杀菌剂环丙唑醇的合成

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	英文篇名：Synthesis of Fungicide Cyproconazole 作者：王世银 英文作者：WANG Shi-yin;Guangdong Greatchem Chemicals Co., Ltd.; 关键词：杀菌剂 ; 环丙唑醇 ; 水合肼 ; N-二氯甲基甲脒 ; 合成 英文关键词：fungicide;;cyproconazole;;hydrazine hydrate;;N-dichloromethyl formamidine;;synthesis 中文刊名：ZJHG 英文刊名：Zhejiang Chemical Industry 机构：广东广康生化科技股份有限公司; 出版日期：2019-06-15 出版单位：浙江化工 年：2019 期：v.50 语种：中文; 页：ZJHG201906003 页数：2 CN：06 ISSN：33-1093/TQ 分类号：14-15

摘要

以1-(4-氯苯基)-2-环丙基-1-丙酮为起始原料,经硫叶立德反应生成环氧化合物,再与水合肼反应,最后与N-二氯甲基甲脒反应合成环丙唑醇,此方法避免了异构体1,3,4-三氮唑的生成,简化了后处理,含量大于98%,总收率为79.1%(以1-(4-氯苯基)-2-环丙基-1-丙酮计)。
        1-(4-chlorophenyl)-2-cyclopropyl-1-propanone was used as the starting material to form an epoxy compound by sulfur ylide reaction, which was then reacted with hydrazine hydrate and finally with N-dichloromethyl. Synthesis of cyproconazole by the reaction of formazan, this method avoided the formation of isomer 1,3,4-triazole, simplifies the post-treatment, the content was more than 98%, the total yield was79.1%(to 1-(4)-Chlorophenyl)-2-cyclopropyl-1-propanone).

引文

[1]Leonard E H,Richardt R D.Studies on hydrogen cyanide.Part 11.The compounds formed by the action of the hydrogen halides on hydrogen cyanide[J].Journal of the Chemical Society,1930:1834-1838.
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