结直肠癌转移机制研究进展
摘要
结直肠癌在我国的发病率比较高,在全球各种恶性肿瘤的发病率中位居第三位,而导致患者发生死亡的主要原因就是癌变发生侵袭和转移。肿瘤转移的步骤比较多,而且也是多阶段性的,牵扯的基因也比较多,其过程比较复杂,例如肿瘤在原发部位发生了脱离,和周围的基质相互融合,肿瘤细胞进入循环系统以及淋巴系统,在内皮细胞壁处粘附,逐渐的外延至血管或者更大的面积,发生了血管增生的现象,最终导致了新的转移灶的形成。因此本次研究针对结直肠癌转移的相关基因、微RNAs、上皮-间质转化、肿瘤干细胞、肿瘤的微循环等问题进行一简要综述。
引文
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[9] Chang CC, Lin CC, Wang CH, et al. miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation. Oncol Lett, 2018,15(5):8107-8117.
[10] Chen WS, Leung CM, Pan HW, et al. Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. Oncol Rep, 2012,28(3):1069-1076.
[11] Dong Y, Zhao J, Wu CW, et al. Tumor suppressor functions of miR-133a in colorectal cancer. Mol Cancer Res, 2013,11(9):1051-1060.
[12]王雅娟,胡洁,赵海燕,等. Tiam1与大肠癌细胞EMT的关系.世界华人消化杂志, 2009,(32):3337-3341.
[13]蔡灿锋,唐超明,曾军,等. GLUD1调控EMT促进结直肠癌细胞侵袭迁移的实验研究.岭南现代临床外科, 2015,(4):456-460.
[14]罗皓,李靖宇,朱震威,等.结直肠癌中RhoC、PRL-3与FMNL2的表达及其意义.热带医学杂志, 2013,(3):271-273,378.
[15] Peng Y, Chen Y, Zhang X, et al. Tumoral cavitation in colorectal cancer patients with unresectable lung metastasis treated with bevacizumab and chemotherapy. J Cancer Res Clin Oncol, 2018,144(7):1339-1346.
[2] Chen W. Cancer statistics:updated cancer burden in China. Chin J Cancer Res, 2015,27(1):1-12.
[3] Boysen AK, Spindler KL, H?yer M, et al. Metastasis directed therapy for liver and lung metastases from colorectal cancer-a population based study. Int J Cancer, 2018,143(12):3218-3226.
[4] Xu J, Zhou J, Dai H, et al. CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin. J Transl Med, 2018,16(1):169.
[5] Shan Y, Ma J, Pan Y, et al. LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1. Cell Death Dis, 2018,9(7):722.
[6] Bian Z, Zhang J, Li M, et al. LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2signaling. Clin Cancer Res, 2018,24(19):4808-4819.
[7] Li Q, Li Y, Li J, et al. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis. Int J Biol Sci,2018,14(7):726-735.
[8] Amawi H, Hussein NA, Ashby CR, et al. Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis. Front Pharmacol, 2018,9:520.
[9] Chang CC, Lin CC, Wang CH, et al. miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation. Oncol Lett, 2018,15(5):8107-8117.
[10] Chen WS, Leung CM, Pan HW, et al. Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. Oncol Rep, 2012,28(3):1069-1076.
[11] Dong Y, Zhao J, Wu CW, et al. Tumor suppressor functions of miR-133a in colorectal cancer. Mol Cancer Res, 2013,11(9):1051-1060.
[12]王雅娟,胡洁,赵海燕,等. Tiam1与大肠癌细胞EMT的关系.世界华人消化杂志, 2009,(32):3337-3341.
[13]蔡灿锋,唐超明,曾军,等. GLUD1调控EMT促进结直肠癌细胞侵袭迁移的实验研究.岭南现代临床外科, 2015,(4):456-460.
[14]罗皓,李靖宇,朱震威,等.结直肠癌中RhoC、PRL-3与FMNL2的表达及其意义.热带医学杂志, 2013,(3):271-273,378.
[15] Peng Y, Chen Y, Zhang X, et al. Tumoral cavitation in colorectal cancer patients with unresectable lung metastasis treated with bevacizumab and chemotherapy. J Cancer Res Clin Oncol, 2018,144(7):1339-1346.