,Rana catesbeiana Shaw[J].Bioresource Technology,2008,99(6):1 690-1 698.
[25]张贵川,袁吕江.食源性生物活性肽的研究进展[J].中国粮油学报,2009(9):157-162.
[26]韩东宁,王艳霞,徐晨阳,等.β-酪啡肽-7对大鼠血糖及脂质过氧化的影响[J].食品科学,2012,33(5):243-247.
[27]GONZALEZ-ORTEGA O,LOPEZ-LIM?N A R,MORALES-DOMNGUEZ J F,et al.Production and purification of recombinant hypocholesterolemic peptides[J].Biotechnology Letters,2015,37(1):41-54.
[28]SUGANO M,GOTO S,YAMADA Y,et al.Cholesterollowering activity of various undigested fractions of soybean protein in rats[J].The Journal of Nutrition,1990,120(9):977-985.
[29]FERREIRA E S,SILVA M A,DEMONTE A,et al.β-Conglycinin(7S)and glycinin(11S)exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet[J].Journal of Functional Foods,2010,2(4):275-283.
[30]姚余祥,张久亮,何慧,等.鹰嘴豆降胆固醇肽的制备及活性[J].中国粮油学报,2015,30(1):33-38.
[31]ZHANG H,YOKOYAMA W H,ZHANG H.Concentration-dependent displacement of cholesterol in micelles by hydrophobic rice bran protein hydrolysates[J].Journal of the Science of Food and Agriculture,2012,92(7):1 395-1 401.
[32]陈文雅,计成,王碧莲.生物活性肽的功能与应用[J].饲料研究,2014(21):38-41.
[33]龚吉军,黄卫文,钟海雁,等.油茶粕多肽对小鼠免疫调节功能的影响[J].中国食品学报,2013,13(12):21-27.
[34]HOU H,FAN Y,LI B F,et al.Purification and identification of immunomodulating peptides from enzymatic hydrolysates of Alaska pollock frame[J].Food Chemistry,2012,134(2):821-828.
[35]FIAT A M,MIGLIORE-SAMOUR D,JOLLE S P,et al.Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities[J].Journal of Dairy Science,1993,76(1):301-310.
[36]李冠楠,夏雪娟,隆耀航,等.抗菌肽的研究进展及其应用[J].动物营养学报,2014(1):17-25.
[37]NONGONIERMA A B,FITZGERALD R J.The scientific evidence for the role of milk protein-derived bioactive peptides in humans:A review[J].Journal of Functional Foods,2015,17:640-656.
[38]NGUYEN N,CHAMPION J,PONCE J,et al.A review of unmet needs in obesity management[J].Obesity Surgery,2012,22(6):956-966.
[39]GUILLOTEAU P,ROME V,DELABY L,et al.Is caseinomacropeptide from milkproteins,an inhibitor of gastric secretion?[J].Regulatory Peptides,2010,159(1-3):129-136.
[40]THOMA-WORRINGER C,SORENSEN J,LOPEZFANDINO R.Health effects and technological features of caseinomacropeptide[J].International Dairy Journal,2006,16(11):1 324-1 333.
[41]HIRA T,MORI N,NAKAMORI T,et al.Acute effect of soybean beta-conglycinin hydrolysate ingestion on appetite sensations in healthy humans[J].Appetite,2011,57(3):765-768.
[42]NASRIA R,AMORB I B,BOUGATEFA A,et al.Anticoagulant activities of goby muscle protein hydrolysates[J].Food Chemistry,2012,133(3):835-841.
[43]马丹丹,王春蕾,朱文丽,等.海洋胶原肽对糖尿病大鼠空腹血糖的影响[J].现代预防医学,2011(23):4 840-4 842,4 849.
[44]ROJAS-RONQUILLO R,CRUZ-GUERRERO A,FLORESNAJERA A,et al.Antithrombotic and angiotensin-converting enzyme inhibitory properties of peptides released from bovine casein by Lactobacillus casei Shirota[J].International Dairy Journal,2012,26(2):147-154.
[45]KIM E K,KIM Y S,HWANG J W,et al.Purification and characterization of a novel anticancer peptide derived from Ruditapes philippinarum[J].Process Biochemistry,2013,48(7):1 086-1 090.
[46]陈锦瑶,张立实.生物活性肽的安全性评价研究进展[J].毒理学杂志,2013(2):142-146.
[47]赵兴坤,赵楠.一种全营养蚕蛹肽功能食品及其制备方法[P],中国.CN101406295,2009-04-15.
[48]赵兴坤,赵楠.一种海参肽功能食品及其制备方法[P],中国.CN101341978,2009-01-14.
[49]周世宁,邱志琦.一种功能肽强化的保健食品[P].中国,CN102356879A,2012-02-22.
[50]BONILLA J,VARGAS F C,OLIVEIRA de T G,et al.Recent patents on the application of bioactive compounds in food:a short review[J].Food Engineering and Processing,2015(5):1-7.
[51]KORHONEN H,PIHLANTO A.Bioactive peptides:production and functionality[J].International Dairy Journal,2006,16(9):946-960.
