BOLD-fMRI技术在眼科疾病中的运用研究进展
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摘要
随着功能磁共振技术的发展,血氧水平依赖(blood oxygenation level dependent,BOLD)功能磁共振成像(functional magnetic resonance imaging,fMRI)技术被广泛应用于视觉、视神经疾病、眼科针灸治疗等眼科领域,为眼科疾病临床诊断、治疗及病理机制的研究提供了新的方法。
With the development of functional magnetic resonance imaging technology, the technology of blood oxygenation level dependent(BOLD) functional magnetic resonance imaging(f MRI) has been widely used in study of vision, optic nerves, and acupuncture treatment on eyes, which provides a new method for clinical diagnosis, treatmentand pathological mechanismresearch of eye disease.
With the development of functional magnetic resonance imaging technology, the technology of blood oxygenation level dependent(BOLD) functional magnetic resonance imaging(f MRI) has been widely used in study of vision, optic nerves, and acupuncture treatment on eyes, which provides a new method for clinical diagnosis, treatmentand pathological mechanismresearch of eye disease.
引文
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[19]祁佩红.DTI和f MRI在前部缺血性视神经病变中的应用研究[D].河南:郑州大学,2010.
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[23]朱蔓佳,胡卡明.“肝经连目系”的功能性磁共振成像研究[J].海南医学院学报,2006,10(3):169-170.
[24]管永清,杨新治.电针刺激视觉相关穴位光明穴的脑BOLD-f MRI研究[J].河北中医,2008,30(10):1065-1067.
[25]黄心洁,赵仓焕,周全,等.视觉刺激状态下电针阳陵泉穴的f MRI研究[J].医学影像学杂志,2010,20(1):1-4.
[2]Ogawa S,Lee TM,Kay AK,et al.Brain magnetic resonance imaging with contrast dependent on blood oxygen[J].Proc Natl Acad Sci USA,1990,87(24):9868-9872.
[3]王小琴,谢清,鲁宏,等,共同性斜视患者大脑皮层激活强度的功能磁共振研究[J].眼科新进展,2015,35(3):258-262.
[4]李传明.屈光参差性弱视Broadmann17、18、19区功能改变的f MRI研究[D].重庆:第三军医大学,2006.
[5]李阳.儿童屈光参差性弱视立体视觉中枢区激活的f MRI远期研究[D].兰州:兰州大学,2016.
[6]Levi DM,Hariharan S,Klein SA.Suppressive and facilitatory spatial interactions in peripheral vision:peripheral crowding is neither size invariant nor simple contrast masking[J].Journal of Vision,2002,2(2):167.
[7]郭明霞,张云亭,张权,等.屈光不正性弱视视皮层激活对视觉信号空间和时间频率依赖性的f MRI研究[J].天津医科大学学报,2008,14(4):18-20.
[8]卢光明,张志强,梁平,等.弱视视觉运动功能的功能磁共振研究[J].中华放射学杂志,2006,40(5):494.
[9]钟玉林,周琼.屈光不正性弱视的血氧水平依赖功能磁共振成像(Bold-f MRI)临床研究进展[J].中国实用眼科杂志,2015,33(8):850-852.
[10]Barnes G,Hess R,Dumoulin S,et al.The cortical deficit in humans with strabismic amblyopia[J].J Physiol,2001,533(Pt 1):281-297.
[11]刘虎,赵堪兴,陈敏,等.斜视性和屈光参差性弱视患者的功能磁共振成像研究[J].中华眼科杂志,2006,42(10):873-877.
[12]吴坷.原发性慢性闭角型青光眼视神经DTI和Bold-f MRI应用[D].郑州:郑州大学,2011.
[13]Qing G,Zhang S,Wang B,et al.Functional MRI signal changes in Primary visual cortex corresponding to the central normal visual field of Patients with Primary open-angle glaucoma[J].Invest Ophthalmol Vis Sci,2010,51(9):4627-4634.
[14]Gu Pta N,yucel YH.Glaucoma and the brain[J].J Glaucoma,2001,10(5 Suppl 1):S28-S29.
[15]刘虎,赵堪兴,张大卫,等.急性视神经炎的功能磁共振成像研究[J].中国实用眼科学杂志,2006,24(2):155-158.
[16]Russ MO,Cleff U,Lanfermann H,et al.Functional magnetic resonance imaging in acute unilateral optic neuritis[J].J Neuroimaging,2002,12(4):339-350.
[17]Jenkins TM,Toosy AT,Ciccarelli O,et al.Neuroplasticity predicts outcome of optic neuritis independent of tissue damage[J].Ann Neurol,2010,67(1):99-113.
[18]Korsholm K,Madsen KH,Frederiksen JL,et al.Recovery from optic neuritis:an ROI-BASED analysis of LGN and visual cortical areas[J].Brain,2007,130(Pts):1244-1253.
[19]祁佩红.DTI和f MRI在前部缺血性视神经病变中的应用研究[D].河南:郑州大学,2010.
[20]马重兵,朱田田,严兴科,等.针刺干预弱视的电生理机制研究进展[J].中国中医眼科杂志,2014,24(5):385-387.
[21]Yoshida T,Tanaka C,Umeda M,et al.Non-invasive measurement of brain activity using functional MRI:toward the study of brain response to acupuncture stimulation[J].Am J Chin Med,1995,23(3-4):319-325.
[22]Cho ZH,Chung SC,Jones JP,et al.New findings of the correlation between acupoints and corresponding brain cortices using functional MRI[J].Proc Natl Acad Sci USA,1998,95(5):2670-2673.
[23]朱蔓佳,胡卡明.“肝经连目系”的功能性磁共振成像研究[J].海南医学院学报,2006,10(3):169-170.
[24]管永清,杨新治.电针刺激视觉相关穴位光明穴的脑BOLD-f MRI研究[J].河北中医,2008,30(10):1065-1067.
[25]黄心洁,赵仓焕,周全,等.视觉刺激状态下电针阳陵泉穴的f MRI研究[J].医学影像学杂志,2010,20(1):1-4.