MGMT、Ki-67在脑胶质瘤中表达及临床价值
|
摘要
目的探讨张力蛋白MGMT、Ki-67在脑胶质瘤中表达及临床价值。方法选取2015年1月～2016年12月在我院和山西省人民医院神经外科接受治疗的脑胶质瘤患者68例作为研究对象,通过免疫组化法(材料来自医院病理实验室库存蜡块)检测68例胶质瘤组织中MGMT和Ki-67的表达情况,分析其表达与年龄、性别及肿瘤部位的关系。结果 MGMT和Ki-67表达在不同年龄、性别及肿瘤部位比较,差异均无统计学意义(P>0.05),随着胶质瘤级别增高,Ki-67在各级别胶质瘤阳性表达率呈增高趋势(正相关),而MGMT表达率与胶质瘤级别没有明显关系。结论 MGMT表达与胶质瘤级别无关,Ki-67表达随着肿瘤级别的增加而增加(呈正相关关系)。
Objective To investigate the expression and clinical value of MGMT and Ki-67 in gliomas.Methods Sixty-eight patients with glioma treated by neurosurgery in our hospital and Shanxi Provincial People's Hospital were selected and examined by immunohistochemistry(68 cases of glioma from the hospital pathology laboratory stock box) The expression of MGMT and Ki-67 in the tissues was analyzed,and the relationship between the expression of MGMT and Ki-67 was analyzed.Results There was no significant difference in the expression of MGMT and Ki-67 in different age, sex and tumor location(P>0.05).With the increase of glioma grade, the positive expression rate of Ki-67 at all levels(P<0.05).There was no significant relationship between MGMT expression and glioma level.Conclusion The expression of MGMT was not related to the glioma level, and the expression of Ki-67 increased with the increase of tumor grade(positive correlation).
Objective To investigate the expression and clinical value of MGMT and Ki-67 in gliomas.Methods Sixty-eight patients with glioma treated by neurosurgery in our hospital and Shanxi Provincial People's Hospital were selected and examined by immunohistochemistry(68 cases of glioma from the hospital pathology laboratory stock box) The expression of MGMT and Ki-67 in the tissues was analyzed,and the relationship between the expression of MGMT and Ki-67 was analyzed.Results There was no significant difference in the expression of MGMT and Ki-67 in different age, sex and tumor location(P>0.05).With the increase of glioma grade, the positive expression rate of Ki-67 at all levels(P<0.05).There was no significant relationship between MGMT expression and glioma level.Conclusion The expression of MGMT was not related to the glioma level, and the expression of Ki-67 increased with the increase of tumor grade(positive correlation).
引文
[1]AL Cohen,H Colman.Glioma biology and molecular markers[J]Cancer Treatment&Research,2015,163(1):15.
[2]B Kinnersley,JS Mitchell,K Gousias,etal.Quantifying the heritability of glioma using genome-wide complex trait analysis[J].Scientific Reports,2015,5:17267.
[3]C Engwer,M Knappitsch,C Surulescu.A multiscale model for glioma spread including cell-tissue interactions and proliferation[J].Mathematical Biosciences&Engineering Mbe,2016,13(2):443.
[4]T Fry,JH Evans,MJ Sanderson.Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or32[J].Microsc Res Tech,2015,52(3):289-300.
[5]KX Ma,HJ Wang,XR Li,etal.Long noncoding RNA MALAT1associates with the malignant status and poor prognosis in glioma[J].Tumor Biology,2015,36(5):3355-3359.
[6]M Ceccarelli,FP Barthel,TM Malta,etal.Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma[J].Cell,2016,164(3):550.
[7]B Auffinger,D Spencer,P Pytel,etal.The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence[J].Expert Review of Neurotherapeuti cs,2015,15(7):1-12.
[2]B Kinnersley,JS Mitchell,K Gousias,etal.Quantifying the heritability of glioma using genome-wide complex trait analysis[J].Scientific Reports,2015,5:17267.
[3]C Engwer,M Knappitsch,C Surulescu.A multiscale model for glioma spread including cell-tissue interactions and proliferation[J].Mathematical Biosciences&Engineering Mbe,2016,13(2):443.
[4]T Fry,JH Evans,MJ Sanderson.Propagation of intercellular calcium waves in C6 glioma cells transfected with connexins 43 or32[J].Microsc Res Tech,2015,52(3):289-300.
[5]KX Ma,HJ Wang,XR Li,etal.Long noncoding RNA MALAT1associates with the malignant status and poor prognosis in glioma[J].Tumor Biology,2015,36(5):3355-3359.
[6]M Ceccarelli,FP Barthel,TM Malta,etal.Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma[J].Cell,2016,164(3):550.
[7]B Auffinger,D Spencer,P Pytel,etal.The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence[J].Expert Review of Neurotherapeuti cs,2015,15(7):1-12.