[52]崔欣,效梅,安立龙.海洋生物活性肽的生理功能及其应用研究进展[J].广东农业科学,2013,40(9):103-105,109.
[53]刘建萍.生物活性肽在饲料中的应用进展[J].饲料与畜牧,2013(8):25-28.
[54]陈琛.大豆多肽的生物功能研究进展[J].饲料研究,2010(5):28-31.
[2]章少在,张少斌.植物源活性肽的研究进展及其吸收机制[J].中国酿造,2011,30(5):1-4.
[3]NONGONIERMA A B,FITZGERALD R J.Biofunctional properties of caseinophosphopeptides in the oral Cavity[J].Caries Research,2012,46(3):234-267.
[4]POWER O,JAKEMAN P,FITZGERALD R J.Antioxidative peptides:enzymatic production,in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides[J].Amino Acids,2013,44(3):797-820.
[5]葛平珍,周才琼.源性活性肽制备与分离纯化的研究进展[J].食品工业科技,2014,35(4):363-368.
[6]UDENIGWE C C,ALUKO R E.Food protein-derived bioactive peptides:production,processing,and potential health benefits[J].Journal of Food Science,2012,77(1):R11-R24.
[7]王丙莲,孟庆军,张利群,等.HPLC-MS/MS在活性多肽检测中的应用[J].食品研究与开发,2007,28(6):159-161.
[8]李建杰,叶磊,荣瑞芬.生物活性肽的酶法制备及分离鉴定研究进展[J].食品研究与开发,2012,33(2):195-199.
[9]BYUN T,KOFOD L,BLINKOVSKY A.Synergistic action of an X-prolyl dipeptidyl aminopeptidase and a non-specific aminopeptidase in protein hydrolysis[J].Journal of Agricultural and Food Chemistry,2001,49(4):2 061-2 063.
[10]程小飞,肖通虎,章表明,等.酶膜反应器及其在生物催化领域的应用[J].高分子通报,2011(8):60-65.
[11]顾浩峰,张富新,张怡,等.乳制品中生物活性肽的研究进展[J].食品工业科技,2013,34(2):370-375+381.
[12]WANG H K,CUI L M,CHEN W,et al.An application in Gouda cheese manufacture for a strain of Lactobacillus helveticus ND01[J].International Journal of Dairy Technology,2011,64(3):386-393.
[13]迟晓星,张涛,王楠.微生物发酵法制备大豆多肽的研究[J].食品科技,2012(2):69-72.
[14]DZIUBA B,DZIUBA M.Milk proteins-derived bioactive peptides in dairy products:molecular,biological and methodological aspects[J].Acta Sci Pol Technol Aliment,2014,13(1):5-25.
[15]孔令明,李芳,陶永霞,等.多肽的功能活性与研究进展[J].中国食品添加剂,2009(3):71-73,67.
[16]KORHONEN H,PIHLANTO A.Food-derived bioactive peptides opportunities for designing future foods[J].Current Pharmaceutical Design,2003,9(16):1 297-1 308.
[17]LUNA-VITAL D A,MOJICA L,GONZALEZ DE MEJIA E,et al.Biological potential of protein hydrolysates and peptides from common bean(Phaseolus vulgaris L.):A review[J].Food Research International,2015,76:39-50.
[18]OSHIMA G,SHIMABUKURO H,NAGASAWA K.Peptide inhibitors of angiotensin converting enzyme in digests of gelation by bacterial collagenase[J].Biochimica Biophysica acta,1979,566(1):128-137.
[19]BALTI R,BOUGATEF A,SILA A,et al.Nine novel angiotensin I-converting enzyme(ACE)inhibitory peptides from cuttlefish(Sepia officinalis)muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats[J].Food chemistry,2015,170:519-525.
[20]GIRGIH A T,UDENIGWE C C,LI H,et al.Kinetics of enzyme inhibition and antihypertensive effects of hemp seed(Cannabis sativa L.)protein hydrolysates[J].Journal of the American Oil Chemists'Society,2011,88(11):1 767-1 774.
[21]SARMADI B H,ISMAIL A.Antioxidative peptides from food proteins:A review[J].Peptides,2010,31(10):1 949-1 956.
[22]张晖,唐文婷,王立,等.抗氧化肽的构效关系研究进展[J].食品与生物技术学报,2013,32(7):673-679.
[23]徐力,李相鲁,吴晓霞,等.一种新的玉米抗氧化肽的制备与结构表征[J].高等学校化学学报,2004,25(3):466-469.
[24]QIAN Z J,JUNG W K,KIM S K.Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin,Rana catesbeiana Shaw[J].Bioresource Technology,2008,99(6):1 690-1 698.
[25]张贵川,袁吕江.食源性生物活性肽的研究进展[J].中国粮油学报,2009(9):157-162.
[26]韩东宁,王艳霞,徐晨阳,等.β-酪啡肽-7对大鼠血糖及脂质过氧化的影响[J].食品科学,2012,33(5):243-247.
