十七味补肾益精丸的研制与临床疗效观察
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摘要
目的:十七味补肾益精丸的研制与临床疗效观察。方法:选取248例少弱精症患者随机分成两组,分别用十七味补肾益精丸和维生素E对进行治疗,三个月后观察治疗前后两组精子浓度、精子活力,血清卵泡生成激素(Follicle Stimulating Hormone,FSH)、睾酮(Teststerone,T)、促黄体生成素(Luteinizing Hormone,LH)水平。结果:十七味补肾益精丸能显著改善精子浓度和活力,血清FSH明显降低,T显著升高。结论:十七味补肾益精丸能明显改善男性少弱精子症的精子质量,其作用机制应是多层次、等环节、多途径相互影响作用的结果,多年来,未发现在使用过程中的不良反应发生,临床使用安全有效,值得进一步推广。
Objective: To study the preparation and clinical efficacy of Shiqiwei Bushen Yijing Wan( 十七味补肾益精丸). Methods:248 patients with oligoasthenozoospermia were randomly divided into two groups, and the patients were treated with Shiqiwei Bushen Yijing Wan or vitamin E. After 3 months, the sperm concentration, sperm motility, serum FSH, T and LH levels in two groups before and after treatment were observed. Results: Shiqiwei Bushen Yijing Wan can significantly improve sperm concentration and vitality, serum FSH level is significantly reduced, and T level is significantly increased. Conclusion: Shiqiwei Bushen Yijing Wan can significantly improve the sperm quality of patients with oligozoospermia,is safe and effective, is worth further promotion.
Objective: To study the preparation and clinical efficacy of Shiqiwei Bushen Yijing Wan( 十七味补肾益精丸). Methods:248 patients with oligoasthenozoospermia were randomly divided into two groups, and the patients were treated with Shiqiwei Bushen Yijing Wan or vitamin E. After 3 months, the sperm concentration, sperm motility, serum FSH, T and LH levels in two groups before and after treatment were observed. Results: Shiqiwei Bushen Yijing Wan can significantly improve sperm concentration and vitality, serum FSH level is significantly reduced, and T level is significantly increased. Conclusion: Shiqiwei Bushen Yijing Wan can significantly improve the sperm quality of patients with oligozoospermia,is safe and effective, is worth further promotion.
引文
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[8]覃光辉,王晓,姚重华,等.淫羊藿苷对雷公藤多苷模型小鼠睾丸病理损伤的影响[J].中医药导报,2009,27(07):8-10.
[9]李轩,白勇,钟树槐,等.五子衍宗丸对不育患者附睾功能和精子活力的影响[J].光明中医,2009,24(07):1222-1223.
[10]杨光旭,魏雪苗.鹿茸多肽药理学活性的研究进展[J].吉林医药学院学报,2017,38(02):126-129.
[2]王全,洪志明,陈德宁.少弱精子症的中医药治疗进展[J].新中医,2014,46(09):170-173.
[3]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015:66-343.
[4]世界卫生组织.人类精液及精子-宫颈粘液相互作用实验室检验手册[S].4版.谷栩群,陈振文,于和鸣,等,译.北京:人民卫生出版社,2001:511.
[5]陆金春,黄宇烽.特发性精液质量异常的诊断与治疗[J].中华男科学杂志,2012,18(01):3-10.
[6]谷龙杰,卢文红,陈振文.精子DNA损伤对体外受精-胚胎移植后受精及妊娠的影响[J].中华优生与遗传杂志,2011,19(07):111-112.
[7]潘晓燕,李勃彤,王政朝,等.中药在治疗哺乳动物生精障碍中的应用与研究[J].时珍国医国药,2011,2(08):1887-1889.
[8]覃光辉,王晓,姚重华,等.淫羊藿苷对雷公藤多苷模型小鼠睾丸病理损伤的影响[J].中医药导报,2009,27(07):8-10.
[9]李轩,白勇,钟树槐,等.五子衍宗丸对不育患者附睾功能和精子活力的影响[J].光明中医,2009,24(07):1222-1223.
[10]杨光旭,魏雪苗.鹿茸多肽药理学活性的研究进展[J].吉林医药学院学报,2017,38(02):126-129.