[27]GONZALEZ-ORTEGA O,LOPEZ-LIM?N A R,MORALES-DOMNGUEZ J F,et al.Production and purification of recombinant hypocholesterolemic peptides[J].Biotechnology Letters,2015,37(1):41-54.
[28]SUGANO M,GOTO S,YAMADA Y,et al.Cholesterollowering activity of various undigested fractions of soybean protein in rats[J].The Journal of Nutrition,1990,120(9):977-985.
[29]FERREIRA E S,SILVA M A,DEMONTE A,et al.β-Conglycinin(7S)and glycinin(11S)exert a hypocholesterolemic effect comparable to that of fenofibrate in rats fed a high-cholesterol diet[J].Journal of Functional Foods,2010,2(4):275-283.
[30]姚余祥,张久亮,何慧,等.鹰嘴豆降胆固醇肽的制备及活性[J].中国粮油学报,2015,30(1):33-38.
[31]ZHANG H,YOKOYAMA W H,ZHANG H.Concentration-dependent displacement of cholesterol in micelles by hydrophobic rice bran protein hydrolysates[J].Journal of the Science of Food and Agriculture,2012,92(7):1 395-1 401.
[32]陈文雅,计成,王碧莲.生物活性肽的功能与应用[J].饲料研究,2014(21):38-41.
[33]龚吉军,黄卫文,钟海雁,等.油茶粕多肽对小鼠免疫调节功能的影响[J].中国食品学报,2013,13(12):21-27.
[34]HOU H,FAN Y,LI B F,et al.Purification and identification of immunomodulating peptides from enzymatic hydrolysates of Alaska pollock frame[J].Food Chemistry,2012,134(2):821-828.
[35]FIAT A M,MIGLIORE-SAMOUR D,JOLLE S P,et al.Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities[J].Journal of Dairy Science,1993,76(1):301-310.
[36]李冠楠,夏雪娟,隆耀航,等.抗菌肽的研究进展及其应用[J].动物营养学报,2014(1):17-25.
[37]NONGONIERMA A B,FITZGERALD R J.The scientific evidence for the role of milk protein-derived bioactive peptides in humans:A review[J].Journal of Functional Foods,2015,17:640-656.
[38]NGUYEN N,CHAMPION J,PONCE J,et al.A review of unmet needs in obesity management[J].Obesity Surgery,2012,22(6):956-966.
[39]GUILLOTEAU P,ROME V,DELABY L,et al.Is caseinomacropeptide from milkproteins,an inhibitor of gastric secretion?[J].Regulatory Peptides,2010,159(1-3):129-136.
[40]THOMA-WORRINGER C,SORENSEN J,LOPEZFANDINO R.Health effects and technological features of caseinomacropeptide[J].International Dairy Journal,2006,16(11):1 324-1 333.
[41]HIRA T,MORI N,NAKAMORI T,et al.Acute effect of soybean beta-conglycinin hydrolysate ingestion on appetite sensations in healthy humans[J].Appetite,2011,57(3):765-768.
[42]NASRIA R,AMORB I B,BOUGATEFA A,et al.Anticoagulant activities of goby muscle protein hydrolysates[J].Food Chemistry,2012,133(3):835-841.
[43]马丹丹,王春蕾,朱文丽,等.海洋胶原肽对糖尿病大鼠空腹血糖的影响[J].现代预防医学,2011(23):4 840-4 842,4 849.
[44]ROJAS-RONQUILLO R,CRUZ-GUERRERO A,FLORESNAJERA A,et al.Antithrombotic and angiotensin-converting enzyme inhibitory properties of peptides released from bovine casein by Lactobacillus casei Shirota[J].International Dairy Journal,2012,26(2):147-154.
[45]KIM E K,KIM Y S,HWANG J W,et al.Purification and characterization of a novel anticancer peptide derived from Ruditapes philippinarum[J].Process Biochemistry,2013,48(7):1 086-1 090.
[46]陈锦瑶,张立实.生物活性肽的安全性评价研究进展[J].毒理学杂志,2013(2):142-146.
[47]赵兴坤,赵楠.一种全营养蚕蛹肽功能食品及其制备方法[P],中国.CN101406295,2009-04-15.
[48]赵兴坤,赵楠.一种海参肽功能食品及其制备方法[P],中国.CN101341978,2009-01-14.
[49]周世宁,邱志琦.一种功能肽强化的保健食品[P].中国,CN102356879A,2012-02-22.
[50]BONILLA J,VARGAS F C,OLIVEIRA de T G,et al.Recent patents on the application of bioactive compounds in food:a short review[J].Food Engineering and Processing,2015(5):1-7.
[51]KORHONEN H,PIHLANTO A.Bioactive peptides:production and functionality[J].International Dairy Journal,2006,16(9):946-960.
[52]崔欣,效梅,安立龙.海洋生物活性肽的生理功能及其应用研究进展[J].广东农业科学,2013,40(9):103-105,109.
[53]刘建萍.生物活性肽在饲料中的应用进展[J].饲料与畜牧,2013(8):25-28.
[54]陈琛.大豆多肽的生物功能研究进展[J].饲料研究,2010(5):28-31.